] 實施例6)4-乙氧基-N-(2-氣-4-((5-(1-甲基-1護化挫-4-基)化咯并[1,2-6]化 嗦-4-基)氧)苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0222]
[0223] 1h Mffi(400MHz,DMS0-d6)Sl0.60(s,lH),7.95-7.85(m,5H),7.69(s,lH),7.50- 7.45(m,4H),7.39-7.35(m,2H),6.95(d,J = 2.細z,lH),6.52(d,J = 8.0Hz,lH),5.74(d,J = 5.2Hz,lH),4.26(q,J = 6.8Hz,2H),3.82(s,3H),1.30(t,J = 6.8Hz,3H)
[0224] MS:583[M+扣+
[0225] 實施例7)4-乙氧基-N-(3-氣-4-( (5-化晚-4-基川比咯并[l,2-bM嗦-4-基)氧)苯 基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0226]
[0227] 1h 醒R(400MHz,DMS0-d6)Sl0.60(s,lH),8.52-8.50(m,2H),8.09-8.06(m,2H), 7.94-7.93(m,1H),7.86(d,J = 8.OHz,1H),7.64-7.62(m,2H),7.49-7.44(m,4H) ,7.39-7.:34 (m,2H),7.16(d,J = 2.細z,lH),6.51(d,J = 8.0Hz,lH),5.96(d,J = 5.2Hz,lH),4.25(q,J = 7.2Hz,2H),1.30(t,J = 7.2Hz,3H)
[022引 MS:580[M+扣 +
[0229] 實施例8)4-乙氧基-N-(3-氣-4-( (5-(喀晚-5-基)化咯并[l,2-b]化嗦-4-基)氧) 苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0230]
[0231] 咕 NMR(400MHz,DMS0-d6)Sl0.61(s,lH),9.04(d,J = 2.8Hz,3H) ,8. ll(t,J = 3.2Hz,2H),7.93-7.90(m,lH),7.86(d,J = 7.6Hz,lH),7.53-7.44(m,4H),7.39-7.:M(m, 2H),7.21(d,J = 2.Wz,lH),6.51(d,J = 8.0Hz,lH),5.96(d,J = 5.2Hz,lH),4.25(q,J = 6.8Hz,2H),1.30(t,J = 7.2Hz,3H)
[0232] MS:581[M+W +
[0233] 實施例9)4-乙氧基-N-(3-氣-4-((5-(6-甲氧基化晚-3-基川比咯并[l,2-b]化嗦- 4-基)氧)苯基)-1-(4-氣苯基)-2-氧代-l,2-二氨R比晚-3-甲酯胺的制備
[0234]
[023引 1h 醒R(400MHz,DMS0-d6)Sl0.59(s,lH),8.38(d,J = 2.4Hz,lH),8.02-8.00(m, 2H),7.94-7.88(m,2H),7.85(d,J=8.0Hz,lH),7.47-7.44(m,4H),7.38-7.:M(m,2H),7.01- 6.99(m,lH),6.82(d,J = 8.4Hz,lH),6.51(d,J = 8.0Hz,lH),5.83(d,J = 5.6Hz,lH),4.26 (q J = 6.8Hz,2H),3.84(s,3H),1.29(t J = 6.8Hz,3H)
[0236] MS:610[M+扣 +
[0237] 實施例10)4-乙氧基-N-(3-氣-4-(巧-(嚷吩-3-基川比咯并[l,2-b]化嗦-4-基)氧) 苯基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[023引
[0239] 1h NMR(400MHz,CDCl3)Sll.66(s,lH),7.96-7.92(m,lH),7.79(d,J = 5.6Hz,lH), 7.76(d,J = 2.細z,lH),7.50(d,J = 8.0Hz,lH),7.44-7.42(m,2H),7.37-7.:M(m,2H),7.30- 7.21(m,4H),7.09(t,J = 8.4Hz,lH),6.91(d,J = 2.細z,lH),6.36(d,J = 8.0Hz,lH),5.67- 5.65(m,lH),4.36(q J = 4.0Hz,2H),1.58(t J = 8.0Hz,3H)
[0240] MS:585[M+扣 +
[OW] 實施例11)4-乙氧基-N-(3-氣-4-((5-(4-甲氧基苯基川比咯并[1,2-帥達嗦-4-基) 氧)苯基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0242]
[0243] iHNMR(400MHz,CDCl3)Sll.60(s,lH),7.93-7.89(m,lH),7.80-7.77(m,2H),7.58- 7.55(m,2H),7.50(d,J = 8.0Hz,lH),7.37-7.:M(m,2H),7.25-7.21(m,2H),7.05(t,J = 8.0Hz,lH),6.91-6.88(m,2H),6.84(d,J = 4.0Hz,lH),6.77(s,lH),6.36(d,J = 8.0Hz,lH), 5.64(d J = 4.0Hz,lH),4.36(q J = 8.0Hz,2H) ,3.81 (s,3H),1.58(tJ = 8.0Hz,3H)
[0244] MS:609[M+扣 +
[0245] 實施例12)4-乙氧基-N-(3-氣-4-( (5-(2-氣苯基)化咯并[l,2-b]化嗦-4-基)氧) 苯基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0246]
[0247] 1h NMR(400MHz,CDCl3)δll.59(s,lH),7.88(dd,J=12.4和2.4Hz,lH),7.83(d,J = 5.2Hz,lH),7.81(d,J=2.細z,lH),7.55-7.49(m,2H),7.37-7.33(m,2H),7.26-7.19(m, 4H),7.13-7.02(m,3H),6.89-6.88(m,lH),6.35(d,J = 8.0Hz,lH),5.67(d,J = 5.2Hz,lH), 4.35(q J = 7.2Hz,2H),1.58(t J = 7.2Hz,3H)
[024引 MS:597[M+W +
[0249] 實施例13州-(4-((5-(3,4-二甲氧基苯基川比咯并[1,2-6]化嗦-4-基)氧)-3-氣苯 基)-4-乙氧基-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0巧0]
[0251] 1h NMR(400MHz,CDCl3)Sll.64(s,lH),7.96-7.92(m,lH),7.80-7.78(m,2H),7.51 (d,J = 8. OHz,IH),7.37-7. :M(m,2H) ,7.25-7.21 (m,4H) ,7.18-7.15(m,IH),7.04( t,J = 8.8Hz,lH),6.89-6.86(m,2H),6.37-6.35(m,lH),5.63(d,J=5.2Hz,lH),4.36(q,J= 6.8Hz,2H),3.89(s,3H),3.83(s,3H),1.58(t,J = 6.8Hz,3H)
[0 巧 2] MS:639[M+扣 +
[0253]實施例14)4-乙氧基-N-(3-氣-4-( (5-(4-氣苯基)化咯并[l,2-bM嗦-4-基)氧) 苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0 巧 4]
[0巧5] 1h NMR(400MHz,CDCl3)δll.63(s,lH),7.92(dd,J=12.4和2.4Hz,lH),7.81(d,J = 5.6Hz,lH),7.78(d,J = 2.Wz,lH),7.60-7.56(m,2H),7.50(d,J = 7.Wz,lH),7.37-7.33 (m,2H) ,7.26-7.21 (m,3H) ,7.06-7.00(m,3H),6.83(d,J = 2.細z,lH),6.35(d,J = 8.0Hz, lH),5.66(d J = 5.2Hz,lH),4.35(q J = 6.細z,2H),1.58(tJ = 6.8Hz,3H)
[0 巧 6] MS:597[M+H]"
[0257] 實施例15)4-乙氧基-N-(3-氣-4-(巧-(嚷吩-2-基川比咯并[l,2-b]化嗦-4-基)氧) 苯基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[ο巧引
[ο巧9] 1η NMR(400MHz,CDCl3)Sll.67(s,1Η) ,7.96-7.92(m,lH),7.80(d,J = 5.2Hz,lH), 7.74(d,J = 2.8Hz,IH),7.52(d,J = 8.0Hz,lH) ,7.38-7.35(m,2H),7.30(d,J = 3.6Hz,lH), 7.24-7.19(m,4H),7.13(t J = 8.細z,lH),7.01(tJ = 4.4Hz,lH),6.94(d,J = 2.4Hz,lH), 6.37(d J = 7.細z,lH),5.68(dJ = 5.2Hz,lH),4.37(qJ = 6.細z,2H),1.59(t,J = 6.細z, 3H)
[0260] MS:585[M+扣+
[0261] 實施例16)N-(4-((5-(2-氯化晚-4-基)化咯并[l,2-b]化嗦-4-基)氧)-3-氣苯 基)-4-乙氧基-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0%2]
[0%3] 1h NMR(400MHz,CDCl3)Sll.72(s,lH),8.30(d,J = 5.2Hz,lH),8.00-7.96(m,lH), 7.91(d J = 5.2Hz,lH),7.83(d,J = 2.細z,lH) ,7.61 (s,lH) ,7.51 (tj = 7.細z,2H),7.38- 7.35(m,2H),7.30(s,lH),7.25-7.22(m,2H),7.08(t,J = 8.8Hz,lH),6.95(d,J = 2.8Hz, lH),6.38(d,J = 8.0Hz,lH),5.81(d,J = 5.2Hz,lH),4.37(q,J = 7.2Hz,2H),1.59(t,J = 7.2Hz,3H)
[0264] MS:614[M+扣+
[02化]實施例i7)n-(4-((5-(1H-化挫-4-基川比咯并[l,2-b]化嗦-4-基)氧)-3-氣苯基)- 4-乙氧基-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0%6]
[0%7] 1h NMR(400MHz,CDCl3)Sll.68(s,lH),7.97-7.93(m,lH),7.89(s,2H),7.78-7.76 (m,2H),7.52(d,J = 7.細z,lH) ,7.38-7.35(m,2H) ,7.30-7.22(m,4H) ,7.11 (t,J = 8.細z, lH),6.89(d,J = 2.4Hz,lH),6.37(d,J = 8.0Hz,lH),5.64(d,J = 5.Wz,lH),4.37(q,J = 6.8Hz,2H),1.59(t,J = 6.8Hz,3H)
[0% 引 MS:569[M+扣 +
[0269] 實施例18)4-乙氧基-N-(3-氣-4-((5-(1-甲基橫酷基)-lH-化挫-4-基川比咯并[1, 2-b ] ?達嗦-4-基)氧)苯基)-1 -(4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0270]
[0271] 1h NMR(400MHz,CDCl3)Sll.67(s,lH),8.21-8.14(m,2H),7.98-7.94(m,lH),7.83 (d,J = 5.細z,lH),7.77(d,J = 2.細z,lH),7.52(d,J = 7.6Hz,lH),7.38-7.35(m,2H),7.33- 7.30(m,lH),7.25-7.22(m,2H),7.12(t,J = 8.8Hz,lH),6.87(d,J = 2.細z,lH),6.37(d,J = 7.6Hz,lH),5.73-5.72(m,lH),4.37(q,J = 7.2Hz,2H),3.31(s,3H),1.59(t,J = 6.8Hz,3H)
[0272] MS:647[M+W +
[0273] 實施例19)4-乙氧基-N-(3-氣-4-( (5-(2-氣化晚-4-基)化咯并[l,2-b]化嗦-4- 基)氧)苯基)-1 -(4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0274]
[0275] 1h NMR(400MHz,CDCl3)Sll.70(s,lH),8.13(d,J = 5.2Hz,lH),7.98-7.95(m,lH), 7.90(d J = 5.細z,lH),7.83(dJ = 2.細z,lH),7.52(dJ = 7.細z,lH),7.46(d,J = 5.2Hz, lH),7.38-7.35(m,2H),7.30-7.19(m,4H),7.07(t,J = 8.4Hz,lH),6.96(d,J = 3.2Hz,lH), 6.37(d J = 8.0Hz,lH),5.81(d J = 5.細z,lH),4.37(qJ = 6.細z,2H),1.58(t,J = 3.細z, 3H)
[0276] MS:598[M+扣+
[0277] 實施例20)N-(4-((5-(5-氯-2-甲氧基化晚-4-基川比咯并[l,2-bM嗦-4-基)氧)- 3-氣苯基)-4-乙氧基-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[027引
[0279] 1h NMR(400MHz,CDCl3)Sll.64(s,lH),7.98(s,lH),7.94-7.91(m,lH),7.87(d,J= 5.2Hz,lH) ,7.81 (d,J = 2.細z,lH) ,7.51 (d,J = 8.0Hz,IH) ,7.41 (s,lH) ,7.37-7.:M(m,2H), 7.24-7.22(m,3H),7.00(t,J = 8.細z,lH),6.94(d,J = 3.2Hz,lH),6.37(d,J = 8.0Hz,lH), 5.73(d J = 5.2Hz,lH),4.36(q J = 6.8Hz,2H),3.88(s,3H),1.58(t J = 6.8Hz,3H)
[0280] MS:644[M+扣 +
[0281] 實施例21)N-(4-((5-(6-氨基化晚-3-基川比咯并[l,2-b]化嗦-4-基)氧)-3-氣苯 基)-4-乙氧基-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0282]
[0283] 1h 醒R(400MHz,DMS0-d6)Sl0.60(s,lH),8.14(d,J=2.0Hz,1H),7.96-7.86(m, 4H),7.61-7.58(m,lH),7.48-7.44(m,4H),7.37(t,J = 8.細z,2H),6.89(d,J = 2.細z,lH), 6.52(d,J = 8.0Hz,lH),6.43(d,J = 8.4Hz,lH),5.85(s,lH),5.76-5.75(m,2H),4.25(q,J = 6.8Hz,2H),1.29(t,J = 6.8Hz,3H)
[0284] MS:595[M+扣+
[02化]實施例22)4-乙氧基-N-(3-氣-4-( (5-(1-贓晚-4-基)-lH-化挫-4-基川比咯并[1, 2-b ] ?達嗦-4-基)氧)苯基)-1 -(4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0286]
[0287] 1η NMR(400MHz,CDCl3)Sll.06(s,lH),7.97-7.94(m,lH),7.79-7.71(m,4H),7.52 (d,J = 7.細z,lH) ,7.38-7.35(m,2H) ,7.26-7.21 (m,3H),7.10(t,J = 8.4Hz,lH),6.85(d,J =2.細z,lH),6.37(dJ = 8.0Hz,lH),5.65(dJ = 5.2Hz,lH),4.37(qJ = 6.8Hz,2H),4.23- 4.18(m,lH),3.24-3.21(m,2H),2.80-2.74(m,2H),2.19-2.15(m,2H),1.91-1.97(m,2H), 1.59(t J = 6.細z,3H)
[028引 MS:652[M+扣 +
[0289] 實施例23)4-乙氧基-N-(3-氣-4-( (5-(3-甲酯基苯基川比咯并[l,2-b]化嗦-4-基) 氧)苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0290]
[0291] 1h NMR(400MHz,CDCl3)Sll.65(s,lH),10.02(s,lH),8.16-8.15(m,lH),7.95-7.91 (m,2H),7.86(d,J = 5.2Hz,lH),7.83(d,J = 2.細z,lH),7.76-7.74(m,lH),7.53-7.48(m, 2H) ,7.38-7.:M(m,2H) ,7.24-7.22(m,3H),7.06(t,J = 8.細z,lH),6.93(d,J = 3.2Hz,lH), 6.37(d J = 7.細z,lH),5.73(dJ = 5.細z,lH),4.37(qJ = 7.2Hz,2H),1.59(t,J = 7.2Hz, 3H)
[0 巧 2] MS:607[M+扣 +
[0293] 實施例24)4-乙氧基-N-(3-氣-4-(巧-(2-(贓嗦-1-基川比晚-4-基川比咯并[l,2-b] 化嗦-4-基)氧)苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0294]
[0295] 1h NMR(400MHz,CDCl3)Sll.60(s,lH),8.15(d,J = 4.0Hz,lH),7.99-7.95(m,lH), 7.86-7.80(m,2H),7.51 (d,J = 8.OHz,IH),7.37-7.:M(m,2H) ,7.25-7.21 (m,3H) ,7.06-7.01 (m,2H),6.95-6.91(m,2H),6.36(d,J = 8.0Hz,lH),5.73(d,J = 8.0Hz,lH),4.36(q,J = 7.2Hz,2H),3.51(t,J = 4.細z,4H),2.93(t,J = 5.2Hz,4H),2.18(s,lH),1.58(t,J = 7.2Hz, 3H)
[0296] MS:665[M+扣+
[0297] 實施例25)N-(4-((5-(6-乙酷氨基化晚-3-基川比咯并[l,2-b]化嗦-4-基)氧)-3- 氣苯基)-4-乙氧基-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[029引
[0299] 1h NMR(400MHz,CDCl3)Sll.63(s,lH),8.51-8.50(m,lH),8.36(s,lH),8.20(d,J= 8.4Hz,lH),7.99-7.90(m,2H),7.85-7.81(m,2H),7.50(d,J = 7.6Hz,lH),7.37-7.:M(m, 2H),7.24-7.22(m,3H),7.03(t,J = 8.細z,lH),6.86(d,J = 2.細z,lH),6.36(d,J = 8.0Hz, lH),5.69(d J = 5.細z,lH),4.36(qJ = 7.2Hz,2H),2.17(s,3H),1.59(tJ = 6.8Hz,3H)
[0300] MS:637[M+W +
[0301] 實施例26)N-(4-((5-(2-乙酷基化晚-4-基川比咯并[l,2-b雌嗦-4-基)氧)-3-氣 苯基)-4-乙氧基-1-( 4-氣苯基-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0302]
[0303] 1h NMR(400MHz,CDCl3)δll.69(s,lH),8.61(d,J = 4.細z,lH),8.33(s,lH),7.99- 7.95(m,lH),7.91(d,J=5.2Hz,lH),7.84(d,J=2.細z,lH),7.78-7.76(m,lH),7.52(d,J= 8.0Hz,lH) ,7.38-7.35(m,2H) ,7.30-7.22(m,3H),7.13(t,J = 8.細z,lH),7.01 (d,J = 2.8Hz,lH),6.37(d J = 8.0Hz,lH),5.80(d J = 5.2Hz,lH),4.36(q J = 7.2Hz,2H),2.73(s, 3H),1.59(t,J = 6.8Hz,3H)
[0304] MS:622[M+扣+
[0305] 實施例27)N-(4-((5-(3-乙酷基苯基川比咯并[l,2-b]化嗦-4-基)氧)-3-氣苯基)- 4-乙氧基-1-(4-氣苯基-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0306]
[0307] iHNMR(400MHz,CDCl3)Sll.64(s,lH),8.27-8.26(m,lH),7.96-7.92(m,lH),7.86- 7.82(m,4H),7.51(d,J = 7.細z,lH),7.44(t,J = 7.7Hz,lH),7.37-7.32(m,2H),7.24-7.22 (m,3H),7.06(t,J = 8.7Hz,lH),6.93(d,J = 2.細z,lH),6.37(d,J = 7.9Hz,lH),5.71(d,J = 5.0Hz,lH),4.37(q,J = 7.0Hz,2H),2.58(s,3H),1.59(t,J = 7.0Hz,3H)
[030引 MS:621[M+W +
[0309] 實施例28)N-(3-氣-4-((5-(化晚-4-基川比咯并[l,2-b]化嗦-4-基)氧)苯基)-4- 甲氧基-2-氧代-1-苯基-l,2-二氨化晚-3-甲酯胺的制備
[0310]
[0;311] 1h NMR(400MHz,CDCl3)Sll.85(s,lH),8.55(d,J = 6.0Hz,2H),8.01-7.97(m,lH), 7.89(d,J = 5.4Hz,lH),7.83(d,J = 2.9Hz,lH),7.60-7.52(m,6H),7.39-7.37(m,2H),7.31- 7.28(m,lH),7.06(t,J = 8.7Hz,lH),6.96(d,J = 2.9Hz,lH),6.41(d,J = 7.9Hz,lH),5.78 (d J = 5.3Hz,lH),4.12(s,3H)
[0;312] MS:548[M+扣 +
[0313] 實施例29)N-(3-氣-4-((5-(3-徑基甲基)苯基)郵咯并[l,2-b]惦嗦-4-基)氧)苯 基)-1-( 4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[0314]
[0315] iHNMR(400MHz,CDCl3)Sll.97(s,lH),8.73-8.71(m,lH),7.93-7.89(m,lH),7.84- 7.80(m,2H),7.65-7.61(m,2H),7.59-7.57(m,lH),7.41-7.25(m,7H),7.08(t,J=8.4Hz, lH),6.90(d,J = 2.4Hz,lH),6.61(t,J = 6.細z,lH),5.71(d,J = 5.細z,lH),4.70(s,2H) [0;316] MS:565[M+扣 +
[0317] 實施例30)4-乙氧基-N-(4-( (5-(3-(乙基橫酷基)苯基)化咯并[l,2-b]化嗦-4- 基)氧)-3-氣苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨R比晚-3-甲酯胺的制備
[031 引
[0;319] 1h NMR(400MHz,CDCl3)Sll.50(s,1H),8.19(t,lH) ,7.92-7.81 (m,4H) ,7.75-7.73 (m,lH),7.52-7.48(m,2H),7.36-7.33(m,2H),7.29-7.20(m,3H),7.10(t,lH),6.92(d,J= 2.細z,lH),6. :M(d,J = 8.0Hz,1H) ,5.74-5.73(m,lH) ,4.38-4.33(q,2H) ,3.04-2.99(q, 2H),1.58(t,J = 7.2Hz,3H),1.16(t,J = 7.6Hz,3H)
[0320] MS:671[M+W +
[0321] 實施例31)4-乙氧基-N-(3-氣-4-( (5-(3-(甲基橫酷基)苯基)化咯并[l,2-b]化 嗦-4-基)氧)苯基)-1-(4-氣苯基)-2-氧代-1,2-二氨化晚-3-甲酯胺的制備
[0322]
[032;3] 1h 醒R(400MHz,CDCl3)Sll.49(s,lH),8.22(t,lH),7.92-7.81(m,4H),7.77(m, lH),7.67(m,lH),7.53-7.47(m,2H),7.36-7.33(m,2H),7.29-7.