專利名稱：：分離自皮膚細胞的組合物及其使用方法
技術領域：
：本發明涉及編碼多肽的多核苷酸、在皮膚細胞中表達的多肽以及治療患者的各種方法，所述治療方法包括給予本發明的多肽或多核苷酸。發明背景皮膚是肌體的最大器官，并起保護層作用。在嚴重燒傷人員發生的皮膚損傷可能由于缺乏對抗外部微生物感染的屏障以及體溫和體液的下降和流失而導致死亡。皮膚組織由若干層組成，最外層是由基底膜支撐并覆蓋在真皮上面的表皮。真皮下面是疏松的結締組織和覆蓋肌肉或骨組織的筋膜。皮膚是自我更新組織，因為皮膚細胞不斷形成和脫落。表皮最深層的細胞是基底細胞，其中富含能夠復制的細胞。這種復制細胞被稱為祖細胞或干細胞。復制細胞又產生稱為‘移行放大細胞(transitamplifyiingcell)’的子細胞。隨著這些細胞由基底層轉移到表皮的更表面層而分化成熟為角質細胞(成熟皮膚細胞)。在此過程中，角質細胞發生角質化并最終由皮膚表面脫落。表皮中的其它細胞包括合成黑色素的黑素細胞，黑色素是負責抗日照的保護性色素。朗格漢斯細胞也位于表皮中，起著加工外源蛋白以呈遞給免疫系統的細胞作用。真皮含有神經、血管和淋巴管、纖維組織和脂肪組織。在真皮中有成纖維細胞、巨噬細胞和肥大細胞。汗腺或皮脂腺以及毛囊穿過表皮和真皮。每根毛發都起源自一個毛囊。當拔出毛發時，毛發會在毛囊的真皮乳頭控制下的上皮細胞再生出來。當皮膚表面破裂時，例如受傷時，干細胞增殖而子代角質細胞遷移至傷口重新彌合組織。因此皮膚細胞具有在創傷作用下激活的基因。這些基因的產物包括數種生長因子，例如介導皮膚細胞增殖的表皮生長因子。可以將在皮膚中激活的基因和這些基因的蛋白產物開發為治療皮膚損傷的藥物。皮膚細胞產生的其它生長因子也可以影響其它類型細胞的生長。因為皮膚癌是一種皮膚細胞生長性紊亂，所以皮膚產生的調節細胞生長的蛋白可以開發為治療皮膚癌的藥物。皮膚產生的調節黑色素產生的蛋白可以用作保護皮膚抵抗有害日照作用的藥物。已知角質細胞分泌細胞因子并表達各種細胞表面蛋白。細胞因子和細胞表面分子是在抗感染的炎癥反應以及累及皮膚的自身免疫疾病中起重要作用的蛋白。因此，皮膚細胞表達的基因及其蛋白產物可開發成治療累及皮膚的炎癥性疾病的藥物。毛發是人體個性的重要部分。皮膚疾病可導致毛發受損。斑禿是一種特征為頭皮毛發片狀缺損的疾病。全禿是癌癥藥物治療的副作用。毛發的生長發育是由在皮膚和真皮乳頭中表達的基因的作用介導的。這樣的基因及其蛋白產物可有效開發為治療毛囊性疾病的藥物。需要新型治療法來促進皮膚傷口的愈合、防止脫發、增強毛發再生或去除毛發以及更有效而沒有副作用地治療自身免疫性皮膚病和炎癥性皮膚病。還需要對皮膚癌的更有效治療方法。因此本領域仍然需要鑒定和分離編碼在皮膚中表達的蛋白的基因，用于開發治療包括皮膚相關疾病在內的疾病的治療藥物。發明概述本發明提供在皮膚細胞中表達的多肽和編碼這些多肽的多核苷酸、包含這些多核苷酸的表達載體和宿主細胞，以及它們的使用方法。在具體的實施方案中，提供分離多核苷酸，所述分離多核苷酸包含選自以下的DNA序列(a)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述的序列；(b)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的互補序列；(c)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向互補序列；(d)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向序列；(e)與(a)-(d)序列相同的可能性為99％的序列；以及(f)與(a)-(d)序列的同一性至少為50％、75％或90％的序列。在其它實施方案中，本發明提供分離多肽以及編碼這樣的多肽的分離多核苷酸，所述分離多肽包含選自以下的氨基酸序列(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；以及(b)與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供序列的同一性至少為50％、75％或90％的序列。還提供包括含選自以下的氨基酸序列的多肽的至少一個功能部分的分離多肽(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；以及(b)與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列的同一性至少為50％、75％或90％的序列。在相關實施方案中，本發明提供包含上述多核苷酸的表達載體以及用所述載體轉化的宿主細胞。進一方面，本發明提供刺激患者角質細胞生長和移動、抑制上皮性癌細胞生長、抑制腫瘤血管發生和血管形成或調節血管生長的方法，包括給予所述患者包含分離多肽的組合物，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、342、343、395、397和398提供的序列；和(b)與SEQIDNO187、196、342、343、395、397和398提供序列的同一性為至少50％、75％或90％的序列。本發明還提供調節患者皮膚炎癥的方法，該方法包括給予所述患者包含分離多肽的組合物，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO338和347提供的序列；和(b)與SEQIDNO338和347提供序列的同一性至少為50％、75％或90％的序列。再一方面，本發明提供刺激患者上皮細胞生長的方法。所述方法包括給予所述患者包含分離多肽的組合物，所述分離多肽包括選自以下的氨基酸序列(a)SEQIDNO129和348提供的序列；和(b)與SEQIDNO129和348提供序列的同一性至少為50％、75％或90％的序列。再一方面，本發明提供抑制HIV-1結合患者白細胞、治療炎性疾病或治療癌癥的方法，所述方法包括給予所述患者包含分離多肽的組合物，所述分離多肽包括選自以下的氨基酸序列(a)SEQIDNO340、344、345和346提供的序列；和(b)與SEQIDNO340、344、345和346提供序列的同一性至少為50％、75％或90％的序列。如下詳述，本發明的分離多核苷酸和分離多肽可有效用于制備治療皮膚疾病的治療藥物。參照以下更詳細的描述可充分理解本發明的上述特征和其它特征以及獲得它們的方法。如同每個參考文獻都單獨結合到本文中一樣，本文公開的所有參考文獻都通過引用整體結合到本文中。附圖簡述圖1圖示huTR1Mrna在人組織中分布的RNA分析結果。圖解He，心臟；Br，大腦；Pl，胎盤；Lu，肺；Li，肝；SM，骨骼肌；Ki，腎；Sp，脾；Th，胸腺；Pr，前列腺；Ov，卵巢。圖2圖示muTR1a和huTR1a的MAP激酶測定結果。如正文所述加入MuTR1a(500ng/ml)、huTR1a(100ng/ml)或LPS(3pg/ml)。圖3圖示muTR1a對新生兒陰莖包皮角質細胞生長的刺激作用。圖4圖示muTR1a和huTR1a對轉化的人角質細胞細胞系HaCaT生長的刺激作用。圖5圖示muTR1a和huTR1a對人上皮癌細胞系A431生長的抑制作用。圖6圖示KS2a抑制IL-2誘導的伴刀豆球蛋白A刺激的小鼠脾細胞生長。圖7圖示KS3a和脫鐵運鐵蛋白組合對大鼠腸上皮細胞(IEC-18)生長的刺激作用。圖8圖示說明TR-1(100ng/ml)、muKS1(100ng/ml)、SDF1α(100ng/ml)和fMLP(10μM)對人PBMC的氧化爆發作用。圖9圖示muKS1和SDF1α對THP-1細胞的趨化作用。圖10圖示在腹膜內注射muKS1(50μg)、GV14B(50μg)和PBS后在C3H/HeJ小鼠中誘導的細胞浸潤。圖11證實huTR1a在CV1/EBNA和HeLa細胞系中誘導ERK1和ERK2的磷酸化作用。圖12圖示用muTR1、huTR1、huTGFα和PBS(均為100ng/ml)刺激后huTR1mRNA在HeLa細胞中的表達。圖13圖示muTR1a在PC-12(圖13A)和HaCaT(圖13B)細胞中對SRE的激活作用。圖14圖示抗EGF受體抗體對huTR1a介導的HaCaT細胞生長的抑制作用。圖15A利用單字母代碼圖示KS2cDNA的核苷酸序列(SEQIDNO464)以及推斷的氨基酸序列(SEQIDNO465)。用負數標示5′UTR。下劃線的NH2-末端氨基酸為預期前導序列，***表示終止密碼子。雙下劃線標示多腺苷酸化信號。圖15B圖示比較KS1的完整可讀框(在圖15B中稱為KLF-1)與其人同源物BRAK和小鼠α-趨化因子mCrg-2、mMig、mSDF-1、mBLC、mMIP2、mKC和mLIX。對于趨化因子而言，以前尚未描述過在KS1和BRAK的半胱氨酸3和半胱氨酸4之間存在另外5個殘基。發明詳述一個方面，本發明提供分離自哺乳動物皮膚細胞的多核苷酸。本文使用的術語“多核苷酸”是指單鏈或雙鏈的脫氧核糖核苷酸堿基聚合物或核糖核苷酸堿基聚合物，包括有義鏈和反義鏈的DNA和RNA分子。該術語包括cDNA、基因組DNA、重組DNA以及全部或部分合成的核酸分子。多核苷酸可以包括完整的基因或其部分。基因是編碼功能蛋白或RNA分子的DNA序列。有效反義多核苷酸可以包括相應的多核苷酸片段，因此“多核苷酸”的定義包括所有有效的反義片段。反義多核苷酸以及涉及反義多核苷酸的技術是本領域眾所周知的，例如Robinson-Benion等，“反義技術”，MethodsinEnzymol.254(23)363-375，1995；和Kawasaki等，Artific.Organs20(8)836-848，1996中有關于它的介紹。可以在合適的嚴格條件下，使用cDNA序列的全部或部分作為篩選合適文庫的探針，通過標準DNA/DNA雜交技術完成對基因組DNA和異鐘DNA的鑒定。或者，可以使用利用寡核苷酸引物的PCR技術擴增和鑒定基因組序列和cDNA序列，所述寡核苷酸引物是根據已知基因組DNA、cDNA和蛋白序列設計的。可以通過常規的合成方法生產相當于鑒定序列和變異體的合成DNA。正如本領域常規使用這些術語一樣，本發明提供的所有多核苷酸都是分離純化的。在具體實施方案中，本發明的多核苷酸包含選自以下序列的DNA序列SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的序列以及SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464序列的變異體。還提供包括所述DNA序列的互補序列、反向互補序列或反向序列以及這些序列的變異體的多核苷酸。以下實例最清晰地闡述了本文使用的術語“互補序列”、“反向互補序列”和“反向序列”的定義。對于序列5′AGGACC3′，互補序列、反向互補序列和反向序列如下互補序列3′TCCTGG5′反向互補序列3′GGTCCT5′反向序列5′CCAGGA3′。另一方面，本發明提供由上述多核苷酸編碼或部分編碼的分離多肽。本文使用的術語“多肽”包含任意長度的氨基酸鏈，包括全長蛋白，其中所述氨基酸殘基與共價肽鍵相連。本文使用的術語“多核苷酸編碼的多肽”包括由包含本文提供的部分分離DNA序列的多核苷酸編碼的多肽。在具體的實施方案中，本發明的多肽包括選自以下序列的氨基酸序列SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列以及這些序列的變異體。本發明的多肽可以通過將編碼所述多肽的DNA序列插入到表達載體中并在合適宿主中表達所述多肽而重組產生。可以使用本領域普通技術人員已知的各種表達載體中的任一種。表達可以在用包含編碼重組多肽的DNA分子的表達載體轉化或轉染的任何合適宿主細胞中進行。合適的宿主細胞包括原核生物細胞、酵母和高等真核細胞。優選使用的宿主細胞是大腸桿菌、昆蟲、酵母或哺乳動物細胞系(諸如COS或CHO)。以此方式表達的DNA序列可以編碼天然多肽、其部分或其其它變異體。在一個相關方面，提供至少包含多肽的功能部分的多肽，所述多肽具有選自以下序列的氨基酸序列SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列及其變異體。本文使用的多肽的“功能部分”是包含影響所述多肽功能必需的活性部位的部分，例如能夠結合一個或多個反應物的分子部分。所述活性部位可以由存在于一個或多個多肽鏈上的幾個獨立部分組成，一般具有高結合親和力。首先通過化學或酶促消化多肽或突變分析編碼多肽的多核苷酸以及隨后表達獲得的突變多肽制備多肽的片段，可鑒定所述多肽的各個功能部分。然后使用例如以下提供的典型測定，測試所述多肽片段或突變多肽，以確定哪個部分保留有生物活性。本發明多肽的各個部分和其它變異體也可以通過合成或重組方法產生。使用本領域一般技術人員周知的技術可以產生少于約100個氨基酸通常少于約50個氨基酸的合成多肽。例如，可以使用任何市售的固相技術，如氨基酸連續加入至增長的氨基酸鏈的Merrifield固相合成法，合成這種多肽。參見Merrifield，J.Am.Chem.Soc.852149-2146，1963。自動合成多肽儀器可從如PerkinElmer/AppliedBioSystems，Inc.(FosterCity，California)的供應商購買，并可按照生產商的說明書操作。可以使用標準誘變技術，如寡核苷酸定點特異性誘變(Kunkel，T.，Proc.Natl.Acad.Sci.USA82488-492，1985)，制備天然多肽變異體。也可以使用允許制備截短多肽的標準技術除去DNA序列的若干部分。一般而言，本文公開的多肽制備成分離的大致純的形式。所述多肽優選至少約80％純度，更優選至少約90％純度，而最優選至少約99％純度。在下文詳述的某些優選實施方案中，將所述分離的多肽加入到用于治療皮膚病的藥用組合物或疫苗中。本文使用的術語“變異體”包括與明確鑒定序列不同的核苷酸或氨基酸序列，其中缺失、取代或添加一個或多個核苷酸或氨基酸殘基。變異體可以是天然等位基因變異體或非天然變異體。變異體序列(多核苷酸或多肽)與本發明的序列的同一性優選為至少50％，更優選至少75％，而最優選至少90％。通過如下所述比較對比兩個序列，確定對比部分的相同殘基數目，將該數除以本發明(查詢)序列的殘基總數，并將結果乘以100，可測得同一性百分率。可以對多核苷酸或多肽序列進行序列對比，并可使用可公開得到的計算機算法測定具體區域相對于另一種多核苷酸或多肽的同一性百分率。兩種對比和鑒定多核苷酸序列相似性的典型算法是BLASTN算法和FASTA算法。可以使用BLASTP和FASTP算法檢測多肽序列的對比和相似性。BLASTX和FASTX算法比較全部讀框中翻譯的核苷酸查詢序列與多肽序列。BLASTN、BLASTP和BLASTX算法可以/blast/executables/在NCBI匿名FTP服務器(ftp//ncbi.nlm.nih.gov)上獲得。FASTA和FASTX算法可在Internet上的ftp站點ftp//tfp.virginia.edu/pub/獲得。可使用FASTA算法確定多核苷酸變異體，該算法設置為文件管理介紹并隨該算法配送的默認參數。隨所述算法配送的FASTA和FASTX1.0x版的自述文件介紹了算法的使用和默認參數。FASTA和FASTX算法的使用在Pearson，WR和Lipman，DJ，“改進的生物序列分析工具”，PNAS852444-2448，1998；和Pearson，WR，“用FASTP和FASTA快速靈敏地對比序列”，MethodsinEnzymology18363-98，1990中也有介紹。優選使用BLASTN算法2.0.4版[1998年2月24日]確定本發明的多核苷酸變異體，該算法設置為文件管理介紹并隨該算法配送的默認參數。優選使用BLASTP算法2.0.4版確定本發明的多肽變異體，該算法設置為文件管理介紹并隨該算法配送的默認參數。URL為http//www.ncbi.nlm.nih.gov/BLAST/newblast.html的NCBIWeb站點和出版物Altschul，StephenF.等，“空位BLAST和PSI-BLAST新一代蛋白質數據庫檢索程序”，NucleicAcidsRes.253389-3402，1997介紹了BLAST算法家族算法(包括BLASTN、BLASTP和BLASTX)的使用。以下工作參數優選用于使用BLASTN測定對比和相似性，得到多核苷酸的E值和同一性百分率Unix運行命令的默認參數如下blastall-pblastn-dembldb-e10-G0-E0-r1-v30-b30-iqueryseq-0results；而參數是-p程序名稱[String]；-d數據庫[String]；-e預期值(E)[Real]；-G空位開放懲罰(cost)(0調用默認運行)[Integer]；-E空位延長懲罰(0調用默認運行)[Integar]；-r核苷酸匹配獎勵(reward)(僅適用于blastn)[Integer]；-v單行描述的數目(V)[Integer]；-b顯示的對比數目(B)[Integer]；-i查詢文件[FileIn]；-oBLAST報告輸出文件[FileOut]任選(Optional)。以下工作參數優選用于使用BLASTP測定對比和相似性，得到多肽的E值和同一性百分率blastall-pblastp-dswissprotdb-e10-Gl-E11-r1-v30-b30-iqueryseq-0results；而參數是-p程序名稱[String]；-d數據庫[String]；-e預期值(E)[Real]；-G空位開放懲罰(0調用默認運行)[Integer]；-E空位延長懲罰(0調用默認運行)[Integer]；-v單行描述的數目(v)[Integer]；-b顯示的對比數目(b)[Integer]；-I查詢文件[FileIn]；-oBLAST報告輸出文件[FileOut]任選。由BLASTN、BLASTP、FASTA或相似算法獲得的查詢序列對一個或多個數據庫序列的“命中”排列和鑒定序列的相似部分。根據相似度和序列重疊長度整理命中情況。對數據庫序列的命中通常代表僅在查詢序列的一部分序列長度上重疊。如下確定多核苷酸或多肽序列的相似性百分率分別使用設定為默認參數的合適算法，例如BLASTN或BLASTP，對比多核苷酸和多肽序列；鑒定對比部分相同的核酸或氨基酸數目；將相同的核酸或氨基酸數目除以本發明的多核苷酸或多肽的核酸或氨基酸的總數；然后再乘以100，得出相似性百分率。舉例來說，在使用默認參數的BLSATN算法進行的對比中，具有220個核酸的查詢多核苷酸在520個核酸的EMBL數據庫中在23個核苷酸的序列段上命中了多核苷酸序列。命中的23個核苷酸包括21個相同的核苷酸、一個空位和一個不同核苷酸。因此，查詢多核苷酸對EMBL數據庫中的命中核苷酸的同一性百分率為21/220乘以100，或為9.5％。多肽序列相似性可以相似的方式確定。BLASTN和BLASTX算法還產生多核苷酸和多肽序列對比的“預期”值。預期值(E)表示在檢索一定大小的數據庫時，對于一定數目的連續序列，人們可“預期”偶然命中數。預期值用作測定對數據庫的命中是否為真實相似性的顯著性閾值。例如，一個多核苷酸命中測得的E值為0.1，其含義可解釋為在一個EMBL數據庫大小的數據庫中，對于具有相似得分(score)的序列的對比部分，人們可以預期簡單偶然匹配為0.1個。按此標準，序列的對比和匹配部分相同的可能性為90％。對于對比和匹配部分E值為0.01或0.01以下的序列，使用BLASTN算法在EMBL數據庫中偶然發現匹配的可能性為1％或更小。使用各種多肽數據庫，諸如SwissProt數據庫，以相似的方式可測定多肽序列的E值。按照一個實施方案，相對于本發明的每個多核苷酸和多肽，“變異”多核苷酸和多肽最好含有這樣的序列與本發明的多核苷酸和多肽相比，含有的核酸或氨基酸數目與本發明的多核苷酸和多肽相同或略少，并且產生的E值為0.01或0.01以下。即變異體多核苷酸或多肽是任何以下序列與本發明的多核苷酸和多肽相同的可能性至少為99％，使用設定為默認參數的BLASTN或BLASTX算法檢測到其E值為0.01或0.01以下。按照一個優選實施方案，變異體多核苷酸是其核酸數目與本發明的多核苷酸相同或略少的序列，它與本發明的多核苷酸相同的可能性至少為99％，使用設定為默認參數的BLASTN算法檢測到其E值為0.01或0.01以下。同樣，按照一個優選實施方案，變異體多肽是其氨基酸數目與本發明的多肽相同或略少的序列，它與本發明的多肽相同的可能性至少為99％，使用設定為默認參數的BLASTP算法檢測到其E值為0.01或0.01以下。變異體多核苷酸序列通常在嚴格條件下與所述多核苷酸序列雜交。本文使用的“嚴格條件”是指在6XSSC、0.2％SDS溶液中預清洗；在65℃、6XSSC、0.2％SDS下雜交過夜；然后在1XSSC、0.1％SDS中于65℃清洗兩次，每次30分鐘，并在0.2XSSC、0.1％SDS中于65℃清洗兩次，每次30分鐘。本文使用的以“x”具體值為基準的術語“x聚體”是指至少包含以下任何一種多核苷酸或多肽的特定數目(“x”)連續殘基的多核苷酸或多肽SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的多核苷酸；SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465多肽。根據具體序列x值可以為約20至約600。本發明的多核苷酸包括至少含下述任何一種多核苷酸或其變異體的特定數目連續殘基(x-聚體)的多核苷酸SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464多核苷酸。本發明的多肽包括至少含下述任何一種多肽的特定數目連續殘基(x-聚體)的多肽SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465多肽。按照優選實施方案，x值至少20，更優選至少40，再更優選至少60，最優選至少80。因此，本發明的多核苷酸包括含SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464提供的多核苷酸或其變異體的20聚體、40聚體、60聚體、80聚體、100聚體、120聚體、150聚體、180聚體、220聚體、250聚體的多核苷酸；或300聚體、400聚體、500聚體或600聚體的多核苷酸。本發明的多肽包括含SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的多肽或其變異體的20聚體、40聚體、60聚體、80聚體、100聚體、120聚體、150聚體、180聚體、220聚體、250聚體的多肽；或300聚體、400聚體、500聚體或600聚體的多肽。可以如以下實施例1所述，通過對哺乳動物皮膚細胞制備的cDNA文庫進行高通量測序，分離本發明的多核苷酸。或者，可以合成基于SEQIDNO1-119、198-274、349-372、399-405、410-412、416、418-455和464所提供序列的寡核苷酸探針，并用于利用雜交或聚合酶鏈反應(PCR)技術鑒定哺乳動物皮膚細胞cDNA文庫或基因組DNA文庫中的陽性克隆。探針的長度可以短于本文提供的序列，但應當至少約10個核苷酸長，優選至少約15個核苷酸長，而最優選至少約20個核苷酸長。適用于所述寡核苷酸探針的雜交和PCR技術是本領域眾所周知的(參見例如Mullis等，ColdSpringHarborSymp.QuantBiol.，51263，1987；Erlich等，PCRTechnology，StocktonPressNY，1989；(Sambrook，J，Fritsch，EF和Maniatis，T編著的MolecularCloningALaboratoryManual，第二版，ColdSpringHarborLaboratoryPress，ColdSpringHarborNewYork，1989)。可以通過限制酶消化、DNA測序等方法分析陽性克隆。另外，可以通過使用本領域熟知技術的合成方法產生本發明的DNA序列。自動合成寡核苷酸的設備可從諸如PerkinElmer/AppliedBiosystemsDivision(FosterCity，California)的供應商處購得，并可按照生產商的說明書操作。因為本發明的多核苷酸序列得自皮膚，所以它們可能編碼在皮膚生長發育以及皮膚對組織損傷和炎癥以及各種疾病狀態反應中起重要作用的蛋白。某些多核苷酸包含編碼信號序列或跨膜結構域的序列，它們使蛋白產物鑒定為分泌分子或受體。這樣的蛋白產物可能是生長因子、細胞因子或其關連受體。幾個多肽序列與已知的生物重要蛋白的相似性超過25％，并因此可能為具有相似生物功能的蛋白。具體來說，本發明多肽在諸如以下的過程中起重要作用誘導毛發生長；使皮膚干細胞分化為特化細胞類型；細胞遷移；細胞增殖和細胞-細胞相互作用。所述多肽對于保持組織完整性很重要，因此在諸如傷口愈合的過程中起重要作用。某些公開多肽在免疫應答中起調節劑作用，尤其是在知道免疫細胞在組織損傷過程中浸潤皮膚，引起皮膚細胞生長分化以后。此外，許多多肽具有免疫活性，這使它們在所有疾病狀態(不但是皮膚，而且包括機體的其它組織)中成為重要的治療標靶。抗本發明多肽的抗體和涉及本發明多肽的小分子抑制劑還可以按照本發明用于調節免疫應答和治療疾病。一方面，本發明提供使用一種或多種本發明多肽或多核苷酸治療患者疾病的方法。本文使用的“患者”是指任何恒溫動物，優選人類。在此方面，所述多肽或多核苷酸一般存在于藥用組合物或疫苗中。藥用組合物可以包含一種或多種多肽，其中每一種都可以包含一個或多個上述序列(或其變異體)以及生理學上可接受的載體。疫苗可以包含一種或多種上述多肽和非特異性免疫應答增強劑，諸如所述多肽攙入到其中的佐劑或脂質體。另一方面，本發明的疫苗或藥用組合物可以含有編碼一種或多種上述多肽的DNA，使得所述多肽可原位產生。在這樣的疫苗和藥用組合物中，所述DNA可以存在于本領域一般技術人員已知的各種傳遞系統中的任一種中，包括核酸表達系統以及細菌和病毒表達系統。合適的核酸表達系統包含在患者體內表達的必需DNA序列(諸如合適的啟動子信號和終止子信號)。細菌傳遞系統包括給予在其細胞表面表達所述多肽的免疫原性部分的細菌(諸如Bacillus-Calmette-Guerin)。在一個優選實施方案中，可以使用病毒表達系統(例如痘苗病毒或其它痘病毒、反轉錄病毒或腺病毒)引入所述DNA，病毒表達系統可能涉及使用非致病性病毒或缺陷型可復制病毒。將DNA加入到所述表達系統中的技術是本領域眾所周知的。所述DNA還可以是“裸”DNA，見例如Ulmer等，Science2591745-1749，1993介紹和Cohen，Science2591691-1692，1993的綜述。可以通過將所述DNA包被在有效轉運至細胞中的生物降解珠上，增加裸DNA的吸收。給予途徑和頻率以及給予劑量各個體之間不同。一般而言，所述藥用組合物和疫苗可以通過注射(例如皮內、肌內、靜脈內或皮下)、鼻內(例如吸入)和口服給予。一般來說，一劑中的多肽量(或一劑所述DNA原位產生的多肽量)為每kg宿主體重約1pg-約100mg，通常為每kg宿主體重約10pg-約1mg，優選為每kg宿主體重約100pg-約1μg。合適的劑量范圍將根據所述患者大小而有所變化，但通常為約0.1ml-約5ml。盡管可以在本發明的藥用組合物中使用本領域一般技術人員已知的任一合適載體，但載體的類型將根據給予方式而有所變化。對于胃腸外給予，諸如皮下注射，所述載體優選包括水、鹽水、醇、脂質、蠟或緩沖液。對于口服給予，可以使用以上載體中的任一種或固體載體，如甘露醇、乳糖、淀粉、硬脂酸鎂、糖精鈉、滑石粉、纖維素、葡萄糖、蔗糖和碳酸鎂。還可以使用生物降解微球(例如聚乳酸半乳糖苷(galactide))作為本發明藥用組合物的載體。合適的生物降解微球公開于例如美國專利第4,897,268和5,075,109號。在本發明的疫苗中可以使用各種佐劑中的任一種，以非特異性增強免疫應答。大多數佐劑包含設計用來保護抗原免受快速分解代謝的物質(諸如氫氧化鋁或礦物油)和免疫應答的非特異性刺激劑(諸如類脂A、百日咳桿菌(Bordetellapertussis)或結核分支桿菌(M.tuberculosis))。合適的佐劑可市售獲得，如弗氏不完全佐劑和弗氏完全佐劑(DifcoLaboratories，Detroit，Michigan)，以及Merck佐劑65(MerckandCompany，Inc.，Rahway，NewJersey)。其它合適的佐劑包括明礬、生物降解微球、單磷酰脂質A和QuilA。本發明的多核苷酸還可在遺傳疾病的鑒定中用作組織標記、用作染色體標志或標記，以及用于設計寡核苷酸，以使用本領域周知技術(諸如Synteni(PaloAlto，California)提供的微陣列技術)檢測表達模式。通過例如使用基于本發明序列的雜交探針或PCR引物篩選DNA表達文庫，可利用本文公開的部分多核苷酸序列獲得全長基因。另外，本發明提供的多核苷酸可用在檢測生物活性、產生抗體、分離相應的配體或受體的測定中，用在定量檢測作為抗炎藥物的蛋白或相關對應配體或受體水平的測定中，以及用在用于皮膚、結締組織和/或神經組織生長或再生的組合物中。實施例1從皮膚細胞表達文庫中分離cDNA序列通過對構建自表1所示的特化嚙齒類或人類皮膚細胞的cDNA表達文庫進行高通量測序，獲得本發明的cDNA序列。表1文庫皮膚細胞類型來源DEPA真皮乳頭大鼠SKTC角質細胞人HNFF新生兒包皮成纖維細胞人MEMS胚胎皮膚小鼠KSCL角質形成細胞干細胞小鼠TRAM移行放大細胞小鼠如下所述制備這些cDNA文庫。真皮乳頭的cDNA文庫(DEPA)使得自大鼠觸須(腮須)的真皮乳頭細胞在培養基中生長，并使用確立的方案由這些細胞提取總RNA。采用Poly(A)QuikmRNA分離試劑盒(Stratagene，LaJolla，California)，按照生產商的說明書，用利用TRIzol試劑(BRLLifeTechnologies，Gaithersburg，Maryland)分離的總RNA獲得mRNA。然后通過使用λZAPcDNA文庫合成試劑盒(Stratagene)經反轉錄合成由所述mRNA制備cDNA表達文庫。角質細胞的cDNA文庫(SKTC)使得自人類新生兒包皮的角質細胞(Mitra，R和Nikoloff，B，載于HandbookofKeratinocyteMethods，第17-24頁，1994)在無血清KSFM(BRLLifeTechnologies)中生長，并與分化細胞(108細胞)一起收獲。通過以10％的終濃度向培養基中加入胎牛血清使角質細胞分化，并在48小時后收獲細胞。用TRIzol試劑(BRLLifeTechnologies)從兩個細胞群中分離總RNA，并采用Poly(A)QuikmRNA分離試劑盒(Stratagene)由總RNA中獲得mRNA。使用PCR-選擇cDNA扣除試劑盒(Clontech，PaloAlto，California)富集分化角質細胞表達的cDNA。簡而言之，由未分化角質細胞(“驅動者mRNA(drivermRNA)”)或分化角質細胞(“測試者mRNA(testermRNA)”)中獲得mRNA，并用于合成cDNA。用RsaI分別消化兩個cDNA群獲得較短的平端分子。通過在所述cDNA末端連接不同的接頭產生兩個測試者群，用過量驅動者cDNA進行兩輪連續雜交。所述接頭只允許分化表達序列進行PCR擴增，然后所述序列連接入T-tailedpBluescript(Hadjeb，N和Berkowitz，GA，BioTechniques2020-221996)中，使得可對包含具有插入片段的載體的細胞進行藍/白選擇。分離白色細胞并利用其獲得用于測序的質粒DNA。人類新生兒成纖維細胞的cDNA文庫(HNFF)在培養基中培養得自人類新生兒包皮移植物的成纖維細胞，并使用確立的方案由這些細胞中提取總RNA。使用Poly(A)QuikmRNA分離試劑盒(Stratagene，LaJolla，California)并按照生產商的說明書由用TRIzol試劑(BRLLifeTechnologies，Gaithersburg，Maryland)分離的總RNA獲得mRNA。然后使用λZAPcDNA文庫合成試劑盒(Stratagene)由所述mRNA經反轉錄酶合成制備cDNA表達文庫。小鼠胚胎皮膚的cDNA文庫(MEMS)顯微解剖交配后13天的Balb/c小鼠胚胎皮膚。在磷酸緩沖鹽水中清洗胚胎皮膚，并利用QuickPrepMicromRNA純化試劑盒(Pharmacia，Sweden)直接分離小鼠胚胎皮膚mRNA。然后使用mRNA按照以上DEPA文庫制備所述制備cDNA文庫。小鼠干細胞(KSCL)和移行放大(TRAM)細胞的cDNA文庫從產后1-2天的新生Balb/c小鼠獲取毛皮，清洗并在胰蛋白酶(BRLLifeTechnologies)中溫育，以分離表皮和真皮。破壞表皮組織以分散細胞，然后在生長培養基中重懸浮，并在按照生產商(Pharmacia，Sweden)的方案制備的Percoll密度梯度上離心。使用羅丹明123(BertoncelloI，HodgsonGS和BradleyTR，ExpHematol，13999-1006，1985)標記沉淀細胞，用流式細胞儀(EpicsEliteCoulterCytometry，Hialeah，Florida)進行分析。然后用交叉反應抗大鼠CD29生物素單克隆抗體(Pharmingen，SanDiego，California；克隆Ha2/5)標記羅丹明標記的小鼠角質細胞的單細胞懸浮液。清洗細胞并與結合抗小鼠CD45藻紅蛋白的單克隆抗體(Pharmingen；克隆30F11.1，10μg/ml)溫育，然后用鏈霉抗生物素光譜紅(SouthernBiotechnology，Birmingham，Alabama)標記。使用表格型(listmode)數據定義分選門(sortgate)，鑒定了4個細胞群CD29明亮羅丹明灰暗CD45陰性細胞；CD29明亮羅丹明明亮CD45陰性細胞；CD29灰暗羅丹明明亮CD45陰性細胞；和CD29灰暗羅丹明灰暗CD45陰性細胞。分離、沉淀細胞，快速冷凍后儲存在-80℃。此方案實施多次，以獲得每種細胞群的足夠制備cDNA文庫的細胞數。已知皮膚干細胞和移行放大細胞表達CD29—整聯蛋白β1鏈。白細胞特異性抗原CD45在分離皮膚干細胞和移行放大細胞時用作排除細胞的標記。角質細胞干細胞比移行放大細胞更有效地排出羅丹明染料。分選CD29明亮羅丹明灰暗的CD45陰性細胞群(推定為角質細胞干細胞；稱為KSCL)和CD29明亮羅丹明明亮的CD45陰性細胞群(角質細胞移行放大細胞，稱為TRAM)，使用QuickPrepMicromRNA純化試劑盒(Pharmacia，Sweden)由每個細胞群直接分離mRNA。然后使用所述mRNA按照以上DEPA文庫的描述制備cDNA文庫。使用PerkinElmer/AppliedBiosystemsDivisionPrism377測序儀對上述cDNA文庫進行高通量測序，獲得cDNA序列。實施例2分離cDNA序列的特征使用計算機算法FASTA和/或BLASTN比較分離的cDNA序列和EMBLDNA數據庫序列。使用計算機算法FASTX和/或BLASTP比較對應的推測蛋白序列(6個讀框中的每一個讀框的DNA都被翻譯成蛋白)和SwissProt數據庫序列。1998年3月21日對SEQIDNO1-119提供的DNA序列與EMBLDNA數據庫序列進行對比(使用FASTA)，以及SEQIDNO120-197提供的氨基酸序列與SwissProt數據庫序列進行對比(使用FASTX)。1998年10月7日對SEQIDNO198-274提供的DNA序列與EMBLDNA數據庫序列進行對比(使用BLASTN)，以及SEQIDNO275-348提供的氨基酸序列與SwissProt數據庫序列進行對比(使用BLASTP)。1999年1月23日對SEQIDNO349-372提供的DNA序列與EMBLDNA數據庫序列進行對比(使用BLASTN)，以及SEQIDNO373-398提供的氨基酸序列與SwissProt數據庫序列進行對比(使用BLASTP)。2000年4月23日對SEQIDNO418-455提供的多核苷酸序列與EMBLDNA數據庫序列進行對比(使用BLASTN)，以及SEQIDNO456-463提供的多肽序列與SwissProt數據庫序列進行對比(使用BLASTP)。用計算機分析分離的cDNA序列及其對應的推測蛋白序列中存在的鑒定分泌分子的信號序列。SEQIDNO1-44、198-238、349-358、399、418-434和440-449提供在序列推測起始位點具有信號序列的分離cDNA序列。使用上述FASTA或BLASTN計算機算法測定SEQIDNO1-6、198-199、349-352、354、356-358和440的cDNA序列與EMBL數據庫序列的同一性小于75％(如上所述測定)。使用上述FASTX或BLASTP計算機算法測定SEQIDNO120-125、275-276、373-380和382的推測氨基酸序列與SwissProt數據庫序列的同一性小于75％(如上所述測定)。對某些分離的部分cDNA序列的進一步測序使得分離了SEQIDNO7-14、200-231、372、418-422、441-448的全長cDNA序列。分別以SEQIDNO126-133、277-308和396提供由SEQIDNO7-14、200-231和372的cDNA序列編碼的氨基酸序列。SEQIDNO418-422的cDNA序列與SEQIDNO7和11-14的cDNA序列編碼相同的氨基酸序列，分別為SEQIDNO126和130-133。使用上述計算機算法FASTA或BLASTN比較所述全長cDNA序列和EMBL數據庫序列，結果顯示與已知序列的同一性小于75％(如上所述測定)。使用上述計算機算法FASTX或BLASTP比較SEQIDNO126-133和277-308提供的氨基酸序列與SwissProt數據庫序列，結果顯示與已知序列的同一性小于75％(如上所述測定)。使用計算機算法FASTA數據庫比較對應于SEQIDNO15-23的cDNA序列的推測氨基酸序列和EMBL數據庫序列，結果顯示與已知序列的同一性小于75％(如上所述測定)。SEQIDNO134-142提供這些推測的氨基酸序列。對某些分離的部分cDNA序列的進一步測序使得分離出SEQIDNO24-44、232-238、423-434和449全長cDNA序列。分別以SEQIDNO143-163、309-315和456提供由SEQIDNO24-44、232-238和429的cDNA序列編碼的氨基酸序列。SEQIDNO423-428、430-434和449的cDNA序列與SEQIDNO27-29、34、35、37、40-44和238的cDNA序列編碼相同的氨基酸序列，分別為SEQIDNO146-148、153、154、156、159-163和315。如上所述使用計算機算法FASTX測定這些氨基酸序列與SwissProt數據庫已知序列的同一性小于75％。對與已知表達序列標志(EST)或公共數據庫中的其它DNA序列的同一性小于75％的分離cDNA序列，或其對應的與已知蛋白序列的同一性小于75％的推測蛋白序列，用計算機分析其存在的編碼推定膜結合分子的跨膜結構域。SEQIDNO45-63、239-253、359-364、400-402、435、436、450-452和455提供在序列中具有一個或多個跨膜結構域的分離cDNA序列。使用FASTA或BLASTN計算機算法發現SEQIDNO45-48、239-249、359-361、363、450、451和455的cDNA序列與EMBL數據庫序列的同一性小于75％(如上所述測定)。使用FASTX或BLASTP數據庫發現由SEQIDNO45-48、239-249、359-361、363、450和451的cDNA序列編碼的氨基酸序列(分別以SEQIDNO164-167、316-326、383、385-388、407-408、460和461提供)與SwissProt數據庫序列的同一性小于75％(如上所述測定)。SEQIDNO455的cDNA序列與SEQIDNO359的cDNA序列編碼相同的氨基酸序列，即SEQIDNO383。比較對應于SEQIDNO49-63、250-253、436和452cDNA序列的氨基酸序列與SwissProt數據庫序列，結果顯示與已知序列的同一性小于75％(如上所述測定)。分別以SEQIDNO168-182、327-330、457和462提供這些推測氨基酸序列。使用自動化檢索程序篩選編碼據報道具有治療和/或診斷用途的分子的序列，測定如以上實施例1所述分離的某些cDNA序列，其編碼的推斷蛋白序列似乎是已知蛋白家族成員。在本文中家族成員定義為翻譯多肽與蛋白家族的已知蛋白或成員的同一性至少為25％。SEQIDNO64-76、254-264、365-369、403、437-439、453和454提供這些cDNA序列。分別以SEQIDNO183-195、331-341、389-393、409、458、459和463提供由SEQIDNO64-76、254-264、365-369、403、438、439和453的cDNA序列編碼的氨基酸序列。SEQIDNO437和454的cDNA序列與SEQIDNO68和262的cDNA序列編碼相同的氨基酸序列，分別為SEQIDNO187和339。使用FASTA或BLASTN計算機算法顯示SEQIDNO64-68、254-264、365-369、453和454的cDNA序列與EMBL數據庫序列的同一性小于75％(如上所述測定)。同樣，顯示SEQIDNO183-195、331-341、389-393、458、459和463的氨基酸序列與SwissProt數據庫序列的同一性小于75％。根據與已知蛋白的相似性，以下提供由SEQIDNO64-76、254-264、365-369、403、438、439、453和454的DNA序列編碼的各蛋白功用。表2新型蛋白的功能因此，這些分離序列編碼影響幾種細胞類型的生長、分化和活化的蛋白。通常可以將它們開發成治療和診斷皮膚損傷、癌癥、生長發育缺陷以及炎癥性疾病的藥物。SEQIDNO77-117、265-267和404-405的多核苷酸序列在角質細胞干細胞(KSCN)或移行放大細胞(TRAM)中差異表達，其根據是這些序列獨自出現在以上兩個文庫任一個中的次數；在一個文庫中超過9次，而在另一個文庫中沒有(AudicS.和ClaverieJ-M，GenomeResearch，7986-995，1997)。使用上述計算機算法FASTA或BLASTN測定，SEQIDNO77-89、265-267和365-369的序列與EMBL和SwissProt數據庫序列的同一性小于75％。這些多核苷酸序列編碼的蛋白用作鑒定和分離這些細胞類型的標志，而抗這些蛋白的抗體可有效用于從細胞的復雜混合物中分離和富集這些細胞。干細胞群獨有的分離多核苷酸及其相應蛋白可用作藥物靶，以改變對皮膚細胞生長和分化的調節，或用于基因打靶以將特異性治療分子轉運至皮膚干細胞。實施例3分離和表征muTR1的人類同源物如以上實施例1所述獲得muTR1(SEQIDNO68)的人同源物，通過篩選50,000pfu寡脫氧胸苷引導的Hela細胞cDNA文庫進行分離。使用標準分子生物學技術(Sambrook，J，Fritsch，EF和Maniatis，T編著，MolecularCloningALaboratoryManual，第二版，ColdSpringHarborLaboratoryPress，ColdSpringHarborNewYork，1989)進行噬菌斑轉移、雜交和篩選。SEQIDNO118提供測定的分離人同源物(huTR1)cDNA序列，SEQIDNO196提供對應的推測氨基酸序列。使用對應于SEQIDNO118編碼區的核苷酸1-459的[α32P]-dCTP標記的雙鏈cDNA探針篩選所述文庫。huTR1多核苷酸序列具有類似于轉化生長因子-α的區，表明該蛋白功能類似于表皮生長因子(EGF)。此EGF樣蛋白用于刺激角質細胞生長和遷移以及抑制上皮性癌細胞生長。因此這種新基因及其編碼蛋白可用作治療創傷的藥物和上皮性癌細胞的調節劑。應用RNA印跡分析RNA轉錄物通過用包含SEQIDNO118的核苷酸96-273并用[α32P]-dCTP放射性標記的探針探測人組織mRNA印跡(Clontech)，進行RNA分析，以測定huTR1mRNA的大小和分布。如Sambrook等(同上)所述進行預雜交、雜交、清洗和探針標記。huTR1mRNA的大小為3.5-4kb，觀察到其在心臟和胎盤中最豐富，而在脾、胸腺、前列腺和卵巢中觀測到的表達水平較低(圖1)。huTR1mRNA在心臟和胎盤中的高豐度表明huTR1在血管形成或保持中起作用，因為與機體的其它組織相比心臟和胎盤組織的血管豐度增加，因此內皮細胞豐度也增加。這再次證明huTR1在腫瘤血管發生和血管形成方面的作用。其支持依據是轉化生長因子-α和EGF能夠誘導血管重產生(Schreiber等，Science2321250-1253，1986)并刺激內皮細胞合成DNA(Schreiber等，Science2321250-1253，1986)及其在各種人類腫瘤中的過量表達。純化muTR1和huTR1將編碼muTR1氨基酸53-103(SEQIDNO342)的muTR1多核苷酸177-329(SEQIDNO268)以及編碼huTR1的氨基酸54-104(SEQIDNO343)的huTR1多核苷酸208-360(SEQIDNO269)克隆入細菌表達載體pProEXHT(BRLLifeTechnologies)，該載體含有一個細菌前導序列和N末端6×組氨酸標記。按照Sambrook等所述(同上)將這些構建物轉化入感受態XL1-Blue大腸桿菌中。在包含100μg/ml氨芐青霉素的Terrific肉湯培養基中于37℃過夜培養這些重組XL1-Blue大腸桿菌的引子培養物。使培養物旋轉減慢并將其接種到500ml包含100μg/ml氨芐青霉素的Terrific肉湯培養基。培養物生長至細胞OD595達到0.4至0.8之間，然后加入IPTG至1mM。過夜誘導所述細胞，離心收集細菌。muTR1多肽(SEQIDNO342，稱為muTR1a)和huTR1多肽(SEQIDNO343，稱為huTR1a)二者都表達在不溶性包涵體中。為了純化muTR1a多肽和huTR1a多肽，在裂解緩沖液(20mMTris-HClpH8.0，10mMβ巰基乙醇，1mMPMSF)中重懸浮細菌細胞沉淀。向裂解細胞中加入1％NP40，并在冰上溫育所述混合物10分鐘。進一步在冰上以95W、4×15秒超聲波破碎裂解物，然后以14,000rpm離心15分鐘沉淀包涵體。獲得的沉淀物在包含0.5％CHAPS(w/v)的裂解緩沖液中重懸浮，在冰上超聲5-10秒。將該混合物儲存在冰上1小時，以14,000rpm于4℃離心15分鐘，棄去上清液。如前所述，使沉淀物再次重懸浮在包含0.5％CHAPS(w/v)的裂解緩沖液中、超聲、離心和去除上清液。沉淀物在增溶緩沖液(6M鹽酸胍、0.5MNaCl、20mMTrisHCl、pH8.0)中重懸浮，以95W、4×15秒超聲處理，然后以14,000rpm于4℃離心20分鐘以除去碎片。上清液在用前儲存于4℃。使用鎳螯合瓊脂糖凝膠柱(AmershamPharmacia，Uppsala，Sweden)并按照生產商推薦的方法，利用包含在細菌前導序列中的N末端6×組氨酸標記純化muTR1a和huTR1a多肽。為了重折疊純化后的蛋白，在1小時內于4℃將所述蛋白溶液加入至其5倍體積的重折疊緩沖液(1mMEDTA、1.25mM還原谷胱甘肽、0.25mM氧化谷胱甘肽、20mMTris-HCl，pH8.0)中。在這段時間內快速攪拌重折疊緩沖液，并且于4℃持續攪拌過夜。然后使用標準方法經超濾濃縮重折疊蛋白。muTR1a和huTR1a多肽的生物活性muTR1和huTR1是EGF家族(包括EGF、TGFα、epiregulin等)的新成員。已知這些生長因子起EGF受體配體的作用。EGF受體激活途徑有許多文獻資料證明。配體與EGF受體一旦結合，則發生一連串事件，包括已知為MAP激酶的蛋白的磷酸化。因此MAP激酶磷酸化可用作EGF受體激活的標記。存在識別2種MAP激酶蛋白-ERK1和ERK2磷酸化形式的單克隆抗體。為了檢測純化的muTR1a和huTR1a多肽是否起EGF受體配體的作用，將人表皮癌細胞系A431(美國典型培養物保藏中心，No.CRL-1555，Manassas，Virginia)細胞接種到6孔培養板中，血清饑餓24小時，然后在無血清條件下用純化的muTR1a或huTR1a刺激5分鐘。作為陽性對照，以相同的方式用10-100ng/ml的TGF-α或EGF刺激細胞。作為陰性對照，用包含不同量LPS的PBS刺激細胞。立即裂解細胞，用Bradford測定法檢測裂解液蛋白濃度。將15μg各樣品蛋白加樣于12％SDS-PAGE凝膠。然后使用標準技術將所述蛋白轉移至PVDF膜。對于蛋白質印跡，在封閉緩沖液(10mMTris-HCl、pH7.6，100mMNaCl，0.1％Tween-20，5％脫脂奶)中于室溫溫育膜1小時。在封閉緩沖液中加入兔抗活性MAP激酶pAb(Promega，Madison，Wisconsin)至50ng/ml，并于4℃溫育過夜。在無脫脂奶的封閉緩沖液中清洗膜30分鐘，然后在室溫下與在封閉緩沖液中稀釋3500倍的抗兔IgG-HRP抗體溫育1小時。在無脫脂奶的封閉緩沖液中清洗膜30分鐘，然后在無脫脂奶和0.1％Tween-20的封閉緩沖液中再清洗5分鐘。然后把膜在ECL試劑中暴露2分鐘，接著放射自顯影5-30分鐘。如圖2所示，發現muTR1a和huTR1a二者均相對于本底水平誘導ERK1和ERK2磷酸化，這表明muTR1和huTR1起細胞表面受體配體的作用，激活MAP激酶信號轉導途徑，可能是EGF受體。如圖11所示，還證實與陰性對照相比，huTR1a誘導培養CV1/EBNA腎上皮細胞的ERK1和ERK2磷酸化。如上所述進行這些測定。表明huTR1a起細胞表面受體配體的作用，激活MAP激酶信號轉導途徑，可能是HeLa和CV1/EBNA細胞的EGF受體。如下測定muTR1a刺激新生兒陰莖包皮(NE)角質細胞生長的能力。在補加牛垂體提取物(BPE)和表皮生長因子(EGF)的KSFM(BRLLifeTechnologies)中培養取自外科手術廢棄物的NF角質細胞。在96孔平底板中于0.1ml未補加的KSFM中進行測定。將MuTR1a、人轉化生長因子α(huTGFα)或PBS-BSA滴定至板中，并向每孔中加入1×103NF角質細胞。在5％CO2氣氛下于37℃溫育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通過MTT染料還原測定細胞生長的程度。如圖3所示，muTR1a和陽性對照人TGFα二者都刺激NF角質細胞生長，而陰性對照PBS-BSA沒有此作用。如下測定muTR1a和huTR1a刺激轉化人角質細胞系HaCaT生長的能力。在96孔平底板中于0.1ml補加0.2％FCS的DMEM(BRLLifeTechnologies)中進行測定。將muTR1a、huTR1a和PBS-BSA滴定至板中，并向每孔中加入1×103HaCaT細胞。在含10％CO2的大氣中于37℃溫育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通過MTT染料還原測定細胞生長的程度。如圖4所示，muTR1a和huTR1a二者都刺激HaCaT細胞生長，而陰性對照PBS-BSA沒有此作用。如下測定muTR1a和huTR1a抑制A431細胞生長的能力。如前所述(J.Cell.Biol.931-4，1982)滴定多肽MuTR1a(SEQIDNO342)和huTR1a(SEQIDNO343)以及PBS-BSA，并如前所述(J.Imm.Meth.93157-165，1986)用MTT染料還原測定細胞死亡。發現muTR1a和huTR1a二者都抑制A431細胞的生長，而陰性對照PBS-BSA不能(圖5)。這些結果表明muTR1和huTR1刺激角質細胞生長和遷移、抑制上皮性癌細胞的生長，并在腫瘤血管發生和血管形成中起作用。因此該新基因與其編碼蛋白可開發成治療創傷、血管發生的藥物和上皮性癌癥的調節物。上調huTR1和mRNA表達在10厘米培養皿中以每皿1×106細胞的濃度接種HeLa細胞(人宮頸腺癌)。培養過夜后，去除培養基并更換為包含100ng/ml的muTR1、huTR1、huTGFα或作為陰性對照的PBS的培養基。18小時后，去除培養基并在2mlTRIzol試劑(GibcoBRLLifeTechnologies，Gaithersburg，Maryland)中裂解細胞。按照生產商的說明書分離總RNA。為鑒定cDNA樣品的huTR1mRNA水平，在標準PCR反應中使用1μlcDNA。30個循環后，由每個PCR反應取出5μl，在1.5％瓊脂糖凝膠上進行分離。通過溴化乙錠染色對條帶顯色。由圖12可見，與用陰性對照PBS刺激的細胞相比，小鼠TR1和人TR1都上調huTR1mRNA水平。而且，TGFα也可以上調huTR1mRNA水平。這些結果表明，TR1能夠維持其自身的mRNA表達以及隨后的蛋白表達，因此預期其能對高水平細胞因子表達參與疾病病理學的疾病(如牛皮癬)發展起作用。而且，因為TGFα可以上調huTR1表達，所以TR1mRNA的上調對于TGFα的作用模式可能是關鍵性的。血清效應元件報導基因測定血清效應元件(SRE)是生長調節許多細胞立即早期基因必需的啟動子元件。已有研究證實，MAP激酶信號轉導途徑可調節SRE活性。本實驗室開發了兩個細胞系，即包含8個SV40啟動子上游SRE和熒光素酶報導基因的PC12(大鼠嗜鉻細胞瘤-神經瘤)和HaCaT(人轉化角質細胞)。在96孔板的每孔中等分5×103細胞，并使它們在其各自的培養基中生長24小時。在5％胎牛血清(FBS)的D-MEM中培養HaCaTSRE細胞，其中在D-MEM中補加2mML-谷氨酸鹽(Sigma，St.Louis，Missouri)、1mM丙酮酸鈉(BRLLifeTechnologies)、0.77mML-天冬酰胺(Sigma)、0.2mM精氨酸(Sigma)、160mM青霉素G(Sigma)、70mM二氫鏈霉素(RocheMolecularBiochemicals，Basel，Switzerland)和0.5mg/ml遺傳霉素(BRLLifeTechnologies)。在5％胎牛血清的HamF12培養基中培養PC12SRE細胞，其中HamF12培養基補加0.4mg/ml遺傳霉素(BRLLifeTechnologies)。然后將培養基改變為0.1％FBS并再溫育24小時。然后從1μg/ml起逐步增加TR1刺激細胞。使用單一劑量的100ng/ml堿性成纖維細胞生長因子(R&DSystems，Minneapolis，Minnesota)或10ng/ml的表皮生長因子(BRLLifeTechnologies)作為陽性對照。在存在muTR1或陽性對照的情況下溫育細胞6小時，在PBS中清洗兩次，并用40μl裂解緩沖液(Promega)裂解細胞。轉移10μl至96孔培養板，并利用Victor2熒光計(Wallac)經直接注射將10μl熒光素酶底物(Promega)加入每孔中，震搖所述板并以3×1秒的間隔讀取每孔的發光。使用以下方程計算SRE誘導倍數SRE誘導倍數＝激動劑平均相對發光/陰性對照平均相對發光。如圖13所示，muTR1激活PC-12(圖13A)和HaCaT(圖13B)細胞二者的SRE。這表明HaCaT和PC-12細胞能夠對muTR1蛋白產生反應并激發反應。在HaCaT細胞的情況下，該反應是一種生長反應。在PC-12細胞的情況下，該反應可以是生長、生長抑制、分化或遷移反應。因此，TR1對于神經細胞發育或其分化為專化神經亞群可能很重要。TR1可能對于神經腫瘤的發生和發展也很重要。EGF受體抑制測定如前所述進行HaCaT生長測定，但是進行了以下改進。在所述培養基中加入EGF和TR1的同時，以62.5ng/ml的濃度加入抗-EGF受體(EGFR)抗體(Promega，Madison，Wisconsin)或陰性對照抗體小鼠IgG(PharMingen，SanDiego，California)。由圖14可見，阻斷EGFR功能的抗體抑制TR1對HaCaT細胞的促有絲分裂性。這表明EGFR對于TR1促有絲分裂信號傳遞到HaCaT細胞是至關重要的。TR1可以直接結合EGF受體。TR1也可以結合能夠與EGFR異二聚化的EGFR家族任何其它成員(例如ErbB-2、-3和/或-4)。HuTR1的剪接變異體按照相同方法由與huTR1相同的文庫分離huTR1變異體。稱為huTR1-1的序列(也叫做TR1δ)是huTR1的剪接變異體，由去除氨基酸15-44和87-137的huTR1ORF組成。這些缺失導致缺失了部分信號序列和其后的氨基末端接頭序列、EGF基元的第二個半胱氨酸殘基之后的殘基以及隨后的跨膜結構域。然而，半胱氨酸殘基147(huTR1ORF編號)可以替代缺失的半胱氨酸并因此可能使二硫橋未受影響。因此，huTR1-1是huTR1的胞內形式。它起huTR1或其它EGF家族成員(包括EGF和TGFα)的激動劑或拮抗劑作用。SEQIDNO412給出了huTR1-1的測定核苷酸序列，而對應的氨基酸序列以SEQIDNO415提供。利用標準方法由HeLa細胞分離的RNA制備cDNA，通過PCR由所述cDNA的第一條鏈分離huTR1的其它4種剪接變異體。huTR1的這些剪接變異體稱為TR1-2(也叫做TR1β)、TR1-3(也叫做TR1γ)、TR1ε和TR1φ。TR1-2由去除氨基酸95-137的huTR1ORF組成。該缺失導致缺失了跨膜結構域。因此TR1-2是huTR1的一種分泌形式，并以等于或高于huTR1的親合性結合TR1受體，因為EGF結構域保持完整。它起huTR1或其它EGF家族成員(包括EGF和TGFα)的激動劑或拮抗劑作用。SEQIDNO410給出了TR1-2的測定cDNA序列，而SEQIDNO413提供對應的氨基酸序列。TR1-3由去除氨基酸36-44和86-136的huTR1ORF組成。這些缺失導致缺失了部分氨基酸末端接頭序列、EGF基元的第二個半胱氨酸之后的殘基以及隨后的跨膜結構域。然而，半胱氨酸殘基147(huTR1ORF編號)可以替代缺失的半胱氨酸并因此可能使二硫橋未受影響。因此，TR1-3也是huTR1的一種分泌形式，并起huTR1或其它EGF家族成員(包括EGF和TGFα)的激動劑或拮抗劑的作用。SEQIDNO411給出了TR1-3的測定cDNA序列，而對應的氨基酸序列為SEQIDNO414。TR1ε由去除氨基酸86-136的huTR1ORF組成。該缺失導致缺失了EGF基元第二個半胱氨酸之后的殘基和跨膜結構域。然而，半胱氨酸殘基147(huTR1ORF編號)可以替代缺失的半胱氨酸并因此可能使二硫橋未受影響。因此，TR1ε也是huTR1的一種分泌形式，并起huTR1或其它EGF家族成員(包括EGF和TGFα)的激動劑或拮抗劑的作用。SEQIDNO371給出了TR1ε的測定cDNA序列，而對應的推測氨基酸序列由SEQIDNO395提供。TR1φ由去除氨基酸36-44和95-136的huTR1ORF組成。這些缺失導致缺失了部分氨基末端接頭序列和跨膜結構域。因此，TR1φ是huTR1的一種分泌形式，并以等于或高于huTR1的親合性結合TR1受體，因為EGF結構域保持完整。它起huTR1或其它EGF家族成員(包括EGF和TGFα)的激動劑或拮抗劑的作用。SEQIDNO416給出了TR1φ的測定核苷酸序列，而對應的推測氨基酸序列由SEQIDNO417提供。實施例4鑒定、分離和表征DP3使用標準細胞生物學技術分離大鼠真皮乳頭和爪墊成纖維細胞，使用得自培養的所述細胞的mRNA通過差異展示RT-PCR(改良自LiangP和PardeeAB，Science257967-071，1992)鑒定叫做DP3的部分cDNA片段。用[α32P]-dCTP標記該雙鏈cDNA，并使用其通過篩選400,000pfu寡脫氧胸苷引導的大鼠真皮乳頭cDNA文庫鑒定全長DP3克隆。SEQIDNO119提供測定的全長DP3cDNA序列，而對應的氨基酸序列由SEQIDNO197提供。使用標準分子生物學技術進行噬菌斑轉移、雜交和篩選。實施例5分離和表征KS1通過RNA印跡分析RNA轉錄物通過用由muKS1的核苷酸268-499組成、用[α32P]-dCTP放射性標記的探針探測小鼠組織mRNA印跡，進行RNA分析，以測定muKS1(SEQIDNO263)mRNA的大小和分布。如Sambrook等(同上)所述進行預雜交、雜交、清洗和探針標記。muKS1mRNA的大小為1.6kb，并觀察到其在大腦、肺或任何肌肉以及心臟中最豐富。還可在下消化道(lowerintestine)、皮膚、骨髓和腎臟中檢測到表達。睪丸、脾、肝、胸腺、胃未見可檢測信號。muKS1的人類同源物使用muKS1(SEQIDNO263)檢索EMBL數據庫(Release50，1998年六月更新)，以鑒定人EST同源物。前三個同源物為以下EST登錄號AA643952、HS1301003和AA865643。它們285個核苷酸、283個核苷酸和285個核苷酸的同源性分別為92.63％、93.64％和94.035％。翻譯時鑒定AA643952和HS1301003中的移碼。組合全部三個EST鑒定huKS1(SEQIDNO270)和翻譯的多肽SEQIDNO344。對比muKS1和huKS1多肽顯示96個氨基酸的同一性為95％。鑒定KSCL009274cDNA序列由未成熟小鼠角質細胞構建直接克隆的cDNA文庫，并對其進行高通量測序。命名為KDCL009274克隆的序列數據顯示，與大鼠巨噬細胞炎性蛋白-2B(MIP-2B)在72個氨基酸上的同一性為35％，而與其鼠類同源物在72個氨基酸上的同一性為32％。1633bp的插入片段(SEQIDNO464；圖15A)包含一個300bp的可讀框和202bp的5′非翻譯區以及1161bp的3′非翻譯區。聚腺苷酸信號AATAAA存在于聚腺苷酸尾上游的19個堿基對。預期成熟多肽(SEQIDNO465)長度為77個氨基酸，包含4個無ELR基序的保守半胱氨酸。根據疏水性情況預測了GLY22和Ser23之間的推定信號肽切割位點。此推定趨化因子與KS1相同。使用BLAST程序對EMBL數據庫篩選全長序列，結果顯示在核苷酸水平上分別與人EST克隆AA643952、AA865643和HS1301003具有一定的同一性。近來描述的人CXC趨化因子BRAK在蛋白質水平上與KS1具有一定的同一性。圖15B對比了KS1(在圖15B中叫做KLF-1)、BRAK和其它鼠α-趨化因子。使用Phylip程序確定KS1和其它α-趨化因子家族成員之間的系統發育關系。KS1和BRAK顯示與其它α-趨化因子的高度趨異性，這支持在多重對比中顯示的較低同源性。muKS1和huKS1的細菌表達和純化將編碼muKS1多肽的氨基酸23-99(SEQIDNO345)的muKS1多核苷酸269-502(SEQIDNO271)以及編碼huKS1多肽的氨基酸19-95(SEQIDNO346)的huKS1多核苷酸55-288(SEQIDNO272)克隆入細菌表達載體pET-16b(Novagen，Madison，Wisconsin)，該載體含有一個細菌前導序列和N末端6×組氨酸標記。按照Sambrook等所述(同上)將這些構建物轉化入感受態XL1-Blue大腸桿菌中。在包含100μg/ml氨芐青霉素的NZY肉湯培養基(Gibco-BRLLifeTechnologies)中于37℃培養包含SEQIDNO271(muKS1a)和SEQIDNO272(huKS1a)的重組BL21(DE3)大腸桿菌(Novagen)的引子培養物。使培養物旋轉減慢，將其接種到800mlNZY肉湯培養基和100μg/ml氨芐青霉素中。培養物生長至細胞OD595達到0.4至0.8之間。用1mMIPTG誘導細菌表達3小時。細菌表達產生約15kDa的muKS1a和huKS1a誘導條帶。muKS1a和huKS1a都表達在不溶性包涵體中。為了純化所述多肽，在裂解緩沖液(20mMTris-HClpH8.0，10mMβ巰基乙醇，1mMPMSF)中重懸浮細菌細胞沉淀。向裂解細胞中加入1％NP-40，并在冰上溫育所述混合物10分鐘。在冰上以95W、4×15秒超聲波進一步破碎裂解物，然后以18,000rpm離心15分鐘，以沉淀所述包涵體。在包含0.5％CHAPS(w/v)的裂解緩沖液中重懸浮包含所述包涵體的沉淀，超聲5-10秒。將該混合物保存在冰上1小時，以14,000rpm于4℃離心15分鐘，并棄去上清液。如前所述，沉淀物再一次在包含0.5％CHAPS(w/v)的裂解緩沖液中重懸浮、超聲、離心和去除上清液。沉淀在增溶緩沖液(6M鹽酸胍、0.5MNaCl、20mMTrisHCl、pH8.0)中重懸浮，以95W、4×15秒超聲處理，并以18,000rpm和4℃離心10分鐘以除去碎片。上清液儲存于4℃。使用鎳螯合瓊脂糖凝膠柱(AmershamPharmacia，Uppsala，Sweden)并按照生產商的方法，利用包含在所述細菌前導序列中的N末端6×組氨酸標記純化muKS1a和huKS1a。蛋白在所述柱上純化兩次，以降低內毒素污染。為了純化后蛋白重折疊，于4℃將所述蛋白溶液在4M-2M尿素梯度的20mMtris-HClpH7.5+10％甘油溶液中透析過夜。然后將所述蛋白對2升20mMTris-HClpH7.5+10％(w/v)甘油再透析兩次。獲得的制備物經SDS-PAGE測定，其純度超過95％。用鱟變形細胞溶解物檢測試劑盒(BIOWhittaker，Walkersville，MD)測定純化蛋白的內毒素污染情況。內毒素水平小于0.1ng/μg蛋白。對KS1胰蛋白酶肽進行內部氨基酸測序。通過在HEK293T細胞中表達產生Fc融合蛋白。用35μgKLF-1plGFcDNA轉染每瓶6×106細胞，產生200ml含Fc的上清液。使用AffiprepA蛋白樹脂(0.3ml柱，Biorad)通過層析分離所述Fc融合蛋白。上樣后，用15mlPBS清洗柱，接著用5ml50mM檸檬酸鈉pH5.0清洗。然后用6柱體積的50mM檸檬酸鈉pH2.5洗脫蛋白，用含60μl2MTris-HClpH8.0的試管收集0.3ml流分。通過SDS-PAGE分析流分。對muKS1和huKS1的肽測序在聚丙烯酰胺凝膠上分離細菌表達的muKS1和huKS1，并鑒定出15kDa的誘導條帶。muKS1的預測大小為9.4kDa。為獲得15kDa條帶的氨基酸序列，通過SDS-PAGE分離20μg重組muKS1和huKS1，并電印跡在ImmobilonPVDF膜(Millipore，Bedford，Massachusetts)上。由新西蘭奧克蘭大學的蛋白質測序小組對muKS1和huKS1胰蛋白酶肽進行內部氨基酸測序。SEQIDNO397和398分別給出了muKS1和huKS1的測定氨基酸序列。這些氨基酸序列證實，所述測定序列與由cDNA序列推定的氨基酸序列相同。以前報導了其它趨化因子的大小差異(RichmondA，BalentienE，ThomasHG，FlaggsG，BartonDE，SpiessJ，BordoniR，FranckeU，DerynckR，“結構上與β-血小板球蛋白相關的生長因子的黑素瘤生長刺激活性的分子特征和染色體作圖”，EMBOJ.72025-2033，1988；LiaoF，RabinRL，YannelliJR，KoniarisLG，VanguriP，FarberJM，“人Nig趨化因子生物化學和功能特征”，J.Exp.Med.1821301-1314，1995)。使用DNASIS(HITACHISoftwareEngineering，SanFrancisco，California)預測這些蛋白的等電聚焦點為10.26。表達并用A蛋白親合層析柱純化的重組Fc標記KS1是一種均一蛋白，分子量為42kDa。氧化爆發測定氧化爆發測定用于測定反應細胞類型。將1×107PBMC細胞重懸浮在5mlHBSS、20mMHEPES、0.5％BSA中，并于37℃和5μl5mM二乙酸二氯-二氫熒光素(H2DCFDA，MolecularProbes，Eugene，Oregon)溫育30分鐘。將2×105H2DCFDA標記的細胞加樣于96孔平底培養板的每個孔中。同時向平底板的孔中加入每種激動劑各10μl，使得最終的濃度為100ng/ml(使用的fMLP為10μM)。然后用Victor21420多標記計數器(Wallac，Turku，Finland)以485nm的激發波長和535nm的發射波長對所述板讀數。在60分鐘內以5分鐘的間隔檢測相對熒光。在PBMC中鑒定出明顯的呼吸爆發，對照處理細胞(TR1)和100ng/mlmuKS1之間相差2.5倍(圖8)。使用人基質衍生因子-1α(SDF1α)(100ng/ml)和10μM甲酰-Met-Leu-Phe(fMLP)作為陽性對照。趨化性測定使用48孔Boyden室(NeuroProbeInc.，CabinJohn，Maryland)按照生產商的方法測試muKS1作用下的細胞遷移。簡而言之，在HBSS、20mMHEPES、0.5％BSA中稀釋激動劑，并將其加入趨化室的底孔中。在相同的緩沖液中以3×105細胞/50μl重懸浮THP-1細胞。用無PVP聚碳酸酯濾膜分開頂孔和底孔，濾膜孔徑為5μm(單核細胞)或3μm(淋巴細胞)。將細胞加入到頂孔，所述室在5％CO2濕潤培養箱中于37℃溫育2小時(單核細胞)和4小時(淋巴細胞)。溫育后，固定濾膜，從上表面刮下細胞。然后用Diff-Quick(DadeInternationalInc.，Miami，Florida)染色濾膜，并在5個隨機選擇的高倍視野中計數遷移細胞。結果表示為遷移指數(測試遷移細胞數除以對照遷移細胞數)。使用此測定，測試muKS1對T細胞和THP-1細胞的作用。0.01ng/ml至100ng/ml的muKS1對THP-1細胞誘導逐漸增強的趨化作用(圖9)。人SDF1α用作陽性對照并獲得等同的遷移。還測試了muKS1對IL-2活化T細胞的作用。然而，即使是高濃度的muKS1也沒有遷移，而SDF-1α顯示明顯的逐漸增強的趨化刺激。因此，muKS1于測試的濃度對于THP-1細胞是趨化性的，而對于IL-2活化T細胞不是趨化性的。流式細胞儀結合研究按以下方式測試KLF-1與THP-1和Jurkat細胞的結合。在3ml清洗緩沖液(2％FBS和0.2％疊氮化鈉的PBS溶液)中重懸浮THP-1或Jurkat細胞(5×106)，于4℃、200g沉淀5分鐘。然后用0.5％小鼠和山羊血清在冰上封閉細胞30分鐘。對細胞進行清洗、沉淀、在50μl的10μg/mlKLF-1Fc中重懸浮，并在冰上溫育30分鐘。溫育后，如前所述制備細胞并重懸浮在50μl的10μg/ml山羊抗人IgG生物素(SouthernBiotechnologyAssociates，AL)中，并在冰上溫育細胞30分鐘。最后，對細胞進行清洗、沉淀和在50μl的10μg/ml鏈霉抗生物素-RPE(SouthernBiotechnologyAssociates，AL)中重懸浮，并在冰上于黑暗中再溫育30分鐘。清洗細胞并在250μl清洗緩沖液中重懸浮，用1μl的10μg/ml碘化丙錠(Sigma)染色，以排除任何死亡細胞。純化的Fc片段(10μg/ml)代替KLF-1Fc用作陰性對照，以測定非特異性結合。在Elite細胞分選器(CoulterCytometry)上使用PE濾片(峰值透光率為575nm，帶寬10nm)布置在對數水平上(onlogscale)分析一萬個閘門事件。呼吸爆發和遷移測定表明，KS1對單核細胞有活性，而對T細胞沒有活性；因此，在與THP-1和Jurkat細胞的結合研究中測試KS1Fc融合蛋白。KS1Fc與單獨的Fc片段相比，顯示對THP-1細胞明顯的正偏移。相反，在相同的實驗中KS1顯示沒有正結合Jurkat細胞。muKS1克隆的全長序列通過測定額外EST的堿基序列擴展muKS1的核苷酸序列。組合所有的EST鑒定全長muKS1(SEQIDNO370)而相應的翻譯多肽序列為SEQIDNO394。通過RNA印跡分析人RNA轉錄物通過用由huKS1核苷酸1-288(SEQIDNO270)組成的放射性標記探針探測人組織印跡(Clontech，PaloAlto，California)，進行RNA印跡分析，以測定muKS1人類同源物mRNA的大小和分布。如Sambrook等所述(同上)進行預雜交、雜交、清洗和探針標記。huKS1mRNA的大小為1.6kb，并觀察到其在腎臟、肝臟、結腸、小腸和脾中最豐富。在胰腺、骨骼肌、胎盤、大腦、心臟、前列腺和胸腺中也可檢測到表達。在肺、卵巢和睪丸未發現檢測信號。通過RNA印跡分析腫瘤組織中的人RNA轉錄物如前所述通過探測腫瘤格形(panel)印跡(Invitrogen，Carlsbad，California)進行RNA印跡分析，以測定huKS1在癌組織中的分布。這些印跡在正常組織和腫瘤組織之間產生直接對比。在正常的子宮和子宮頸組織觀測到mRNA，而在相應的腫瘤組織中沒有觀測到。相反，表達在乳瘤中被上調，而在正常乳房組織中被下調。在卵巢或卵巢腫瘤中均未發現檢測信號。給C3H/HeJ小鼠注射細菌重組muKS1將18只C3H/HeJ小鼠分為3組并腹膜注射muKS1、GV14B或磷酸緩沖鹽水(PBS)。GV14B是一種細菌表達的重組蛋白，用作陰性對照。第1組的小鼠注射50μgmuKS1的1mlPBS溶液；第2組小鼠注射50μgGV14B的1mlPBS溶液；而第3組小鼠注射1mlPBS。18小時后，通過用2×4ml收獲溶液(0.02％EDTA的PBS溶液)進行腹膜內灌洗分離出小鼠腹膜腔中的細胞。對每組的各只小鼠進行活細胞計數。注射50μgmuKS1小鼠的細胞數量平均升高3倍(圖10)。對3只C3H/HeJ小鼠的左后腳皮下注射20μg細菌重組muKS1。在所述小鼠右側相同部位注射相同體積的PBS。18小時后，檢測小鼠的炎癥情況。所有注射細菌重組muKS1的小鼠的爪墊都顯示紅腫。根據組織學，注射muKS1的部位存在單核細胞和多形核細胞混合表型的炎性反應。對裸鼠注射細菌表達的muKS1a為確定炎性反應是否是需要T細胞，使用裸鼠重復所述實驗。用75μl在磷酸緩沖鹽水中稀釋10倍的Hypnorm(JanssenPharmaceuticals，Buckinghamshire，England)腹膜內麻醉2只裸鼠。在左后爪、耳和背部左側皮下注射20μg細菌表達的muKS1a(SEQIDNO345)。在所述小鼠右側相同部位注射相同體積的磷酸緩沖鹽水。留置小鼠18小時后檢測小鼠的炎癥。兩只小鼠在注射細菌表達蛋白的耳部和爪部都顯示紅腫。在兩個后背部位未能鑒定出明顯的炎癥。挑選小鼠并由耳部、背部和爪部取活組織檢查樣品，在3.7％甲醛鹽水中固定。對活檢組織進行包埋、切片，并用Haemotoxylin和曙紅染色。注射muKS1a的部位多形核粒細胞顯著增加，而注射磷酸緩沖鹽水的部位具有低本底水平的多形核粒細胞浸潤。討論趨化因子是一個功能眾多的高度堿性分泌性蛋白的龐大超家族(Baggiolini等，Annu.Rev.Immunol.，15675-705，1997；Ward等，Immunity，91-11，1998；Horuk，Nature，393524-525，1998)。muKS1和huKS1多肽序列與CXC趨化因子具有相似性，表明該蛋白的作用與其它CXC趨化因子類似。裸鼠的體內數據支持此假設。因此可預期此趨化因子樣蛋白刺激白細胞、上皮細胞、基質細胞和神經細胞遷移；促進血管發生和血管形成；促進神經元圖式發育、造血干細胞轉移、角質干細胞和上皮干細胞圖式發生和發育、白細胞活化和增殖；并促進傷口愈合過程中的遷移。近來已經證明，趨化因子受體起HIV-1感染CD4+細胞的共受體作用(Cairns等，NatureMedicine，4563-568，1998)，并且高循環水平的趨化因子可以使暴露于HIV病毒的對象一定程度的免疫性(Zagury等，Proc.Natl.Acad.Sci.USA953857-3861，1998)。此新基因與其編碼蛋白因此可有效用作上皮細胞、淋巴樣細胞、骨髓細胞、基質細胞和神經細胞遷移以及癌癥的調節劑；用作治療癌癥、神經退行性疾病、炎癥性自身免疫病(如牛皮癬、哮喘和節段性回腸炎)和傷口愈合的藥物；以及用作預防HIV-1結合和感染白細胞的藥物。此外，我們證明用muKS1注射C3H/HeJ小鼠時，muKS1促進腹膜腔細胞數量可計量性增加。而且，我們證實，muKS1誘導人外周血單核細胞氧化爆發以及誘導人單核細胞白血病細胞系THP-1遷移，說明單核細胞/巨噬細胞是KS1效應細胞類型之一。除此之外，我們證明huKS1在許多非淋巴組織(諸如結腸和小腸)以及乳腺腫瘤中高水平表達。huKS1還在正常子宮和子宮頸組織中表達，但在其相應腫瘤組織中被徹底下調。近來已經顯示，非ELR趨化因子表現出制管張素特性。以前已經證實兩種非-ELR趨化因子IP-10和Mig在腫瘤消退過程中上調(TannenbaumCS，TubbsR，ArmstrongD，FinkeJH，BukowskiRM，HamiltonTA，“CXC趨化因子IP-10和Mig對IL-12介導的小鼠RENCA腫瘤退化是必不可少的”，J.Immunol.161927-932，1998)，表達水平與腫瘤大小負相關(KaneganeC，SgadariC，KaneganeH，Teruya-FeldstineJ，YaoO，GuptaG，FarberJM，LiaoF，LiuL，TosatoG，“CXC趨化因子IP-10和Mig與IL-12抗腫瘤效應有關”，J.Leuko.Biol.64384-392，1998)。而且，IP-10和Mig的中和抗體將降低抗腫瘤作用，表明這些分子對抗腫瘤作用產生影響。因此，預期在子宮頸和子宮瘤的情況下，KS1應具有相似的特性。數據證明，KS1涉及細胞遷移，表明單核細胞/巨噬細胞是KS1效應細胞類型之一。人表達數據結合體外和體內生物學證明，KS1可能是細胞遷移的有效調節劑，并可作為治療炎癥性疾病(如節段性回腸炎、潰瘍性結腸炎和類風濕性關節炎)和癌癥(諸如子宮頸腺癌、子宮平滑肌瘤和乳房侵襲性導管癌)的藥物。實施例6KS2的特征鑒定KS2包含一個跨膜結構域，并起膜結合配體或受體的作用。RNA分析表明，KS2mRNA在小鼠角質細胞系Pam212中表達，與在小鼠角質細胞中鑒定的cDNA一致。哺乳動物表達為了表達KS2，將胞外結構域與具有C-末端6×組氨酸標記的免疫球蛋白G恒定區(Fc)的氨基末端相融合。這可通過將編碼多肽KS2的氨基酸1-215(SEQIDNO347)的KS2多核苷酸20-664(SEQIDNO273)克隆入哺乳動物表達載體pcDNA3(Invitrogen，NVLeek，Netherlands)，并融合至具有C-末端6×組氨酸標記的免疫球蛋白G恒定區(Fc)的氨基末端。如Sambrook等所述(同上)將此構建物轉化入感受態XL1-Blue大腸桿菌中。使用DEAE-葡聚糖經用180μgKS1a轉染的5×T175培養瓶中的Cos-1細胞而表達KS2a的Fc融合構建物。7天后收獲上清液，并使其通過Ni-NTA柱。由該柱洗脫結合的KS2a并對PBS透析。如下測定KS2a的Fc融合多肽抑制IL-2誘導的伴刀豆球蛋白A刺激的小鼠脾細胞生長的能力。由BALA/c小鼠脾制備單細胞懸液，并在補加2mML-谷氨酸鹽、1mM丙酮酸鈉、0.77mML-天冬酰胺、0.2mML-精氨酸、160mM青霉素G、70mM硫酸二氫鏈霉素、5×10-2mMβ巰基乙醇和5％FCS的DMEM(Gibco-BRL)(cDMEM)中清洗。用2μg/ml伴刀豆球蛋白A于37℃在10％CO2中刺激脾細胞(4×106/ml)24小時。由培養物收獲細胞，在cDMEM中清洗3次，并在補加10ng/mlrhuIL-2的cDMEM中以1×105細胞/ml重懸浮。在96孔圓底板中于0.2mlcDMEM中進行所述測定。將KS2a的Fc融合多肽、PBS、LPS和BSA滴定在所述板中，并向每孔中加入1×104活化T細胞(0.1ml)。在含10％CO2的大氣中于37℃溫育所述板2天。通過在培養的最后4小時用0.25uCi/ml氚化胸苷脈沖處理所述細胞，此后將細胞收獲在玻璃纖維過濾墊上，并利用標準液體閃爍技術測定胸苷摻入程度，從而測定增殖度。如圖6所示，發現KS2aFc融合多肽抑制IL-2誘導的伴刀豆球蛋白A刺激的小鼠脾細胞的生長，而陰性對照PBS、BSA和LPS不能。該數據證明，KS2在皮膚角質細胞中表達，并抑制細胞因子誘導的脾細胞的生長。這提示KS2對皮膚炎癥和惡性腫瘤具有調節作用。實施例7KS3的特征鑒定KS3編碼一個40個氨基酸的多肽(SEQIDNO129)。KS3包含一個23個氨基酸的信號序列，它能產生17個氨基酸的成熟多肽(SEQIDNO348；稱為KS3a)。合成制備KS3a(ChironTechnologies，Victoria，Australia)，并觀察到其增強轉鐵蛋白誘導的大鼠腸上皮細胞IEC-18細胞的生長。在96孔平底板中于0.1ml補加0.2％FCS的DMEM(GIBCO-BRLLifeTechnologies)中進行測定。或單獨或與750ng/ml脫鐵運鐵蛋白或與750ng/mlBSA一起將KS3a(SEQIDNO348)、脫鐵運鐵蛋白、培養基和PBS-BSA滴定到所述板中，并向每孔中加入1×103IEC-18細胞。在含10％CO2的大氣中于37℃溫育所述板5天。如前所述(J.Imm.Meth.93157-165，1986)通過MTT染料還原測定細胞生長的程度。如圖7所示，發現KS3a加上脫鐵運鐵蛋白增強轉鐵蛋白誘導的IEC-18細胞的生長，而單獨的KS3a或PBS-BSA不能，表明KS3a和脫鐵運鐵蛋白協同誘導IEC-18細胞的生長。該數據表明，KS3是上皮源性的，并刺激腸上皮細胞生長。這表明KS3對創傷愈合、輻射或藥物性腸疾病的保護和腸上皮的完整性具有作用。在所附序列表中給出了SEQIDNO1-465。在所附序列表中使用的多核苷酸或多肽序列的編碼符合WIPO標準ST.25(1988)，附錄2。本文引用的所有參考文獻，包括專利文獻和非專利文獻，都通過引用整體結合到本文中。盡管已經按照具體的實施方案描述了本發明，但可在不背離本發明范圍的情況下進行改變和修飾，本發明的范圍僅受限于所附權利要求書的范圍。說明書的核苷酸和氨基酸序列表序列表<110>Watson，JamesD.Strachan，LornaSleeman，MatthewOnrust，ReneMurison，JamesG.Kumble，KrishanandD.<120>分離自皮膚細胞的組合物及其使用方法<130>11000.1011c2PCT<160>465<170>FastSEQforWindows版本3.0<210>1<211>696<212>DNA<213>大鼠<400>1aattcggcacgaggccgaggcgggcaggcaccagccagagcagctggcggcagacagtcg60gaccgagacagttggaccgagacagtcgaacggtctaacagggcctggcttgcctacctg120gcagctgcacccggtccttttcccagagctggttctgtgggtcaacatggtcccctgctt180cctcctgtctctgctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccct240cccggcctccttcctggaggaagtggcgggcagtggggaagctgagggttcttcagcctc300ttccccaagcctgctgccgccccggactccagccttcagtcccacaccagggaggaccca360gcccacagctccggtcggccctgtgccacccaccaacctcctggatgggatcgtggactt420cttccgccagtatgtgatgctcattgcggtggtgggctcgctgacctttctcatcatgtt480catagtctgcgcggcactcatcacgcgccagaagcacaaggccacagcctactacccgtc540ctctttccccgaaaagaagtatgtggaccagagagaccgggctggggggccccatgcctt600cagcgaggtccctgacagggcacctgacagccggcaggaagagggcctggacttcttcca660gcagctccaggctgacattctggcttgctactcaga696<210>2<211>475<212>DNA<213>大鼠<400>2cggtatcgataagcttgatatcgaattcctgcaggtcgacactagtggatccaaagaatt60cggcacgagaaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattc120tttaaggatggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccag180gacccagaagctgcccaccagagatgaggaactttttcagatgcagatccgggataaggc240attgtttcacgattcatccgtgattccagatggagctgaaatcagcagttacctatttag300agatacacctagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcac360agtgacaccttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgagga420gtccagtgcagatgggtcaggtgacccagaaccacttgaccagcagaagcagcag475<210>3<211>381<212>DNA<213>人<220><400>3ctggagatcctggggatccaggtgatcccggtagaaccaggcagatttgttgtagatgac60tggctggtgaggttagtcttcgttccactggacagggaaagcttgaaacttgggctctgc120cgtccagaaaggtttgttttcagaagcacttccttttcctcactttcttttaatttcttc180ctttccatgaatttacttattggatccataatattatcatcatttttagttttgtcagat240ggagacactacagcttctccatcttccatgtcatcttcatctgtgttaaaccacatctct300tcttcatcttctagtgtctggcatctcttcgatatctgtgattcctcaaaatggaacgca360tactgtcaagtttgggggtaa381<210>4<211>311<212>DNA<213>人<400>4agcgtggtcgcggccgaggtactacagactttgtgataaggctgaagcttggggcatcgt60cctagaaacggtggccacagctggggttgtgacctcggtggccttcatgctcactctccc120gatcctcgtctgcaaggtgcaggactccaacaggcgaaaaatgctgcctactcagtttct180cttcctcctgggtgtgttgggcatctttggcctcaccttcgccttcatcatcggactgga240cgggagcacagggcccacacgcttcttcctctttgggatcctcttttccatctgcttctc300ctgcctgctgg311<210>5<211>514<212>DNA<213>小鼠<400>5ctggagctcgcgcgcctgcaggtcgacactagtggatccaaagcttaaaagagactccac60ccactccagtagaccggggactaaaacagaaattctgagaaagcagcaagaagcagaaga120aatagctatttcacagcagtaacagaagctacctgctataataaagacctcaacactgct180gaccatgatcagcccagcctggagcctcttcctcatcgggactaaaattgggctgttctt240ccaagtggcacctctgtcagttgtggctaaatcctgtccatctgtatgtcgctgtgacgc300aggcttcatttactgtaacgatcgctctctgacatccattccagtgggaattccggagga360tgctacaacactctaccttcagaacaaccaaataaacaatgttgggattccttccgattt420gaagaacttgctgaaagtacaaagaatatacctataccacaacagtttagatgaattccc480taccaaccttccaaagtatgtcaaagagttacat514<210>6<211>1059<212>DNA<213>小鼠<400>6ggcacgagcctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatccta60cagaagctcatggggagccccagactggcagccttgctcctgtctctcccgctactgctc120atcggcctcgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccac180tgtctcctggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccct240ctcttggtgaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggaca300ccagcatccttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcga360atttccatcccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagcct420tcagctgcagaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacct480gaattctcctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggc540cccaaggccagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagc600ccttttgatacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattc660cttctgccctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaa720aagtgtcccttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgc780ttcactgactacagccagcacaatcagatggtcatggctctgacactccgctgcccactg840aaactggaggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttccc900aacgccacagcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccc960cagctctgctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagt1020ggctctctcccatcctggactgtgagcatggatacccag1059<210>7<211>861<212>DNA<213>大鼠<400>7gaattcggcacgagaggagagaaagagaagtgtgcacaaagaaacttgtattattattaa60ttagcacctagcttgtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaa120gaagaaaaaaaaaaaacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaa180tgagagaacagacccagttctcgacccttgcttctcaaggtcctcccaccaggctgccaa240agcaagatggtgttgctctgatccagtcagtattcttttgacttttttttttaatctcca300ggttttggttcaggctcccatattcataccctggctcatttagctttccctcatgttgtg360ggttcttctgtccctcacccccttactctccccactgatattcttcccagtcaagactgt420ggctctggaagaaatatccaccatttgcagagctgatgttctgtagatcgtaatgttgaa480gcgctgggtgtcctggttggcagaatcactcctgtattactctggtacataggtgtctcc540tgatagactccctggccttagtcatggggtgttttctagaggcagactaagacaggagtc600aaaaaagatttagaggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagt660tctactcaggatcccgagtgtttctgtagatgtagattggaatgtgtccataacagagag720gccagtgagagacatccccaaggacctgccaggctttccttcgctccaggaagacgcacc780atcactcaaaaggggtttcctagaaagaaagacaagtgacttaaaaaatctgccagtggg840ttcttgaagtcatcgaaccta861<210>8<211>398<212>DNA<213>小鼠<400>8gtcaccagcaaaggtggaaacaaattctttgaaggactctgacagccctgggtctccaag60gctgctgggaccagtcttagcctcttgtggcaagtggtaggaatgtgaatctttgcgacc120agggggatcagaaatggggtctcccatttctggtgtctgcccagtccttccaggtgggct180cttcgtagccctggggtggattttcctcctcttccacagagatgctttttctctgcatac240catgtctgctggtttcccataatctccctcaaacccacaccaccctccactgaggctcag300ccccagagccatgaaaactcccaccagtttccaggatagagtctggacagaactggggcc360ctggttgccaagtggtgaaaaaaggaatggcccccctg398<210>9<211>1060<212>DNA<213>小鼠<220><400>9agaacattcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatgg60cagcagaaaccttcacagacatcttcatttcctggtccggcccacggattggcaggccat120ggggttgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctcc180ccttgcttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggc240tgctctcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccc300tatcccgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatg360aaaccatgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcagg420ctgctaccaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacc480tgcgctctatccctgacacccctgtccccacctaccaagatcccctctacctggaagacc540aggtaccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgaca600cagaggatgagtgttggtcagacaatgagattgtcccccagccacctgttcggccccgag660agaagcctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgag720agggcacctcacgctccctgaaggtccgaacccggaaaaaggccatgccctcagacatgg780acagctagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgc840tgctacaccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgt900ggtaccctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctattta960ttgccttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctacc1020gacgaaaccaaaagtccaaccagctgtgttcattccttct1060<210>10<211>353<212>DNA<213>小鼠<400>10ggaaagtcatctacctgctggtggcctccatcagagccgggagatctccactgtgtgtat60ggagaccgcattgatagcttactctcttcctgaactacaggatgaaggccatggctctga120gcctaggagcaagcccagtgcttgcttttctcctctctgggtacagtgatggttaccaag180tgtgtagtaggttcggaagcaaagtgcctcagtttctgaactagaactacagctctgtct240gccttagcacagacaggcgttgtctcattcctctcacctgccctacccatgcatgactcg300tccgcttattgaggggcaggtgagtcatctgagatgctatttgaaacatgaga353<210>11<211>969<212>DNA<213>小鼠<400>11cggcacgagagagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaa60caaagagaccgacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaa120tcttgtctccatcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcat180ctatagaatctccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaa240catccgggttacagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgct300ggatgaagtttacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgca360ggacagcataggcagcatgggcctagggcagggccagccttgaagtgggcagcctggtca420cagaactgtggctagtcccaacttcccctggcctggcctggctgtgagtggctagcagct480ggcacagtcagtaccgtatgtctctcctcagaggtcccaaagacagagaagagctttgag540gagaggctaaccttcaaggccttcctgctcaagtttgtgaactcttacactcccatcttc600tatgtcgccttcttcaaaggccggtttgttggtcggcccggtgactacgtgtacatcttc660cgctctttccggatggaggagtgtgccccgggcggctgcctcatggagctctgtatccag720ctgagcatcattatgctgggcaagcagctaatccagaacaatctcttcgagattggcatc780ccgaagatgaaaaagttcatccgctacctgaagctgcgcagacagagcccctcagaccgt840gaagagtacgtgaagcggaagcagcgctatgaggtggacttcaacctcgaacctttcgcc900ggcctcacgcccgagtacatggaaatgatcattcagttcggctttgtcaccctgtttgtt960gcgtccttc969<210>12<211>1411<212>DNA<213>小鼠<400>12ggcacgaggcaacttggacactaaagctaggtaccagcctgttagtttacatgagttcaa60aattcaggtcagggtctctgaaatggagtctgaatttaaaagctttggcctctcatgtga120ataatacatatgtcatgtgtcatttgaatagtttcagtcacacacactttgtatttctct180aagtgtaacgcatgtgtagtgggtggttgtagtatgatttctccgtctttcttgtttgaa240tgtttggacttgtgcacgtgtgcacatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtg300tgtgtatttgctcctgtggctatgtgcatgtgccatgtgggtgtgtgtgcttgtgggggc360cagaggttaggtaccttcctctatctctccaccctggtggtttttgttttgttttgtttt420gttttggaccaggtctatcactgataagctaggttggatggcttctgagaagagtctgcc480tctctgtccccctgcccctyctccccccagccctcaggttacagataagtgccacaagtc540cttgtcctttcaagtagcctctagggatccaggctcatatccttgtgcttactgactgag600ccacctctcagctccctcagccccgttttacacgttaactttgtctcctgtctatgcctg660ctctcttcagtgaccccttccgttttcctttcactcttttctctgaatagatttgtgtgc720gagagactattatcatatggatgcataaatatcatctgcaaagtcaatcgcaggaaagac780ttagagtctctttagctttatgactgtaaaggattccgcttcttgccattgattcagctt840ttttgccattgatcctttattagagatcaattagagtcgtatacaaagaccttggctggg900ccctgagggtctatctcaggctaggccctgagggtctatctcaggctaggccctgagggt960ctatctcaggatagatggatttaactgcttttctcaagacgcttttactctctcgttgaa1020ttctttttaaacttttaattgacattgtacttgcattcttatgggaaacagggtgaccca1080cacacatgtgtacacaggtacacacacagtcaggtcagcatagctggtatgttgttgttt1140atgttggggacagtcagattggtattgtttttgcactgtgctgtggaacattggaaaacc1200ttatctgatggtgaccctgtgcctactaacagccctcactaggatacattttggagtctc1260tggcaaccacaattttgctctatttccatgagtccagcatctctactactgcatagaagt1320aaaaaaaaaaaaaaaaaactcgagagtacttctagagcggccgcgggccccccctcgagg1380tcgacggtatcgataagcttgatatcgaatt1411<210>13<211>888<212>DNA<213>小鼠<400>13ggcacgagaggaccttgaccgacatccagaccacgggacccgactggatgtctcaccctg60cccctgcaggccctgtcccttccaaaacaggcacttctgtcacaggatactttttttttt120aacttaaatttgcttgggggaggggagcagttctagttccatgaggcacaaatggaggtc180aaagagcaacttgccgatgtctcttctctcctcccactgtgtgggtagtaggaattgaat240caggttatcgatcttggggctgagccatctctgtggcccacagagcacttatatgtggtt300acttgttgctctcacattgtcagtgtacagcttggtggcctttgtcactggcatgctctg360tgacactgttgtgataaaaatgttgatgagtttacacaaatctagtaaattgaacccaag420agccaagtgtggtggtgtacccttaattccagcactttgggggcaagttcaggtagttct480ctgaatttgagagcctcctggcccacatagtgagttccatggctgcgtagttgcaaaaga540acaccaacacctttcccccacaaatagaattgtactgaaggtcacagtcagagaaagcat600agcaaggatggctgctctgagcccctcctgtgcacttctgtagacctagccccggtgtct660aaatggagtctgattttagcacctgcacttgactgctgtgctccaccctgacccgcctty720tcctgatcccagattgctagaactttgaccaaaatgggacttaattggagttgtgattgg780katgttcattgatttaaagtgctctttacattttaaggaaactaaccctttgggtaagaa840aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa888<210>14<211>547<212>DNA<213>小鼠<400>14gaattcggcacgagcctaaatgctgggattaaaggcgtgcgccactactgccaggctgtt60ttttttttttttttttttttattaatgatctgccagacaaagagatgtcctttttggtgc120aaaagtcacccaatgcttgaagtcactatatttgattagctctgtaactgatacacaaat180aaaactttccattatggataatacattatctattattatttatctcttgttcatttttgc240aatttctgtacttgactcccagttgagtacaaggtgcctttggtggttttccaaggatct300tgaggttacatgaaattgctgatgatgtctgttgaaagcattgtatggaggcctgaggta360tatttggcctgagagcagagtttttaaaatagagcctgctggaaaagctagctggagctt420ctgactactttagaaaggcactgtttgaagcacaggccatgaagtaagacttgctttcta480gttaaattgaggttttttgtttttttaagtcwttagtgtatagagatttcctacattttt540tgtggtt547<210>15<211>318<212>DNA<213>大鼠<400>15ctgacatgaagccccctaagacccaaagattggttcctgctgtgacatgcctaccatgtg60gccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacaccaccctgtc120aaagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagttttcgga180taaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatgtggttct240tgaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggagaggtcct300aggcatatgtcactccat318<210>16<211>856<212>DNA<213>大鼠<400>16gaattcggcacgagcggcacgagcggccccgaagggggctgcacgggcgacttggcggcg60atggctcgagctccggcggcgacgacggtggccggaggcggcggctcctcctccttctcc120tcctgggcttgggcccggcggtgatccgagctggcggccgcggcccccckatgagactgt180tggcgggctggctgtgcctgagcctggcgtccgtgtggctggcgcggargatgtggacgc240tgcggagcccgctctcccgctctctgtacgtgaacatgactagcggccctggcgggccag300cggcggccaccggcggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaat360tatgcgaatcacttcagtctgtctttgttcagagttatcttgaccaaggaacacagatct420tcttaaacaacagcattgagaaatctggctggctgtttatccaactctatcattcttttg480tatcatctgtttttaccctgtttatgtctagaacatctattaacgggttgctaggaagag540gctccatgtttgtgttctcaccagatcagtttcagagactgcttaaaattaatccggact600ggaaaacccatagacttcttgatttaggtgctggagatggagaagtcacgaaaatcatga660gccctcattttgaagaaatttatgccactgaactttctgaaacaatgatctggcagctcc720agaagaagaaatacagagtgcttggtataaatgaatggcagaatacagggttccagtatg780atgtcatcagctgcttaaatctgctggatcgctgtgatcagcctctgacattgttaaaag840atatcagaatgtcttg856<210>17<211>349<212>DNA<213>大鼠<400>17ccaaagaattcggcacgaggcggctcgggatggcggcccccatggaccggacccatggtg60gccgggcagcccgggcgctgcggcgggctctggcgctggcctcgctggccgggctattgc120tgagcggcctggcgggtgctctccccaccctcgggcccggctggcggcgccaaaaccccg180agccgccggcctcccgcacccgctcgctgctgctggacgccgcttcgggccagctgcgcc240tggagtacggcttccaccccgatgcggtggcctgggctaacctcaccaacgccatccgcg300agactgggtgggcctatctggacctgggcacaaatggcagctacaagtg349<210>18<211>1057<212>DNA<213>大鼠<220><400>18cctgcaggaagggtggcccccagtatcgggtcccccaaaacccttgcgtgaatgacaggt60gtacctcccgcagagagtacatggagatcaactgtcccagggctgtagggaaaagcctgt120aatgggacactccttcccgctgcaggtcgacactagtggatccaaagaattcggcacgag180gcggaagcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctg240gtgctagtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagag300gaactcgttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacg360cgttgggattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagcc420ctgggacagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggc480ttttggaggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctc540tgggtctggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaat600gtcctctcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcact660cccacagcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgc720tatgctgtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctc780ctgccctgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccac840accagttaccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcacc900agtatctcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccgga960caggggaagaaagaggcctgtccattggcatctcagagcctagtttatgtggacatcaca1020ggctacagccaggacaacgaaacactggaggtgagca1057<210>19<211>750<212>DNA<213>大鼠<400>19ggcacgagcggcatctcaagctgctgcaagcaggactgagcactaccagagcagcaacct60cggatggccctggacgtggcacgcgcggggcacagaggcaagaagacttgatgaagcctc120tcttcccaacccatatccagaaagaacgatttagatgacagtttttagaaaggtgaccac180catgatctcctggatgctcttggcctgtgcccttccgtgtgctgctgacccaatgcttgg240tgcctttgctcgcagggacttccagaagggtggtcctcaactggtgtgcagtctgcctgg300tccccaaggcccacctggccctccaggagcaccaggatcctcaggaatggtgggaagaat360gggttttcctggtaaggatggccaagacggccaggacggagaccgaggggacagtggaga420agaaggtccacctggcaggacaggcaaccgaggaaaacaaggaccaaagggcaaagctgg480ggccattgggagagcgggtcctcgaggacccaagggggtcagtggtacccccgggaaaca540tggtataccgggcaagaagggacctaagggcaagaaaggggaacctgggctcccaggccc600ctgtagctgcggcagtagccgagccaagtcggccttttcggtggcggtaaccaagagtta660cccacgtgagcgactgcccatcaagtttgacaagattctgatgaatgagggaggccacta720caatgcatccagtggcaagttcgtctgcag750<210>20<211>849<212>DNA<213>大鼠<400>20gataatycggsacgaggggccgccgagtcccgccgggtcggtgtagctcgctgccgacgc60tgcgacgctcgtgggtgccgtgttcggcttttcctgtctacttcagtgcaccgctgcagc120tccggcctcgggtctgacgcgccacagcatggcttccgctttggaggagttgcagaaaga180cctagaagaggtcaaagtgctgctggaaaagtccactaggaaaagactacgtgatactct240tacaaatgaaaaatccaagattgagacggaactaaggaacaagatgcagcagaagtcaca300gaagaaaccagaatttgataatgaaaagccagctgctgtggttgctcctcttacaacagg360gtacactgtgaaaatcagtaattatggatgggatcagtcagataagtttgtgaaaatcta420cattactttaactggagttcatcaggttcctgctgagaatgtgcaagtacacttcacaga480gaggtcatttgatcttttggtaaaaaacctcaatggcaagaattactccatgattgtgaa540caatcttttgaaacctatctctgtggaaagcagttcaaaaaaagtcaagactgatacagt600tattatcctatgtagaaagaaagcagaaaacacacgatgggactacttaactcaggtgga660aaaagaatgcaaagagaaagaaaagccttcctacgacactgaggcagatcctagtgaggg720attaatgaatgttctaaagaaaatttatgaagatggagatgatgacatgaagcgaaccat780taataaagcgtgggtggaatcccgagagaagcaagccagggaagacacagaattcctgca840gcccggggg849<210>21<211>312<212>DNA<213>人<400>21ttcgagcggccgcccgggcaggtaccagcacatgctgtggtgatgctggtttgtgttccc60acctcactcacactcagccctggcatctcctctcctggctctgtttgagtggcagcgtca120atggcctttctgctctggagctcgtccctgtggctgctgaagtagtcttcctcactaaca180gtagaggactcacagtcatggggcttgcgctctgccttgcctctgcgggcatctctgggt240ccaggtccgccttcctgggagtacctcggccgcgaccaacgctaatcaagcttatcgata300ccgtcgacctcg312<210>22<211>1023<212>DNA<213>小鼠<400>22gcgcggcccgggggactcacattccccggtcccccctccgccccacgcggctgggccatg60gacgccagatggtgggcagtagtggtactcgccacactcccttccttgggagcaggtgga120gagtcacccgaagcccctccgcagtcctggacacagctgtggctcttccgcttcttgttg180aatgtagcgggctatgccagctttatggtacctggctacctcctggtgcagtacttaaga240cggaagaactacctggagacaggcaggggtctctgcttccccctggtgaaagcctgtgtg300tttggcaatgagcccaaggctcctgatgaggttctcctggctccgcggacagagacagcg360gaatccaccccgtcttggcaggtcctgaagctggtcttctgtgcctcgggtctccaggtg420tcctatctgacttggggcatactgcaggaaagagtgatgactggcagctacggggccaca480gccacatcaccaggagagcatttcacagactcccagtttctggtgctgatgaaccgtgtg540ctggcgctggttgtggcaggcctctactgtgtcctgcgcaagcagccccgtcatggtgca600cccatgtaccggtactcctttgccagtctgtcaaatgtgcttagcagctggtgccagtat660gaagcacttaagttcgtcagcttccctacccaggtgctggcgaaggcctccaaggtgatc720cctgtcatgatgatgggaaagctggtgtcccggcgcagctatgaacactgggaatacctg780actgccggcctcatctccattggagtgagcatgtttcttctatccagtggaccagagcct840agaagctctccagccaccacactctctggcttggtcctactggcaggctatattgctttc900gacagcttcacctcaaattggcaggatgccctgtttgcctataagatgtcatcggtgcag960atgatgtttggggtcaatttattctcctgtcttttcacagtaggctcactactggaacag1020ggg1023<210>23<211>997<212>DNA<213>小鼠<400>23ggcacgaggacttctgctagtacttgctcctggcggtggctgagcaaccggtctcaccag60catgctctgcctgtgcctgtatgtgcccatcgccggggcggctcagactgagttccagta120ctttgagtccaaggggcttcctgccgagctgaaatccatcttcaaactcagtgtctttat180cccctctcaagagttctccacataccgccaatggaagcagaaaattgtgcaagcaggtga240caaggaccttgatgggcaactggactttgaagagtttgtacattacctccaagatcatga300gaaaaaactgaggctggtgttcaagagtctggacaaaaagaatgatggtcgaatcgatgc360tcaggagatcatgcagtccctgcgggacctgggtgtcaagatctcggaacagcaggcgga420gaagattcttaagagcatggataagaatggcacgatgaccatcgactggaacgagtggag480ggactaccacctcctgcaccctgtggagaacatcccggagatcatcctgtactggaagca540ctcgacgatcttcgatgtcggtgagaatctgacagtcccagatgagttcacagtggagga600gaggcagacggggatgtggtggaggcacctggtggcaggaggtggggcaggggcagtttc660cagaacctgcactgcccccctggacagactgaaggtgctcatgcaggtccatgcctcccg720cagcaacaacatgtgcatcgtaggtggattcacacagatgattcgagaagggggagccaa780gtcactctggcggggcaacggcatcaatgtcctcaaaattgcccctgagtcggccatcaa840attcatggcatatgagcagatgaaacggcttgtcggtagtgatcaggagacgctgaggat900ccacgaaaggcttgtggcaggctccttggccggagccattgcccagagtagcatctaccc960aatggaggttctgaagacccgaatggccctgcggaaa997<210>24<211>529<212>DNA<213>大鼠<400>24aaagcttccatcctcaacatgccactagtgacgacactcttctacgcctgcttctatcac60tacacggagtccgaggggaccttcagcagtccagtcaacctgaagaaaacattcaagatc120ccagacagacagtatgtgctgacagccttggctgcgcgggccaagcttagagcctggaat180gatgtcgacgccttgttcaccacaaagaactggttgggttacaccaagaagagagcaccc240attggcttccatcgagttgtggaaattttgcacaagaacagtgcccctgtccagatattg300caggaatatgtcaatctggtggaagatgtggacacaaagttgaacttagccactaagttc360aagtgccatgatgttgtcattgatacttgccgagacctgaaggatcgtcaacagttgctt420gcatacaggagcaaagtagataaaggatctgctgaggaagagaaaatcgatgtcatcctc480agcagctcgcaaattcgatggaagaactaaggttcttttgctacccaga529<210>25<211>1230<212>DNA<213>大鼠<400>25aagaattcggcacgaggccatggctggttgggcgggggccgagctctcggtcctgaaccc60gctgcgtgcgctgtggctgttgctggccgccgccttcctgctcgcactgctgctgcagct120ggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgggaa180gaccaagcagtccggctcgcggcgccccgccgtctgcagggccttcgacgtccccaagag240gtacttttctcacttctacgtcgtctcagtgttatggaatggctccctgctctggttcct300gtctcagtctctgttcctgggagcgccgtttccaagctggctttgggctttgctcagaac360tcttggggtcacgcagttccaagccctggggatggagtccaaggcttctcggatacaagc420aggcgagctggctctgtctaccttcttagtgttggtgttcctctgggtccatagtcttcg480gagactcttcgagtgcttctacgtcagcgtcttctctaacacggccattcacgtcgtgca540gtactgtttcgggctggtctactatgtccttgttggcctgaccgtactgagccaagtgcc600catgaatgacaagaacgtgtacgctctggggaagaatctactgctacaagctcggtggtt660ccacatcttgggaatgatgatgttcttctggtcctctgcccatcagtataagtgccacgt720cattctcagcaatctcaggagaaataagaaaggtgtggtcatccactgccagcacagaat780cccctttggagactggttcgagtatgtgtcttctgctaactacctagcagagctgatgat840ctacatctccatggctgtcaccttcgggctccacaacgtaacctggtggctggtggtgac900ctatgtcttcttcagccaagccttgtctgcgttcttcaaccacaggttctacaaaagcac960atttgtgtcctacccaaagcataggaaagctttcctcccgttcttgttttgaacaggctt1020tatggtgaagagcgcagcccaggtgacaggttcccttcctcgagacgctgagacaggctg1080aagtacactttctgcagctggcgcccgccaggctgctaccgagctgcgcgctcttccagg1140acctcatccgctacgggaagaccaagcagtccggctcgcggcgccccgccgtctgcagcc1200cgggggatccactagttctagagcgccgcc1230<210>26<211>393<212>DNA<213>大鼠<400>26ggcagcaagaagcaacccgcaagctaggagtctgtcagcgagggcaggggctgcctggtt60ggggtaggagtgggagcagggccagcaggagggtctgaggaagccattcaaagcgagcag120ctgggagagctggggagccgggaagggcctacagactacaagagaggatcctggcgtctg180ggcctcctgggtcatcaccatgaggccacttcttgccctgctgcttctgggtctggcatc240aggctctcctcctctggacgacaacaagatccccagcctgtgtcccgggcagcccggcct300cccaggcacaccaggccaccacggcagccaaggcctgcctggccgtgacggcctgatggc360cgcgacggtgcacccggagtccgggagagaaac393<210>27<211>778<212>DNA<213>大鼠<400>27ctgcaggtcgacactagtggatccaaagattcggcacgagataaggcacatttgcttcat60aaaataaaaaaaaaggaaatttacttagccgcatgtcagtcacccaaattttgagtgtac120aaatgaaatggaaaacatttattacacaaatttaattacaattctagggaataaacatgc180aaatcagatggagctcaatctgcaggcgctgatcctctccccctggtttgcagtctgtgc240acctcctggattcgcccgcgaccaggcagtcagaggcctggctcttgcaggcaggaggat300cactgttgtaaagaacagcgtcacatttagcgcatctggcgtagtagcagtttttaacac360tttgcgcaggtgcctcccttcccccacccgcgctttgttaggtctacctctctaaatctc420tgccttcctcgcacagtaagtgacctctccatgacaaagggcccccagacagcagttata480aatcaatgtgttttgggtttgtttgtttgtttgttttgttttaaagaaaaacccggccat540gcttggtggcacttgcctttaatagtagcgcttggtagacagaggcaagcggttctctgt600aagttcaaggccagcctggtctacacagtgagaccgggtctcaaaaacaaaacaacaaaa660aacaactcctattgaatccactacaggaagggggggcgcggatcactgtctgcaaactaa720agtgacttgagctcctgtcacagcctttccagcaagggcaagcttctttattagttat778<210>28<211>1123<212>DNA<213>大鼠<400>28gggccccccctcgagtcgacgktatcgataagcttgatatcgaattcctgcaggtcgaca60ctagtggatccaaagaattcggcacgagcctgaggcgactacggtgcgggtgccgggtgc120cgggtgcctacagcccccatcagcttccccggggagattctgccgatttgtcacgagcca180tgctcaggaggcagctcgtctggtggcacctgctggctttgcttttcctcccattttgcc240tgtgtcaagatgaatacatggagtctccacaagctggaggactgcccccagactgcagca300agtgttgccatggagattatggattccgtggttaccaagggccccctggacccccaggtc360ctcctggcattccaggaaaccatggaaacaatggaaataacggagccactggccacgaag420gggccaagggtgagaaaggagacaaaggcgacctggggcctcgaggggaacgggggcagc480atggccccaaaggatagaagggatacccaggggtgccaccagagctgcagattgcgttca540tggcttctctagcgactcacttcagcaatcagaacagtggcattatcttcagcagtgttg600agaccaacattggaaacttcttcgatgtcatgactggtagatttggggcccccgtatcag660gcgtgtatttcttcaccttcagcatgatgaagcatgaggacgtggaggaagtgtatgtgt720accttatgcacaatggtaacacggtgttcagcatgtacagctatgaaacaaagggaaaat780cagatacatccagcaaccatgcagtgctgaagttggccaaaggagatgaagtctggctaa840gaatgggcaacggtgccctccatggggaccaccagcgcttctctaccttcgcaggctttc900tgctttttgaaactaagtgatgaggaagtcaggatagctccatgctaagggcgatttgta960ggtgagctagggttgttaggatctgaggggtgttggagttgggcttctctatggagtatt1020taactgttacattggtcacactgctactcattctaatggcataccaattatgttggatac1080tttaggggctaggaagaatagaccacaaggtaatattcccaga1123<210>29<211>849<212>DNA<213>大鼠<400>29aattcggcacgaggtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaag60gttattctcctggttcactggctgttgacaacctggggctgcttggcgttctcaggctcc120tatgcttggggcaacttcactatcctggccctgggtgctgtgggctgtggcccagcggga180ctctgttgatgccattggcatgtttcttggtggcttggttgccaccatcttcctggacat240tatctacattagcatcttctactcaagcgttgccgttggggacactggccgcttcagtgc300cggcatggccatcttcagcttgctgctgcaagcccttctcctgctgcctcgtctaccaca360tgcaccgggcagcgagggggtgagctcccgctccgctcggatttcttcggaccttctcag420gaacatagtgcctaccagacaattgactcgtcagactcacctgcagacccccttgcaagc480ctggagaacaagggccaagctgccccccgggggtactgaagctgtccctggccgtcctgg540ggcccagcaggatgcttgtcaccttctttactggacctacaatggggtatcctccattcc600ctgccacagaggtggcctgagtcatgtgccctcggaggtcccagctgagaagagcccagt660cctaattctccatgctgcccctccattcaagacacctgttaacccctgggctagaactgt720ggttggtttcttcccctcctccccatcactataacacacaaccgccgagctgtgcagagt780gttcagggccatccaggccttatgggccaatgatcactgcctctcaggctaccccaaggt840gacccagcc849<210>30<211>1015<212>DNA<213>大鼠<220><400>30gaattcggcacgagggagcaagaagcaacccgaagctaggagtctgtcagcgagggcagg60ggctgcctggttggggtaggagtgggagcagggccagcaggagggtctgaggaagccatt120caaagcgagcagctgggagagctggggagccgggaagggcctacagactacaagagagga180tcctggcgtctgggcctcctgggtcatcaccatgaggccacttcttgccctgctgcttct240gggtctggcatcaggctctcctcctctggacgacaacaagatccccagcctgtgtcccgg300gcagcccggcctcccaggcacaccaggccaccacggcagccaaggcctgcctggccgtga360cggccgtgatggccgcgacggtgcacccggagctccgggagagaaaggcgagggcgggag420accgggactacctgggccacgtggggagcccgggccgcgtggagaggcaggacctgtggg480ggctatcgggcctgcgggggagtgctcggtgcccccacgatcagccttcagtgccaagcg540atcagagagccgggtacctccgccagccgacacacccctacccttcgaccgtgtgctgct600caatgagcagggacattacgatgccactaccggcaagttcacctgccaagtgcctggtgt660ctactactttgctgtccatgccactgtctaccgggccagcctacagtttgatcttgtcaa720aaatggccaatccatagcttctttcttccagttttttggggggtggccaaagccagcctc780gctctcagggggtgcgatggtgaggctagaacctgaggaccaggtatgggttcaggtggg840tgtgggtgattacattggcatctatgccagcatcaaaacagacagtaccttctctggatt900tctcgtctattctgactggcacagctccccagtcttcgcttaaaatacagtgaacccgga960gctggcacttgctcctagtggagggtgtgacattggtccagcgcgcataccagga1015<210>31<211>452<212>DNA<213>人<400>31ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>32<211>434<212>DNA<213>小鼠<400>32accaccaagcagatggaatgctggcacacccatgcacctgcatggcgtcacaggtggaag60attgttaaaaaattgacatcagaaatatttacagaaatagatacctgtttgaataaagtt120agagatgaaatttttgctaaacttcaaccgaagcttagatgcacattaggtgacatggaa180agtcctgtgtttgcacttcctgtactgttaaagcttgaaccccatgttgaaagcctcttt240acatattctttttcttggaattttgaatgttcccattgtggacaccagtaccaaaacagg300tgtgtgaagagtctggtcacctttaccaatattgttcctgagtggcatccactcaatgct360gcccattttggtccatgtaacagctgcaacagtaaatcacaaataagaaaaatggtgttg420gaaagagcgtcgcc434<210>33<211>903<212>DNA<213>小鼠<400>33ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaaggaatgtggg420gtatctggggccacaccattacctgtgggcttgctcctggagccaaaccctgcagcctta480agagagaggggcctgacctgctctctttccctccctagctccaggcctcctctcctgcct540cgtcactcctgtgttctggcctcttgagtgcctttggaggtgtctctgacctgtgaggat600cagagacagtccccgtttttaaacttcgacaattgacttttatttccttttctaattttt660attattttttaaaacaaccaggatgattatcacatctactcccccatccgtccagaaaag720ccccaaattgattccttcagggtctggcctgcccaggctctattccacatgtgcaggttc780caacagcttaaccctattctcttcccagtcatctgctgcaggtatagctgtctcatgccc840ctgcctgcctattctggccagtaccctaagccccaagatctccagcccctgccccagtat900cct903<210>34<211>1359<212>DNA<213>小鼠<220><221>不確定<222>(644)...(644)<400>34caaagaattcggcacgagaccggcctcactatgtctgccattttcaattttcagagtctg60ttgactgtaatcttgctgcttatatgtacatgtgcttatatccgatccctggcacccagc120atcctggacagaaataaaactggactattgggaatattttggaagtgtgcccgaattggg180gaacgcaagagtccttatgtcgccatatgctgtatagtgatggccttcagcatcctcttc240atacagtagctttggaaactaccagcatgtgcttgctatcagactgtaaacaaggacttg300cctccagaaaataatgggaagaatggttaagccatttgtctctgaacatggaatgagata360aacttcaagatgctgttctctatttttatgctattggaccaatgagctgaatgaataatt420aagatgtaacagttcaatacacaggaatgtgattgtatccatcaacctcagttctctcac480tccagtattacattctgcaaatgtcattctgttgtgtcaggactgcttttcataaggttc540ttcgggcacgaagtagaaacccagtggcaaattccaaggctcctttgactagggcttcaa600aataatgtcttcacagaatggtacctctagcgactgtcctattnttattgagaaaaaaac660ttgttctatttttgttgttgttactgttcttatggattgcattcatatttaaaccctttg720gattgctaaccagagtacctctattcttggcaaattccgcagtttattacaggtgtttaa780agtattttaaacaaaactctgaatttctttagttagcctaagagttggcttctagtcaca840aagatacagctgccacactgtgacgaagagcaccttagaaagaaaagcagcaagtgagcg900gtgagcaagtaagcaccgtgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctc960tgtagtcttgtcttccaaatagaacgtccatcgtagttacccaaaggtggtatttgtggt1020gttcttaatgcagtgctttaagtctagtgtatgttctgtcagcttgaactggaatctctc1080ttgtaactttgtaggttataaacatatctcatatctgctttagtctgggtactatgctct1140aagtacatttcagctttgacacagaatgtgaatagacgaatatcaaaggatacttacaag1200tttgtatccaacatttcttcaggttcagctgaaaatcagttactgtttcaaaacaaagag1260gaattaaatcctagctgaaaactatacatagcatttattaattaattactgggtttaact1320gctctttttaaaagtttgaaaaaaaaaaaaaaaaactcg1359<210>35<211>797<212>DNA<213>小鼠<400>35aattcggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgct60ggttgcgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcc120catctggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagta180cttaagtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcag240cgtggatcaactcatggagctggccgggttgagctgtgccacggctattgccaaggctta300tccccccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaa360taacggaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaac420tatctattaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtca480gaaaatggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaaggga540aaccctagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgca600actcactttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagag660aagaagtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacag720taagggaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaa780aaaaaaaaaaaaactcg797<210>36<211>896<212>DNA<213>小鼠<400>36ttaaggttttcagactttatttcatggtatttgacattgacacatactgagttagtaaca60agataccatgcagctccctctagcctcggatcaccgaagcaggaagaaggtcagactgcc120cccatcccagatttgcttagtttgtctcccaatgtgctggactttaaagacagggaatgg180agaagcagatggatgcttcagtttcagtcatttttggctctatagtgatctctgccttcc240tgtacctgtccttggctggaccctgggcagtaactgtcactcagatgaggacgatcatca300ttacaatggaccaactgagggatgccctcatattagaccaattaaaagttgctgtgagtt360aaaccaggaatgaccgcacttccacatcagaaatcaaacaaaatcaatggttgaagaaca420tggttaggagcctggctaggtatctttgagagatggatgcagctggctactcaggcaggt480aagcaatggaggtcagccacaccctatcgtgatgcactccccatgttcagggtaactgaa540gaagtgggtaaggccagctgaaggccagtcagggcaacttagatgtagcctggcttctac600ttccagcctccggggacaggcaaacacattttgggaagtaagatgatgtcccaattatta660tcagttttttgatatcacagtattgtcacagggagcactgggggtccaggctagcctggg720gtgaggctggccctcagcacacacaggagagcagcttaagtgggacctaaaaaggaccca780atgttacttggtttaatgaaggccccctcaaccccaacagcccctcctgctcagggacac840agttctcacccaattacacattaataacacacaaacagtgcctagcaatgggccag896<210>37<211>501<212>DNA<213>小鼠<400>37ctgcaggtcgacactagtggatccaaagaattcggcacgagaatcatggcgccgtcgctg60tggaaggggcttgtaggtgtcgggctttttgccctagcccacgctgccttttcagctgcg120cagcatcgttcttatatgcgactaacagaaaaggaagatgaatcattaccaatagatata180gttcttcagacacttctggcctttgcagttacctgttatggcatagttcatatcgcaggg240gagttcaaagacatggatgccacttcagaattaaagaataagacatttgataccttaagg300aatcacccatctttttatgtgtttaaccatcgtggtcgagtgctgttccggccttcagat360gcaacaaattcttcaaacctagatgcattgtcctctaatacatcgttgaagttacgaaag420tttgactcactgcgccgttaagctttttacaaattaaataacaggacagacacagaattg480agtattggagtttggggtgta501<210>38<211>766<212>DNA<213>小鼠<400>38gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaaagagcatgtccaaggtaccggggccaggagcactgc420ctgcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgag480aagcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagt540tgagagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagc600ataagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacatttta660tagctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcat720tacaagtggctttttgctgggcggttggcggggggcggggggacct766<210>39<211>480<212>DNA<213>小鼠<400>39ggcacgaggaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctc60cgcctggcctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggt120tggctttcctttttagtttttttactttttagtttagtttgttcttttccttccccaata180aatcattctcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaa240gtaggccccagtccataaggaggtgtgaacacacccccttactgcttatcacccatttga300caggaacgcccaggaggggagggggaggggaagaggtgagttctgcacagtcggacattt360ctgttgcttttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggcctt420cagatatgcacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc480<210>40<211>962<212>DNA<213>小鼠<400>40ggcacgagattagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgc60cattcatctctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaa120aaatgatgccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccag180cagcaacagcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggact240ggatcgaaacagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttc300ggacggccagtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgctt360gcccctgccggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccg420gaggagctctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagct480gcagtgtcaggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtg540caagaggtacacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagc600caagcccgcccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtct660gagctagacctggactgactaggaagcatctgctacccagatttgattgcttggaagact720ctctctcgagcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatc780aagcccagcaggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgt840aatgagtggtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatccca900gtcatttctttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaa960aa962<210>41<211>794<212>DNA<213>小鼠<400>41ggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttg60cgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatct120ggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaa180gtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtgg240atcaactcatggagctggccgggttgagctgtgccacggctattgccaaggcttatcccc300ccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacg360gaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatct420attaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaa480tggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccc540tagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgcaactca600ctttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaa660gtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagg720gaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaa780aaaaaaaactcgag794<210>42<211>1152<212>DNA<213>小鼠<400>42ggcacgagcttctcagggcctgccacccaaataagtctggccctagcctcaactctctct60caggctgggccacaggaagctgctgactggccacttgacaccctccccctaaagctaatg120tctgtgactatagggaggttagcactttttctaattggaattcttctctgtcctgtggcc180ccatccctcacccgctcttggcctggaccagatacatgcagcctctttctccagcacagc240ctttccctgagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcat300gtatgcattcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagcca360cgcgggtcttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgag420gttggggggtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcggggg480tgacacgaggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttcc540magactgcagagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaa600aaacaaaacaaaaataactctgaagggcgggaggatacccaagcctgatgcctgagagga660gtccctagacttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagag720aattttttggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctt780tttggctgccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacag840gagaagctcctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctcc900ccagggactcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgcca960accctgtctcctggcattgggctccggctctacctccccaagcagggcgaggccccgcct1020tctcagcctagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgccc1080acacaggtgacagtcccaagtagataacctccatgggacaagttgggtgttgccttaccc1140gcctgcccagcc1152<210>43<211>446<212>DNA<213>小鼠<400>43ggcacgagcttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatg60tttgtttgttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcaga120actcctggagctggagttagagacaatggtgagctgccttgtggatgttgggaattgaac180ccaggtcctctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaa240attatttttttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaa300ctaatatagattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaa360aacaagaactagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctga420gttcagtctccaggaaccacacagtg446<210>44<211>391<212>DNA<213>小鼠<400>44ggcacgagcccacgtctatgttcaccttcgttgttctggtaatcaccatcgtcatctgtc60tctgccacgtctgctttggacacttcaaatacctcagtgcccacaactacaagattgaac120acacagagacagatgccgtgagctccagaagtaatggacggccccccactgctggcgctg180tccccaaatctgcgaaatacatcgctcaggtgctgcaggactcagagggggacggggacg240gagatggggctcctgggagctcaggcgatgagcccccatcgtcctcctcccaagacgagg300agttgctgatgcctcctgatggcctcacggacacagacttccagtcatgcgaggacagcc360tcatagagaatgagattcaccagtaaggggt391<210>45<211>516<212>DNA<213>大鼠<400>45cctcctgtctctgctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccct60cccggcctccttcctggaggaagtggcgggcagtggggaagctgagggttcttcagcctc120ttccccaagcctgctgccgccccggactccagccttcagtcccacaccagggaggaccca180gcccacagctccggtcggccctgtgccacccaccaacctcctggatgggatcgtggactt240cttccgccagtatgtgatgctcattgcggtggtgggctcgctgacctttctcatcatgtt300catagtctgcgcggcactcatcacgcgccagaagcacaaggccacagcctactacccgtc360ctctttccccgaaaagaagtatgtggaccagagagaccgggctggggggccccatgcctt420cagcgaggtccctgacagggcacctgacagccggcaggaagagggcctggacttcttcca480gcagctccaggctgacattctggcttgctactcaga516<210>46<211>306<212>DNA<213>小鼠<400>46gtcaccagcaaaggtggaaacaaattctttgaaggactctgacagccctgggtctccaag60gctgctgggaccagtcttagcctcttgtggcaagtggtaggaatgtgaatctttgcgacc120agggggatcagaaatggggtctcccatttctggtgtctgcccagtccttccaggtgggct180cttcgtagccctggggtggattttcctcctcttccacagagatgctttttctctgcatac240catgtctgctggtttcccaaaatctcccgcaaacccacaccaccctccactgaggctcag300ccccag306<210>47<211>439<212>DNA<213>小鼠<400>47gaaaactcgcaggacgctcactggacagcttgggcttttttcagttgattttatggtttg60catctttctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaa120gcacatattactgagccattgcaagcaatgggaggggtccacaatgacacacacacacac180acacacacacatacacatacacacacccccgagacagtgccagagctaacagcctacatg240tgtattttggccaaacttggaaaataggtttccttcttcgttttgcttccagccttttat300ttgcaagtgatcttccatgcagtatgaaacatgcagacagcactggagtgtggcaagagt360gagcttgccccacaagtctctcggggatgttgtactcttgtgtgtgtttacagtatcatg420gctgttacatctactggtc439<210>48<211>159<212>DNA<213>小鼠<220><221>不確定<222>(3)...(3)<400>48cangtacgctcactggaacagcttgggcttttttcagttgattttatggtttgcatcttt60ctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaagcacata120ttactgagccattgcaagcaatgggaggggtccacaatg159<210>49<211>465<212>DNA<213>大鼠<400>49gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaaggttattctcctgg60ttcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggca120acttcactatcctggccctgggtgctgtgggctgtggcccagcgggactctgttgatgcc180attggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagc240atcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatc300ttcagcttgctgctgcaagcccttctcctgctgcctcgtctaccacatgcaccgggcagc360gagggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgcct420accagacaattgactcgtcagactcacctgcagacccccttgcaa465<210>50<211>337<212>DNA<213>大鼠<220><400>50ctcgtgccgaaatcggcagagcgtcgctcctgtgctgtgggnctaagctggncgnctgtg60gnatcgtcctcagcgnctggggagtgatcatgttgataatgctcgggatatttttcaatg120tccattctgctgtggtaatttagnatgtccccttcacagagaaagattttnagaacggcc180ctcagaacatatacaacctgtacgagcaagtcagctacaactgtttcatcgccgcgggcc240tctacctcctcctcgggggcttctccttctgcnaagttcgtctcaataagcgcaaggaat300acatggtgcgctagagcgnagtccnactctccccatt337<210>51<211>371<212>DNA<213>大鼠<220><221>不確定<222>(80)...(80)<221>不確定<222>(312)...(312)<221>不確定<222>(319)...(319)<221>不確定<222>(353)...(354)<400>51gatgcgccctggagccgactgggctgcggtctgcgctttgtggccttcctggcgaccgag60ctgctccctcccttccagcnggcgaattcagcccgacgagctgtggctttaccggaaccc120gtacgtgaaggcggaatacttccccaccggccccatgtttgtcattgcctttctcacccc180actgtccctgatcttcttcgccaagtttctgaggaaagctgacgccgaccgacagcgagc240aagcctgcctcgctgccagccttgccctagcgctaaatggtgtctttaccaacatcataa300gactgatagtgngcaaggncacgcccaaattgcttctaccgagtgttccccgnncgggat360tgcccattctt371<210>52<211>228<212>DNA<213>大鼠<400>52ttccgcgggcgtcatgacggctgcggtgttctttggttgcgccttcatcgccttcgggcc60cgcgctctccctttacgtcttcaccatcgccactgatcctttgcgagtcatcttcctcat120cgccggtgccttcttctggttggtgtctctgctgctttcgtctgttttctggttcctagt180gagagtcatcactgacaacagagatggaccagtacagaattacctgct228<210>53<211>361<212>DNA<213><400>53cgtggacactgctgaggaatgataccgagtggtaggtcagaagaagatgctgtgaacacc60aggactttaatcttatgcttgaaaatgccagatgttgttcgggggacaacttgtatcttt120ctagcagcagatctgtagtttgtatagcctcaacaacaattttaaataagatggagaata180aattattgaggggactaggctatatgcatttgccttcatccacccatgtttattaagaat240cattgtgcttaataataccaagactaagcaccataaccaagaaatactaatgtaaagatt300gtttcttgtttcaggaatggttaattcttcaacgttggtatgataatgataacttgtttt360g361<210>54<211>403<212>DNA<213><220><400>54ttgcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtcagt60ggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttcata120ttggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaacct180gaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttttct240tctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctataat300aacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcaccttc360aagtccgtgacacgggaagacactgggacatacacttgtatgg403<210>55<211>413<212>DNA<213>人<400>55tagcgtggtcgcggccgaggtacgactcggtgctcgccctgtccgcggccttgcaggcca60ctcgagccctaatggtggtctccctggtgctgggcttcctggccatgtttgtggccacga120tgggcatgaagtgcacgcgctgtgggggagacgacaaagtgaagaaggcccgtatagcca180tgggtggaggcataattttcatcgtggcaggtcttgccgccttggtagcttgctcctggt240atggccatcagattgtcacagacttttataaccctttgatccctaccaacattaagtatg300agtttggccctgccatctttattggctgggcagggtctgccctagtcatcctgggaggtg360cactgtctcctgttcctgtcctggggataagagcagggctgggtacctgcccg413<210>56<211>452<212>DNA<213>人<400>56ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>57<211>190<212>DNA<213>大鼠<220><400>57ttcgcggcccngtcgacggcattggcaaatagtcaaacctgggaagtaaaaagcaaaacc60aaaaacaaaaccaaagaaacaaactaaaacaaaacaagaaaaaccaacatttcttcaatt120cagtgtgcaacatatataaaacagaaatactaactctacaggcagtatgtcgacgcggcc180gcgtattcgg190<210>58<211>413<212>DNA<213>小鼠<400>58ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaagga413<210>59<211>325<212>DNA<213>小鼠<220><221>不確定<222>(213)...(213)<221>不確定<222>(223)...(223)<221>不確定<222>(227)...(227)<221>不確定<222>(243)...(243)<400>59ggtatcacccaggcccacttatccatctacagcgagtagtatggcggccttccttgtaac60aggctttttcttttctctcttcgtggtgcttgggatggaacccagggctttgtttaggcc120tgacaaggctctgcccctgagctgtgccaagcccacctccctctgtgtacaaagctcctt180tcttgggtgaccaacatcttcctgtctttgagnaaccaggggncagnatgggagccaccc240agnagttaattaaaccaggttcatcgggagtttgctgaaatgttaagcatactctgttct300agagagggagtgaagaaaggggcca325<210>60<211>372<212>DNA<213>小鼠<400>60ggccagcaggaccgcggtcatgagcctctgcaggtgtcaacaaggctcaaggagcaggat60ggatctcgatgtggttaacatgtttgtgattgcgggtgggaccctggccattccaatcct120ggcatttgttgcgtctttcctcctgtggccttcagcactgataagaatctattattggta180ctggcggaggacactgggcatgcaagttcgctacgcacaccatgaggactatcagttctg240ttactccttccggggcaggccaggacacaagccatccatccttatgctccatggattctc300cgcacacaaaggacatgtggctcagcgtggccaagttccttcccgaaagaacctgcactt360tggctgtgtgga372<210>61<211>363<212>DNA<213>小鼠<220><221>不確定<222>(15)...(15)<400>61gggcgcgcaggcggnaccggtggcggcggggctgctgctggctaattggcacaggactgc60gggccgcgacatggactgtcctgtgcagcccgaattccagcctcgttgtagccaggcaca120ccaagagctttccaccaaagaagcccctccaagcactgaccatgtctattatggaccaca180gccccaccaccggggtggtaacggtcattgtcatcctcatcgccatagctgccctggggg240gcttgatcctgggctgctggtgctacctgcggctgcagcgcatcagccagtcagaggatg300aggagagcatcgtgggtgatggcgagacaaaggagcccttttactggtgcagtactctgc360taa363<210>62<211>399<212>DNA<213>小鼠<400>62aagggtcctgaagtcagttgttgcatcaaatacttcatttttggcttcaatgtcatattt60tggtttttgggaataacgtttcttggaatcggactgtgggcgtggaatgaaaaaggtgtc120ctctccaacatctcgtccatcaccgacctcggtggctttgacccagtgtggcttttcctc180tgagtggccagcccgagcctgagctctgtcaatgacatccaaggagaaaatgaggttaat240gagagacattaattaaacactccctcaccccaccgcaccaaaccagttgggttcttctga300tattctggaatactctgggctatgttttatgtttatttcttttttaatcggttgtatttt360ggtctttttttttcttcttctttttcttttgctcccaaa399<210>63<211>399<212>DNA<213>小鼠<220><400>63caaagcccactgtaggctccgctgaggtagcgattgctgtatttctggtcatctgcatca60tagtggtcttaaccatcctgggctactgtttcttcaagaaccaaagaaaggaattccaca120gtcccctgcaccacccacctcccacaccagccagctccactgtttccaccacagaggaca180cagagcacctggtctataatcacacaacccagcctctctgagcctgggactcttgccagt240cttaccaggtcctgcttgccaagacagaagctagaacctggaaaaacttggggaccagac300tcttcctacctctttcctgggcatacttacgctgtctcagaagacagatctctgggcctc360tcgcaggagtctcagctgcactcaggccagttcctgggg399<210>64<211>2481<212>DNA<213>大鼠<400>64gaactgtatctggatgggaaccagtttacactggtcccgaaggaactctccaactacaaa60catttaacacttatagacttaagtaacaacagaataagcaccctttccaaccaaagcttc120agcaacatgacccaacttctcaccttaattctcagttacaaccgtctgagatgtatccct180ccacggacctttgatggattgaaatctcttcgtttactgtctctacatggaaatgacatt240tctgtcgtgcctgaaggtgcctttggtgacctttcagccttgtcacacttagcaattgga300gccaaccctctttactgtgattgtaacatgcagtggttatccgactgggtgaagtcggaa360tataaggaacctggaattgcccgctgtgccggtcccggagaaatggcagataaattgtta420ctcacaactccctccaaaaattttacatgtcaaggtcctgtggatgttactattcaagcc480aagtgtaacccctgcttgtcaaatccatgtaaaaatgatggcacctgtaacaatgacccg540gtggatttttatcgatgcacctgcccatatggtttcaagggccaggactgtgatgtcccc600attcatgcctgtacaagtaatccatgtaaacatggaggaacttgccatttaaaaccaagg660agagaaacatggatttggtgtacttgtgctgatgggtttgaaggagaaagctgtgacatc720aatattgatgattgcgaagataatgattgtgaaaataattctacatgcgttgatggaatt780aacaactacacgtgtctttgcccaccggaatacacaggcgaactgtgtgaggaaaaactg840gacttctgtgcacaagacctgaatccctgccagcatgactccaagtgcatcctgacgcca900aagggattcaagtgtgactgcactccgggatacattggtgagcactgtgacatcgacttt960gatgactgccaagataacaagtgcaaaaacggtgctcattgcacagatgcagtgaacgga1020tacacatgtgtctgtcctgaaggctacagtggcttgttctgtgagttttctccacccatg1080gtcttccttcgcaccagcccctgtgataattttgattgtcagaatggagcccagtgtatc1140atcagggtgaatgaaccaatatgccagtgtttgcctggctacttgggagagaagtgtgag1200aaattggtcagtgtgtcaattttggtaaacaaagagtcctatcttcagattccttcagcc1260aaggttcgacctcagacaaacatcacacttcagattgccacagatgaagacagcggcatc1320ctcttgtacaagggtgacaaggaccacattgctgtggaatctatcgagggcattcgagcc1380agctatgacaccggctctcacccggcttctgccatttacagtgtggagacaatcaatgat1440ggaaacttccacattgtagagctactgaccctggattcgagtctttccctctctgtggat1500ggaggaagccctaaaatcatcaccaatttgtcaaaacaatctactctgaatttcgactct1560ccactttacgtaggaggtatgcctgggaaaaataacgtggcttcgctgcgccaggcccct1620gggcagaacggcaccagcttccatggctgtatccggaacctttacattaacagtgaactg1680caggacttccggaaagtgcctatgcaaaccggaattctgcctggctgtgaaccatgccac1740aagaaagtgtgtgcccatggcacatgccagcccagcagccaatcaggcttcacctgtgaa1800tgtgaggaagggtggatggggcccctctgtgaccagagaaccaatgatccctgtctcgga1860aacaaatgtgtacatgggacctgcttgcccatcaacgccttctcctacagctgcaagtgc1920ctggagggccacggcggggtcctctgtgatgaagaagaagatctgtttaaccccctgcca1980ggtgatcaagtgcaagcacgggaagtgcaggctctctgggctcgggcagccctattgtgg2040atgcagcagtggattcaccggggacagctgacacagagaatttcttgtcgaggggaacgg2100ataagggattattaccaaagcagcagggtacgctgcctgtcaaacgactagaagtatctc2160gcttggagtgcagaggcgggtgtgctggggggcagtgctgtggacctctgagaagcaaga2220ggcggaaatactctttcgaatgcacagatggatcttcatttgtggacgaggtcgagaagg2280tggtgaagtgcggctgcacgagatgtgcctcctaagtgcagctcgagaagcttctgtctt2340tggcgaaggttgtacacttcttgaccatgttggactaattcatgcttcataatggaaata2400tttgaaatatattgtaaaatacagaacagacttatttttattatgataataaagaattgt2460ctgcatttggaaaaaaaaaaa2481<210>65<211>3008<212>DNA<213>小鼠<220><400>65tagacgggagcctgtggctacaagccactcagcctgatgacgccggccactatacctgtg60ttcccagcaatggctttctgcatccaccgtcagcttctgcctatctcactgtgctctacc120cagcccaggtgacagtcatgcctcccgagacacccctgcccactggcatgcgtggggtga180tccggtgtccggttcgtgctaatcccccactactgtttgtcacctggaccaaagacggac240aggccttgcagctggacaagttccctggctggtccctgggcccagaaggttccctcatca300ttgcccttgggaatgaggatgccttgggagaatactcctgcaccccctacaacagtcttg360gtactgctggaccctcccctgtgacccgggtgctgctcaaggctcccccggcttttatag420accagcccaaggaagaatatttccaagaagtagggcgggagctactcatcccgtgctccg480cccggggagaccctcctcctattgtctcttgggccaaggtgggccgggggctgcagggcc540aggcccaggtggacagcaacaacagcctcgtccttcgacccctgaccaaggaggcccagg600gacgatgggaatgcagtgccagcaatgctgtagcccgtgtgaccacttccaccaatgtat660atgtgctaggcaccagcccccatgtcgtcaccaatgtgtctgtggtacctttacccaagg720gtgccaatgtctcttgggagcctggctttgatggtggctatctgcagagattcagtgtct780ggtataccccactagccaagcgtcctgaccgagcccaccatgactgggtatctctggctg840tgcctatcggggctacacacctcctagtgccagggctgcaggctcacgcgcagtatcagt900tcagtgtccttgctcagaataagctgggcagtgggcccttcagtgagattgtcctgtcta960taccagaagggcttcctaccacaccggctgcccctgggctgcctgcaaccaggagcagag1020tgtgagcctgacttcccacgtggagagaagatcagaggcggatcctggcgcagacgtttt1080cggtggcgtcgggcagccctgcgccgattcatcaggcaggcagctaggatgctcacaagg1140accgccacgcccaagaagcagactccacccacaacaccagccaatacaggctggggcagg1200agacctggtagctgtgtgcgggaggggtacacctccaggccggaagtggagatgttggct1260acgttgctggggtcactgacgtagctatcagcgaaggccacgaggcgaaactcatagaga1320acgtccttgatgaggccaggcaccagcagctggatttctgtgcccgccacaccttggtcc1380aggatctcccagccttgggagccttgccgtccctccaggatgtagccatccagcctccca1440gggatgagttctgggggatccctctgatcttctctccacgtgggaagtcaggctcacact1500ctgctcctggttcaggcagccctgacagcgtgaccaagttcaagctccaaggctccccag1560ttcccatcctacgccagagtctgctctggggggagcctgctcgaccgcctagccctcacc1620cggattctccacttggccggggacccttaccattagagcccatttgcaggggcccagatg1680ggcgctttgtgatgggacccactgtggccccctcacaagaaaagttatgtctggagcgcc1740cagaacctcggacctcagctaaacgcttggcccagtcctttgactgtagcagtagcagcc1800ccagtggggtcccacaacccctctgcattacagacatcagccccgtggggcagcctcttg1860cagccgtgcctagccccctaccaggtccaggacccctgctccagtatctgagcctaccct1920tcttccgagagatgaatgtggacggggactggccacctcttgaggagcccacgcctgctt1980cggcttcaaaattcatggatagtcaagccctgccccacctatctttccttccaccaccag2040actcacctcctgcaaatctcagggcaagtgcttcctgggacactgatgggggtcggggtc2100tcctcagagcccccttacacagctttggctgattggactctgagggagcgggtcttgccg2160ggccttctttctgctgcccctcgtggtagcctcaccagccagagcatgggaggggcaagc2220gcctccttcctgcgccctccctcacagccccctccgcaggggaagctacctcagtccact2280ccaggagacacaaagcagctggggccagtggcccccgaaaggtggccccgcaagggaaca2340tgtggtgacagtcacaaaaaggaggaaccacctctgtggatgagaactatgaatgggatt2400cggaattcccaggggacatggagctgctagagacctggcacccaggcttggccagttctc2460ggacccatcctgaacttgagccagagttaggtgtcaagactccagaggagagctgtctcc2520tgaacccaacccacgctgccggccccgaggcccgctgtgctgcccttcgggaggaattcc2580tagctttccgcagacgcagggatgctaccagggcccggctaccagcctatcagcagtcca2640tctcttaccctgaacaggctactctgctatgagcccgcttagtgtgaaactaagaaaggc2700ttatatggatttgcaaaggagtccaagactttggctccaagctggggtactgcccctacc2760tctctgtgtctcggtggcctggtggtaggcttgagtgagcttggtatagagttggatgta2820ctgactctttaattgagtttgggagctgaacaggaatgtgtgtgtgtgtgtgtgtgtgtg2880tgtgtgtgtgtgtgtgcgcgcgcaagcgcaagcgcgagttcgaaagtggtgtttatggtg2940tgggtgcaggttttttttttttaaaaaacaggtggataataaatgtttggaaccgttaaa3000aaaaaaaa3008<210>66<211>1888<212>DNA<213>小鼠<220><221>不確定<222>(1690)...(1690)<221>不確定<222>(1755)...(1755)<221>不確定<222>(1864)...(1864)<400>66aaagtggagggcgagggccggggccggtgggctctggggctgctgcgcaccttcgacgcc60ggcgaattcgcaggctgggagaaggtgggctcgggcggcttcgggcaggtgtacaaggtg120cgccatgtgcactggaagacgtggctcgcgatcaagtgctcgcccagtctgcacgtcgac180gacagggaacgaatggagctcctggaggaagctaagaagatggagatggccaagttccga240tacattctacctgtgtacggcatatgccaggaacctgtcggcttggtcatggagtacatg300gagacaggctccctggagaagctgctggcctcagagccattgccttgggacctgcgcttt360cgcatcgtgcacgagacagccgtgggcatgaacttcctgcattgcatgtctccgccactg420ctgcacctagacctgaagccagcgaacatcttgctggatgcccactaccaaatgtcaaga480tttcttgactttgggctggccaagtgcaatggcatgtcccactctcatgacctcagcatg540gatggcctgtttggtacaatcggctacctccctccagagcgaattcgtgagaagagccgc600ttgtttgacaccaaacatgatgtatacagcttcgccattgtgatctggggtgtgcttaca660cagaataatccatttgcagatgaaaagaacatcctacacatcatgatgaaagtggtaaag720ggccaccgcccagagctgccacccatctgcagaccccggccgcgtgcctgtgccagcctg780atagggctcatgcaacggtgctggcatgcagacccacaggtgcggcccaccttccaagaa840attacctctgaaacagaagacctttgtgagaagcctgatgaggaggtgaaagacctggct900catgagccaggcgagaaaagctctctagagtccaagagtgaggccaggcccgagtcctca960cgcctcaagcgcgcctctgctccccccttcgataacgactgcagtctctccgagttgctg1020tcacagttggactctgggatcttcccaagactcttgaaaggccccgaagagctcagccga1080agttcctctgaatgcaagctcccatcgtccagcagtggcaagaggctctcgggggtgtcc1140tcagtggactcagccttttcctccagaggatcgctgtcactgtcttttgagcgggaagct1200tcaacaggcgacctgggccccacagacatccagaagaagaagctagtggatgccatcata1260tcaggggacaccagcaggctgatgaagatcctacagccccaagatgtggacttggttcta1320gacagcagtgccagcctgctgcacctggctgtggaggccggacaggaggagtgtgtcaag1380tggctgctgcttaacaatgccaaccccaacctgaccaacaggaagggctctacaccactg1440catatggctgtggagcggaagggacgtggaattgtggagctactgctagcccggaagacc1500agtgtcaatgccaaggatgaagaccagtggactgccctgcactttgcagcccaaaatggg1560gatgaaggccagcacaaggctgctgctagagaagaatgcttctgtcaatgaggtggactt1620tgagggccgaacacccatgcatgtagcctgccagcatggacaggagaacattgtgcgcac1680cctgctccgncgtggtgtggatgtgggcctgcagggaaaggatgcctggttgcctctgca1740ctatgctgcctgcanggccaccttcccattgttaagctgctagccaagcagcctggggtg1800agtgtgaatgcccagacactaacgggaggacaccctgacctgctgttcaaaggggcattt1860accngtggctcgcattctcattgacctg1888<210>67<211>1260<212>DNA<213>大鼠<400>67gtcgctttgggtatcagatggatgaaggcaaccagtgtgtggatgtggacgagt60gtgcgacagattcacaccagtgcaaccctacccagatctgtatcaacacggaaggagggt120acacctgctcctgcactgatgggtactggcttctggaagggcagtgcctagatattgatg180aatgtcgctatggttactgccagcagctctgtgcgaatgttcctggatcctattcctgta240cgtgtaaccctggcttcaccctcaacgatgatggaaggtcttgccaagatgtgaacgagt300gtgaaactgagaacccctgtgttcagacctgcgtcaacacctatggttctttcatctgcc360gctgtgacccaggatatgaactggaggaagatggcattcactgcagtgatatggatgagt420gcagcttctccgagttcctctgtcaacatgagtgtgtgaaccagccgggctcatacttct480gctcatgccctccaggctacgtcttgttggaagataaccgaagctgccaggatatcaatg540aatgtgagcaccggaaccacacatgcactcccctgcagacttgctacaatctgcaagggg600gcttcaaatgtatcgaccccatcgtctgcgaggagccttatctgctgattggggataacc660gctgtatgtgccctgctgagaatactggctgcagggaccagccattcaccatcttgtttc720gggacatggatgtggtatcaggacgctctgttcctgctgacatcttccagatgcaagcaa780cgacccgataccctggcgcctattacattttccagatcaaatctgggaacgagggtcgag840agttctacatgcggcaaacagggcctatcagtgccaccctggtgatgacacgccccatca900aagggcctcgggacatccagctggacttggagatgatcaccgtcaacactgtcatcaact960tcagaggcagctccgtgatccgactgcggatatacgtgtcccagtatccgttctgagcct1020cgggttaaggcctctgacactgccttttaccacgccgagggacaggaggagagaagaacc1080ccaacgagggacaggaggagagaagaaaccagcaagaatgagagcgagacagacattgca1140cctttcctgctgaacatctccctggggcatcagcctagcatcctgacccctacctgtact1200atcgcaaactgtcactctgaaggacaccatgccccagttcctatgatgcagtagtatcca1260<210>68<211>1729<212>DNA<213>小鼠<400>68gaattcggcacgagcagaatatggctctgggggttctgatagcagtctgcctcttgttca60aagcaatgaaggcagcactgagcgaagaagcagaggtgatccctcctagcacagcacagc120agagcaactggacatttaacaacaccgaagctgactacatagaagaacctgtagctctga180agttctctcatccttgtctggaagaccataatagttactgcattaatggagcatgtgcat240tccaccatgagctgaagcaagccatttgcagatgctttactggttatacgggacaacgat300gtgagcatttgaccctaacttcgtatgctgtggattcttatgaaaaatacattgcgattg360ggattggcgtcggattgctaattagtgcttttcttgctgtcttctattgctacataagaa420aaaggtgtataaatctgaaatcaccctacatcatctgctctggagggagcccattgtgag480accttataagacatagtcatcaagccatttgtcaaaagccacagggaatccaatggagat540ctttggatgatacaaaatgtgataagctaacttgaaaataatggtggtttgggtcacaat600gcagtaactgaccattggttcttagctttggtcatcgttgggtgccatggaagctatggg660aatgagctacagtaacagaagccaagttcactacccttctttgggtttgctgttgggtgg720ttgttgtcactgcaggaagatttgttctatacttctgaccatctcagatgtgaattttca780ttttaattgttttctactacacatcaatcaagtccaagtaatgccatttccgggttcttc840gggcactcaacattttgggccacccgcctcgatggacctaatagcaaagtatctgtcctt900atggaatttcagggaatttggtatcaatttttagatgaaaacagtgaatgtctcagctcc960ttgagtgaaccaaagatgcattacacctaaaccactaaaagaaaatggaatatccaaggc1020agcataaatcctacccagctggtgacaacagtttgcaaacttcattcatgtagtttggaa1080gaagcagataaattcctgaggactgaaagtcacctggacagcagatccagagcaggcaaa1140ggtagctggttcctatatcgaccataaagcctgtgtgggctcatctgtcccctgatgttt1200ttgcctatcatctcagccttacattggaagactcacacttggtatccatcgcttgaactg1260aagttcgacaattcacctaatgactaaaagcttacaattgttcccaaaatatataggaac1320aacagcatgtggaatgtaaccattttttgacgtgttgatagcatatttgcacatgggtta1380aaaaaagaaacagtcgtagaaatacttattagggaatcagtatccctccttggaattgct1440tctgctacatgattcaatcttgggcaagtctcttatattctttgtggtttggttccattc1500tctacaagacccatgcagttccaaaattgaactctaatagaactaaaaaatacctcctat1560aactgcatggcaggcaagattatcctcaatgcttccatcctcagccccgtttctaaccct1620caaatacccacgaatattatccttactatatattgtcatgttcagtttgtaaaataataa1680cttattttgaaaagaaataaaaaatgaaattacaaagcaaaaaaaaaaa1729<210>69<211>355<212>DNA<213>大鼠<400>69ctcgtgccgcaattcggcacgaggattcgctatactgcatatgaccgagcctacaaccgg60gccagctgcaagttcattgtaaaagtacaagtgagacgctgtcctattctgaaaccacca120cagcatggctacctcacctgcagctcagcgggggacaactatggtgcgatctgtgaatac180cactgcgatggtggttatgaacgccaagggaccccttcccgagtctgtcagtcaagtcga240cagtggtctggatcaccacctgtctgtactcctatgaagattaatgtcaatgttaactca300gctgctggcctcctggatcagttctatgagaaacagcgactcctcatagtctcag355<210>70<211>1421<212>DNA<213>人<400>70gattagcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtc60agtggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttc120atattggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaa180cctgaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttt240tcttctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctat300aataacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcacc360ttcaagtccgtgacacgggaagacactgggacatacacttgtatggtctctgaggaaggc420ggcaacagctatggggaggtcaaggtcaagctcatcgtgcttgtgcctccatccaagcct480acagttaacatcccctcctctgccaccattgggaaccgggcagtgctgacatgctcagaa540caagatggttccccaccttctgaatacacctggttcaaagatgggatagtgatgcctacg600aatcccaaaagcacccgtgccttcagcaactcttcctatgtcctgaatcccacaacagga660gagctggtctttgatcccctgtcagcctctgatactggagaatacagctgtgaggcacgg720aatgggtatgggacacccatgacttcaaatgctgtgcgcatggaagctgtggagcggaat780gtgggggtcatcgtggcagccgtccttgtaaccmtgattctcctgggaatcttggttttt840ggcatctggtttgcctatagccgaggccactttgacagaacaaagaaagggacttcgagt900aagaaggtgatttacagccagcctagtgcccgaagtgaargagaattcaaacagacctcg960tcattcctggtgtgagcctggtcggctcaccgcctatcatctgcatttgccttactcagg1020tgctaccggactctggcccctgatgtctgkagtttmacaggatgccttatttgtctttta1080caccccacagggccccctacttcttcggatgtgtttttaataatgtcagctatgtgcccc1140atcctccttcatgccctccctccctttcctaccactgmtgagtggcctggaacttgttta1200aagtgtttattccccatttctttgagggatcaggaaggaatcctgggtatgccattgact1260tcccttctaagtagacagcaaaaatggcgggggtcgcaggaatmtacactcaactgccca1320cctggctggcagggatctttgaataggtatcttgagcttggttctgggctctttccttgt1380gtacctgcccgggcggccgctcgaaatcaagcttatcgata1421<210>71<211>378<212>DNA<213>人<400>71tagcgtggtcgcggccgaggtacaaaaaaaccttacataaattaagaatgaatacattta60caggcgtaaatgcaaaccgcttccaactcaaagcaagtaacagcccacggtgttctggcc120aaagacatcagctaagaaaggaaactgggtcctacggcttggactttccaaccctgacag180acccgcaagacaaaacaactggttcttgccagcctctagagaaatcccagaacactcagc240cctgacacgttaataccctgcacagatcagaggctgctggccacacagactcaccaagcc300acagacttgtcttccacaagcacgttcttaccttagccacgaagtgacccaagccacacg360tacctgcccgggcggccg378<210>72<211>267<212>DNA<213>小鼠<400>72ggggcatgggccatgctgtatggagtctcgatgctctgtgtgctggacctaggtcagccg60agtgtagttgaggagcctggctgtggccctggcaaggttcagaacggaagtggcaacaac120actcgctgctgcagcctgtatgctccaggcaaggaggactgtccaaaagaaaggtgcata180tgtgtcacacctgagtaccactgtggagaccctcagtgcaagatctgcaagcactacccc240tgccaaccaggccaaagggtggaagtc267<210>73<211>1633<212>DNA<213>小鼠<220><400>73ggcacgagcgggagcctgctactgccctgctgggttccttggggccgactgtagccttgc60ctgtccacagggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggc120ggcatgtgacccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattg180tgagcgcggctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcag240gaatgggggcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggg300gccacactgtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtg360ttcctgtcagaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctgg420cttctatggtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgcca480gagagtttgcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctg540ccctgctggcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggaga600tggctgcctgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcct660ctgcctttgcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccg720ctttgggccgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccat780cagtgggcagtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccac840acagctgtcctctatcagaccagcaccccagcactccagcagcaaggccatgaagcacta900actcagaggaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctc960tgctggtgactaagatagaggtggcacttttggatccacacctcttctggaaagccatgg1020attgctgtggacagctatggatagtcatatagccacacacccgggctccatggtcatggg1080gaagaaggcctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgt1140ttacatggggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggat1200gggaccaaggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggc1260catggactgctgcagccagccaactgtttacctggaaatgtagtccagaccatatttata1320taaggtatttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcct1380gaccccagaacttaggcagtggcctgtggggtctccagcaagtgggatcaagggttttgt1440aaaacccagtgagttaaaggcacagtggtgtccccattgcctgggtttctgtgctttctg1500tagactccgtgggtccttccaagagcaggtggcctgagggttcttgaatgggaacctcctgt1560acccctctgtaatgacatgcatgtaatgtaatgcttcagtcaccttagggttcttcctga1620cttccagctctag1633<210>74<211>1252<212>DNA<213>小鼠<400>74ggaagagccgtgcaataatgggtctgaaatccttgcttataacatcgatctgggagacag60ctgcattactgtgggcaacactaccacacacgtgatgaagaacctccttccagaaacgac120ataccggatcagaattcaggctatcaatgaaattggagttggaccatttagtcagttcat180taaagcaaaaactcggccattaccgccttcgcctcctaggcttgagtgtgctgcgtctgg240tcctcagagcctgaagctcaagtggggagacagtaactccaagacacatgctgctggtga300catggtgtacacactacagctggaagacaggaacaagaggtttatctcaatctaccgagg360acccagccacacctacaaggtccagagactgacagagtttacctgctactccttcaggat420ccaggcaatgagcgaggcaggggaggggccttactcagaaacctacaccttcagcacaac480caaaagcgtgcctcccaccctcaaagcacctcgagtgacgcagttagaagggaattcctg540tgaaatcttctgggagacggtaccaccgatgagaggcgaccctgtgagctacgttctaca600ggtgctggttggaagagactctgagtacaagcaggtgtacaagggagaagaagccacatt660ccaaatctcaggcctccagagcaacacagattacaggttccgcgtgtgtgcctgccgccg720ctgtgtggacacgtctcaggagctcagtggcgcgttcagcccctctgcggctttcatgtt780acaacagcgtgaggttatgcttacaggggacctgggaggcatggaagaagccaagatgaa840gggcatgatgcccaccgacgaacagtttgctgcactcatcgtgcttggcttcgcgaccct900gtccattttgtttgcctttatattacagtacttcttaatgaagtaaatccagcaggccag960tggtatgctcggaacgccacacgttttaatacacatttactcagagcctcccctttttac1020gctgtttcgttctttgatttatacgcttctcttgttttacacatttagctaggggaaaga1080gtttggctgcacctatttgagatgcaaaactaggaagaggttaaactggattttttttta1140aacaataataaataaaggaataaagaagagaaggaagcggcgggcaagctccagacaccg1200agagccagtgtgcccaacgagcttgccttgtcgggcttcccgtgtgcttctg1252<210>75<211>2411<212>DNA<213>小鼠<400>75tcggcacgagagtgggtacaccttactacatgtctccagagagaatacatgaaaatggat60acaacttcaagtctgacatctggtctcttggctgtctgctatatgagatggctgcactgc120agagtcctttctacggcgacaagatgaacttgtattctctgtgtaagaagatagagcagt180gtgactacccgcctctcccgtcagatcactattcggaggagctacgacagctagttaata240tatgcatcaacccagatccagagaagcgacccgacatcgcctatgtttatgatgtggcaa300agaggatgcatgcatgtaccgcaagcacctaaactgtacaagatcctgaagacggcaacc360aagataacttaaaagtgtttttgtgcagatcatacctccccgcttatgtctgggtgttaa420gattactgtctcagagctaatgcgctttgaatccttaaccagttttcatatgagcttcat480ttttctaccaggctcaatcaccttcccaatccacaactttgggatgctcagatggcacca540agaatgcaagcccaacaagagtttttcgtttgagaattgtttcgagtttctgctgataga600ctgtgtttatagatagtcagtgcccgatggtgaagcacacacacataggcacatgtccag660agcgatgcagaacctgaggaaggacctgggcatttgacttgtttgcttttaagtcactta720atggacgttgtagtggacatgattgtgaacttctgatttttttcttttaagtttcaagta780catgttttagttcttagcattagagatctcaaatataattcttataagacatgcagacat840aaactttttgagaaagatttaaaatttttagtttatacattcaaaatgcaactattaaat900gtgaaagcatagaggtcaaaatgtgagttggacactgaagtctatgttttaatgcctttg960aaagcctttttttgtgtgtgtttaaatggtataaatgaacccattttaaaacgtggttaa1020ggacttgtttgcctggcgtgatagtcatgtttaacatgcacaaggctttgtgtttttatt1080gtacatttgaagaatattcttggaataatcttgcagtagttatagttcaatttctttaca1140aatctaaatacacttaactcataactatacactgtaatgcaagcatatattgttattcat1200atattgaagttttgatcagttcctcttcagaatcttttttatccaagttactttcttatt1260tatattgtgtgtgcatttcatccattaaatgtttcagattttctgagaatgagttccctt1320tttaaaatatatttggtatgccaacacttttttaggattgaaaaaaaatttttttaaatg1380tttgggtcattctaggtgcatctgttttctcttgttagaaagaaaaggtgtgtgttaaaa1440tgtgcctgtgaatgtcgatattgtttggcagggttataattttagagtatgctctagagt1500atgttgaacagcgtgaagactggcccttactgaagacagaactgttccaagagcagcatt1560cccgttgagatgctttggagtaaagtactgtgtatgacgatgacagacattttagttaag1620ggggtgaaaaaaaaaggaggggtatttaggaaaccctgaggtggaattttggtgaatgtc1680ttcatcttaataccagccaattccttcagagaattgtggagccaaagaacagagtaatcg1740tggctgttgcagaacacggtgtgccatggtagagcattgggaaggctcatcctgccggtg1800ggtcggtcagacagccctgtgttggggagcttgtactctggcccacagagctcggttgat1860tttcttacagagtattctttctacagttattttcaagtaattgtaaattttcaaagtaat1920atctcatcttttaattcactatgtatgctgtcgtagacaaaggaaatctgggtttttttt1980tgtttttgtttttgtttttttttgtcttgaaggctgaactgggtacatcccagatcttag2040tggctcataggatatacccagaggcatgaagaaatggcttccggtgaccatttgtgttgk2100gktatatcccattgtaatgtcacaggactgattgagatgaaacatccccttcctacaaga2160gttgttttctttccatatttaaaaacatgaggttctgcctggcagtgatggtacacacct2220ttaatcccagcacccgggaggcagaggcaggaggatttctgagttcgaggccagcctggt2280ctacaaagtgagttccaggacagccaggactacacagagaaatcctgtctcaaaaaacca2340aaactaaatgaaaatacaaggcttctccccttgtagtgactttgctttatgaatttgtct2400caaaaaaaaaa2411<210>76<211>1335<212>DNA<213>小鼠<400>76acccaaacagcccgggaccatgctgtcgctccgctccttgcttccacacctgggactgtt60cctgtgcctggctctgcacttatccccctccctctctgccagtgataatgggtcctgcgt120ggtccttgataacatctacacctccgacatcttggaaatcagcactatggctaacgtctc180tggtggggatgtaacctatacagtgacggtccccgtgaacgattcagtcagtgccgtgat240cctgaaagcagtgaaggaggacgacagcccagtgggcacctggagtggaacatatgagaa300gtgcaacgacagcagtgtctactataacttgacatcccaaagccagtcggtcttccagac360aaactggacagttcctacttccgaggatgtgactaaagtcaacctgcaggtcctcatcgt420cgtcaatcgcacagcctcaaagtcatccgtgaaaatggaacaagtacaaccctcagcctc480aacccctattcctgagagttctgagaccagccagaccataaacacgactccaactgtgaa540cacagccaagactacagccaaggacacagccaacaccacagccgtgaccacagccaatac600cacagccaataccacagccgtgaccacagccaagaccacagccaaaagcctggccatccg660cactctcggcagccccctggcaggtgccctccatatcctgcttgtttttctcattagtaa720actcctcttytaaagaaaactggggaagcagatctccaacctccaggtcatcctcccgag780ctcatttcaggccagtgcttaaacatacccgaatgaaggttttatgtcctcagtccgcag840ctccaccaccttggaccacagacctgcaacactagtgcacttgagggatacaaatgcttg900cctggatctttcagggcacaaattccgcttcttgtaaatacttagtccatccatcctgcg960tgtaacctgaagttctgactctcagtttaacctgttgacagccaatctgaacttgtgttt1020cttgccaaaggtattcccatgagcctcctgggtgtgggggtggggagggaatgatccttc1080tttactttcaaactgatttcagatttctggccaaacctactcaggttgcaaaggacttat1140gtgacttatgtgactgtaggaaaaagagaaatgagtgatcatcctgtggctactagcaga1200tttccactgtgcccagaccagtcggtaggttttgaaggaagtatatgaaaactgtgcctc1260agaagccaatgacaggacacatgactttttttttctaagtcaaataaacaatatattgaa1320caaggaaaaaaaaaa1335<210>77<211>440<212>DNA<213>小鼠<220><400>77gagaagccttgcccactcaaatacctgggc60catcagctgcaccggctccactcccatctgctccaggccctgaagagaagccaacacttt120tcaggcccctcaacctccacatcagaacaggcagagcctgtggtgtcagctgttgatcca180aaggcaacccttggtggggttggggttgtaaagtagtgatgctaatttctaagcaacaag240ctctgagctgcagcccccaggccctccagggcagtccagggcagtgccagggttcagggt300agttctaggggtctagtatctggatcaacaagtcccagagttgggcccagtggctgctga360cttgttcaatgaccaagaatatacgacctaaccttttttatttggttgggcaaccacagc420tccgagtaagtcatcaaggc440<210>78<211>204<212>DNA<213>小鼠<400>78ctccataaaattcctcaaaatctgttcccccagcagatttcctgtgccatcttgggctcc60cttcctattctttcccgtctttagggcctcctcacagtgttgttttctaacaacgcaggc120atgagaaggcactcactgtgtgctccctcaggcctggcctctcctggtgattgtcttctt180cctctgtgtcctcttcatcccaat204<210>79<211>300<212>DNA<213>小鼠<220><400>79tatttatgacttgggttaagggagtttgctgtgcaatcatgaagaccagagttcagatcc60cagcacccatatagcaagagagcatacaagaagcacctgtgactgcactctgaagaatcc120aacaccttcttctggcctccatggcacacagaaccccccaacacatgctcatccactctc180aaagagacatacataaaaataaatatttaggtcctgggtccctcagagactagtcttcac240aggtcctaaatacaaacgagcggaccgcaaagggtgagggagtggatgaagaagcta300<210>80<211>214<212>DNA<213>小鼠<400>80cccagaccctgtgtcagctatcccagcagaaaaagaagatgcggaccctctcagcaagtc60aggtgaggaaacccaggaagcagggtcatgaccccgcagaggtcggggctcctggtgcag120aggatcagatcttgtgtgacttctgtcttggggccagcagagtaagggcagtgaaatcct180gtctgacctgcatggtgaaatactgtaaggagca214<210>81<211>152<212>DNA<213>小鼠<220><400>81ccccttaactaacccaggaccttccactaagtggaaggctccaccatccacagagggggc60cagtcatttttaagcacacggaccttttgtgagacagtcgtgatcttaactgtggtgtca120ctgatggagctgaacggtatcccctaaaagta152<210>82<211>181<212>DNA<213>小鼠<220><400>82tctcagtgatgatgagaagctccggaggaggcaggagaaagcagggccccgcccctccct60gggtctccacccacccacgcccgctaaggtcacctgttctcccatggagatgatgaagaa120gctcatagctggacaaggcccggaacctcagcccagtaaccgacctacttcccgcctggg180a181<210>83<211>332<212>DNA<213>小鼠<220><400>83tatagagatggtgatgtaatgggccagggtgtaagcttcaacctgggggattttgctggt60tttgttgtttccctgtgtagccctaacaagcctgtgtagaccaggctggctttaactttg120cagatgacattcacgtctacttctctctgtgttggggttatgggtctgcacacctgccca180ggcctaggctgggggattttgaagtatcttagattatggagtagacccagagtttgcaag240tatctgctttaaagtgacacataaacatagcctcctgaccatcttccacagtgggaccct300gatctggcctctccctggaagaagagagaaag332<210>84<211>213<212>DNA<213>小鼠<400>84gcaggcagataacaatgattactggacagagtgcttcaacgcattggaacaggggaggca60atatgtggataatcccacaggcgggaaagtggacgaggctctggtgagaagtgccaccgt120acattgttggccgcacagcaacgtgctggacacaagcatgctctcatccccagatgtggt180gcgcatgctgctgtccctgcagcccttcctgca213<210>85<211>273<212>DNA<213>小鼠<220><400>85ccggctctctctctcctccttccccgcctcttctgcctcccctgcctggaactctgatga60ggagggaccaggtggtcaggcaccccagtctgatcaggactcctgtggcctccagagttt120cactcccccgtccatcctgaagcgggctcctcgggagcgtccaggtcacgtggcctttaa180cggcatcaccgtctactatttcccacggtgccagggattcaccagtgtgcccagccgtg240gtggctgtaccctgggcatggcttctcggcaca273<210>86<211>218<212>DNA<213>小鼠<400>86ctcagccgcctgctctgggggctggagggtctcccacttaactgtgtctgccgttcaggg60ggctcacccagtgctgcgctacacagaggttttccctccagctccagtccgtcctgccta120ctccttctataaccgcctccaagagctggcctcactgttgccccggccggataagccctg180cccagcctatgtggagcctatgactgtggtttgtcacc218<210>87<211>335<212>DNA<213>小鼠<400>87gaggtggggtgggtgcatagcctgcctgcaattgctgccgctgggcttaacgtgttgtga60gctggccggtttcctacacagcagcacctgccatggagcctggccacaaggccactcaga120gctgggtggacagagtgtgaccagaaactccctgtgggttctgataaaggattctcccat180aggcaaggttcagagaacctgggcctcctgttctcagggaggcctgtctatccccagcct240ctgagctgtttcgtcctagttggtgagttaagtggcatagccctcttgaggcctctgatg300tggaaggggcacagaattgcaattattcttgcatg335<210>88<211>410<212>DNA<213>小鼠<400>88aaaccccgccaggaaacaaataccggtgtatcggctttactgaatgcatttattcccaaa60gggaaactgaaaagcaacctagggacactgtaagcagaaagctgaggcttttaaaaaccc120accttggcaatgtaacttgggaggttcccacacacccagggctgtgcatcgtgaaattct180gtctcctgagacgctgagaaacccttccttgcagctataatgggcctggccgcccagtgt240ggagctgtagcttcccacgacgtagccctcaggaacttcaggagggatgccacagtctat300ttctgaaaacaaaaccgtgtcaacttctttactttacaaatgcaagttttcagaatccac360catctctctgcacccataccccatgcctcacaccccagaccctgtgttag410<210>89<211>279<212>DNA<213>小鼠<220><400>89gtgcagagagtggattgtcagtggactgctcagttacaaatgggacatctaacacacaca60cacacacacacacacacacacacacacacacaccccaaggcttagagaccattgcagaag120agaagagtttatgggaaatcttggagaaaacattggatggtttgagagaatggttaggag180atcagactagctagtccaggaagcagtgaaggggggcggggttagaagatgaggtcagaa240gacagggtggagggcattgtccgacagaaccattgctgt279<210>90<211>398<212>DNA<213>小鼠<400>90ccaccaacccagaaatttgacaaaggggttgaatgttggactttgcgtccttccccggca60gtggatgtactgttttgagccctgtgtggaacttctgaacttcgtgctgtaactttcaga120actcttagacatgggtgtgctcactgaactctagggtctgtgtgctagatgctgccaacg180ctgtattcaggacctgaagtgagtacccgtgtggatccagaccaatccagtgtgagacta240ctgaagaacatctgttgccagaacggccacaccaaacagatggagtgccccagcacttag300cttcttaaataacatcggaaccattcagccagcgagtctgtgtttgctttttgttaaatt360gtccgccgaatctaaattcctccaaaaggcttgtgacc398<210>91<211>279<212>DNA<213>小鼠<400>91gttgttacttcagttgctctcggcgggaattcttaaactgcatcctgagtgagggagctt60tggcgagaaagcaagacccagtggtagacagattagcattactgtacagcttctttgggt120gttcgaggaagcccggctggaccatagtggccacggcggtgaggtaggcgtggacagggc180tgaccagtccaagttaaggacgttcgggtccatgttaaccctgccttgtacgtccagcat240cgtaagaaaaaacacttgagaacccgaagaggagatgga279<210>92<211>401<212>DNA<213>小鼠<400>92aaaaagttttaccaaaaccttttattgacttttataaattagatagtatttcaaagttta60tgtagaatcgtattctttgaaactgtacttagcagagcagaagaggcctgctgacgctag120cacgctctgcaatgaatcatgtggcaccgagtctacgccaaggcccccgagaaactttat180tccatagatgggcagatggttcccaaagttacactacagaactacaaatcgactcttaaa240attaaaacgggactttacaagcattctagaagactcaaacttgaagcaatttttggaaaa300taaatgtacagagaaaagatcttgaagctactgaacagagaaccctcattaaccgagcaa360atacatcctatggagcttccgaggagtacacagacagaccg401<210>93<211>339<212>DNA<213>小鼠<400>93ccactgaccttcccagaaggtgacagccggcggcggatgttgtcaaggagccgagatagt60ccagcagtgcctcggtacccagaagacgggctgtctccccccaaaagacggcgacattcg120atgagaagtcaccacagtgatctcacattttgcgagattatcctgatggagatggagtcc180catgatgcagcctggcctttcctagagcctgtgaaccctcgcttggtgagtggataccga240cgtgtcatcaagaaccctatggatttttccaccatgcgagaacgcctgctccgtggaggg300tacactagctcagaagagtttgcagctgatgctctgctg339<210>94<211>55<212>DNA<213>小鼠<400>94ggggtgtgggcaacttggataacctcagctgcttccatctggctgacatctttgg55<210>95<211>186<212>DNA<213>小鼠<400>95ggactctggcttcctggggctgcggccgacctcggtggatcccgctctgaggcggcggcg60gcggggccccagaaacaagaagcgcggctggaggaggctcgccgaggagccgctggggtt120agaggtcgaccagttcctggaagacgtccggctacaggagcgcacgaccggtggcttgtt180ggcaga186<210>96<211>244<212>DNA<213>小鼠<400>96ggtgaccaaaaccccttctgcccccttcccagagactctgacttgaccctctttccaatt60ccctctccccaaggccatggattatgaagcccctctgtaagatggtgagccaggggccct120aagagggcatgaggcacaccctgatcactgtctcaggcctttgtgggcactgactcgacc180ctggcccacctcacgcccccaggccagttggcaactggtggctcttgagggctcttacgc240cctt244<210>97<211>116<212>DNA<213>小鼠<220><221>不確定<222>(11)...(11)<221>不確定<222>(13)...(13)<221>不確定<222>(41)...(41)<400>97acccggtctgngnactgcccgccttctggggcttcctttanaggatacagtcttttaccc60atctaggactcctgccaccctgactgctgacttacagctatgaggtcccggcttct116<210>98<211>307<212>DNA<213>小鼠<400>98ccccgggccatctgtcgccataccgggcccgtgcaagcttttgcaggttttagaagatgg60cgaattcatgacacctgtgatccaggacaacccctcaggctggggtccctgtgccgttcc120tgagcaatttcgggatatgccctaccagccattcagcaaaggagatcggctgggaaaggt180tgcagactggacaggggccacataccaggacaagaggtacacaaacaagtattcctctca240gttcggtggggggagtcagtatgcatatttccatgaggaggatgagacaagctttccagc300tgggtgg307<210>99<211>360<212>DNA<213>小鼠<220><400>99ccttggtgcaccagctccagcctcaggacttcctcctcctggccctgacagcccagctct60tgtcccagcagaatccagtgacaggaaggagtttctgaggcaggggaggaggcttctcca120tgggaaccagacagccttgcttcactgtataagtgccctgatcacacgcagaatgaagtg180ccaggttgctcagaagcacaaagggtgtggctactggccctaaccatggactacgtggtt240ctaaccaaagactctagaactctggggtgggggagaaacaatgtgttctgtgctccagaa300ctcggcttcctggcccatatggatgggcttggcaaggaacctacctcttctctaaggt360<210>100<211>257<212>DNA<213>小鼠<400>100tgccgcgctgagagggggggccgcaccaccagcgccaccaccaccaccgccgccgccgcc60gggtggggtgggaggggcgggagccaccgctaccgccgccgcctcccgggtgggcgccct120tctccttagacgccggcgacccaggacgagggcttcatcactgtaaatggttgcaagccg180acaaagctgcacctcctgaaaaagacggacagcccatcgcgtgagctgtagaaatttgtg240gacgcatttctatcggt257<210>101<211>203<212>DNA<213>小鼠<400>101ccaaagtgcccattgtgattcaagacgatagccttcccacggggccccctccacagatcc60gcatcctcaagaggcccaccagcaacggtgtggtcagcagccccaactccaccagcaggc120cagcccttcctgtcaagtccctagcacagcgggaggcagagtatgcagaggctcggagac180ggatcctaggcagtgccagccct203<210>102<211>300<212>DNA<213>小鼠<400>102agtacagagacctcggctgcagcttaaacctcggacagtggcaacgcccctcaatcaagt60agccaaccccaactcagccatctttgggggagccaggcccagagaggaagtggttcagaa120ggagcaagaatgagcttaggttgggagggaatggggcgtgggggagctggagcaagacca180cggcctggtggcagccggtcgccctacaggccccattcccgcctggcactgtcctcctta240cagcggaaacacagagcttgtgagtgcatgtcagctgttaacaagtggtttctagtacat300<210>103<211>370<212>DNA<213>小鼠<220><400>103cagcaactgtttcaggagctgcacggtgtacgcctgctgactgatgcgctggaactaaca60ctgggcgtggcccccaaagaaaaccctccggtgatgcttccagcccaagagacggagagg120gccatggagatcctcaaagtgctctttaatatcacctttgactctgtcaagagggaagtt180gatgaggaagatgctgccctttaccggtacctggggactcttctgcggcactgcgtgatg240gttgaagctgctggggaccgcacagaggagttccacggccacacggtgaatctcctgggg300aacttgcccctcaagtgtttggatgtgcttctggccctggagctccacgaaggatcctta360gagtcaatgg370<210>104<211>423<212>DNA<213>小鼠<400>104tttcccagcctggtggagcagccgactggcgagtgtgccaactgtcccgtgcttcccagc60tcctaccttgcctgtcttctctctcctgggaagatgttcctggtggggctgacgggaggc120atcgcctcaggcaagagctccgtcatccaggtattccaacagctgggctgtgctgtaatc180gacgtggacgtcattgcgcggcacgttgtccagccagggtatcctgcccaccggcgtata240gtagaggcctttggcactgaagtcttgctggagaatggcgacatcgaccgcaaggtcctc300ggagacctgatcttcaaccagcctgaccgtcggcagctgctcaactccattacccaccct360gagatccgcaaggaaatgatgaaggagaccttcaagtacttctccgaggtaccgatacgt420gat423<210>105<211>117<212>DNA<213>小鼠<400>105agcttggtgctgttcatatttaaactgataaagactcttcataggagctgagggtagcaa60gcccgcgtcggtgactggggtctcacacaggttcagcacttggagcatagtgaggtg117<210>106<211>133<212>DNA<213>小鼠<400>106ttttttttttaaaataccaccatttccaatcccaaaagaacatggcacttgtttgtttct60tccccttctcattcattccagactttcaagtgttttcttcaatactgaggctttctcctg120cagctctggtctg133<210>107<211>217<212>DNA<213>小鼠<220><221>不確定<222>(1)...(1)<221>不確定<222>(11)...(11)<221>不確定<222>(18)...(23)<221>不確定<222>(34)...(34)<221>不確定<222>(37)...(38)<221>不確定<222>(40)...(42)<221>不確定<222>(50)...(52)<221>不確定<222>(55)...(58)<221>不確定<222>(152)...(152)<221>不確定<222>(155)...(155)<221>不確定<222>(165)...(165)<400>107nttttttttgngcgcacnnnnnngnnnncgcccnggnngnnnagcctacnnncannnngt60tttcttctccaggctgaagacctgaacgtcaagttggaaggggagccttccatgcggaaa120ccaaagcagcggccgcggccggagcccctcancanccccaccaangcgggcactttcatc180gcccctcctgtctactccaacatcaccccttaccaga217<210>108<211>346<212>DNA<213>小鼠<220><400>108gggcatagaaggcatctcgaaaagaatacttatttgaattgaaggaagatgaagaggcct60gcaggaaggctcagaagacaggagtgttttacctctttcatgacctggatcctttgctcc120aggcgtcaggacatcgatacctggtgccccggcttagccgagcagagttggaagggctgc180tgggtaagttcggacaggattcgcaaagaattgaagattcggtgctggttgggtgctccg240agcagcaggaagcatggtttgctttggatctaggtctgaagagtgcctcctccagccgtg300gacaagtatcgctgctccagcagcttgactgctgtaaagaggatct346<210>109<211>242<212>DNA<213>小鼠<400>109ccacattgtccacaactggaaggcacgatggttcatccttcggcagaacacgctcctgta60ttacaagctagagggtggccggcgagtaaccccgcccaaggggaggattgtccttgatgg120ctgcaccatcacctgcccctgcctggagtatgaaaaccggccgctcctcattaaactgaa180gacccgaacttccactgagtacttcctggaagcctgttctcgagaggagagagactcctg240gg242<210>110<211>310<212>DNA<213>小鼠<220><400>110cccggccgggaatccaggtggtagctggtggagtcgcctccggagagtgacgcgcagact60cggctcccccgcggcccgccctcctgccggcctcgccgcggtctcccttgctccctgaga120tcgctgagcgctgagcagcggcccgggagaggaggccttgggcgacggggcgcggagagg180gagggcgggcgggcagtgggggcgccgcggatctctatatggcgacggctctgtcgggtc240tggctgtccggctgtcgcgctcggccgnccgcccgctcctatggggtcttctgcaa-gg300ggctgacccg310<210>111<211>228<212>DNA<213>小鼠<400>111ttcttttttaacatttggtggtttttttctttactctttttttcttttccttctttttct60gccctcaaccccccaactcctttggtatgaagtacttttaacatttatatttcattgtta120cactttaaattttgtaaggaaaactctgatatttcattcctcctgaaccactaatgttag180aatttatttctaagaatcagtcaacatgtatactcttaatagtgaatt228<210>112<211>292<212>DNA<213>小鼠<400>112gtggggtcccagacttgccaaccaaagggccattcctggtatatggttctggcttcagct60ctggtggcatggactatggtatggttggtggcaaggaggctgggaccgagtctcgcttca120aacagtggacctcaatgatggaagggctgccatctgtggccacacaagaagccaccatgc180acaaaaacggcgctatagtggcccctggtaagacccgaggaggttcaccatacaaccagt240ttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtga292<210>113<211>255<212>DNA<213>小鼠<220><400>113ttagatgacttaggactttaatgttttccatgcagtcgattgaaaacactgatacatgaa60caaccagaaaaagacctcagcaatgtatagacctggaatatatagtgttgccctggttaa120actacaagaacagccacgtgatcacagtttgagggtggaaggcaggggtgtgactgagtt180ttgtttaacggcctaaccgaaaagcaaagaatcaaccatttcttctacttgtggcaagaa240acgagagtcatggtg255<210>114<211>197<212>DNA<213>小鼠<400>114gacccacatgtgaacagccgcgtgtatgtcacactgctctgtgtgtgatttcttcacgtg60tgcatgtgcgctcttggtctttccacttattgcctcgttcgtaagaaaccaaccataagg120tgccaaggaggttttattccttttttttttaaagatgacaaatgtacagatgttagtaca180gatgttaatgtacagat197<210>115<211>205<212>DNA<213>小鼠<400>115aaaacatttcacaaaacagcaaaacaaaattgatacaatcaaaaaaacaacactataacc60aacataggtgaaaacagccaaacacataatgtacaatctggtgttccaggacaaacatct120gtcatatacatggtatatacatatatactttttcactcaatatattatgacaatatatat180ttaaaattttgttatagacaaaaaa205<210>116<211>202<212>DNA<213>小鼠<220><400>116cctccctcatcctctacttcccttttccttcctgcttgattttctcattccagaccccta60tgcacacacacacacacacacacacacacacacgaacacacgcacacacacacacacacg120cacacacacactgtccatccatagttacttatttagttttccattcctagagagatctaa180tcatcccctagtcagtgcctaa202<210>117<211>240<212>DNA<213>小鼠<400>117ccgccaggagaggagatacacagccagtgatgtggaccaccggatggctgttgctgctgc60cgcttctgctgtgtgaaggagcgcaagccctggagtgctacagctgcgtgcagaaggcgg120acgatggatgcgctccgcacaggatgaagacagtcaaatgtggtcccggggtggacgtct180gtaccgaggccgtgggagcggtagagaccatccacgggcaattctctgtggcggtgcggg240<210>118<211>527<212>DNA<213>人<400>118ccgtcagtctagaaggataagagaaagaaagttaagcaactacaggaaatggctttggga60gttccaatatcagtctatcttttattcaacgcaatgacagcactgaccgaagaggcagcc120gtgactgtaacacctccaatcacagcccagcaaggtaactggacagttaacaaaacagaa180gctcacaacatagaaggacccatagccttgaagttctcacacctttgcctggaagatcat240aacagttactgcatcaacggtgcttgtgcattccaccatgagctagagaaagccatctgc300aggtgttttactggttatactggagaaaggtgtgagcacttgactttaacttcatatgct360gtggattcttatgaaaaatacattgcaattgggattggtgttggattactattaagtggt420tttcttgttattttttactgctatataagaaagaggtgtctaaaattgaaatcgccttac480aatgtctgttctggagaaagacgaccactgtgaggcctttgtgaaga527<210>119<211>655<212>DNA<213>大鼠<400>119atggcgcgccccgcgccctggtggtggctgcggccgctggcggcgctcgccctggcgctg60gcgctggtccgggtgccctcagcccgggccgggcagatgccgcgccccgcagagcgcggg120cccccagtacggctcttcaccgaggaggagctggcccgctacagcggcgaggaggaggat180caacccatctacttggcagtgaagggagtggtgttcgatgtcacctctgggaaggagttt240tatggacgtggagccccctacaacgccttggccgggaaggactcgagcagaggtgtggcc300aagatgtcgctggatcctgcagacctcactcatgacatttctggtctcactgccaaggag360ctggaagccctcgatgacatcttcagcaaggtgtacaaagccaaataccccattgttggc420tacacggcccgcaggatcctcaacgaggatggcagccccaacctggacttcaagcctgaa480gaccagccccattttgacataaaggacgagttctaatgtctagctgagaagctggttcta540gggagaggtgaggggacaggagttaaatgtcccacggaacaagcaggggaagcctctgag600tgctctgcatctgaataaaactgatatttaactgggaaaaaaaaaaaaaaaaaaa655<210>120<211>176<212>蛋白質<213>大鼠<400>120MetValProCysPheLeuLeuSerLeuLeuLeuLeuValArgProAla151015ProValValAlaTyrSerValSerLeuProAlaSerPheLeuGluGlu202530ValAlaGlySerGlyGluAlaGluGlySerSerAlaSerSerProSer354045LeuLeuProProArgThrProAlaPheSerProThrProGlyArgThr505560GlnProThrAlaProValGlyProValProProThrAsnLeuLeuAsp65707580GlyIleValAspPhePheArgGlnTyrValMetLeuIleAlaValVal859095GlySerLeuThrPheLeuIleMetPheIleValCysAlaAlaLeuIle100105110ThrArgGlnLysHisLysAlaThrAlaTyrTyrProSerSerPhePro115120125GluLysLysTyrValAspGlnArgAspArgAlaGlyGlyProHisAla130135140PheSerGluValProAspArgAlaProAspSerArgGlnGluGluGly145150155160LeuAspPhePheGlnGlnLeuGlnAlaAspIleLeuAlaCysTyrSer165170175<210>121<211>116<212>蛋白質<213>大鼠<400>121MetGluLeuLeuTyrTrpCysLeuLeuCysLeuLeuLeuProLeuThr151015SerArgThrGlnLysLeuProThrArgAspGluGluLeuPheGlnMet202530GlnIleArgAspLysAlaLeuPheHisAspSerSerValIleProAsp354045GlyAlaGluIleSerSerTyrLeuPheArgAspThrProArgArgTyr505560PhePheMetValGluGluAspAsnThrProLeuSerValThrValThr65707580ProCysAspAlaProLeuGluTrpLysLeuSerLeuGlnGluLeuPro859095GluGluSerSerAlaAspGlySerGlyAspProGluProLeuAspGln100105110GlnLysGlnGln115<210>122<211>64<212>蛋白質<213>人<400>122MetAsnLeuLeuIleGlySerIleIleLeuSerSerPheLeuValLeu151015SerAspGlyAspThrThrAlaSerProSerSerMetSerSerSerSer202530ValLeuAsnHisIleSerSerSerSerSerSerValTrpHisLeuPhe354045AspIleCysAspSerSerLysTrpAsnAlaTyrCysGlnValTrpGly505560<210>123<211>68<212>蛋白質<213>人<400>123MetLeuThrLeuProIleLeuValCysLysValGlnAspSerAsnArg151015ArgLysMetLeuProThrGlnPheLeuPheLeuLeuGlyValLeuGly202530IlePheGlyLeuThrPheAlaPheIleIleGlyLeuAspGlySerThr354045GlyProThrArgPhePheLeuPheGlyIleLeuPheSerIleCysPhe505560SerCysLeuLeu65<210>124<211>110<212>蛋白質<213>小鼠<400>124MetIleSerProAlaTrpSerLeuPheLeuIleGlyThrLysIleGly151015LeuPhePheGlnValAlaProLeuSerValValAlaLysSerCysPro202530SerValCysArgCysAspAlaGlyPheIleTyrCysAsnAspArgSer354045LeuThrSerIleProValGlyIleProGluAspAlaThrThrLeuTyr505560LeuGlnAsnAsnGlnIleAsnAsnValGlyIleProSerAspLeuLys65707580AsnLeuLeuLysValGlnArgIleTyrLeuTyrHisAsnSerLeuAsp859095GluPheProThrAsnLeuProLysTyrValLysGluLeuHis100105110<210>125<211>330<212>蛋白質<213>小鼠<400>125MetGlySerProArgLeuAlaAlaLeuLeuLeuSerLeuProLeuLeu151015LeuIleGlyLeuAlaValSerAlaArgValAlaCysProCysLeuArg202530SerTrpThrSerHisCysLeuLeuAlaTyrArgValAspLysArgPhe354045AlaGlyLeuGlnTrpGlyTrpPheProLeuLeuValArgLysSerLys505560SerProProLysPheGluAspTyrTrpArgHisArgThrProAlaSer65707580PheGlnArgLysLeuLeuGlySerProSerLeuSerGluGluSerHis859095ArgIleSerIleProSerSerAlaIleSerHisArgGlyGlnArgThr100105110LysArgAlaGlnProSerAlaAlaGluGlyArgGluHisLeuProGlu115120125AlaGlySerGlnLysCysGlyGlyProGluPheSerPheAspLeuLeu130135140ProGluValGlnAlaValArgValThrIleProAlaGlyProLysAla145150155160SerValArgLeuCysTyrGlnTrpAlaLeuGluCysGluAspLeuSer165170175SerProPheAspThrGlnLysIleValSerGlyGlyHisThrValAsp180185190LeuProTyrGluPheLeuLeuProCysMetCysIleGluAlaSerTyr195200205LeuGlnGluAspThrValArgArgLysLysCysProPheGlnSerTrp210215220ProGluAlaTyrGlySerAspPheTrpGlnSerIleArgPheThrAsp225230235240TyrSerGlnHisAsnGlnMetValMetAlaLeuThrLeuArgCysPro245250255LeuLysLeuGluAlaSerLeuCysTrpArgGlnAspProLeuThrPro260265270CysGluThrLeuProAsnAlaThrAlaGlnGluSerGluGlyTrpTyr275280285IleLeuGluAsnValAspLeuHisProGlnLeuCysPheLysPheSer290295300PheGluAsnSerSerHisValGluCysProHisGlnSerGlySerLeu305310315320ProSerTrpThrValSerMetAspThrGln325330<210>126<211>37<212>蛋白質<213>大鼠<400>126MetLeuTrpValLeuLeuSerLeuThrProLeuLeuSerProLeuIle151015PhePheProValLysThrValAlaLeuGluGluIleSerThrIleCys202530ArgAlaAspValLeu35<210>127<211>42<212>蛋白質<213>小鼠<400>127MetGlySerProIleSerGlyValCysProValLeuProGlyGlyLeu151015PheValAlaLeuGlyTrpIlePheLeuLeuPheHisArgAspAlaPhe202530SerLeuHisThrMetSerAlaGlyPhePro3540<210>128<211>253<212>蛋白質<213>小鼠<400>128MetMetTyrTrpIleValPheAlaIlePheMetAlaAlaGluThrPhe151015ThrAspIlePheIleSerTrpSerGlyProArgIleGlyArgProTrp202530GlyTrpGluGlyProHisHisHisHisHisLeuAlaSerGlySerHis354045LysProLeuProLeuLeuThrHisArgPheProPheTyrTyrGluPhe505560LysMetAlaPheValLeuTrpLeuLeuSerProTyrThrLysGlyAla65707580SerLeuLeuTyrArgLysPheValHisProSerLeuSerArgHisGlu859095LysGluIleAspAlaCysIleValGlnAlaLysGluArgSerTyrGlu100105110ThrMetLeuSerPheGlyLysArgSerLeuAsnIleAlaAlaSerAla115120125AlaValGlnAlaAlaThrLysSerGlnGlyAlaLeuAlaGlyArgLeu130135140ArgSerPheSerMetGlnAspLeuArgSerIleProAspThrProVal145150155160ProThrTyrGlnAspProLeuTyrLeuGluAspGlnValProArgArg165170175ArgProProIleGlyTyrArgProGlyGlyLeuGlnGlySerAspThr180185190GluAspGluCysTrpSerAspAsnGluIleValProGlnProProVal195200205ArgProArgGluLysProLeuGlyArgSerGlnSerLeuArgValVal210215220LysArgLysProLeuThrArgGluGlyThrSerArgSerLeuLysVal225230235240ArgThrArgLysLysAlaMetProSerAspMetAspSer245250<210>129<211>40<212>蛋白質<213>小鼠<400>129MetLysAlaMetAlaLeuSerLeuGlyAlaSerProValLeuAlaPhe151015LeuLeuSerGlyTyrSerAspGlyTyrGlnValCysSerArgPheGly202530SerLysValProGlnPheLeuAsn3540<210>130<211>87<212>蛋白質<213>小鼠<400>130MetIleAlaValThrPheAlaIleValLeuGlyValIleIleTyrArg151015IleSerThrAlaAlaAlaLeuAlaMetAsnSerSerProSerValArg202530SerAsnIleArgValThrValThrAlaThrAlaValIleIleAsnLeu354045ValValIleIleLeuLeuAspGluValTyrGlyCysIleAlaArgTrp505560LeuThrLysIleGlyGluCysHisValGlnAspSerIleGlySerMet65707580GlyLeuGlyGlnGlyGlnPro85<210>131<211>70<212>蛋白質<213>小鼠<400>131MetPheGlyLeuValHisValCysThrCysValCysValCysValCys151015ValCysValCysValCysIleCysSerCysGlyTyrValHisValPro202530CysGlyCysValCysLeuTrpGlyProGluValArgTyrLeuProLeu354045SerLeuHisProGlyGlyPheCysPheValLeuPheCysPheGlyPro505560GlyLeuSerLeuIleSer6570<210>132<211>63<212>蛋白質<213>小鼠<400>132MetTrpLeuLeuValAlaLeuThrLeuSerValTyrSerLeuValAla151015PheValThrGlyMetLeuCysAspThrValValIleLysMetLeuMet202530SerLeuHisLysSerSerLysLeuAsnProArgAlaLysCysGlyGly354045ValProLeuIleProAlaLeuTrpGlyGlnValGlnValValLeu505560<210>133<211>39<212>蛋白質<213>小鼠<400>133MetAspAsnThrLeuSerIleIleIleTyrLeuLeuPheIlePheAla151015IleSerValLeuAspSerGlnLeuSerThrArgCysLeuTrpTrpPhe202530SerLysAspLeuGluValThr35<210>134<211>90<212>蛋白質<213>大鼠<400>134MetProThrMetTrpProLeuLeuHisValLeuTrpLeuAlaLeuVal151015CysGlySerValHisThrThrLeuSerLysSerAspAlaLysLysAla202530AlaSerLysThrLeuLeuGluLysThrGlnPheSerAspLysProVal354045GlnAspArgGlyLeuValValThrAspIleLysAlaGluAspValVal505560LeuGluHisArgSerTyrCysSerAlaArgAlaArgGluArgAsnPhe65707580AlaGlyGluValLeuGlyIleCysHisSer8590<210>135<211>193<212>蛋白質<213>大鼠<400>135MetThrSerGlyProGlyGlyProAlaAlaAlaThrGlyGlyGlyLys151015AspThrHisGlnTrpTyrValCysAsnArgGluLysLeuCysGluSer202530LeuGlnSerValPheValGlnSerTyrLeuAspGlnGlyThrGlnIle354045PheLeuAsnAsnSerIleGluLysSerGlyTrpLeuPheIleGlnLeu505560TyrHisSerPheValSerSerValPheThrLeuPheMetSerArgThr65707580SetIleAsnGlyLeuLeuGlyArgGlySerMetPheValPheSerPro859095AspGlnPheGlnArgLeuLeuLysIleAsnProAspTrpLysThrHis100105110ArgLeuLeuAspLeuGlyAlaGlyAspGlyGluValThrLysIleMet115120125SerProHisPheGluGluIleTyrAlaThrGluLeuSerGluThrMet130135140IleTrpGlnLeuGlnLysLysLysTyrArgValLeuGlyIleAsnGlu145150155160TrpGlnAsnThrGlyPheGlnTyrAspValIleSerCysLeuAsnLeu165170175LeuAspArgCysAspGlnProLeuThrLeuLeuLysAspIleArgMet180185190Ser<210>136<211>106<212>蛋白質<213>大鼠<400>136MetAlaAlaProMetAspArgThrHisGlyGlyArgAlaAlaArgAla151015LeuArgArgAlaLeuAlaLeuAlaSerLeuAlaGlyLeuLeuLeuSer202530GlyLeuAlaGlyAlaLeuProThrLeuGlyProGlyTrpArgArgGln354045AsnProGluProProAlaSerArgThrArgSerLeuLeuLeuAspAla505560AlaSerGlyGlnLeuArgLeuGluTyrGlyPheHisProAspAlaVal65707580AlaTrpAlaAsnLeuThrAsnAlaIleArgGluThrGlyTrpAlaTyr859095LeuAspLeuGlyThrAsnGlySerTyrLys100105<210>137<211>286<212>蛋白質<213>大鼠<400>137MetAlaAlaAlaMetProLeuGlyLeuSerLeuLeuLeuLeuValLeu151015ValGlyGlnGlyCysCysGlyArgValGluGlyProArgAspSerLeu202530ArgGluGluLeuValIleThrProLeuProSerGlyAspValAlaAla354045ThrPheGlnPheArgThrArgTrpAspSerAspLeuGlnArgGluGly505560ValSerHisTyrArgLeuPheProLysAlaLeuGlyGlnLeuIleSer65707580LysTyrSerLeuArgGluLeuHisLeuSerPheThrGlnGlyPheTrp859095ArgThrArgTyrTrpGlyProProPheLeuGlnAlaProSerGlyAla100105110GluLeuTrpValTrpPheGlnAspThrValThrAspValAspLysSer115120125TrpLysGluLeuSerAsnValLeuSerGlyIlePheCysAlaSerLeu130135140AsnPheIleAspSerThrAsnThrValThrProThrAlaSerPheLys145150155160ProLeuGlyLeuAlaAsnAspThrAspHisTyrPheLeuArgTyrAla165170175ValLeuProArgGluValValCysThrGluAsnLeuThrProTrpLys180185190LysLeuLeuProCysSerSerLysAlaGlyLeuSerValLeuLeuLys195200205AlaAspArgLeuPheHisThrSerTyrHisSerGlnAlaValHisIle210215220ArgProIleCysArgAsnAlaHisCysThrSerIleSerTrpGluLeu225230235240ArgGlnThrLeuSerValValPheAspAlaPheIleThrGlyGlnGly245250255LysLysGluAlaCysProLeuAlaSerGlnSerLeuValTyrValAsp260265270IleThrGlyTyrSerGlnAspAsnGluThrLeuGluValSer275280285<210>138<211>198<212>蛋白質<213>大鼠<400>138MetThrValPheArgLysValThrThrMetIleSerTrpMetLeuLeu151015AlaCysAlaLeuProCysAlaAlaAspProMetLeuGlyAlaPheAla202530ArgArgAspPheGlnLysGlyGlyProGlnLeuValCysSerLeuPro354045GlyProGlnGlyProProGlyProProGlyAlaProGlySerSerGly505560MetValGlyArgMetGlyPheProGlyLysAspGlyGlnAspGlyGln65707580AspGlyAspArgGlyAspSerGlyGluGluGlyProProGlyArgThr859095GlyAsnArgGlyLysGlnGlyProLysGlyLysAlaGlyAlaIleGly100105110ArgAlaGlyProArgGlyProLysGlyValSerGlyThrProGlyLys115120125HisGlyIleProGlyLysLysGlyProLysGlyLysLysGlyGluPro130135140GlyLeuProGlyProCysSerCysGlySerSerArgAlaLysSerAla145150155160PheSerValAlaValThrLysSerTyrProArgGluArgLeuProIle165170175LysPheAspLysIleLeuMetAsnGluGlyGlyHisTyrAsnAlaSer180185190SerGlyLysPheValCys195<210>139<211>233<212>蛋白質<213>大鼠<400>139MetAlaSerAlaLeuGluGluLeuGlnLysAspLeuGluGluValLys151015ValLeuLeuGluLysSerThrArgLysArgLeuArgAspThrLeuThr202530AsnGluLysSerLysIleGluThrGluLeuArgAsnLysMetGlnGln354045LysSerGlnLysLysProGluPheAspAsnGluLysProAlaAlaVal505560ValAlaProLeuThrThrGlyTyrThrValLysIleSerAsnTyrGly65707580TrpAspGlnSerAspLysPheValLysIleTyrIleThrLeuThrGly859095ValHisGlnValProAlaGluAsnValGlnValHisPheThrGluArg100105110SerPheAspLeuLeuValLysAsnLeuAsnGlyLysAsnTyrSerMet115120125IleValAsnAsnLeuLeuLysProIleSerValGluSerSerSerLys130135140LysValLysThrAspThrValIleIleLeuCysArgLysLysAlaGlu145150155160AsnThrArgTrpAspTyrLeuThrGlnValGluLysGluCysLysGlu165170175LysGluLysProSerTyrAspThrGluAlaAspProSerGluGlyLeu180185190MetAsnValLeuLysLysIleTyrGluAspGlyAspAspAspMetLys195200205ArgThrIleAsnLysAlaTrpValGluSerArgGluLysGlnAlaArg210215220GluAspThrGluPheLeuGlnProGly225230<210>140<211>38<212>蛋白質<213>人<400>140MetGlyLeuAlaLeuCysLeuAlaSerAlaGlyIleSerGlySerArg151015SerAlaPheLeuGlyValProArgProArgProThrLeuIleLysLeu202530IleAspThrValAspLeu35<210>141<211>322<212>蛋白質<213>小鼠<400>141MetAspAlaArgTrpTrpAlaValValValLeuAlaThrLeuProSer151015LeuGlyAlaGlyGlyGluSerProGluAlaProProGlnSerTrpThr202530GlnLeuTrpLeuPheArgPheLeuLeuAsnValAlaGlyTyrAlaSer354045PheMetValProGlyTyrLeuLeuValGlnTyrLeuArgArgLysAsn505560TyrLeuGluThrGlyArgGlyLeuCysPheProLeuValLysAlaCys65707580ValPheGlyAsnGluProLysAlaProAspGluValLeuLeuAlaPro859095ArgThrGluThrAlaGluSerThrProSerTrpGlnValLeuLysLeu100105110ValPheCysAlaSerGlyLeuGlnValSerTyrLeuThrTrpGlyIle115120125LeuGlnGluArgValMetThrGlySerTyrGlyAlaThrAlaThrSer130135140ProGlyGluHisPheThrAspSerGlnPheLeuValLeuMetAsnArg145150155160ValLeuAlaLeuValValAlaGlyLeuTyrCysValLeuArgLysGln165170175ProArgHisGlyAlaProMetTyrArgTyrSerPheAlaSerLeuSer180185190AsnValLeuSerSerTrpCysGlnTyrGluAlaLeuLysPheValSer195200205PheProThrGlnValLeuAlaLysAlaSerLysValIleProValMet210215220MetMetGlyLysLeuValSerArgArgSerTyrGluHisTrpGluTyr225230235240LeuThrAlaGlyLeuIleSerIleGlyValSerMetPheLeuLeuSer245250255SerGlyProGluProArgSerSerProAlaThrThrLeuSerGlyLeu260265270ValLeuLeuAlaGlyTyrIleAlaPheAspSerPheThrSerAsnTrp275280285GlnAspAlaLeuPheAlaTyrLysMetSerSerValGlnMetMetPhe290295300GlyValAsnLeuPheSerCysLeuPheThrValGlySerLeuLeuGlu305310315320GlnGly<210>142<211>312<212>蛋白質<213>小鼠<400>142MetLeuCysLeuCysLeuTyrValProIleAlaGlyAlaAlaGlnThr151015GluPheGlnTyrPheGluSerLysGlyLeuProAlaGluLeuLysSer202530IlePheLysLeuSerValPheIleProSerGlnGluPheSerThrTyr354045ArgGlnTrpLysGlnLysIleValGlnAlaGlyAspLysAspLeuAsp505560GlyGlnLeuAspPheGluGluPheValHisTyrLeuGlnAspHisGlu65707580LysLysLeuArgLeuValPheLysSerLeuAspLysLysAsnAspGly859095ArgIleAspAlaGlnGluIleMetGlnSerLeuArgAspLeuGlyVal100105110LysIleSerGluGlnGlnAlaGluLysIleLeuLysSerMetAspLys115120125AsnGlyThrMetThrIleAspTrpAsnGluTrpArgAspTyrHisLeu130135140LeuHisProValGluAsnIleProGluIleIleLeuTyrTrpLysHis145150155160SerThrIlePheAspValGlyGluAsnLeuThrValProAspGluPhe165170175ThrValGluGluArgGlnThrGlyMetTrpTrpArgHisLeuValAla180185190GlyGlyGlyAlaGlyAlaValSerArgThrCysThrAlaProLeuAsp195200205ArgLeuLysValLeuMetGlnValHisAlaSerArgSerAsnAsnMet210215220CysIleValGlyGlyPheThrGlnMetIleArgGluGlyGlyAlaLys225230235240SerLeuTrpArgGlyAsnGlyIleAsnValLeuLysIleAlaProGlu245250255SerAlaIleLysPheMetAlaTyrGluGlnMetLysArgLeuValGly260265270SerAspGlnGluThrLeuArgIleHisGluArgLeuValAlaGlySer275280285LeuAlaGlyAlaIleAlaGlnSerSerIleTyrProMetGluValLeu290295300LysThrArgMetAlaLeuArgLys305310<210>143<211>163<212>蛋白質<213>大鼠<400>143MetProLeuValThrThrLeuPheTyrAlaCysPheTyrHisTyrThr151015GluSerGluGlyThrPheSerSerProValAsnLeuLysLysThrPhe202530LysIleProAspArgGlnTyrValLeuThrAlaLeuAlaAlaArgAla354045LysLeuArgAlaTrpAsnAspValAspAlaLeuPheThrThrLysAsn505560TrpLeuGlyTyrThrLysLysArgAlaProIleGlyPheHisArgVal65707580ValGluIleLeuHisLysAsnSerAlaProValGlnIleLeuGlnGlu859095TyrValAsnLeuValGluAspValAspThrLysLeuAsnLeuAlaThr100105110LysPheLysCysHisAspValValIleAspThrCysArgAspLeuLys115120125AspArgGlnGlnLeuLeuAlaTyrArgSerLysValAspLysGlySer130135140AlaGluGluGluLysIleAspValIleLeuSerSerSerGlnIleArg145150155160TrpLysAsn<210>144<211>330<212>蛋白質<213>大鼠<400>144MetAlaGlyTrpAlaGlyAlaGluLeuSerValLeuAsnProLeuArg151015AlaLeuTrpLeuLeuLeuAlaAlaAlaPheLeuLeuAlaLeuLeuLeu202530GlnLeuAlaProAlaArgLeuLeuProSerCysAlaLeuPheGlnAsp354045LeuIleArgTyrGlyLysThrLysGlnSerGlySerArgArgProAla505560ValCysArgAlaPheAspValProLysArgTyrPheSerHisPheTyr65707580ValValSerValLeuTrpAsnGlySerLeuLeuTrpPheLeuSerGln859095SerLeuPheLeuGlyAlaProPheProSerTrpLeuTrpAlaLeuLeu100105110ArgThrLeuGlyValThrGlnPheGlnAlaLeuGlyMetGluSerLys115120125AlaSerArgIleGlnAlaGlyGluLeuAlaLeuSerThrPheLeuVal130135140LeuValPheLeuTrpValHisSerLeuArgArgLeuPheGluCysPhe145150155160TyrValSerValPheSerAsnThrAlaIleHisValValGlnTyrCys165170175PheGlyLeuValTyrTyrValLeuValGlyLeuThrValLeuSerGln180185190ValProMetAsnAspLysAsnValTyrAlaLeuGlyLysAsnLeuLeu195200205LeuGlnAlaArgTrpPheHisIleLeuGlyMetMetMetPhePheTrp210215220SerSerAlaHisGlnTyrLysCysHisValIleLeuSerAsnLeuArg225230235240ArgAsnLysLysGlyValValIleHisCysGlnHisArgIleProPhe245250255GlyAspTrpPheGluTyrValSerSerAlaAsnTyrLeuAlaGluLeu260265270MetIleTyrIleSerMetAlaValThrPheGlyLeuHisAsnValThr275280285TrpTrpLeuValValThrTyrValPhePheSerGlnAlaLeuSerAla290295300PhePheAsnHisArgPheTyrLysSerThrPheValSerTyrProLys305310315320HisArgLysAlaPheLeuProPheLeuPhe325330<210>145<211>301<212>蛋白質<213>大鼠<400>145MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGlnProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnArgCysLeuLeuGlyLeuProValTrpGluGlySerProHisLeu275280285ProThrGlyHisTrpLeuArgGluLeuTrpSerLeuLeu290295300<210>146<211>61<212>蛋白質<213>大鼠<400>146MerGluAsnIleTyrTyrThrAsnLeuIleThrIleLeuGlyAsnLys151015HisAlaAsnGlnMetGluLeuAsnLeuGlnAlaLeuIleLeuSerPro202530TrpPheAlaValCysAlaProProGlyPheAlaArgAspGlnAlaVal354045ArgGlyLeuAlaLeuAlaGlyArgArgIleThrValVal505560<210>147<211>105<212>蛋白質<213>大鼠<400>147MetLeuArgArgGlnLeuValTrpTrpHisLeuLeuAlaLeuLeuPhe151015LeuProPheCysLeuCysGlnAspGluTyrMetGluSerProGlnAla202530GlyGlyLeuProProAspCysSerLysCysCysHisGlyAspTyrGly354045PheArgGlyTyrGlnGlyProProGlyProProGlyProProGlyIle505560ProGlyAsnHisGlyAsnAsnGlyAsnAsnGlyAlaThrGlyHisGlu65707580GlyAlaLysGlyGluLysGlyAspLysGlyAspLeuGlyProArgGly859095GluArgGlyGlnHisGlyProLysGly100105<210>148<211>210<212>蛋白質<213>大鼠<400>148MetLeuGlyAlaThrSerLeuSerTrpProTrpValLeuTrpAlaVal151015AlaGlnArgAspSerValAspAlaIleGlyMetPheLeuGlyGlyLeu202530ValAlaThrIlePheLeuAspIleIleTyrIleSerIlePheTyrSer354045SerValAlaValGlyAspThrGlyArgPheSerAlaGlyMetAlaIle505560PheSerLeuLeuLeuGlnAlaLeuLeuLeuLeuProArgLeuProHis65707580AlaProGlySerGluGlyValSerSerArgSerAlaArgIleSerSer859095AspLeuLeuArgAsnIleValProThrArgGlnLeuThrArgGlnThr100105110HisLeuGlnThrProLeuGlnAlaTrpArgThrArgAlaLysLeuPro115120125ProGlyGlyThrGluAlaValProGlyArgProGlyAlaGlnGlnAsp130135140AlaCysHisLeuLeuTyrTrpThrTyrAsnGlyValSerSerIlePro145150155160CysHisArgGlyGlyLeuSerHisValProSerGluValProAlaGlu165170175LysSerProValLeuIleLeuHisAlaAlaProProPheLysThrPro180185190ValAsnProTrpAlaArgThrValValGlyPhePheProSerSerPro195200205SerLeu210<210>149<211>301<212>蛋白質<213>大鼠<400>149MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGinProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnArgCysLeuLeuGlyLeuProValTrpGluGlySerProHisLeu275280285ProThrGlyHisTrpLeuArgGluLeuTrpSerLeuLeu290295300<210>150<211>80<212>蛋白質<213>人<400>150MetLysLeuSerGlyMetPheLeuLeuLeuSerLeuAlaLeuPheCys151015PheLeuThrGlyValPheSerGlnGlyGlyGlnValAspCysGlyGlu202530PheGlnAspThrLysValTyrCysThrArgGluSerAsnProHisCys354045GlySerAspGlyGlnThrTyrGlyAsnLysCysAlaPheCysLysAla505560IleValLysSerGlyGlyLysIleSerLeuLysHisProGlyLysCys65707580<210>151<211>27<212>蛋白質<213>小鼠<400>151MetLeuLysAlaSerLeuHisIleLeuPheLeuGlyIleLeuAsnVal151015ProIleValAspThrSerThrLysThrGlyVal2025<210>152<211>86<212>蛋白質<213>小鼠<400>152MetLeuGlnGlyProAlaProSerCysPheTrpValPheSerGlyIle151015CysValPheTrpAspPheIlePheIleIlePhePheAsnValLeuSer202530LeuGlyAsnArgGluIleSerAlaLysAspPheAlaAspGlnProAla354045GlyAlaGlnGlyMetTrpGlyIleTrpGlyHisThrIleThrCysGly505560LeuAlaProGlyAlaLysProCysSerLeuLysArgGluGlyProAsp65707580LeuLeuSerPheProPro85<210>153<211>72<212>蛋白質<213>小鼠<400>153MetSerAlaIlePheAsnPheGlnSerLeuLeuThrValIleLeuLeu151015LeuIleCysThrCysAlaTyrIleArgSerLeuAlaProSerIleLeu202530AspArgAsnLysThrGlyLeuLeuGlyIlePheTrpLysCysAlaArg354045IleGlyGluArgLysSerProTyrValAlaIleCysCysIleValMet505560AlaPheSerIleLeuPheIleGln6570<210>154<211>169<212>蛋白質<213>小鼠<400>154MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>155<211>61<212>蛋白質<213>小鼠<400>155MetGluLysGlnMetAspAlaSerValSerValIlePheGlySerIle151015ValIleSerAlaPheLeuTyrLeuSerLeuAlaGlyProTrpAlaVal202530ThrValThrGlnMetArgThrIleIleIleThrMetAspGlnLeuArg354045AspAlaLeuIleLeuAspGlnLeuLysValAlaValSer505560<210>156<211>131<212>蛋白質<213>小鼠<400>156MetAlaProSerLeuTrpLysGlyLeuValGlyValGlyLeuPheAla151015LeuAlaHisAlaAlaPheSerAlaAlaGlnHisArgSerTyrMetArg202530LeuThrGluLysGluAspGluSerLeuProIleAspIleValLeuGln354045ThrLeuLeuAlaPheAlaValThrCysTyrGlyIleValHisIleAla505560GlyGluPheLysAspMetAspAlaThrSerGluLeuLysAsnLysThr65707580PheAspThrLeuArgAsnHisProSerPheTyrValPheAsnHisArg859095GlyArgValLeuPheArgProSerAspAlaThrAsnSerSerAsnLeu100105110AspAlaLeuSerSerAsnThrSerLeuLysLeuArgLysPheAspSer115120125LeuArgArg130<210>157<211>133<212>蛋白質<213>小鼠<400>157MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysGluHisVal505560GlnGlyThrGlyAlaArgSerThrAlaCysThrLeuSerCysArgAla65707580ProAsnAlaSerSerSerGlyThrMetProGlyThrArgSerAlaGly859095SerThrLysAsnArgValAspAspHisGlyLysLysAsnSerArgPro100105110ValGluArgLeuGlnGlnArgThrLeuGlnIleLysIleLysAlaLeu115120125SerPheSerGlnAla130<210>158<211>78<212>蛋白質<213>小鼠<400>158GlyThrArgLysProLeuProMetGluAlaHisSerArgArgGluLys151015AlaSerGlyLeuArgLeuAlaTrpHisTyrGluCysSerGlyValSer202530ValTrpTrpMetCysValLeuGlyTrpLeuSerPheLeuValPheLeu354045LeuPheSerLeuValCysSerPheProSerProIleAsnHisSerHis505560MetLeuProCysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>159<211>206<212>蛋白質<213>小鼠<400>159MetLeuProProAlaIleHisLeuSerLeuIleProLeuLeuCysIle151015LeuMetArgAsnCysLeuAlaPheLysAsnAspAlaThrGluIleLeu202530TyrSerHisValValLysProValProAlaHisProSerSerAsnSer354045ThrLeuAsnGlnAlaArgAsnGlyGlyArgHisPheSerSerThrGly505560LeuAspArgAsnSerArgValGlnValGlyCysArgGluLeuArgSer65707580ThrLysTyrIleSerAspGlyGlnCysThrSerIleSerProLeuLys859095GluLeuValCysAlaGlyGluCysLeuProLeuProValLeuProAsn100105110TrpIleGlyGlyGlyTyrGlyThrLysTyrTrpSerArgArgSerSer115120125GlnGluTrpArgCysValAsnAspLysThrArgThrGlnArgIleGln130135140LeuGlnCysGlnAspGlySerThrArgThrTyrLysIleThrValVal145150155160ThrAlaCysLysCysLysArgTyrThrArgGlnHisAsnGluSerSer165170175HisAsnPheGluSerValSerProAlaLysProAlaGlnHisHisArg180185190GluArgLysArgAlaSerLysSerSerLysHisSerLeuSer195200205<210>160<211>169<212>蛋白質<213>小鼠<400>160MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>161<211>114<212>蛋白質<213>小鼠<400>161MetSerValThrIleGlyArgLeuAlaLeuPheLeuIleGlyIleLeu151015LeuCysProValAlaProSerLeuThrArgSerTrpProGlyProAsp202530ThrCysSerLeuPheLeuGlnHisSerLeuSerLeuSerLeuArgLeu354045GlyGlnSerLeuGluGlyGlyLeuSerValCysPheHisValCysIle505560HisAlaCysGluCysValAlaCysCysArgValLeuTrpAspProLys65707580ProArgGlySerSerLeuCysArgTrpValLeuGlySerIleThrCys859095LeuPheMetTyrGluValGlyGlyTrpThrGlnGlyGlyLeuIleVal100105110SerLeu<210>162<211>46<212>蛋白質<213>小鼠<400>162MetHisTyrProCysLeuAlaCysLeuPheValAsnValHisTrpCys151015PheAlaTrpMetCysIleLeuValLysMetSerGluLeuLeuGluLeu202530GluLeuGluThrMetValSerCysLeuValAspValGlyAsn354045<210>163<211>122<212>蛋白質<213>小鼠<400>163MetPheThrPheValValLeuValIleThrIleValIleCysLeuCys151015HisValCysPheGlyHisPheLysTyrLeuSerAlaHisAsnTyrLys202530IleGluHisThrGluThrAspAlaValSerSerArgSerAsnGlyArg354045ProProThrAlaGlyAlaValProLysSerAlaLysTyrIleAlaGln505560ValLeuGlnAspSerGluGlyAspGlyAspGlyAspGlyAlaProGly65707580SerSerGlyAspGluProProSerSerSerSerGlnAspGluGluLeu859095LeuMetProProAspGlyLeuThrAspThrAspPheGlnSerCysGlu100105110AspSerLeuIleGluAsnGluIleHisGln115120<210>164<211>60<212>蛋白質<213>大鼠<400>164MetSerPheValLysIleGluAlaThrProThrGlnThrLysTrpPro151015PheSerValValProGlnSerLeuLeuValThrValTyrIleCysTyr202530IlePheLeuValIlePhePhePhePhePheGluAlaCysGlnGluVal354045LeuCysSerPhePheAspPheSerArgArgArgGly505560<210>165<211>57<212>蛋白質<213>小鼠<400>165MetGlySerProIleSerGlyValCysProValLeuProGlyGlyLeu151015PheValAlaLeuGlyTrpIlePheLeuLeuPheHisArgAspAlaPhe202530SerLeuHisThrMetSerAlaGlyPheProLysSerProAlaAsnPro354045HisHisProProLeuArgLeuSerPro5055<210>166<211>75<212>蛋白質<213>小鼠<400>166LysThrArgArgThrLeuThrGlyGlnLeuGlyLeuPheSerValAsp151015PheMetValCysIlePheLeuPheLeuPhePheCysPheLeuPhePro202530PheProLeuPheLeuValArgLysHisIleLeuLeuSerHisCysLys354045GlnTrpGluGlySerThrMetThrHisThrHisThrHisThrHisIle505560HisIleHisThrProProArgGlnCysGlnSer657075<210>167<211>52<212>蛋白質<213>小鼠<400>167ValArgSerLeuGluGlnLeuGlyLeuPheSerValAspPheMetVal151015CysIlePheLeuPheLeuPhePheCysPheLeuPheProPheProLeu202530PheLeuValArgLysHisIleLeuLeuSerHisCysLysGlnTrpGlu354045GlySerThrMet50<210>168<211>119<212>蛋白質<213>大鼠<400>168MetLeuGlyAlaThrSerLeuSerTrpProTrpValLeuTrpAlaVal151015AlaGlnArgAspSerValAspAlaIleGlyMetPheLeuGlyGlyLeu202530ValAlaThrIlePheLeuAspIleIleTyrIleSerIlePheTyrSer354045SerValAlaValGlyAspThrGlyArgPheSerAlaGlyMetAlaIle505560PheSerLeuLeuLeuGlnAlaLeuLeuLeuLeuProArgLeuProHis65707580AlaProGlySerGluGlyValSerSerArgSerAlaArgIleSerSer859095AspLeuLeuArgAsnIleValProThrArgGlnLeuThrArgGlnThr100105110HisLeuGlnThrProLeuGln115<210>159<211>104<212>蛋白質<213>大鼠<220><400>169LeuValProLysSerAlaArgAlaSerLeuLeuCysCysGlyProLys151015LeuAlaAlaCysGlyIleValLeuSerAlaTrpGlyValIleMetLeu202530IleMetLeuGlyIlePhePheAsnValHisSerAlaValXaaIleXaa354045AspValProPheThrGluLysAspPheGluAsnGlyProGlnAsnIle505560TyrAsnLeuTyrGluGlnValSerTyrAsnCysPheIleAlaAlaGly65707580LeuTyrLeuLeuXaaGlyGlyPheSerPheCysGlnValArgLeuAsn859095LysArgLysGluTyrMetValArg100<210>170<211>123<212>蛋白質<213>大鼠<220><221>不確定<222>(27)...(27)<221>不確定<222>(104)...(104)<221>不確定<222>(118)...(118)<400>170MetArgProGlyAlaAspTrpAlaAlaValCysAlaLeuTrpProSer151015TrpArgProSerCysSerLeuProSerSerXaaArgIleGlnProAsp202530GluLeuTrpLeuTyrArgAsnProTyrValLysAlaGluTyrPhePro354045ThrGlyProMetPheValIleAlaPheLeuThrProLeuSerLeuIle505560PhePheAlaLysPheLeuArgLysAlaAspAlaAspArgGlnArgAla65707580SerLeuProArgCysGlnProCysProSerAlaLysTrpCysLeuTyr859095GlnHisHisLysThrAspSerXaaGlnGlyHisAlaGlnIleAlaSer100105110ThrGluCysSerProXaaGlyIleAlaHisSer115120<210>171<211>75<212>蛋白質<213>大鼠<400>171SerAlaGlyValMetThrAlaAlaValPhePheGlyCysAlaPheIle151015AlaPheGlyProAlaLeuSerLeuTyrValPheThrIleAlaThrAsp202530ProLeuArgValIlePheLeuIleAlaGlyAlaPhePheTrpLeuVal354045SerLeuLeuLeuSerSerValPheTrpPheLeuValArgValIleThr505560AspAsnArgAspGlyProValGlnAsnTyrLeu657075<210>172<211>79<212>蛋白質<213>人<400>172LysThrSerTyrHisTyrHisThrAsnValGluGluLeuThrIlePro151015GluThrArgAsnAsnLeuTyrIleSerIleSerTrpLeuTrpCysLeu202530ValLeuValLeuLeuSerThrMetIleLeuAsnLysHisGlyTrpMet354045LysAlaAsnAlaTyrSerLeuValProSerIleIleTyrSerProSer505560TyrLeuLysLeuLeuLeuArgLeuTyrLysLeuGlnIleCysCys657075<210>173<211>134<212>蛋白質<213>人<220><400>173LeuArgGlyArgGlyArgGlyValCysSerGlnGluSerPheGlyGly151015CysCysValSerGlyLeuIleAlaMetGlyThrLysAlaGlnValGlu202530ArgLysLeuLeuCysLeuPheIleLeuAlaIleLeuLeuCysSerLeu354045AlaLeuGlySerValThrValHisSerSerGluProGluValArgIle505560ProGluAsnAsnProValLysLeuSerCysAlaTyrSerGlyPheSer65707580SerProArgValGluTrpLysPheAspGlnGlyAspThrThrArgLeu859095ValCysTyrAsnAsnLysIleThrAlaSerTyrGluAspArgValThr100105110PheLeuProThrGlyIleThrPheLysSerValThrArgGluAspThr115120125GlyThrTyrThrCysMet130<210>174<211>137<212>蛋白質<213>人<400>174AlaTrpSerArgProArgTyrAspSerValLeuAlaLeuSerAlaAla151015LeuGlnAlaThrArgAlaLeuMetValValSerLeuValLeuGlyPhe202530LeuAlaMetPheValAlaThrMetGlyMetLysCysThrArgCysGly354045GlyAspAspLysValLysLysAlaArgIleAlaMetGlyGlyGlyIle505560IlePheIleValAlaGlyLeuAlaAlaLeuValAlaCysSerTrpTyr65707580GlyHisGlnIleValThrAspPheTyrAsnProLeuIleProThrAsn859095IleLysTyrGluPheGlyProAlaIlePheIleGlyTrpAlaGlySer100105110AlaLeuValIleLeuGlyGlyAlaLeuSerProValProValLeuGly115120125IleArgAlaGlyLeuGlyThrCysPro130135<210>175<211>43<212>蛋白質<213>人<400>175MetLysLeuSerGlyMetPheLeuLeuLeuSerLeuAlaLeuPheCys151015PheLeuThrGlyValPheSerGlnGlyGlyGlnValAspCysGlyGlu202530SerArgThrProArgProThrAlaLeuGlyAsn3540<210>176<211>63<212>蛋白質<213>大鼠<400>176ProAsnThrArgProArgArgHisThrAlaCysArgValSerIleSer151015ValPheTyrMetLeuHisThrGluLeuLysLysCysTrpPhePheLeu202530PheCysPheSerLeuPheLeuTrpPheCysPheTrpPheCysPheLeu354045LeuProArgPheAspTyrLeuProMetProSerThrArgProArg505560<210>177<211>52<212>蛋白質<213>小鼠<400>177MetLeuGlnGlyProAlaProSerCysPheTrpValPheSerGlyIle151015CysValPheTrpAspPheIlePheIleIlePhePheAsnValLeuSer202530LeuGlyAsnArgGluIleSerAlaLysAspPheAlaAspGlnProAla354045GlyAlaGlnGly50<210>178<211>62<212>蛋白質<213>小鼠<400>178ValSerProArgProThrTyrProSerThrAlaSerSerMetAlaAla151015PheLeuValThrGlyPhePhePheSerLeuPheValValLeuGlyMet202530GluProArgAlaLeuPheArgProAspLysAlaLeuProLeuSerCys354045AlaLysProThrSerLeuCysValGlnSerSerPheLeuGly505560<210>179<211>123<212>蛋白質<213>小鼠<400>179AlaSerArgThrAlaValMetSerLeuCysArgCysGlnGlnGlySer151015ArgSerArgMetAspLeuAspValValAsnMetPheValIleAlaGly202530GlyThrLeuAlaIleProIleLeuAlaPheValAlaSerPheLeuLeu354045TrpProSerAlaLeuIleArgIleTyrTyrTrpTyrTrpArgArgThr505560LeuGlyMetGlnValArgTyrAlaHisHisGluAspTyrGlnPheCys65707580TyrSerPheArgGlyArgProGlyHisLysProSerIleLeuMetLeu859095HisGlyPheSerAlaHisLysGlyHisValAlaGlnArgGlyGlnVal100105110ProSerArgLysAsnLeuHisPheGlyCysVal115120<210>180<211>120<212>蛋白質<213>小鼠<220><221>不確定<222>(5)...(5)<400>180AlaArgArgArgXaaArgTrpArgArgGlyCysCysTrpLeuIleGly151015ThrGlyLeuArgAlaAlaThrTrpThrValLeuCysSerProAsnSer202530SerLeuValValAlaArgHisThrLysSerPheProProLysLysPro354045LeuGlnAlaLeuThrMetSerIleMetAspHisSerProThrThrGly505560ValValThrValIleValIleLeuIleAlaIleAlaAlaLeuGlyGly65707580LeuIleLeuGlyCysTrpCysTyrLeuArgLeuGlnArgIleSerGln859095SerGluAspGluGluSerIleValGlyAspGlyGluThrLysGluPro100105110PheTyrTrpCysSerThrLeuLeu115120<210>181<211>60<212>蛋白質<213>小鼠<400>181LysGlyProGluValSerCysCysIleLysTyrPheIlePheGlyPhe151015AsnValIlePheTrpPheLeuGlyIleThrPheLeuGlyIleGlyLeu202530TrpAlaTrpAsnGluLysGlyValLeuSerAsnIleSerSerIleThr354045AspLeuGlyGlyPheAspProValTrpLeuPheLeu505560<210>182<211>72<212>蛋白質<213>小鼠<220><400>182LysProThrValGlySerAlaGluValAlaIleAlaValPh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euMetGlnArgCysTrpHisAlaAspPro260265270GlnValArgProThrPheGlnGluIleThrSerGluThrGluAspLeu275280285CysGluLysProAspGluGluValLysAspLeuAlaHisGluProGly290295300GluLysSerSerLeuGluSerLysSerGluAlaArgProGluSerSer305310315320ArgLeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeu325330335SerGluLeuLeuSerGlnLeuAspSerGlyIlePheProArgLeuLeu340345350LysGlyProGluGluLeuSerArgSerSerSerGluCysLysLeuPro355360365SerSerSerSerGlyLysArgLeuSerGlyValSerSerValAspSer370375380AlaPheSerSerArgGlySerLeuSerLeuSerPheGluArgGluAla385390395400SerThrGlyAspLeuGlyProThrAspIleGlnLysLysLysLeuVal405410415AspAlaIleIleSerGlyAspThrSerArgLeuMetLysIleLeuGln420425430ProGlnAspValAspLeuValLeuAspSerSerAlaSerLeuLeuHis435440445LeuAlaValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeu450455460AsnAsnAlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeu465470475480HisMetAlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeu485490495AlaArgLysThrSerValAsnAlaLysAspGluAspGlnTrpThrAla500505510LeuHisPheAlaAlaGlnAsnGlyAspGluGlyGlnHisLysAlaAla515520525AlaArgGluGluCysPheCysGln530535<210>186<211>337<212>蛋白質<213>大鼠<220><400>186ArgPheGlyTyrGlnMetAspGluGlyAsnGlnCysValAsp151015ValAspGluCysAlaThrAspSerHisGlnCysAsnProThrGlnIle202530CysIleAsnThrGluGlyGlyTyrThrCysSerCysThrAspGlyTyr354045TrpLeuLeuGluGlyGlnCysLeuAspIleAspGluCysArgTyrGly505560TyrCysGlnGlnLeuCysAlaAsnValProGlySerTyrSerCysThr65707580CysAsnProGlyPheThrLeuAsnAspAspGlyArgSerCysGlnAsp859095ValAsnGluCysGluThrGluAsnProCysValGlnThrCysValAsn100105110ThrTyrGlySerPheIleCysArgCysAspProGlyTyrGluLeuGlu115120125GluAspGlyIleHisCysSerAspMetAspGluCysSerPheSerGlu130135140PheLeuCysGlnHisGluCysValAsnGlnProGlySerTyrPheCys145150155160SerCysProProGlyTyrValLeuLeuGluAspAsnArgSerCysGln165170175AspIleAsnGluCysGluHisArgAsnHisThrCysThrProLeuGln180185190ThrCysTyrAsnLeuGlnGlyGlyPheLysCysIleAspProIleVal195200205CysGluGluProTyrLeuLeuIleGlyAspAsnArgCysMetCysPro210215220AlaGluAsnThrGlyCysArgAspGlnProPheThrIleLeuPheArg225230235240AspMetAspValValSerGlyArgSerValProAlaAspIlePheGln245250255MetGlnAlaThrThrArgTyrProGlyAlaTyrTyrIlePheGlnIle260265270LysSerGlyAsnGluGlyArgGluPheTyrMetArgGlnThrGlyPro275280285IleSerAlaThrLeuValMetThrArgProIleLysGlyProArgAsp290295300IleGlnLeuAspLeuGluMetIleThrValAsnThrValIleAsnPhe305310315320ArgGlySerSerValIleArgLeuArgIleTyrValSerGlnTyrPro325330335Phe<210>187<211>152<212>蛋白質<213>小鼠<400>187MetAlaLeuGlyValLeuIleAlaValCysLeuLeuPheLysAlaMet151015LysAlaAlaLeuSerGluGluAlaGluValIleProProSerThrAla202530GlnGlnSerAsnTrpThrPheAsnAsnThrGluAlaAspTyrIleGlu354045GluProValAlaLeuLysPheSerHisProCysLeuGluAspHisAsn505560SerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuLysGln65707580AlaIleCysArgCysPheThrGlyTyrThrGlyGlnArgCysGluHis859095LeuThrLeuThrSerTyrAlaValAspSerTyrGluLysTyrIleAla100105110IleGlyIleGlyValGlyLeuLeuIleSerAlaPheLeuAlaValPhe115120125TyrCysTyrIleArgLysArgCysIleAsnLeuLysSerProTyrIle130135140IleCysSerGlyGlySerProLeu145150<210>188<211>118<212>蛋白質<213>大鼠<220><400>188LeuValProGlnPheGlyThrArgIleArgTyrThrAlaTyrAspArg151015AlaTyrAsnArgAlaSerCysLysPheIleValLysValGlnValArg202530ArgCysProIleLeuLysProProGlnHisGlyTyrLeuThrCysSer354045SerAlaGlyAspAsnTyrGlyAlaIleCysGluTyrHisCysAspGly505560GlyTyrGluArgGlnGlyThrProSerArgValCysGlnSerSerArg65707580GlnTrpSerGlySerProProValCysThrProMetLysIleAsnVal859095AsnValAsnSerAlaAlaGlyLeuLeuAspGlnPheTyrGluLysGln100105110ArgLeuLeuIleValSer115<210>189<211>299<212>蛋白質<213>人<220><400>189MetGlyThrLysAlaGlnValGluArgLysLeuLeuCysLeuPheIle151015LeuAlaIleLeuLeuCysSerLeuAlaLeuGlySerValThrValHis202530SerSerGluProGluValArgIleProGluAsnAsnProValLysLeu354045SerCysAlaTyrSerGlyPheSerSerProArgValGluTrpLysPhe505560AspGlnGlyAspThrThrArgLeuValCysTyrAsnAsnLysIleThr65707580AlaSerTyrGluAspArgValThrPheLeuProThrGlyIleThrPhe859095LysSerValThrArgGluAspThrGlyThrTyrThrCysMetValSer100105110GluGluGlyGlyAsnSerTyrGlyGluValLysValLysLeuIleVal115120125LeuValProProSerLysProThrValAsnIleProSerSerAlaThr130135140IleGlyAsnArgAlaValLeuThrCysSerGluGlnAspGlySerPro145150155160ProSerGluTyrThrTrpPheLysAspGlyIleValMetProThrAsn165170175ProLysSerThrArgAlaPheSerAsnSerSerTyrValLeuAsnPro180185190ThrThrGlyGluLeuValPheAspProLeuSerAlaSerAspThrGly195200205GluTyrSerCysGluAlaArgAsnGlyTyrGlyThrProMetThrSer210215220AsnAlaValArgMetGluAlaValGluArgAsnValGlyValIleVal225230235240AlaAlaValLeuValThrLeuIleLeuLeuGlyIleLeuValPheGly245250255IleTrpPheAlaTyrSerArgGlyHisPheAspArgThrLysLysGly260265270ThrSerSerLysLysValIleTyrSerGlnProSerAlaArgSerGlu275280285GlyGluPheLysGlnThrSerSerPheLeuVal290295<210>190<211>91<212>蛋白質<213>人<400>190GlnProThrValPheTrpProLysThrSerAlaLysLysGlyAsnTrp151015ValLeuArgLeuGlyLeuSerAsnProAspArgProAlaArgGlnAsn202530AsnTrpPheLeuProAlaSerArgGluIleProGluHisSerAlaLeu354045ThrArgTyrProAlaGlnIleArgGlyCysTrpProHisArgLeuThr505560LysProGlnThrCysLeuProGlnAlaArgSerTyrLeuSerHisGlu65707580ValThrGlnAlaThrArgThrCysProGlyGly8590<210>191<211>89<212>蛋白質<213>小鼠<400>191GlyAlaTrpAlaMetLeuTyrGlyValSerMetLeuCysValLeuAsp151015LeuGlyGlnProSerValValGluGluProGlyCysGlyProGlyLys202530ValGlnAsnGlySerGlyAsnAsnThrArgCysCysSerLeuTyrAla354045ProGlyLysGluAspCysProLysGluArgCysIleCysValThrPro505560GluTyrHisCysGlyAspProGlnCysLysIleCysLysHisTyrPro65707580CysGlnProGlyGlnArgValGluVal85<210>192<211>299<212>蛋白質<213>小鼠<220><400>192AlaArgAlaGlyAlaCysTyrCysProAlaGlyPheLeuGlyAlaAsp151015CysSerLeuAlaCysProGlnGlyArgPheGlyProSerCysAlaHis202530ValCysThrCysGlyGlnGlyAlaAlaCysAspProValSerGlyThr354045CysIleCysProProGlyLysThrGlyGlyHisCysGluArgGlyCys505560ProGlnAspArgPheGlyLysGlyCysGluHisLysCysAlaCysArg65707580AsnGlyGlyLeuCysHisAlaThrAsnGlySerCysSerCysProLeu859095GlyTrpMetGlyProHisCysGluHisAlaCysProAlaGlyArgTyr100105110GlyAlaAlaCysLeuLeuGluCysSerCysGlnAsnAsnGlySerCys115120125GluProThrSerGlyAlaCysLeuCysGlyProGlyPheTyrGlyGln130135140AlaCysGluAspThrCysProAlaGlyPheHisGlySerGlyCysGln145150155160ArgValCysGluCysGlnGlnGlyAlaProCysAspProValSerGly165170175ArgCysLeuCysProAlaGlyPheArgGlyGlnPheCysGluArgGly180185190CysLysProGlyPhePheGlyAspGlyCysLeuGlnGlnCysAsnCys195200205ProThrGlyValProCysAspProIleSerGlyLeuCysLeuCysPro210215220ProGlyArgAlaGlyThrThrCysAspLeuAspCysArgArgGlyArg225230235240PheGlyProGlyCysAlaLeuArgCysAspCysGlyGlyGlyAlaAsp245250255CysAspProIleSerGlyGlnCysHisCysValAspSerTyrThrGly260265270ProThrCysArgGluValProThrGlnLeuSerSerIleArgProAla275280285ProGlnHisSerSerSerLysAlaMetLysHis290295<210>193<211>314<212>蛋白質<213>小鼠<220><400>193GluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsnIleAsp151015LeuGlyAspSerCysIleThrValGlyAsnThrThrThrHisValMet202530LysAsnLeuLeuProGluThrThrTyrArgIleArgIleGlnAlaIle354045AsnGluIleGlyValGlyProPheSerGlnPheIleLysAlaLysThr505560ArgProLeuProProSerProProArgLeuGluCysAlaAlaSerGly65707580ProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLysThrHis859095AlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArgAsnLys100105110ArgPheIleSerIleTyrArgGlyProSerHisThrTyrLysValGln115120125ArgLeuThrGluPheThrCysTyrSerPheArgIleGlnAlaMetSer130135140GluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSerThrThr145150155160LysSerValProProThrLeuLysAlaProArgValThrGlnLeuGlu165170175GlyAsnSerCysGluIlePheTrpGluThrValProProMetArgGly180185190AspProValSerTyrValLeuGlnValLeuValGlyArgAspSerGlu195200205TyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIleSerGly210215220LeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCysArgArg225230235240CysValAspThrSerGlnGluLeuSerGlyAlaPheSerProSerAla245250255AlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAspLeuGly260265270GlyMetGluGluAlaLysMetLysGlyMetMetProThrAspGluGln275280285PheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIleLeuPhe290295300AlaPheIleLeuGlnTyrPheLeuMetLys305310<210>194<211>109<212>蛋白質<213>小鼠<400>194GlyThrArgValGlyThrProTyrTyrMetSerProGluArgIleHis151015GluAsnGlyTyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeu202530LeuTyrGluMetAlaAlaLeuGlnSerProPheTyrGlyAspLysMet354045AsnLeuTyrSerLeuCysLysLysIleGluGlnCysAspTyrProPro505560LeuProSerAspHisTyrSerGluGluLeuArgGlnLeuValAsnIle65707580CysIleAsnProAspProGluLysArgProAspIleAlaTyrValTyr859095AspValAlaLysArgMetHisAlaCysThrAlaSerThr100105<210>195<211>237<212>蛋白質<213>小鼠<400>195MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThrLeuGlySerProLeuAlaGlyAlaLeu210215220HisIleLeuLeuValPheLeuIleSerLysLeuLeuPhe225230235<210>196<211>154<212>蛋白質<213>人<400>196MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaHisAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysPheThrGlyTyrThrGlyGluArgCysGlu859095HisLeuThrLeuThrSerTyrAlaValAspSerTyrGluLysTyrIle100105110AlaIleGlyIleGlyValGlyLeuLeuLeuSerGlyPheLeuValIle115120125PheTyrCysTyrIleArgLysArgCysLeuLysLeuLysSerProTyr130135140AsnValCysSerGlyGluArgArgProLeu145150<210>197<211>171<212>蛋白質<213>大鼠<400>197MetAlaArgProAlaProTrpTrpTrpLeuArgProLeuAlaAlaLeu151015AlaLeuAlaLeuAlaLeuValArgValProSerAlaArgAlaGlyGln202530MetProArgProAlaGluArgGlyProProValArgLeuPheThrGlu354045GluGluLeuAlaArgTyrSerGlyGluGluGluAspGlnProIleTyr505560LeuAlaValLysGlyValValPheAspValThrSerGlyLysGluPhe65707580TyrGlyArgGlyAlaProTyrAsnAlaLeuAlaGlyLysAspSerSer859095ArgGlyValAlaLysMetSerLeuAspProAlaAspLeuThrHisAsp100105110IleSerGlyLeuThrAlaLysGluLeuGluAlaLeuAspAspIlePhe115120125SerLysValTyrLysAlaLysTyrProIleValGlyTyrThrAlaArg130135140ArgIleLeuAsnGluAspGlySerProAsnLeuAspPheLysProGlu145150155160AspGlnProHisPheAspIleLysAspGluPhe165170<210>198<211>1399<212>DNA<213>小鼠<400>198ggcaaagacttcggcacgagasaacagcaaagcagagctggctgcagccattcactggcc60tcgggcgggcgtgccacagaggcagttgaagtgaaagtgaaagagaaacgataagagaac120ggagaccacaggtgctaagtgagggtgctcacagaaccccctcttcagccagagatcact180agcaggggaactgtggagaaggcagccagcaaggaagagcctgagagtagcctccatggg240cttggagcccagctggtatctgctgctctgtttggctgtctctggggcagcagggactga300ccctcccacagcgcccaccacagcagaaagacagcggcagcccacggacatcatcttaga360ctgcttcttggtgacagaagacaggcaccgcggggcttttgccagcagtggggacaggga420gagggccttgcttgtgctgaagcaggtaccagtgctggatgatggctccctggaaggcat480cacagatttccaggggagcactgagaccaaacaggattcacctgttatctttgaggcctc540agtggacttggtacagattccccaggcagaggcgttgctccatgctgactgcagcgggaa600ggcagtgacctgcgagatctccaagtatttcctccaggccagacaagaggccacttttga660gaaagcacattggttcatcagcaacatgcaggtttctagaggtggccccagtgtctccat720ggtgatgaagactctaagagatgctgaagttggagctgtccggcaccctacactgaacct780acctctgagtgcccagggcacagtgaagactcaagtggagttccaggtgacatcagagac840ccaaaccctgaaccacctgctggggtcctctgtctccctgcactgcagtttctccatggc900accagacctggacctcactggcgtggagtggcggctgcagcataaaggcagcggccagct960ggtgtacagctggaagacagggcaggggcaggccaagcgcaagggcgctacactggagcc1020tgaggagctactcagggctggaaacgcctctctcaccttacccaacctcactctaaagga1080tgaggggacctacatctgccagatctccacctctctgtatcaagctcaacagatcatgcc1140acttaacatcctggctccccccaaagtacaactgcacttggcaaacaaggatcctctgcc1200ttccctcgtctgcagcattgccggctactatcctctggatgtgggagtgacgtggattcg1260agaggagctgggtggaattccagcccaagtctctggtgcctccttctccagcctcaggca1320gagcacgatgggaacctacagcatttcttccacggtgatggctgacccaggccccacagg1380tgccacttatacctgccaa1399<210>199<211>469<212>DNA<213>大鼠<400>199ggggcgctggccagtcatggcggagccttgggctgggcagtttctgcaagctttgcccgc60cacggtgctcggagcgctgggcaccctgggcagcgagtttctgcgggagtgggagacaca120agatatgcgagtgactctcttcaagcttctcctgctttggttggtgttaagtctcctggg180catccagctggcgtgggggttctacgggaacacagtgaccgggttgtatcaccgtccagg240gaaatggcagcaaatgaagctctcaaaactcacagagaataaaggaaggcagcaggagaa300gggtctccagagatatcgctgggtctgctggctcctgtgctgtaccttgctgctatccag360accccttaggcaactgcagagggcttgggttgggggactggagtaccatgatgctcccag420ggtgagcctccactgccctcagccttgcctccaacagcgtcaggtactg469<210>200<211>529<212>DNA<213>大鼠<400>200aaagcttccatcctcaacatgccactagtgacgacactcttctacgcctgcttctatcac60tacacggagtccgaggggaccttcagcagtccagtcaacctgaagaaaacattcaagatc120ccagacagacagtatgtgctgacagccttggctgcgcgggccaagcttagagcctggaat180gatgtcgacgccttgttcaccacaaagaactggttgggttacaccaagaagagagcaccc240attggcttccatcgagttgtggaaattttgcacaagaacagtgcccctgtccagatattg300caggaatatgtcaatctggtggaagatgtggacacaaagttgaacttagccactaagttc360aagtgccatgatgttgtcattgatacttgccgagacctgaaggatcgtcaacagttgctt420gcatacaggagcaaagtagataaaggatctgctgaggaagagaaaatcgatgtcatcctc480agcagctcgcaaattcgatggaagaactaaggttcttttgctacccaga529<210>201<211>1230<212>DNA<213>大鼠<400>201aagaattcggcacgaggccatggctggttgggcgggggccgagctctcggtcctgaaccc60gctgcgtgcgctgtggctgttgctggccgccgccttcctgctcgcactgctgctgcagct120ggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgggaa180gaccaagcagtccggctcgcggcgccccgccgtctgcagggccttcgacgtccccaagag240gtacttttctcacttctacgtcgtctcagtgttatggaatggctccctgctctggttcct300gtctcagtctctgttcctgggagcgccgtttccaagctggctttgggctttgctcagaac360tcttggggtcacgcagttccaagccctggggatggagtccaaggcttctcggatacaagc420aggcgagctggctctgtctaccttcttagtgttggtgttcctctgggtccatagtcttcg480gagactcttcgagtgcttctacgtcagcgtcttctctaacacggccattcacgtcgtgca540gtactgtttcgggctggtctactatgtccttgttggcctgaccgtactgagccaagtgcc600catgaatgacaagaacgtgtacgctctggggaagaatctactgctacaagctcggtggtt660ccacatcttgggaatgatgatgttcttctggtcctctgcccatcagtataagtgccacgt720cattctcagcaatctcaggagaaataagaaaggtgtggtcatccactgccagcacagaat780cccctttggagactggttcgagtatgtgtcttctgctaactacctagcagagctgatgat840ctacatctccatggctgtcaccttcgggctccacaacgtaacctggtggctggtggtgac900ctatgtcttcttcagccaagccttgtctgcgttcttcaaccacaggttctacaaaagcac960atttgtgtcctacccaaagcataggaaagctttcctcccgttcttgttttgaacaggctt1020tatggtgaagagcgcagcccaggtgacaggttcccttcctcgagacgctgagacaggctg1080aagtacactttctgcagctggcgcccgccaggctgctaccgagctgcgcgctcttccagg1140acctcatccgctacgggaagaccaagcagtccggctcgcggcgccccgccgtctgcagcc1200cgggggatccactagttctagagcgccgcc1230<210>202<211>778<212>DNA<213>大鼠<400>202ctgcaggtcgacactagtggatccaaagattcggcacgagataaggcacatttgcttcat60aaaataaaaaaaaaggaaatttacttagccgcatgtcagtcacccaaattttgagtgtac120aaatgaaatggaaaacatttattacacaaatttaattacaattctagggaataaacatgc180aaatcagatggagctcaatctgcaggcgctgatcctctccccctggtttgcagtctgtgc240acctcctggattcgcccgcgaccaggcagtcagaggcctggctcttgcaggcaggaggat300cactgttgtaaagaacagcgtcacatttagcgcatctggcgtagtagcagtttttaacac360tttgcgcaggtgcctcccttcccccacccgcgctttgttaggtctacctctctaaatctc420tgccttcctcgcacagtaagtgacctctccatgacaaagggcccccagacagcagttata480aatcaatgtgttttgggtttgtttgtttgtttgttttgttttaaagaaaaacccggccat540gcttggtggcacttgcctttaatagtagcgcttggtagacagaggcaagcggttctctgt600aagttcaaggccagcctggtctacacagtgagaccgggtctcaaaaacaaaacaacaaaa660aacaactcctattgaatccactacaggaagggggggcgcggatcactgtctgcaaactaa720agtgacttgagctcctgtcacagcctttccagcaagggcaagcttctttattagttat778<210>203<211>1123<212>DNA<213>大鼠<400>203gggccccccctcgagtcgacgktatcgataagcttgatatcgaattcctgcaggtcgaca60ctagtggatccaaagaattcggcacgagcctgaggcgactacggtgcgggtgccgggtgc120cgggtgcctacagcccccatcagcttccccggggagattctgccgatttgtcacgagcca180tgctcaggaggcagctcgtctggtggcacctgctggctttgcttttcctcccattttgcc240tgtgtcaagatgaatacatggagtctccacaagctggaggactgcccccagactgcagca300agtgttgccatggagattatggattccgtggttaccaagggccccctggacccccaggtc360ctcctggcattccaggaaaccatggaaacaatggaaataacggagccactggccacgaag420gggccaagggtgagaaaggagacaaaggcgacctggggcctcgaggggaacgggggcagc480atggccccaaaggatagaagggatacccaggggtgccaccagagctgcagattgcgttca540tggcttctctagcgactcacttcagcaatcagaacagtggcattatcttcagcagtgttg600agaccaacattggaaacttcttcgatgtcatgactggtagatttggggcccccgtatcag660gcgtgtatttcttcaccttcagcatgatgaagcatgaggacgtggaggaagtgtatgtgt720accttatgcacaatggtaacacggtgttcagcatgtacagctatgaaacaaagggaaaat780cagatacatccagcaaccatgcagtgctgaagttggccaaaggagatgaagtctggctaa840gaatgggcaacggtgccctccatggggaccaccagcgcttctctaccttcgcaggctttc900tgctttttgaaactaagtgatgaggaagtcaggatagctccatgctaagggcgatttgta960ggtgagctagggttgttaggatctgaggggtgttggagttgggcttctctatggagtatt1020taactgttacattggtcacactgctactcattctaatggcataccaattatgttggatac1080tttaggggctaggaagaatagaccacaaggtaatattcccaga1123<210>204<211>434<212>DNA<213>小鼠<400>204accaccaagcagatggaatgctggcacacccatgcacctgcatggcgtcacaggtggaag60attgttaaaaaattgacatcagaaatatttacagaaatagatacctgtttgaataaagtt120agagatgaaatttttgctaaacttcaaccgaagcttagatgcacattaggtgacatggaa180agtcctgtgtttgcacttcctgtactgttaaagcttgaaccccatgttgaaagcctcttt240acatattctttttcttggaattttgaatgttcccattgtggacaccagtaccaaaacagg300tgtgtgaagagtctggtcacctttaccaatattgttcctgagtggcatccactcaatgct360gcccattttggtccatgtaacagctgcaacagtaaatcacaaataagaaaaatggtgttg420gaaagagcgtcgcc434<210>205<211>783<212>DNA<213>小鼠<400>205aattcggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgct60ggttgcgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcc120catctggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagta180cttaagtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcag240cgtggatcaactcatggagctggccgggttgagctgtgccacggctattgccaaggctta300tccccccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaa360taacggaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaac420tatctattaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtca480gaaaatggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaaggga540aaccctagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgca600actcactttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagag660aagaagtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacag720taagggaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaa780aaa783<210>206<211>480<212>DNA<213>小鼠<400>206aaatgaaaactcttggarctcgcgcgcctgcaggtcgacactagtggatccaaagaattc60ggcacgagttaaggttttcagactttatttcatggtatttgacattgacacatactgagt120tagtaacaagataccatgcagctccctctagcctcggatcaccgaagcaggaagaaggtc180agactgcccccatcccagatttgcttagtttgtctcccaatgtgctggactttaaagaca240gggaatggagaagcagatggatgcttcagtttcagtcatttttggctctatagtgatctc300tgccttcctgtacctgtccttggctggaccctgggcagtaactgtcactcagatgaggac360gatcatcattacaatggaccaactgagggatgccctcatattagaccaattaaaagttgc420tgtgagttaaaccaggaatgaccgcacttccacatcagaaatcaaacaaaatcaatggtt480<210>207<211>501<212>DNA<213>小鼠<400>207ctgcaggtcgacactagtggatccaaagaattcggcacgagaatcatggcgccgtcgctg60tggaaggggcttgtaggtgtcgggctttttgccctagcccacgctgccttttcagctgcg120cagcatcgttcttatatgcgactaacagaaaaggaagatgaatcattaccaatagatata180gttcttcagacacttctggcctttgcagttacctgttatggcatagttcatatcgcaggg240gagttcaaagacatggatgccacttcagaattaaagaataagacatttgataccttaagg300aatcacccatctttttatgtgtttaaccatcgtggtcgagtgctgttccggccttcagat360gcaacaaattcttcaaacctagatgcattgtcctctaatacatcgttgaagttacgaaag420tttgactcactgcgccgttaagctttttacaaattaaataacaggacagacacagaattg480agtattggagtttggggtgta501<210>208<211>480<212>DNA<213>小鼠<400>208ggcacgaggaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctc60cgcctggcctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggt120tggctttcctttttagtttttttactttttagtttagtttgttcttttccttccccaata180aatcattctcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaa240gtaggccccagtccataaggaggtgtgaacacacccccttactgcttatcacccatttga300caggaacgcccaggaggggagggggaggggaagaggtgagttctgcacagtcggacattt360ctgttgcttttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggcctt420cagatatgcacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc480<210>209<211>962<212>DNA<213>小鼠<400>209ggcacgagattagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgc60cattcatctctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaa120aaatgatgccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccag180cagcaacagcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggact240ggatcgaaacagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttc300ggacggccagtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgctt360gcccctgccggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccg420gaggagctctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagct480gcagtgtcaggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtg540caagaggtacacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagc600caagcccgcccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtct660gagctagacctggactgactaggaagcatctgctacccagatttgattgcttggaagact720ctctctcgagcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatc780aagcccagcaggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgt840aatgagtggtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatccca900gtcatttctttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaa960aa962<210>210<211>778<212>DNA<213>小鼠<400>210ggcacgaggctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttg60cgggctcgcgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatct120ggtggggaacacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaa180gtcaggaggaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtgg240atcaactcatggagctggccgggttgagctgtgccacggctattgccaaggcttatcccc300ccacgtctatgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacg360gaggggatgggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatct420attaccccaaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaa480tggacattcctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccc540tagcggaatccaaccagacttactcatctcactgacggcacccaagaagtctgcaactca600ctttactggccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaa660gtaccagctgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagg720gaggtgggtaggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaa778<210>211<211>1152<212>DNA<213>小鼠<400>211ggcacgagcttctcagggcctgccacccaaataagtctggccctagcctcaactctctct60caggctgggccacaggaagctgctgactggccacttgacaccctccccctaaagctaatg120tctgtgactatagggaggttagcactttttctaattggaattcttctctgtcctgtggcc180ccatccctcacccgctcttggcctggaccagatacatgcagcctctttctccagcacagc240ctttccctgagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcat300gtatgcattcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagcca360cgcgggtcttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgag420gttggggggtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcggggg480tgacacgaggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttcc540magactgcagagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaa600aaacaaaacaaaaataactctgaagggcgggaggatacccaagcctgatgcctgagagga660gtccctagacttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagag720aattttttggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctt780tttggctgccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacag840gagaagctcctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctcc900ccagggactcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgcca960accctgtctcctggcattgggctccggctctacctccccaagcagggcgaggccccgcct1020tctcagcctagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgccc1080acacaggtgacagtcccaagtagataacctccatgggacaagttgggtgttgccttaccc1140gcctgcccagcc1152<210>212<211>446<212>DNA<213>小鼠<400>212ggcacgagcttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatg60tttgtttgttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcaga120actcctggagctggagttagagacaatggtgagctgccttgtggatgttgggaattgaac180ccaggtcctctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaa240attatttttttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaa300ctaatatagattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaa360aacaagaactagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctga420gttcagtctccaggaaccacacagtg446<210>213<211>2728<212>DNA<213>小鼠<400>213ggggagggagggccctgttttggcggagcagggcgcgcggctgggcccctgaagtggagc60gagagggaggcgcttcgccgggtgccactgccggggaggctcgtcgggacccagcgccgg120tcgcggctccctcaggatcgatgcaccgcggttaacccgtgaggaggcggcggccgggga180agatggtgttgccgacagtgttaattctgctcctctcctgggcggcggggctgggaggtg240agacacgaccccgggcggcgacggagcggcggtcggtcgggccgagcgcacgtcgcggag300ccgggccgcgcgtgtcaggtctcctcggcttctgtcagctctctcagctcgcctcagccg360accccgagcgacgctccccgcgcgctattgtccctcgcgcgccccgaccgcgctcccgcc420ggcggccctgcctgcccggcttctcgcgccgctttccccgggagcggcggagcccaggcc480agccgccctcgcgcactccgcagccacctcagccctgccggggtccgagccccgggaccg540cgcagactcgcagcaacttgcgaggttggcagcgcggcgggagcattgttctgcaagcga600gcgagcggacccgggccgggtgtcggacgccggtgtgcgtgtcccacccgagtgccttcc660ctccgcctcgtgctcttttcggagtgtttgtagccagcgcgccggaggttgtgtgtgtgt720gtgtgtctgtcgttctgtctgtctgtcttctgtctccccggggcaagactttagttgact780gaggagaagggcaagccgttttaggatgctcttcgatccatctgtctttttgagttgagt840ccacagagaagcaagaccgacccttcctgggcgaaccaacttgcagagttttcttaaact900ctcaggtggagcagacgtactgcttagtcagaggattgtcagggctgtgctccctccccc960tgcaaattggagttcactgttgcttcaagtttcctgatgcttcgggtttgagacagcggt1020atttcattcccaggctttcctaggacaggttgcatgattattttgttcctatgagaaagt1080gctttaccataggtaagctaatttgccgcccaagtgtctggagagaggttagcttaaaag1140cattgaattggaaacaacccccagaacttccaggggtgcttcggatggttgtcagcagcc1200taatttgatactttagaaaatatcctagtgttttctgtagtgtattgtctgtgttcatcc1260ctttgtctcattgacttaaactgcaggacccagcctatttttgtctggcattctgcttac1320tctgaagttggttttgtgtactcagtttctgttgttgtgtgtactattcatttattaagt1380acacattttagatgacagccactaatagatgcttatttttgttttgtttttgttttttgt1440tttttttaagaaccagattgcagaccgtttgtaaagagcctctttatttaacatttgtat1500ttctgtaacacggcttatagtcctggctggctgttttcactttttgtgattatggtcagg1560aattagacactgttctctatgaggtaataaaatctaagttaaatgtgatacactttgata1620acgtagtgatacaaaatgccttttattaaggaaaactaaaaccaatgtggcctgttgttt1680ggggaaaaaagtaaattaacagcataagcattgtgggtgaagagttttattcagatcttt1740ggagtttctttctgcactaagtaatgattcaaaggccaggttttgttgtgcttctgctaa1800aaacttaaaaaaaaaaataaaagttttcacttaagtattatgtcaaatttgtaatacttg1860agtatgtaggtatatttataatttggggctgtggaatgtagcccagtggcaattgcctag1920caaggccatgcaaggctttggattcaacatctctgtttaaggcccaaaactcctcctatg1980tttatttgtaactcattatactatatgctgggttttttttttttatctgaactgaatcgc2040atatagctaagtttatatatttttgtgatgttttgtaggctagtgtgcattcaaacttag2100tagatattggctgtagtgcattggaaagttgaaatgtttgtaaggttagggtagttgtag2160aaatacagaactttaaggtataagccatgttcaggtgaaactaaactctgttggttgctt2220tcatcttgcctgtttgtgttaatcactgttgtgtgtgaatgtttttcttactgcacataa2280tgtgaggggtgggaagctggaaggaggcaataaagtgcttaaatactaaaacaacttttc2340tagttttcccttctatgttggtggatgtcctgcccagtgttgtatttgtagaaagatacc2400atgatagtttttgagtttatgaagtgtctgtatggaagtattcatatatctgtacaaaat2460gcttctaaaaagttatttgttgcctagcaaaatggctcagtaggtgggagcacttgcttt2520gaaagcctgactatctgatttctagtccccatccctttagttgaaggagagaaccaactc2580ctgaaaattatcttttgaccttcacatgcacaccatggttcctcgtgcccttactcacac2640atgtacactacacacaattataagataataaagttatttggagacgtgttaggaacttat2700tggcactatcctgattagccacaatttt2728<210>214<211>2046<212>DNA<213>大鼠<400>214cggtatcgataagcttgatatcgaattcctgcaggtcgacactagtggatccaaagaatt60cggcacgagaaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattc120tttaaggatggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccag180gacccagaagctgcccaccagagatgaggaactttttcagatgcagatccgggataaggc240attgtttcacgattcatccgtgattccagatggagctgaaatcagcagttacctatttag300agatacacctagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcac360agtgacaccttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgagga420gtccagtgcagatgggtcaggtgacccagaaccacttgaccagcagaagcagcagatgac480tgatgtggagggcacagaactgttctcctacaagggcaatgatgtagagtattttctgtc540ttcaagttccccatctggtttgtatcagttggagcttctttcaacagagaaagacacaca600tttcaaagtatatgccaccaccactccagaatctgatcaaccataccctgacttaccata660tgaccccagagttgatgtgacctctattggacgtaccacagtcactttggcctggaagca720aagccccacagcttctatgctgaaacaacccatagagtactgtgtggtcatcaacaagga780gcacaatttcaaaagcctttgtgcagcagaaacaaaaatgagtgcagatgatgccttcat840ggtggcgcccaaacctggcctagactttagcccctttgactttgcccatttcggatttcc900aacagataatttgggtaaggatcgcagcttcctggcaaagccttctcccaaagtggggcg960ccatgtctactggaggcctaaggttgacataaaaaaaatctgcataggaagtaaaaatat1020tttcacagtctccgacctgaagcccaatacccagtactactttgatgtcttcatggtcaa1080taccaacactaacatgaacacagcttttgtgggtgcctttgccaggaccaaggaggaggc1140aaaacagaagacagtggagctcaaagatgggagggtcacagatgtggtcgttaaaaggaa1200agggaaaaagtttctacggtttgctccagtctcctctcaccaaaaagtcaccctctttat1260tcactcttgtatggacactgttcaagtccaagtgagaagagatgggaagctgcttctgtc1320acagaatgtggaaggcattcggcagttccagttaagaggaaaacccaaaggaaagtacct1380cattcgactgaaaggcaacaagaaaggagcatcaatgttgaaaatactagccaccaccag1440gcccagtaagcacgcattcccctctcttcctgatgacacaagaatcaaagcctttgacaa1500gctacgcacttgctcttcagtcacggtggcttggcttggcacccaagagaggagaaagtt1560ttgtatctacagaaaggaagtgggtggaaactacagtgaagagcagaagagaagagagag1620aaaccagtgcctaggaccagacaccagaaagaagtcagagaaggttctttgcaagtactt1680ccacagccaaaacctgcagaaagcagtgacgacagagacaatcagagatctgcaacctgg1740caagtcttacctactggacgtttatgttgtaggacatgggggacactctgtgaagtatca1800gagtaaacttgtgaaaacaaggaaggtctgttagttaccttaagtgaagatcagtagaac1860tcccggagagatatggaatcacactgcctgttactgactactctcatgacaaacagaagt1920tgtacttgaaagaaaggataacaacatgtgtacattgatgcctgtgtaatgtaacgtgga1980gacttgtattcacgcacacctgtggtacttagggtccatctgtctaatgctggctaatgt2040caaagg2046<210>215<211>493<212>DNA<213>小鼠<400>215cccacccagcagaagatcctctaccaatgaatgctgactgagcctgcccaactttttgtg60cacaagaagaaccagccaccttcacacagcagcctccggcttcactttaggaccctagca120ggagcactggccctttcttcaacacagatgagttggggactacagattctcccctgcctg180agcctaatccttcttctttggaaccaagtgccagggcttgagggtcaagagttccgattt240gggtcttgccaagtgacaggggtggttctcccagaactgtgggaggccttctggactgtg300aagaacactgtgcaaactcaggatgacatcacaagcatccggctgttgaagccgcaggtt360ctgcggaatgtctcggtaatcagatgggaaggggatagctagctctctaagaggggctga420tgggagtcgttcccttctgctctgatccctatacaggacaaggctgagcatgaggcaaag480tggtctctgtctg493<210>216<211>511<212>DNA<213>小鼠<400>216gggcatagtgctggagtagatgagaattctatgtcatgttcccaaggcaaccaggagaag60attgtcttccaggtagcttggagaagggtctcagagtgatgcatttcctccaatgcccac120tccaacagggctatttccctggccaagcatattcaaaccaccacagtgactaaaggccaa180gtggatggatgtctggtctgggttgccactggagaccttgtggatatatgaggctgtgct240gccttggctgctgatggggcaggggcatgcctgggtctgtggtcctattgcactctgggt300ctttgttaatgtcccaggcttatgttaccaccaaaagccattcagatgcccctggtctgg360attgctgcccgaagcactgtgctagccctgcctcttgctgaccaccacactcagaagagc420tgtccctacctcttgcctgggcagcacaatagagctgaccctgatgaagtggaagcactg480gtgaactggctccctccttcatctactgtag511<210>217<211>1107<212>DNA<213>大鼠<400>217cggcatctcaagctgctgcaagcaggactgagcactaccagagcagcaacctcggatggc60cctggacgtggcacgcgcggggcacagaggcaagaagacttgatgaagcctctcttccca120acccatatccagaaagaacgatttagatgacagtttttagaaaggtgaccaccatgatct180cctggatgctcttggcctgtgcccttccgtgtgctgctgacccaatgcttggtgcctttg240ctcgcagggacttccagaagggtggtcctcaactggtgtgcagtctgcctggtccccaag300gcccacctggccctccaggagcaccaggatcctcaggaatggtgggaagaatgggttttc360ctggtaaggatggccaagacggccaggacggagaccgaggggacagtggagaagaaggtc420cacctggcaggacaggcaaccgaggaaaacaaggaccaaagggcaaagctggggccattg480ggagagcgggtcctcgaggacccaagggggtcagtggtacccccgggaaacatggtatac540cgggcaagaagggacctaagggcaagaaaggggaacctgggctcccaggcccctgtagct600gcggcagtagccgagccaagtcggccttttcggtggcggtaaccaagagttacccacgtg660agcgactgcccatcaagtttgacaagattctgatgaatgagggaggccactacaatgcat720ccagtggcaagttcgtctgcagcgtgccagggatctattactttacctatgacattacgc780tggccaacaaacacctggccatcggcctagtgcacaatggccagtaccgcattcggactt840ttgacgccaacaccggcaaccacgacgtggcctcgggctccaccatcctagctctcaagg900agggtgatgaagtctggttacagattttctactcggagcagaatggactcttctacgacc960cttattggaccgacagcctgttcaccggcttcctcatctacgctgatcaaggagacccca1020atgaggtatagacaagctggggttgagccgtccaggcagggactaagattccgcaagggt1080gctgatagaagaggatctctgaactga1107<210>218<211>1001<212>DNA<213>大鼠<400>218ggagcaagaagcaacccgaagctaggagtctgtcagcgagggcaggggctgcctggttgg60ggtaggagtgggagcagggccagcaggagggtctgaggaagccattcaaagcgagcagct120gggagagctggggagccgggaagggcctacagactacaagagaggatcctggcgtctggg180cctcctgggtcatcaccatgaggccacttcttgccctgctgcttctgggtctggcatcag240gctctcctcctctggacgacaacaagatccccagcctgtgtcccgggcagcccggcctcc300caggcacaccaggccaccacggcagccaaggcctgcctggccgtgacggccgtgatggcc360gcgacggtgcacccggagctccgggagagaaaggcgagggcgggagaccgggactacctg420ggccacgtggggagcccgggccgcgtggagaggcaggacctgtgggggctatcgggcctg480cgggggagtgctcggtgcccccacgatcagccttcagtgccaagcgatcagagagccggg540tacctccgccagccgacacacccctacccttcgaccgtgtgctgctcaatgagcagggac600attacgatgccactaccggcaagttcacctgccaagtgcctggtgtctactactttgctg660tccatgccactgtctaccgggccagcctacagtttgatcttgtcaaaaatggccaatcca720tagcttctttcttccagttttttggggggtggccaaagccagcctcgctctcagggggtg780cgatggtgaggctagaacctgaggaccaggtatgggttcaggtgggtgtgggtgattaca840ttggcatctatgccagcatcaaaacagacagtaccttctctggatttctcgtctattctg900actggcacagctccccagtcttcgcttaaaatacagtgaacccggagctggcacttgctc960ctagtggagggtgtgacattggtccagcgcgcataccagga1001<210>219<211>2206<212>DNA<213>大鼠<400>219gtttcgtcttaacgccctctctgcgttggcagaactggccgtgggctcccgctggtacca60tggaacatctcagcccacacagactaagcggagactgatgttggtggcgttcctcggagc120atccgcggtgactgcaagtaccggtctcctgtggaagaaggctcacgcagaatctccacc180gagcgtcaacagcaagaagactgacgctggagataaggggaagagcaaggacacccggga240agtgtccagccatgaaggaagcgctgcagacactgcggccgagccttacccagaggagaa300gaagaagaagcgttctggattcagagacagaaaagtaatggagtatgagaataggatccg360agcctactccacaccagacaaaatcttccggtattttgccaccttgaaagtaatcaacga420acctggtgaaactgaagtgttcatgaccccacaggactttgtgcgctccataacacccaa480tgagaagcagccagaacacttgggcctggatcagtacataataaagcgcttcgatggaaa540gaaaattgcccaggaacgagaaaagtttgctgacgaaggcagcatcttctatacccttgg600agagtgtggactcatctccttctctgactacatcttcctcacaacggtgctctccactcc660tcagagaaatttcgaaattgccttcaagatgtttgacttgaatggagatggagaagtaga720catggaggagtttgagcaggttcaaagcatcattcgctcccagaccagcatgggcatgcg780tcacagagatcgtccaactactgggaacaccctcaagtctggcttatgttcggccctcac840gacctacttttttggagctgatctcaaagggaaactgaccattaaaaacttcctggaatt900tcagcgtaaactgcagcatgacgttctaaagctggagtttgaacgccatgacccggtaga960cgggagaatctctgagaggcagttcggtggcatgctgctggcctacagtggagtgcagtc1020caagaagctgaccgccatgcagaggcagctgaagaagcacttcaaggatgggaagggcct1080gactttccaggaggtggagaacttcttcactttcctgaagaacattaatgacgtggacac1140tgcgttaagcttttaccacatggctggagcatccctcgataaagtgaccatgcagcaagt1200ggccaggacagtggcgaaagtcgagctgtcggaccacgtgtgtgacgtggtgtttgcact1260ctttgactgcgacggcaatggggagctgagcaataaggagtttgtctccatcatgaagca1320gcggctgatgagaggcctggagaagcccaaggacatgggctttacccgtctcatgcaggc1380catgtggaaatgtgcccaagaaaccgcctgggactttgctctacccaaatagtaccccac1440ctcctgcaccttagcaccccgcaatcctggagtggccttcatgctgctgatgcttctggg1500agtagtgcccacatccccatctttctggaagtgacctctggcctcagctggctgacctct1560ccatcctcccctgacccagtcagtgttccgctaggctctgaatctgcagtcagatcaaag1620gtctaagacaggaacaagtcttcaaagcagagaccatagctcccttaaccagtgccccgt1680gggtaaatgcggggagccctcccacactggcagccccaggaggcatctctgcagtctctc1740actgtggatttaagtaacacaaacgtccctgccatcttcctcccactgttttaaagctgc1800aagtttggaaatactctggcaggcaaagggaagtctgtgatgaacggtaatgcagatgac1860cctggtaccctgatctggcagggcacctggtcaggggaagggtctgcgtcagacaccagc1920ggcaccaggaaggctctttgccaccagcacagctcccgattcaaagtcgctgctttgagc1980ggctctccagaacctcctgctcttttttttttcctcccggctccctgcgatgcctcctct2040gggactctgcttcactagagccagggctgagcccctgttccttgtgtcttgtcccctctc2100tatagacctgcagagcgcagctcagagcctatctgccctctgtctaatacactcgtaaat2160atcactttaattatagcactttgcaggaaataccccaaaaaaaaaa2206<210>220<211>376<212>DNA<213>人<400>220atcggcatcaccttctacaacaagtggctgacaaagagcttccatttccccctcttcatg60acgatgctgcacctggccgtgatcttcctcttctccgccctgtccagggcgctggttcag120tgctccagccacagggcccgtgtggtgctgagctgggccgactacctcagaagagtggct180cccacagctctggcgacggcgcttgacgtgggcttgtccaactggagcttcctgtatgtc240accgtctcgctgtgagtactggccatgccctgctgcctcccttcaggctgaagctgtctg300tctgtccagcggggtgtctgcacacccggctgctaggccagccactccaccactctggga360ccagcccttgctctct376<210>221<211>433<212>DNA<213>人<400>221agcttcttctcagagcaaacagtaagcaacagaaaatatacatttgatgaaacattcttt60gcattagagaaacatgaaaataaatataattcaaggaagtataatgattctctaatatgt120ctttctcagacctgtactagtttaccggttcaagaagctctcatcacatttttcacttgt180attttacatattgctattcgggtaattcaaataaaatgcaggtcttgtaaaagaataaaa240acattgacaagtatgcatgtgccagggaccaaattagagggttctttggtgcagttagtc300caaattctcagatttgaaggataatatgtaccaataaaaaaaaaatctgctgctagacat360ttacagcagtgctctgtcttgcttcacattagaaatcgaaaacagctgttctcaacaagc420caattttattttt433<210>222<211>530<212>DNA<213>人<400>222gtttcaagcctgtaatcatagcgttgggaatgctaaggcagaatcccatagttgagggca60gcctgagttagatagagaaacactgccaaactcaaaaatattcagtctgaggatgactta120atattgactttgtaagaagtatactcttggaaataggtgctaagcaaatagtgtttggga180cctctaagcttatgtgaccggagttttactcttttgtccttaattttctcattttctttt240gactggtgaaaagttgcagtgtaagttagaatttggctcgaagcctgcttccttagttga300atgccctgtgttttgtttttttttttttttttgagcacttcaaaaagtatgatatatagt360tccttaatgttaggactctatataccttcagaggcatgtgtgttgggattgaaattcaaa420ttctgatcatgtgaaaatggcactagttgttagaggaagtctctccttcaatctcagcat480ttacttacatactaactgaagagaaaatcacgtctcctagttctttgtaa530<210>223<211>550<212>DNA<213>小鼠<400>223aagctgctggttttaaatatttactttcccaggaggtgggtttcttcaggtgtttgttta60aagagggctgtcacaggtgaatggtttggggaacccttcttggcagagttttagctgcct120tactgaacattgtcccaacagaaagttcctatcgttctccttccttcttggcaggcttca180ggttttgctgcagcccctggagccaacattttggttgtgggaggctgacctcttgcctgc240ctccttgtgtggacagagtggtgaagacgtattcctcacctccttgcctttcagtaaatg300gccacgatgtgactatttgttgaggtttccagcctcttccaagaccttgccaggctgagt360ggggcctgagagcttgcaggcacttaaagcttcctggcaaaggggccggccacaggcaga420gggaaaggaacaggtcagaggcgttgctctggcagaggcggctcgggctgcccatcgtgt480ttctgcggggttgaggtgggctcccttctttgtagatgcctttcctctcgtaataacaac540tccttgcccc550<210>224<211>470<212>DNA<213>小鼠<400>224aggcctgttcaccaccactcctgttctccgctaagcttttctttggcttttggtggtttg60ttttttgttactgttattcaacagttcagcctaattataccatggcagagaacgagcctt120ttatgtttgggctgtgccactgaactgtttactgtagcgtgtgggtgaaggtggaactaa180tgggctcagtccttacctcctgcttctgtgtaggaggctcagccgaggcttggaactggc240taccttcagccagcagtcttttcccctgctgtatagcaacccttctacccttgcttttct300tgcttcctcatcttcactcaaccttaagcagagttcaaagactcaacttcaacattggtc360atctgggtgtgtatttatatgtgaataatgatatcagatccagagtaacacctttgctgt420cttcttaggatgggtgagtgcacggggctcgggctctttgctgaatactt470<210>225<211>1752<212>DNA<213>大鼠<400>225ggcacgagctgacatgaagccccctagacccagagattggttcctgctgtgacatgccta60ccatgtggccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacacca120ccctgtcaaagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagt180tttcggataaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatg240tggttcttgaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggag300aggtcctaggctatgtcactccatggaacagccatggctatgatgttgccaaggtctttg360ggagcaagttcacacagatctcaccagtctggttgcagctgaagagacgtggtcgggaga420tgtttgaaatcacaggcctccatgatgtggaccaagggtggatgcgagctgtcaagaagc480atgccaaaggcgtgcgcatagtgcctcggcttctgtttgaagactggacttacgatgatt540tccgaagcgtcctagacagtgaggatgagatagaagagctcagcaagactgtggtacagg600tggcaaagaaccagcattttgacggctttgtggtggaggtctggagccagttgctgagcc660agaaacatgtaggcctcattcacatgcttactcacttggctgaggcgctgcaccaggcca720ggctgctggtcattctggtcatcccacctgctgtcacccctgggactgaccagctgggca780tgtttacacacaaggagtttgagcagctggcccccatactagatggcttcagcctcatga840catacgactactccacatcacagcagcctggccctaatgctccattgtcatggatccgag900cctgtgttcaggtcctagaccccaagtcacagtggcgtagcaagatcctcctgggattga960acttctatggcatggattatgcagcctccaaggatgcccgtgagcctgtcattggagcca1020gggcagttttgaaggtggctctgccattggctgtctcatcccagcagatctggacattgg1080gaagaggagggtccaccagtgccctactcctggcaggcttggggctggcctcagagccct1140gtacaaagagcgaggaggttccaaagaagagcctcttagatacagtttggcactggcagg1200gagagccaggagcactgtgtagaggtcgtcttcacacctggatcctagtgagcgcggtcc1260cgcaggcctgcacatgcctgtttcagtgatggcctcacgaggcagcaccggctctagctg1320cactgctttctttgattagctttggccatgggagacacaggtagcagcatagcgggtcag1380gaacctcttgagcagatccaaccaaaggctttttgtcacttgccagctctgcatggtcag1440cctgtgacaccgtctcactcaaggccttctggagttggccctcagctcagatgtcatgtg1500agggataccctaaggagatgatggggctccctcttgcctgagcttgcaggattggatctt1560gggcagatcagggcagtggaaacgtcagaccttctacccgtacatacagacgctgaagga1620ccacaggccccgtgtggtatgggacagccaggctgcggaacacttctttgagtacaagaa1680gaatcgcggcgggaggcacgttgtcttctacccaacgctgaagtctctgcaggtgcggct1740ggagctagccag1752<210>226<211>2165<212>DNA<213>小鼠<400>226ggcacgagcctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatccta60cagaagctcatggggagccccagactggcagccttgctcctgtctctcccgctactgctc120atcggcctcgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccac180tgtctcctggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccct240ctcttggtgaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggaca300ccagcatccttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcga360atttccatcccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagcct420tcagctgcagaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacct480gaattctcctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggc540cccaaggccagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagc600ccttttgatacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattc660cttctgccctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaa720aagtgtcccttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgc780ttcactgactacagccagcacaatcagatggtcatggctctgacactccgctgcccactg840aaactggaggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttccc900aacgccacagcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccc960cagctctgctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagt1020ggctctctcccatcctggactgtgagcatggatacccaggcccagcagctgacgcttcac1080ttttcttcgaggacatatgccaccttcagtgctgcctggagtgacccaggtttggggccg1140gatacccccatgcctcctgtgtacagcatcagccagacccagggctcagtcccagtgacg1200ctagacctcatcatccccttcctgaggcaggagaattgcatcctggtgtggaggtcagat1260gtccattttgcctggaagcacgtcttgtgtcctgatgacgccccttaccctactcagctg1320ttgctccggtccctaggctccggtcgaacaaggccagttttactcctacatgcagcggac1380tcagaggcacagcgacgcctggtgggagctttggccgaactgctgcggacggcgctggga1440ggtggacgcgacgtgatcgtggatctctgggaagggacgcacgtagcacgcattggacca1500ctgccgtggctttgggcagcgcgggagcgcgtggcgcgggagcagggcacagtgctgctc1560ctgtggaactgtgcgggtcccagcaccgcctgcagcggtgacccgcaggctgcgtccctt1620cgcaccttgttgtgcgctgctccacgtccgctgctgctcgcctacttcagtcgcctctgc1680gccaaaggtgacatcccccggccgctgcgcgctctgccacgctaccgcctgcttcgtgac1740ctgccgcgcctgctgagagcactggatgctcagcctgccaccctagcctccagctggagt1800caccttggggctaagcggtgcttgaaaaaccgtctggagcagtgtcacctgctggaactt1860gaggctgccaaagatgactaccaaggctcaaccaatagtccctgtggtttcagctgtctg1920tagcctcagcctgtgtagcaacagcaggaactccagaatgaggcctcacacatgtactct1980ttgggggtgcttcttgtcccccaaaccgtaagactcaccttaagtcccacacttgaccaa2040cctccctcacatttgctccctcttagagttcctgagaggaacttgggctttcctgatagg2100tcctcagccctttctgagaaggagggacgatttttccatttcttttcaaaactgaaaaaa2160aaaaa2165<210>227<211>1348<212>DNA<213>小鼠<220><221>不確定<222>(644)...(644)<400>227caaagaattcggcacgagaccggcctcactatgtctgccattttcaattttcagagtctg60ttgactgtaatcttgctgcttatatgtacatgtgcttatatccgatccctggcacccagc120atcctggacagaaataaaactggactattgggaatattttggaagtgtgcccgaattggg180gaacgcaagagtccttatgtcgccatatgctgtatagtgatggccttcagcatcctcttc240atacagtagctttggaaactaccagcatgtgcttgctatcagactgtaaacaaggacttg300cctccagaaaataatgggaagaatggttaagccatttgtctctgaacatggaatgagata360aacttcaagatgctgttctctatttttatgctattggaccaatgagctgaatgaataatt420aagatgtaacagttcaatacacaggaatgtgattgtatccatcaacctcagttctctcac480tccagtattacattctgcaaatgtcattctgttgtgtcaggactgcttttcataaggttc540ttcgggcacgaagtagaaacccagtggcaaattccaaggctcctttgactagggcttcaa600aataatgtcttcacagaatggtacctctagcgactgtcctattnttattgagaaaaaaac660ttgttctatttttgttgttgttactgttcttatggattgcattcatatttaaaccctttg720gattgctaaccagagtacctctattcttggcaaattccgcagtttattacaggtgtttaa780agtattttaaacaaaactctgaatttctttagttagcctaagagttggcttctagtcaca840aagatacagctgccacactgtgacgaagagcaccttagaaagaaaagcagcaagtgagcg900gtgagcaagtaagcaccgtgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctc960tgtagtcttgtcttccaaatagaacgtccatcgtagttacccaaaggtggtatttgtggt1020gttcttaatgcagtgctttaagtctagtgtatgttctgtcagcttgaactggaatctctc1080ttgtaactttgtaggttataaacatatctcatatctgctttagtctgggtactatgctct1140aagtacatttcagctttgacacagaatgtgaatagacgaatatcaaaggatacttacaag1200tttgtatccaacatttcttcaggttcagctgaaaatcagttactgtttcaaaacaaagag1260gaattaaatcctagctgaaaactatacatagcatttattaattaattactgggtttaact1320gctctttttaaaagtttgaaaaaaaaaa1348<210>228<211>2296<212>DNA<213>小鼠<220><221>不確定<222>(2255)...(2255)<400>228ctggagctcgcgcgcctgcaggtcgacactagtggatccaaagcttaaaagagactccac60ccactccagtagaccggggactaaaacagaaattctgagaaagcagcaagaagcagaaga120aatagctatttcacagcagtaacagaagctacctgctataataaagacctcaacactgct180gaccatgatcagcccagcctggagcctcttcctcatcgggactaaaattgggctgttctt240ccaagtggcacctctgtcagttgtggctaaatcctgtccatctgtatgtcgctgtgacgc300aggcttcatttactgtaacgatcgctctctgacatccattccagtgggaattccggagga360tgctacaacactctaccttcagaacaaccaaataaacaatgttgggattccttccgattt420gaagaacttgctgaaagtacaaagaatatacctataccacaacagtttagatgaattccc480taccaaccttccaaagtatgtcaaagagttacatttgcaagagaataacataaggactat540cacctatgattcactttcgaaaattccgtatctggaagagttacacttggatgataactc600agtctcggctgttagcatcgaagagggagcatttcgagacagtaactatctgcggctgct660ttttctgtcccgtaaccaccttagcacaatcccggggggcttgcccaggactattgagga720attacgcctggatgacaatcgcatatcaacgatctcttccccatcacttcatggtctcac780aagcctgaaacgcctggttttagatggaaacttgttgaacaaccatggtttgggtgacaa840agttttcttcaacttagtaaacttaacagagctgtccctggtgaggaattccttgacagc900agcgccagtgaaccttcccggcacaagcctgaggaagctttaccttcaagacaaccatat960caaccgggtacccccaaatgctttttcttatttaaggcagctgtatcgactcgatatgtc1020taataataacctaagcaatttacctcagggtatctttgatgatttggacaatataaccca1080actgattcttcgcaacaatccttggtattgtggatgcaagatgaaatgggtacgagactg1140gttacagtcgctaccggtgaaggtcaatgtgcgtgggctcatgtgccaagccccagaaaa1200ggtccgtggaatggctatcaaggacctcagtgcagaactgtttgattgtaaagacagtgg1260gattgtgagcaccattcagataaccactgcaatacccaacacagcatatcctgctcaagg1320acagtggccagctcctgtgaccaaacaaccagatattaaaaaccccaagctcattaagga1380tcagcgaactacaggcagcccctcacggaaaacaattttaattactgtgaaatctgtcac1440ccctgacacaatccacatatcctggagacttgctctgcctatgactgctctgcgactcag1500ctggcttaaactgggccatagcccagcctttggatctataacagaaacaatcgtaacagg1560agaacgcagtgaatacttggtcaccgccctagaacctgaatcaccctatagagtatgcat1620ggttcccatggaaaccagtaacctttacctgtttgatgaaacacctgtttgtattgagac1680ccaaactgcccctcttcgaatgtacaaccccacaaccaccctcaatcgagagcaagagaa1740agaaccttacaaaaatccaaatttacctttggctgccatcattggtggggctgtggccct1800ggtaagcatcgccctccttgctttggtgtgttggtatgtgcataggaacgggtcactgtt1860ttcacggaactgtgcgtacagcaaagggcggaggagaaaggatgactatgcagaagccgg1920tactaagaaagacaactccatcctggaaatcagggaaacttctttccagatgctaccgat1980aagcaatgaacccatctccaaggaggagtttgtaatacacaccatatttcctccgaatgg2040gatgaatctgtacaagaacaacctcagtgagagcagtagtaaccggagctacagagacag2100tggcatcccagactcggaccactcacactcatgatgcaaggaggtcccacaccagactgt2160tccgggtttttttttaaaaaacctaagaaaggtgatggtaggaactctgttctactgcaa2220aacactggaaaagagactgagagaagcaatgtacntgtacatttgccatataatttatat2280ttaagaactttttatt2296<210>229<211>1704<212>DNA<213>大鼠<220><400>229ccaaagaattcggcacgaggcggctcgggatggcggcccccatggaccggacccatggtg60gccgggcagcccgggcgctgcggcgggctctggcgctggcctcgctggccgggctattgc120tgagcggcctggcgggtgctctccccaccctcgggcccggctggcggcgccaaaaccccg180agccgccggcctcccgcacccgctcgctgctgctggacgccgcttcgggccagctgcgcc240tggagtacggcttccaccccgatgcggtggcctgggctaacctcaccaacgccatccgcg300agactgggtgggcctatctggacctgggcacaaatggcagctacaagtggatcccccggg360ctgcaggcctatgcagctggtgtggtggaggcctctgtgtccgaggagctcatctacatg420cactggatgaacacggtggtcaattactgcggccccttcgagtacgaagtcggctactgt480gagaagctcaagagcttcctggaggccaacctggagtggatgcagagggaaatggagctt540agcccggactcgccatactggcaccaggtgcggctgaccctcgggctgcagctgaagagg600cctggaggacagctatgaaggccgtttaaccttcccaactgggaggttcaacatcaaacc660cttggggttcctcctgctgcaggaatctctggagatctggaagacctagagacagccctg720aataagaccaacgaccaagcgcttccgtgggctccggttcgtgctctgccctcatcaagc780tgctgcccggcagccatgatctcctggtggctcacaacacttggaactcctaccagaaca840tgttacgcatcatcatggagtcccccgggctgcagttccgggaggggccgcaagaaggag900taccccctgattgccggcaacaacttgattttttcgtcttacccgggcaccatcttctcc960ggtgatgacttctacatcctgggcagtgggctggtcaccctggagaccaccaatcggcaa1020caaagaacccaagcgctgtggaagtacgtgcaaccccagggctgtgtgctggagtggatt1080cgaaacattgtggccaacccgcctggccttggatggggccacctgggcagatgtcttcag1140gcggttcaatagtggcacgtataataaccagtggatgattgtggactacaaggcattcat1200ccccaatgggcccagccctggaagccgggtgctcaccatcctagaacagatcccgggcat1260ggtggtggtggcatcccccgggctgcaggaattcgatatcaagcttatcgatacacgtcg1320aaccctcgagccaagatcttccagagggaccagtcactagtagaggacgtagacaccatg1380gtccggctcatgaggtacaatgacttccttcatgaccctctgtcgttgtgtgaggcctgc1440agcccgaagcccaacgcagagaacgccatctctgccccgctctgatctcaaccctgctaa1500ntggctcctacccatttcaggccctgcgtcagcgcgcccatggcggcattgatgtgaagg1560tgaccagcgttgcactggctaagtacatgagcatgctggcagccagtggccccacgtggg1620accagttgccaccgttccagtggagtaaatcaccattccacaacatgctgcacatgggcc1680aagcctgatctttggatgttctca1704<210>230<211>2004<212>DNA<213>大鼠<400>230ctcgaggtcgacggtatcgataagcttgattaattaaccctcactaaagggaacaaaagc60tggagctcgcgsgctgcaggtcgacactagtggatccaaagaattcggcacgaggcggaa120gcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctggtgcta180gtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagaggaactc240gttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacgcgttgg300gattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagccctggga360cagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggcttttgg420aggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctctgggtc480tggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaatgtcctc540tcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcactcccaca600gcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgctatgct660gtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctcctgccc720tgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccacaccagt780taccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcaccagtatc840tcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccggacagggg900aagaaagactggtctctcttccgcatgttctcccggactctcacagaggcctgtccattg960gcatctcagagcctagtttatgtggacatcacaggctacagccaggacaacgaaacactg1020gaggtgagccctcccccaacttccacataccaggatgtcattttgggcaccaggaagacc1080tatgccgtctatgacttgtttgacacagccatgatcaataactcccgaaacctcaacatc1140cagctcaaatggaagagacccccagataatgaagccctgcccgtgcccttcctgcatgca1200cagcggtacgtgagtggttatgggctacagaagggcgagctgagcaccctgttgtacaac1260tctcatccttaccgggccttccctgtgctgctactggatgctgtgccctggtacctgcgg1320ctgtatgtgcacaccctcaccatcacctccaagggcaaggataataaaccaagttatatc1380cactaccagcctgcccaggaccggcagcagccccacctcctggagatgctcattcagctg1440ccggccaactccgtcaccaaggtctccatccagtttgaacgagccctgctcaagtggaca1500gaatacacgccagaccccaaccatggcttctatgtcagcccatctgtcctcagtgccctt1560gtgcccagcatggtggcagccaaaccagtggactgggaagagagccctctcttcaacacc1620ttgttcccggtgtctgatggctccagctactttgtccgactctacacagagcccttgcta1680gtgaacctgcccacccccgacttcagcatgccctacaatgtgatctgccttacatgcact1740gtggtggccgtgtgctatggctccttctacaatctcctcacccgaaccttccacattgaa1800gagcccaaatccggcggcctggccaagcggctggctaacctcatccggcgtgctcgtggt1860gttccccctctctaagattccctttcttcagcaactacagcttcatactcacctgcccca1920ggggagcagtggcagggctttttctgccatgccctctttccccagagttagcttctgaag1980ctaactccccctggatctggtctg2004<210>231<211>1397<212>DNA<213>大鼠<400>231cgggccccccctcgaggtcgacggtatcgataagcttgattaattaaccctcactaaagg60gaacaaaagctggagctcgcgcgcctgcaggtcgacactagtggatccaaagaattcggc120acgagcggcacgagcggccccgaagggggctgcacgggcgacttggcggcgatggctcga180gctccggcggcgacgacggtggccggaggcggcggctcctcctccttctcctcctgggct240tgggcccggcggtgatccgagctggcggccgcggccccccgatgagactgttggcgggct300ggctgtgcctgagcctggcgtccgtgtggctggcgcggaggatgtggacgctgcggagcc360cgctctcccgctctctgtacgtgaacatgactagcggccctggcgggccagcggcggcca420cgggcggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaattatgcgaat480cacttcagtctgtctttgttcagagttatcttgaccaaggaacacagatcttcttaaaca540acagcattgagaaatctggctggctatttatccaactctatcattcttttgtatcatctg600tttttagcctgtttatgtctagaacatctattaacgggttgctaggaagaggctccatgt660ttgtgttctcaccagatcagtttcagagactgcttaaaattaatccggactggaaaaccc720atagacttcttgatttaggtgctggagatggagaagtcacgaaaatcatgagccctcatt780ttgaagaaatttatgccactgaactttctgaaacaatgatctggcagctccagaagaaga840aatacagagtgcttggtataaatgaatggcagaatacagggttccagtatgatgtcatca900gctgcttaaatctgctggatcgctgtgatcagcctctgacattgttaaaagatatcagaa960gtgtcttggagcccacccaaggcagggtcatcctggccttggttttgccctttcatccct1020atgtggaaaacgtaggtggcaagtgggagaaaccatcagaaattctggaaatcaagggac1080agaattgggaagagcaagtgaatagcctgcctgaggtgttcaggaaagctggctttgtca1140tcgaagctttcactagactgccatacctgtgtgaaggtgacatgtacaatgactactatg1200ttctggacgacgctgtctttgttctcagaccagtgtaaacatgtggaggcccaagtcttc1260agagtcacccctggaatctgccctccagaagaggaggtgcatccagtgatgtgaggggga1320cctctggggactgtcattctcagtatcatgtaggaatttaaaaagccaaaatactaattc1380tttctttgtagtgtgta1397<210>232<211>861<212>DNA<213>大鼠<400>232gaattcggcacgagaggagagaaagagaagtgtgcacaaagaaacttgtattattattaa60ttagcacctagcttgtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaa120gaagaaaaaaaaaaaacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaa180tgagagaacagacccagttctcgacccttgcttctcaaggtcctcccaccaggctgccaa240agcaagatggtgttgctctgatccagtcagtattcttttgacttttttttttaatctcca300ggttttggttcaggctcccatattcataccctggctcatttagctttccctcatgttgtg360ggttcttctgtccctcacccccttactctccccactgatattcttcccagtcaagactgt420ggctctggaagaaatatccaccatttgcagagctgatgttctgtagatcgtaatgttgaa480gcgctgggtgtcctggttggcagaatcactcctgtattactctggtacataggtgtctcc540tgatagactccctggccttagtcatggggtgttttctagaggcagactaagacaggagtc600aaaaaagatttagaggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagt660tctactcaggatcccgagtgtttctgtagatgtagattggaatgtgtccataacagagag720gccagtgagagacatccccaaggacctgccaggctttccttcgctccaggaagacgcacc780atcactcaaaaggggtttcctagaaagaaagacaagtgacttaaaaaatctgccagtggg840ttcttgaagtcatcgaaccta861<210>233<211>445<212>DNA<213>小鼠<400>233ggaagtagaagggcccggcgttttcatggcggcgtcctgggggcaggtgcttgctctggt60gctggtggccgcactgtggggtggcacgcagccgctgctgaagcgagcctcctccggcct120ggagcaagtgcgtgagcggacgtgggcctggcagctgttgcaggagataaaggctctctt180cgggaatactgaggtgcgtctagctctcacggacgagcccctgaaaatttcaccataggt240cggccgtattcccagcccatctcttactcactagaagttcctggaagagtcatttatcct300cttacctgatgccctttctcctcaatcagagtggatcccttctctactacttgactttgg360catcaacagatctgacgttagctgtgcccatctgcaactctctggccatcgtctttacac420tgattgttgggaaggtccttggaga445<210>234<211>565<212>DNA<213>人<400>234cagcatcctcaatcaatccaacagcatattcggttgcatcttctacacactacagctatt60gttaggttgcctgcggacacgctgggcctctgtcctgatgctgctgagctccctggtgtc120tctcgctggttctgtctacctggcctggatcctgttcttcgtgctctatgatttctgcat180tgtttgtatcaccacctatgctatcaacgtgagcctgatgtggctcagtttccggaaggt240ccaagaaccccagggcaaggctaagaggcactgagccctcaacccaagccaggctgacct300ctgctttgctttggcatgtgagccttgcctaagggggcatatctgggtccctagaaggcc360ctagatgtggggcttctagattaccccctcctcctgccatacccgcacatgacaatggac420caaatgtgccacacgctcgctcttttttacacccagtgcctctgactctgtccccatggg480ctggtctccaaagctctttccattgcccagggagggaaggttctgagcaataaagtttct540tagatcaatcaaaaaaaaaaaaaaa565<210>235<211>476<212>DNA<213>人<400>235ggtggctttcattggtgctgtccccggcataggtccatctctgcagaagccatttcagga60gtacctggaggctcaacggcagaagcttcaccacaaaagcgaaatgggcacaccacaggg120agaaaactggttgtcctggatgtttgaaaagttggtcgttgtcatggtgtgttacttcat180cctatctatcattaactccatggcacaaagttatgccaaacgaatccagcagcggttgaa240ctcagaggagaaaactaaataagtagagaaagttttaaactgcagaaattggagtggatg300ggttctgccttaaattgggaggactccaagccgggaaggaaaattcccttttccaacctg360tatcaatttttacaacttttttcctgaaagcagtttagtccatactttgcactgacatac420tttttccttctgtgctaaggtaaggtatccaccctcgatgcaatccaccttgtttt476<210>236<211>607<212>DNA<213>人<400>236tatgtccactaacaatatgtcggacccacggaggccgaacaaagtgctgaggtacaagcc60cccgccgagcgaatgtaacccggccttggacgacccgacgcggactacatgaacctgctg120ggcatgatcttcagcatgtgcggcctcatgcttaagctgaagtggtgtgcttgggtcgct180gtctactgctccttcatcagctttgccaactctcggagctcggaggacacgaagcaaatg240atgagtagcttcatgctgtccatctctgccgtggtgatgtcctatctgcagaatcctcag300cccatgacgcccccatggtgataccagcctagaagggtcacattttggaccctgtctatc360cactaggcctgggctttggctgctaaacctgctgccttcagctgccatcctggacttccc420tgaatgaggccgtctcggtgcccccagctggatagagggaacctggccctttcctaggga480acaccctaggcttacccctcctgcctcccttcccctgcctgctgctgggggagatgctgt540ccatgtttctaggggtattcatttgctttctcgttgaaacctgttgttaataaagttttt600cactctg607<210>237<211>513<212>DNA<213>小鼠<400>237ttctccattacctctatgcctaatattcatcagccttcattactctctagcatattcacc60ttgattcaacagattcaaacttcctacagccttctactgatgtcttacaagctcttgcct120ctgtgcctttctcatgctattctttttgcttagattgctctttggtcccagctcatgttc180atcactcccttcaaagcctttcttcctttatatcttctgactgagctctccctgattgac240atcacctcatgcgatgacctccctcattctgtgctgcctcagcacttatcttttgagttt300gtactgtggtccatgtacttactaatatgttgctttgtaattattttctagcactctgtg360ttacagtttcatatttgtatttatttccaaaattaaattgtaagctccttgagggcagga420ataataacttttacatttgtatctctgcacccccgagtgcctagtatagtgctgagcaca480tagtaggcgtttaataaatgcttgttgaagtat513<210>238<211>944<212>DNA<213>大鼠<400>238ggcacgaggggccgccgagtcccgccgggtcggtgtagctcgctgccgacgctgcgacgc60tcgtgggtgccgtgttcggcttttcctgtctacttcagtgcaccgctgcagctccggcct120cgggtctgacgcgccacagcatggcttccgctttggaggagttgcagaaagacctagaag180aggtcaaagtgctgctggaaaagtccactaggaaaagactacgtgatactcttacaaatg240aaaaatccaagattgagacggaactaaggaacaagatgcagcagaagtcacagaagaaac300cagaatttgataatgaaaagccagctgctgtggttgctcctcttacaacagggtacactg360tgaaaatcagtaattatggatgggatcagtcagataagtttgtgaaaatctacattactt420taactggagttcatcaggttcctgctgagaatgtgcaagtacacttcacagagaggtcat480ttgatcttttggtaaaaaacctcaatggcaagaattactccatgattgtgaacaatcttt540tgaaacctatctctgtggaaagcagttcaaaaaaagtcaagactgatacagttattatcc600tatgtagaaagaaagcagaaaacacacgatgggactacttaactcaggtggaaaaagaat660gcaaagagaaagaaaagccttcctacgacactgaggcagatcctagtgagggattaatga720atgttctaaagaaaatttatgaagatggagatgatgacatgaagcgaaccattaataaag780cgtgggtggaatcccgagagaagcaagccagggaagacacagaattctgaggctttaaaa840gtcctgtgggaaccgtcatgtggagtgctcgtgtttccagtagggactgttggtgaactg900cacacatgtgttcatgtgggtatgtagttttggacagatgacta944<210>239<211>386<212>DNA<213>大鼠<400>239ctcgtgccgaattcggcacgagtggcgagatggggaatgcggccctgggagcggagctgg60gcgtgcgggtcctgctctttgtggccttcctggcgaccgagctgctccctcccttccagc120ggcggattcagcccgaggagctgtggctttaccggaacccgtacgtggaggcggaatact180tccccaccggccccatgtttgtcattgcctttctcaccccactgtccctgatcttcttcg240ccaagtttctgaggaaagctgacgccaccgacagcaagcaagcctgcctcgctgccagcc300ttgccctagctctgaatggtgtctttaccaacatcataaaactgatagtgggcaggccac360gcccagatttcttctaccgatgcttc386<210>240<211>228<212>DNA<213>大鼠<400>240ttccgcgggcgtcatgacggctgcggtgttctttggttgcgccttcatcgccttcgggcc60cgcgctctccctttacgtcttcaccatcgccactgatcctttgcgagtcatcttcctcat120cgccggtgccttcttctggttggtgtctctgctgctttcgtctgttttctggttcctagt180gagagtcatcactgacaacagagatggaccagtacagaattacctgct228<210>241<211>452<212>DNA<213>人<400>241ttcgagcggccgcccgggcaggttgaaactttagaaagaagagccgggaggatgtattgg60ttgttaggaaaatgtaggctaccagtagaaaatgacattctctattaataagatctgagg120tgcgacacacataattgtcccaatttttaagattgatggggagcatgaagcattttttta180atgtgttggcaggccccattaaatgcataaactgcataggactcatgtggtctgaatgta240ttttagggctttctgggaattgtcttgacagagaacctcagctggacaaagcagccttga300tctgagtgagctaactgacacaatgaaactgtcaggcatgtttctgctcctctctctggc360tcttttctgctttttaacaggtgtcttcagtcagggaggacaggttgactgtggtgagtc420caggacaccaaggcctactgcactcgggaacc452<210>242<211>1311<212>DNA<213>小鼠<400>242ctgcaacaaggctgttggttcctctccaatgggctccagtgaagggctcctgggcctggg60ccctgggcccaatggtcacagtcacctgctgaagaccccactgggtggccagaaacgcag120tttttcccacctgctgccctcacctgagcccagcccagagggcagctacgtgggccagca180ctcccagggcctcggcggccactacgcggactcctacctgaagcggaagaggattttcta240aggggtcgacaccagagatgctccaagggcctgcaccaagttgcttttgggttttttctg300gtatttgtgttttctgggattttatttttattattttttttaatgtcctttctttgggta360atagagaaatctctgcaaaagactttgctgaccaaccagctggagctcaaggaatgtggg420gtatctggggccacaccattacctgtgggcttgctcctggagccaaaccctgcagcctta480agagagaggggcctgacctgctctctttccctccctagctccaggcctcctctcctgcct540cgtcactcctgtgttctggcctcttgagtgcctttggaggtgtctctgacctgtgaggat600cagagacagtccccgtttttaaacttcgacaattgacttttatttccttttctaattttt660attattttttaaaacaaccaggatgattatcacatctactcccccatccgtccagaaaag720ccccaaattgattccttcagggtctggcctgcccaggctctattccacatgtgcaggttc780caacagcttaaccctattctcttcccagtcatctgctgcaggtatagctgtctcatgccc840ctgcctgcctattctggccagtaccctaagccccaagatctccagcccctgccccagtat900ccttgccttctgatgccttaaagttgggccacaggtcctgctgggtcagagcctcacaga960tgcggagctccaaaagctccgctcaggaccaaagagctctggcctagggttcatcctttc1020tccaggtgtctgccctgtggacagaaggctaaagccttgatcttggcaaaccaccccttt1080tgcccaaagcctggatgcagagaccagtattttctgctggcttcaacagtctcccctgct1140gtctgtgaaaggtgaccattgtacccaggccactgggcctctaccatgttctttcaaacc1200caggtcattaccatccccaggctggatcactggagcaggcctcctctctgtccatgtgag1260ggggacctaggggctctgcccttagccagctgagccaccaccagcctccct1311<210>243<211>399<212>DNA<213>小鼠<400>243aagggtcctgaagtcagttgttgcatcaaatacttcatttttggcttcaatgtcatattt60tggtttttgggaataacgtttcttggaatcggactgtgggcgtggaatgaaaaaggtgtc120ctctccaacatctcgtccatcaccgacctcggtggctttgacccagtgtggcttttcctc180tgagtggccagcccgagcctgagctctgtcaatgacatccaaggagaaaatgaggttaat240gagagacattaattaaacactccctcaccccaccgcaccaaaccagttgggttcttctga300tattctggaatactctgggctatgttttatgtttatttcttttttaatcggttgtatttt360ggtctttttttttcttcttctttttcttttgctcccaaa399<210>244<211>1421<212>DNA<213>小鼠<220><221>不確定<222>(1370)...(1370)<221>不確定<222>(1395)...(1395)<400>244gccgaggcgggcaggcaccagccagagcagctggcggcagacagtcggaccgagacagtt60ggaccgagacagtcgaacggtctaacagggcctggcttgcctacctggcagctgcacccg120gtccttttcccagagctggttctgtgggtcaacatggtcccctgcttcctcctgtctctg180ctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccctcccggcctccttc240ctggaggaagtggcgggcagtggggaagctgagggttcttcagcctcttccccaagcctg300ctgccgccccggactccagccttcagtcccacaccagggaggacccagcccacagctccg360gtcggccctgtgccacccaccaacctcctggatgggatcgtggacttcttccgccagtat420gtgatgctcattgcggtggtgggctcgctgacctttctcatcagttcatagtctgcgcgg480cactcatcacgcgccagaagcacaaggccacagcctactacccgtcctctttccccgaaa540agaagtatgtggaccagagagaccgggctggggggccccatgccttcagcgaggtccctg600acagggcacctgacagccggcaggaagagggcctggactcctcccagcagctccaggctg660acattctggctgctactcagaacctccggtctccagctagagccctgccaggcagtgggg720agggaacaaaacaggtgaagggtgggtcggaggaggaggaggagaaggaagaggaggtgt780tcagtggccaggaggagccccgggaagccccagtatgtggggtcactgaagagaagccgg840aggtccctgacgagacagcctcagcagaggctgaaggggttcccgcagccagcgagggcc900aaggggaaccagaagggtctttctccttagcccaggaaccccagggagcagctggtcctt960ccgaaaggtcctgtgcctgcaacagaatctcccctaatgtgtaacaggccccagaactgt1020gaggcctgactcttgggtcctcgaaggtcacctccttggtcaagaaaggcattcagcttt1080gactgcttcttgacaccctgccttggccattgtgggtgccaatcctgaccctgaatgggc1140aaagctgctggcctctggtgtaccccaggaaacaccaccccaagttccagcgcccttaat1200gactctcacatcctgggggcttcaccccgaagcaccacttttctggaaggggaaggtcag1260acacatcccagtttggagccgcaatgaggcagtcctcagaacagaaggggaacaggccag1320aggctgactgtgacatacacagtaaacacccctgcttgcaccttggctgnggagacaaga1380ggggctgttgatcanatggcctgcggtgtcctatctgccgt1421<210>245<211>461<212>DNA<213>小鼠<400>245cgcctgcaggtcgacactagtggatccaaagttctttttcttttctttttcttttttttg60tgtgtgtgtgttttggtttgttgttgttttggttttcctggaactcactctgtagaccag120gctagccccaaactcagaaatctgcctcccgagtgctgggactaagggtgtgcaccacca180ctgccctggtgcagatgactcctttaaggagctagagtaacccttgttcgcctcggtgag240agtctgagaatcaggcgctttggctacacagctcaatttacacagccaagcctttagctt300ctatgtgtgctgggcatggacagagcctcctcatcgccagtgatgatggccgggtttcca360ggcagccgtggtcctgtctgaatattgtctctaactgccacagtttcagagaaaggggaa420caagttctcctttgcttcttgccctcccagatagacccttg461<210>246<211>1280<212>DNA<213>小鼠<400>246ttggactcgcgcgcctgcaggtcgacactagtggatccaaagaattcggcacgagagaac60attcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatggcagca120gaaaccttcacagacatcttcatttcctggtccggcccaaggattggcaggccatggggt180tgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctccccttg240cttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggctgctc300tcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccctatcc360cgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatgaaacc420atgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcaggctgct480accaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacctgcgc540tctatccctgacacccctgtccccacctaccaagatcccctctacctggaagaccaggta600ccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgacacagag660gatgagtgttggtcagacaatgagattgtcccccagccacctgttgggccccgagagaag720cctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgagagggc780acctcacgctccctgaaggtccgaaccccgaaaaaggccatgccctcagacatggacagc840tagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgctgcta900caccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgtggtac960cctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctatttattgcc1020ttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctaccgacga1080aaccaaaagtccaaccagctgtgttcattccttcttgtccttcaaaatacttgacagcct1140tttccaaggcctggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttacg1200tacactagctgcatgtttcgtgttggtgagtgaggtcaggcttatgaatatttttatata1260aataaataccaaacagtgaa1280<210>247<211>833<212>DNA<213>大鼠<400>247gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaaggttattctcctgg60ttcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggca120acttcactatcctggccctgggtgtgtgggctgtggcccagcgggactctgttgatgcca180ttggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagca240tcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatct300tcagcttgctgctgaagcccttctcctgctgcctcgtctaccacatgcaccgggagcgag360ggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgcctacc420agacaattgactcgtcagactcacctgcagacccccttgcaagcctggagaacaagggcc480aagctgccccccgggggtactgaagctgtccctggccgtcctggggcccagcaggatgct540tgtcaccttctttactggacctacaatggggtatcctccattccctgccacagaggtggc600ctgagtcatgtgccctcggaggtcccagctgagaagagcccagtcctaattctccatgct660gcccctccattcaagacacctgttaacccctgggctagaactgtggttggtttcttcccc720tcctccccatcactataacacacaaccgccgagctgtgcagagtgttcagggccatccag780gccttatgggccaatgatcactgcctctcaggctaccccaaggtgacccagcc833<210>248<211>1308<212>DNA<213>大鼠<400>248gccgaggcgggcaggcaccagccagagcagctggcggcagacagtcggaccgagacagtt60ggaccgagacagtcgaacggtctaacagggcctggcttgcctacctggcagctgcacccg120gtccttttcccagagctggttctgtgggtcaacatggtcccctgcttcctcctgtctctg180ctgctacttgtgaggcctgcgcctgtggtggcctactctgtgtccctcccggcctccttc240ctggaggaagtggcgggcagtggggaagctgagggttcttcagcctcttccccaagcctg300ctgccgccccggactccagccttcagtcccacaccagggaggacccagcccacagctccg360gtcggccctgtgccacccaccaaccttctggatgggatcgtggacttcttccgccagtat420gtgatgctcattgcggtggtgggctcgctgacctttctcatcatgttcatagtctgcgcg480gcactcatcacgcgccagaagcacaaggccacagcctactacccgtcctctttccccgaa540aagaagtatgtggaccagagagaccgggctggggggccccatgccttcagcgaggtccct600gacagggcacctgacagccggcaggaagagggcctggactcctcccagcagctccaggct660gacattctggctgctactcagaacctccggtctccagctagagccctgccaggcagtggg720gagggaacaaaacaggtgaagggtgggtcggaggaggaggaggagaaggaagaggaggtg780ttcagtggccaggaggagccccgggaagccccagtatgtggggtcactgaagagaagccg840gaggtccctgacgagacagcctcagcagaggctgaaggggttcccgcagccagcgagggc900caaggggaaccagaagggtctttctccttagcccaggaaccccagggagcagctggtcct960tccgaaaggtcctgtgcctgcaacagaatctcccctaatgtgtaacaggccccagaactg1020tgaggcctgactcttgggtcctcgaaggtcacctccttggtcaagaaaggcattcagctt1080tgactgcttcttgacaccctgccttggccattgtgggtgccaatcctgaccctgaatggg1140caaagctgctggcctctggtgtaccccaggaaacaccaccccaagttccagcgcccttaa1200tgactctcaccatcctgggggcttcaccccgaagcaccacttctctggaaggggaaggtc1260agacacatcccagttggagccgcaatgaggcagtcctcagaacagaag1308<210>249<211>1212<212>DNA<213>人<400>249tagcgtggtcgcggccgaggtactacagactttgtgataaggctgaagcttggggcatcg60tcctagaaacggtggccacagctggggttgtgacctcggtggccttcatgctcactctcc120cgatcctcgtctgcaaggtgcaggactccaacaggcgaaaaatgctgcctactcagtttc180tcttcctcctgggtgtgttgggcatctttggcctcaccttcgccttcatcatcggactgg240acgggagcacagggcccacacgcttcttcctctttgggatcctcttttccatctgcttct300cctgcctgctggctcatgctgtcagtctgaccaagctcgtccgggggaggaagccccttt360ccctgttggtgattctgggtctggccgtgggcttcagcctagtccaggatgttatcgcta420ttgaatatattgtcctgaccatgaataggaccaacgtcaatgtcttttctgagctttccg480ctcctcgtcgcaatgaagactttgtcctcctgctcacctacgtcctcttcttgatggcgc540tgaccttcctcatgtcctccttcaccttctgtggttccttcacgggctggaagagacatg600gggcccacatctacctcacgatgctcctctccattgccatctgggtggcctggatcaccc660tgctcatgcttcctgactttgaccgcaggtgggatgacaccatcctcagctccgccttgg720ctgccaatggctgggtgttcctgttggcttatgttagtcccgagttttggctgctcacaa780agcaacgaaaccccatggattatcctgttgaggatgctttctgtaaacctcaactcgtga840agaagagctatggtgtggagaacagagcctactctcaagaggaaatcactcaaggttttg900aagagacaggggacacgctctatgccccctattccacacattttcagctgcagaaccagc960ctccccaaaaggaattctccatcccacgggcccacgcttggccgagcccttacaaagact1020atgaagtaaagaaagagggcagctaactctgtcctgaagagtgggacaaatgcagccggg1080cggcagatctagcgggagctcaaagggatgtgggcgaaatcttgagtcttctgagaaaac1140tgtacctgcccgggcggccgctcgaaatcaagcttatcgataccgtcgacctcgaggggg1200ggcccggtacac1212<210>250<211>453<212>DNA<213>人<400>250aagaattccaaatgcttacttttctggtgcagaaagattgttgggaacagacaggaacca60atgtgggaattcaacttcaagttcaaaaaacagtcccctaggttaaagagcaagtgtaca120ggaggattgcagcctcccgttcagtacgaagatgttcataccaatccagaccaggactgc180tgcctactgcaggtcaccaccctcaatttcatctttattccgattgtcatgggaatgata240tttactctgtttactatcaatgtgagcacggacatgcggcatcatcgagtgagactggtg300ttccaagattcccctgtccatggtggtcggaaactgcgcagtgaacagggtgtgcaagtc360atcctggaccagtgcacagcgttcggctctttgactggtggcatcctcagtacccattct420ccctgagagcgtagttactgcttcccatccctt453<210>251<211>242<212>DNA<213>人<400>251gagagagagaactagtctcgagttttttgtatttttatttttgttcatctgctgctgttt60acattctggggggttagggggagtccccctccctccctttcccccccaagcacagagggg120agaggggccagggaagtggatgtctcctcccctcccaccccaccctgttgtagcccctcc180taccccctccccatccaggggctgtgtattattgtgagcgaataaacagagagacgctaa240ca242<210>252<211>358<212>DNA<213>人<400>252gatggccccagtcccaagttggccctgtggctgccctcaccagctcccacagcagcccca60acagccctgggggaggctggtcttgccgagcacagccagagggatgaccggtggctgctg120gtggcactcctggtgccaacgtgtgtctttttggtggtcctgcttgcactgggcatcgtg180tactgcacccgctgtggcccccatgcacccaacaagcgcatcactgactgctatcgctgg240gtcatccatgctgggagcaagagcccaacagaacccatgccccccaggggcagcctcaca300ggggtgcagacctgcagaaccagcgtgtgatggggtgcagacccccctcatggagtat358<210>253<211>568<212>DNA<213>人<400>253catctgtcatggcggctgggctgtttggtttgagcgctcgccgtcttttggcggcagcgg60cgacgcgagggctcccggccgcccgcgtccgctgggaatctagcttctccaggactgtgg120tcgccccgtccgctgtggcgggaaagcggcccccagaaccgaccacaccgtggcaagagg180acccagaacccgaggacgaaaacttgtatgagaagaacccagactcccatggttatgaca240aggaccccgttttggacgtctggaacatgcgacttgtcttcttctttggcgtctccatca300tcctggtccttggcagcacctttgtggcctatctgcctgactacaggatgaaagagtggt360cccgccgcgaagctgagaggcttgtgaaataccgagaggccaatggccttcccatcatgg420aatccaactgcttcgaccccagcaagatccagctgccagaggatgagtgaccagttgcta480agtggggctcaagaagcaccgccttccccaccccctgcctgccattctgacctcttctca540gagcacctaattaaaggggctgaaagtc568<210>254<211>1421<212>DNA<213>人<400>254gattagcgtggtcgcggccgaggtgtctgttcccaggagtccttcggcggctgttgtgtc60agtggcctgatcgcgatggggacaaaggcgcaagtcgagaggaaactgttgtgtctcttc120atattggcgatcctgttgtgctccctggcattgggcagtgttacagtgcactcttctgaa180cctgaagtcagaattcctgagaataatcctgtgaagttgtcctgtgcctactcgggcttt240tcttctccccgtgtggagtggaagtttgaccaaggagacaccaccagactcgtttgctat300aataacaagatcacagcttcctatgaggaccgggtgaccttcttgccaactggtatcacc360ttcaagtccgtgacacgggaagacactgggacatacacttgtatggtctctgaggaaggc420ggcaacagctatggggaggtcaaggtcaagctcatcgtgcttgtgcctccatccaagcct480acagttaacatcccctcctctgccaccattgggaaccgggcagtgctgacatgctcagaa540caagatggttccccaccttctgaatacacctggttcaaagatgggatagtgatgcctacg600aatcccaaaagcacccgtgccttcagcaactcttcctatgtcctgaatcccacaacagga660gagctggtctttgatcccctgtcagcctctgatactggagaatacagctgtgaggcacgg720aatgggtatgggacacccatgacttcaaatgctgtgcgcatggaagctgtggagcggaat780gtgggggtcatcgtggcagccgtccttgtaaccctgattctcctgggaatcttggttttt840ggcatctggtttgcctatagccgaggccactttgacagaacaaagaaagggacttcgagt900aagaaggtgatttacagccagcctagtgcccgaagtgaaagagaattcaaacagacctcg960tcattcctggtgtgagcctggtcggctcaccgcctatcatctgcatttgccttactcagg1020tgctaccggactctggcccctgatgtctgtagtttcacaggatgccttatttgtctttta1080caccccacagggccccctacttcttcggatgtgtttttaataatgtcagctatgtgcccc1140atcctccttcatgccctccctccctttcctaccactggtgagtggcctggaacttgttta1200aagtgtttattccccatttctttgagggatcaggaaggaatcctgggtatgccattgact1260tcccttctaagtagacagcaaaaatggcgggggtcgcaggaatctacactcaactgccca1320cctggctggcagggatctttgaataggtatcttgagcttggttctgggctctttccttgt1380gtacctgcccgggcggccgctcgaaatcaagcttatcgata1421<210>255<211>1464<212>DNA<213>小鼠<400>255ggcacgagcgggagcctgctactgccctgctgggttccttggggccgactgtagccttgc60ctgtccacagggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggc120ggcatgtgacccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattg180tgagcgcggctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcag240gaatgggggcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggg300gccacactgtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtg360ttcctgtcagaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctgg420cttctatggtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgcca480gagagtttgcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctg540ccctgctggcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggaga600tggctgcctgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcct660ctgcctttgcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccg720ctttgggccgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccat780cagtgggcagtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccac840acagctgtcctctatcagaccagcaccccagcactccagcagcaaggccatgaagcacta900actcagaggaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctc960tgctggtgactaagatagaggtggcacttttggatccacacctcttctggaaagccatgg1020attgctgtggacagctatggatagtcatatagccacacacccgggctccatggtcatggg1080gaagaaggcctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgt1140ttacatggggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggat1200gggaccaaggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggc1260catggactgctgcagccagccaactgtttacctggaaatgtagtccagaccatatttata1320taaggtatttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcct1380gaccccagaacttaggcagtggcctgtggggtctccagcaagtggga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12>DNA<213>小鼠<400>263gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacct764<210>264<211>1697<212>DNA<213>小鼠<400>264gcgcggcccgggggactcacattccccggtcccccctccgccccacgcggctgggccatg60gacgccagatggtgggcagtagtggtactcgccacactcccttccttgggagcaggtgga120gagtcacccgaagcccctccgcagtcctggacacagctgtggctcttccgcttcttgttg180aatgtagcgggctatgccagctttatggtacctggctacctcctggtgcagtacttaaga240cggaagaactacctggagacaggcaggggtctctgcttccccctggtgaaagcctgtgtg300tttggcaatgagcccaaggctcctgatgaggttctcctggctccgcggacagagacagcg360gaatccaccccgtcttggcaggtcctgaagctggtcttctgtgcctcgggtctccaggtg420tcctatctgacttggggcatactgcaggaaagagtgatgactggcagctacggggccaca480gccacatcaccaggagagcatttcacagactcccagtttctggtgctgatgaaccgtgtg540ctggcgctggttgtggcaggcctctactgtgtcctgcgcaagcagccccgtcatggtgca600cccatgtaccggtactcctttgccagtctgtcaaatgtgcttagcagctggtgccagtat660gaagcacttaagttcgtcagcttccctacccaggtgctggcgaaggcctccaaggtgatc720cctgtcatgatgatgggaaagctggtgtcccggcgcagctatgaacactgggaatacctg780actgccggcctcatctccattggagtgagcatgtttcttctatccagtggaccagagcct840agaagctctccagccaccacactctctggcttggtcctactggcaggctatattgctttc900gacagcttcacctcaaattggcaggatgccctgtttgcctataagatgtcatcggtgcag960atgatgtttggggtcaatttattctcctgtcttttcacagtaggctcactactggaacag1020ggggccctactggagggggcacgcttcatggggcggcacagtgagtttgcgctccatgct1080ctcctcctctccatctgctccgcctttgggcagctcttcatcttctacaccattggacaa1140tttggagctgctgtcttcactatcatcatgactctacgccaggctattgccatcctcctc1200tcctgcctcctctatggccatactgtcactgtggtggggggactgggagtagctgtggtc1260ttcactgccctcctactcagagtctatgcccggggccggaagcagcggggaaagaaggct1320gtgcccactgagcccccagtacagaaggtgtgagcagtgcagtaaagaccctcatcttct1380gaggcactggctcagtatcagcatacagcagaggattggagccctggaggcagcctcttt1440tgccttaaaagcccccacttcatggaaatgacagctgtgggtgtttggttagaggtgacc1500cagagctcctcccccaatctctgaaatcttgctggtggccaagcaaaccagcaccagggc1560tttgctcatagcacgcacccttgaggctaccaggcaccagctgggaagagaatttacagg1620tcctgcagttcccctaggggccagtgagaatggtgctgtgccagaagggacaaaggcccc1680cagcccagttggggccc1697<210>265<211>159<212>DNA<213>小鼠<220><400>265gttttcttctccaggctgaagacctgaacgtcaagttggaaggggagccttccatgcgga60aaccaaagcagcggccgcggccggagcccctcatcatccccaccaaggcgggcactttca120tcgcccctcctgtctactccaacatcaccccttaccaga159<210>266<211>292<212>DNA<213>小鼠<400>266gtggggtcccagacttgccaaccaaagggccattcctggtatatggttctggcttcagct60ctggtggcatggactatggtatggttggtggcaaggaggctgggaccgagtctcgcttca120aacagtggacctcaatgatggaagggctgccatctgtggccacacaagaagccaccatgc180acaaaaacggcgctatagtggcccctggtaagacccgaggaggttcaccatacaaccagt240ttgatataatcccaggtgacacactgggtggccatacgggtcctgctggtga292<210>267<211>339<212>DNA<213>小鼠<400>267ccactgaccttcccagaaggtgacagccggcggcggatgttgtcaaggagccgagatagt60ccagcagtgcctcggtacccagaagacgggctgtctccccccaaaagacggcgacattcg120atgagaagtcaccacagtgatctcacattttgcgagattatcctgatggagatggagtcc180catgatgcagcctggcctttcctagagcctgtgaaccctcgcttggtgagtggataccga240cgtgtcatcaagaaccctatggatttttccaccatgcgagaacgcctgctccgtggaggg300tacactagctcagaagagtttgcagctgatgctctgctg339<210>268<211>153<212>DNA<213>小鼠<400>268ctgaagttctctcatccttgtctggaagaccataatagttactgcattaatggagcatgt60gcattccaccatgagctgaagcaagccatttgcagatgctttactggttatacgggacaa120cgatgtgagcatttgaccctaacttcgtatgct153<210>269<211>153<212>DNA<213>人<400>269ttgaagttctcacacctttgcctggaagatcataacagttactgcatcaacggtgcttgt60gcattccaccatgagctagagaaagccatctgcaggtgttttactggttatactggagaa120aggtgtgagcacttgactttaacttcatatgct153<210>270<211>288<212>DNA<213>人<400>270gcggccgcgctgctcctgctgctgctggcgctgtacaccgcgcgtgtggacgggtccaaa60tgcaagtgctcccggaagggacccaagatccgctacagcgacgtgaagaagctggaaatg120aagccaaagtacccgcactgcgaggagaagatggttatcatcaccaccaagagcgtgtcc180aggtaccgaggtcaggagcactgcctgcaccccaagctgcagagcaccaagcgcttcatc240aagtggtacaacgcctggaacgagaagcgcagggtctacgaagaatag288<210>271<211>234<212>DNA<213>小鼠<400>271tccaagtgtaagtgttcccggaaggggcccaagatccgctacagcgacgtgaagaagctg60gaaatgaagccaaagtacccacactgcgaggagaagatggttatcgtcaccaccaagagc120atgtccaggtaccggggccaggagcactgcctgcaccctaagctgcagagcaccaaacgc180ttcatcaagtggtacaatgcctggaacgagaagcgcagggtctacgaagaatag234<210>272<211>234<212>DNA<213>人<400>272tccaaatgcaagtgctcccggaagggacccaagatccgctacagcgacgtgaagaagctg60gaaatgaagccaaagtacccgcactgcgaggagaagatggttatcatcaccaccaagagc120gtgtccaggtaccgaggtcaggagcactgcctgcaccccaagctgcagagcaccaagcgc180ttcatcaagtggtacaacgcctggaacgagaagcgcagggtctacgaagaatag234<210>273<211>645<212>DNA<213>小鼠<400>273atgctgtcgctccgctccttgcttccacacctgggactgttcctgtgcctggctctgcac60ttatccccctccctctctgccagtgataatgggtcctgcgtggtccttgataacatctac120acctccgacatcttggaaatcagcactatggctaacgtctctggtggggatgtaacctat180acagtgacggtccccgtgaacgattcagtcagtgccgtgatcctgaaagcagtgaaggag240gacgacagcccagtgggcacctggagtggaacatatgagaagtgcaacgacagcagtgtc300tactataacttgacatcccaaagccagtcggtcttccagacaaactggacagttcctact360tccgaggatgtgactaaagtcaacctgcaggtcctcatcgtcgtcaatcgcacagcctca420aagtcatccgtgaaaatggaacaagtacaaccctcagcctcaacccctattcctgagagt480tctgagaccagccagaccataaacacgactccaactgtgaacacagccaagactacagcc540aaggacacagccaacaccacagccgtgaccacagccaataccacagccaataccacagcc600gtgaccacagccaagaccacagccaaaagcctggccatccgcact645<210>274<211>63<212>DNA<213>小鼠<400>274gggtacagtgatggttaccaagtgtgtagtaggttcggaagcaaagtgcctcagtttctg60aac63<210>275<211>388<212>蛋白質<213>小鼠<400>275MetGlyLeuGluProSerTrpTyrLeuLeuLeuCysLeuAlaValSer151015GlyAlaAlaGlyThrAspProProThrAlaProThrThrAlaGluArg202530GlnArgGlnProThrAspIleIleLeuAspCysPheLeuValThrGlu354045AspArgHisArgGlyAlaPheAlaSerSerGlyAspArgGluArgAla505560LeuLeuValLeuLysGlnValProValLeuAspAspGlySerLeuGlu65707580GlyIleThrAspPheGlnGlySerThrGluThrLysGlnAspSerPro859095ValIlePheGluAlaSerValAspLeuValGlnIleProGlnAlaGlu100105110AlaLeuLeuHisAlaAspCysSerGlyLysAlaValThrCysGluIle115120125SerLysTyrPheLeuGlnAlaArgGlnGluAlaThrPheGluLysAla130135140HisTrpPheIleSerAsnMetGlnValSerArgGlyGlyProSerVal145150155160SerMetValMetLysThrLeuArgAspAlaGluValGlyAlaValArg165170175HisProThrLeuAsnLeuProLeuSerAlaGlnGlyThrValLysThr180185190GlnValGluPheGlnValThrSerGluThrGlnThrLeuAsnHisLeu195200205LeuGlySerSerValSerLeuHisCysSerPheSerMetAlaProAsp210215220LeuAspLeuThrGlyValGluTrpArgLeuGlnHisLysGlySerGly225230235240GlnLeuValTyrSerTrpLysThrGlyGlnGlyGlnAlaLysArgLys245250255GlyAlaThrLeuGluProGluGluLeuLeuArgAlaGlyAsnAlaSer260265270LeuThrLeuProAsnLeuThrLeuLysAspGluGlyThrTyrIleCys275280285GlnIleSerThrSerLeuTyrGlnAlaGlnGlnIleMetProLeuAsn290295300IleLeuAlaProProLysValGlnLeuHisLeuAlaAsnLysAspPro305310315320LeuProSerLeuValCysSerIleAlaGlyTyrTyrProLeuAspVal325330335GlyValThrTrpIlsArgGluGluLeuGlyGlyIleProAlaGlnVal340345350SerGlyAlaSerPheSerSerLeuArgGlnSerThrMetGlyThrTyr355360365SerIleSerSerThrValMetAlaAspProGlyProThrGlyAlaThr370375380TyrThrCysGln385<210>276<211>151<212>蛋白質<213>大鼠<400>276MetAlaGluProTrpAlaGlyGlnPheLeuGlnAlaLeuProAlaThr151015ValLeuGlyAlaLeuGlyThrLeuGlySerGluPheLeuArgGluTrp202530GluThrGlnAspMetArgValThrLeuPheLysLeuLeuLeuLeuTrp354045LeuValLeuSerLeuLeuGlyIleGlnLeuAlaTrpGlyPheTyrGly505560AsnThrValThrGlyLeuTyrHisArgProGlyLysTrpGlnGlnMet65707580LysLeuSerLysLeuThrGluAsnLysGlyArgGlnGlnGluLysGly859095LeuGlnArgTyrArgTrpValCysTrpLeuLeuCysCysThrLeuLeu100105110LeuSerArgProLeuArgGlnLeuGlnArgAlaTrpValGlyGlyLeu115120125GluTyrHisAspAlaProArgValSerLeuHisCysProGlnProCys130135140LeuGlnGlnArgGlnValLeu145150<210>277<211>163<212>蛋白質<213>大鼠<400>277MetProLeuValThrThrLeuPheTyrAlaCysPheTyrHisTyrThr151015GluSerGluGlyThrPheSerSerProValAsnLeuLysLysThrPhe202530LysIleProAspArgGlnTyrValLeuThrAlaLeuAlaAlaArgAla354045LysLeuArgAlaTrpAsnAspValAspAlaLeuPheThrThrLysAsn505560TrpLeuGlyTyrThrLysLysArgAlaProIleGlyPheHisArgVal65707580ValGluIleLeuHisLysAsnSerAlaProValGlnIleLeuGlnGlu859095TyrValAsnLeuValGluAspValAspThrLysLeuAsnLeuAlaThr100105110LysPheLysCysHisAspValValIleAspThrCysArgAspLeuLys115120125AspArgGlnGlnLeuLeuAlaTyrArgSerLysValAspLysGlySer130135140AlaGluGluGluLysIleAspValIleLeuSerSerSerGlnIleArg145150155160TrpLysAsn<210>278<211>330<212>蛋白質<213>大鼠<400>278MetAlaGlyTrpAlaGlyAlaGluLeuSerValLeuAsnProLeuArg151015AlaLeuTrpLeuLeuLeuAlaAlaAlaPheLeuLeuAlaLeuLeuLeu202530GlnLeuAlaProAlaArgLeuLeuProSerCysAlaLeuPheGlnAsp354045LeuIleArgTyrGlyLysThrLysGlnSerGlySerArgArgProAla505560ValCysArgAlaPheAspValProLysArgTyrPheSerHisPheTyr65707580ValValSerValLeuTrpAsnGlySerLeuLeuTrpPheLeuSerGln859095SerLeuPheLeuGlyAlaProPheProSerTrpLeuTrpAlaLeuLeu100105110ArgThrLeuGlyValThrGlnPheGlnAlaLeuGlyMetGluSerLys115120125AlaSerArgIleGlnAlaGlyGluLeuAlaLeuSerThrPheLeuVal130135140LeuValPheLeuTrpValHisSerLeuArgArgLeuPheGluCysPhe145150155160TyrValSerValPheSerAsnThrAlaIleHisValValGlnTyrCys165170175PheGlyLeuValTyrTyrValLeuValGlyLeuThrValLeuSerGln180185190ValProMetAsnAspLysAsnValTyrAlaLeuGlyLysAsnLeuLeu195200205LeuGlnAlaArgTrpPheHisIleLeuGlyMetMetMetPhePheTrp210215220SerSerAlaHisGlnTyrLysCysHisValIleLeuSerAsnLeuArg225230235240ArgAsnLysLysGlyValValIleHisCysGlnHisArgIleProPhe245250255GlyAspTrpPheGluTyrValSerSerAlaAsnTyrLeuAlaGluLeu260265270MetIleTyrIleSerMetAlaValThrPheGlyLeuHisAsnValThr275280285TrpTrpLeuValValThrTyrValPhePheSerGlnAlaLeuSerAla290295300PhePheAsnHisArgPheTyrLysSerThrPheValSerTyrProLys305310315320HisArgLysAlaPheLeuProPheLeuPhe325330<210>279<211>61<212>蛋白質<213>大鼠<400>279MetGluAsnIleTyrTyrThrAsnLeuIleThrIleLeuGlyAsnLys151015HisAlaAsnGlnMetGluLeuAsnLeuGlnAlaLeuIleLeuSerPro202530TrpPheAlaValCysAlaProProGlyPheAlaArgAspGlnAlaVal354045ArgGlyLeuAlaLeuAlaGlyArgArgIleThrValVal505560<210>280<211>105<212>蛋白質<213>大鼠<400>280MetLeuArgArgGlnLeuValTrpTrpHisLeuLeuAlaLeuLeuPhe151015LeuProPheCysLeuCysGlnAspGluTyrMetGluSerProGlnAla202530GlyGlyLeuProProAspCysSerLysCysCysHisGlyAspTyrGly354045PheArgGlyTyrGlnGlyProProGlyProProGlyProProGlyIle505560ProGlyAsnHisGlyAsnAsnGlyAsnAsnGlyAlaThrGlyHisGlu65707580GlyAlaLysGlyGluLysGlyAspLysGlyAspLeuGlyProArgGly859095GluArgGlyGlnHisGlyProLysGly100105<210>281<211>27<212>蛋白質<213>小鼠<400>281MetLeuLysAlaSerLeuHisIleLeuPheLeuGlyIleLeuAsnVal151015ProIleValAspThrSerThrLysThrGlyVal2025<210>282<211>169<212>蛋白質<213>小鼠<400>282MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>283<211>61<212>蛋白質<213>小鼠<400>283MetGluLysGlnMetAspAlaSerValSerValIlePheGlySerIle151015ValIleSerAlaPheLeuTyrLeuSerLeuAlaGlyProTrpAlaVal202530ThrValThrGlnMetArgThrIleIleIleThrMetAspGlnLeuArg354045AspAlaLeuIleLeuAspGlnLeuLysValAlaValSer505560<210>284<211>131<212>蛋白質<213>小鼠<400>284MetAlaProSerLeuTrpLysGlyLeuValGlyValGlyLeuPheAla151015LeuAlaHisAlaAlaPheSerAlaAlaGlnHisArgSerTyrMetArg202530LeuThrGluLysGluAspGluSerLeuProIleAspIleValLeuGln354045ThrLeuLeuAlaPheAlaValThrCysTyrGlyIleValHisIleAla505560GlyGluPheLysAspMetAspAlaThrSerGluLeuLysAsnLysThr65707580PheAspThrLeuArgAsnHisProSerPheTyrValPheAsnHisArg859095GlyArgValLeuPheArgProSerAspAlaThrAsnSerSerAsnLeu100105110AspAlaLeuSerSerAsnThrSerLeuLysLeuArgLysPheAspSer115120125LeuArgArg130<210>285<211>78<212>蛋白質<213>小鼠<400>285GlyThrArgLysProLeuProMetGluAlaHisSerArgArgGluLys151015AlaSerGlyLeuArgLeuAlaTrpHisTyrGluCysSerGlyValSer202530ValTrpTrpMetCysValLeuGlyTrpLeuSerPheLeuValPheLeu354045LeuPheSerLeuValCysSerPheProSerProIleAsnHisSerHis505560MetLeuProCysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>286<211>206<212>蛋白質<213>小鼠<400>286MetLeuProProAlaIleHisLeuSerLeuIleProLeuLeuCysIle151015LeuMetArgAsnCysLeuAlaPheLysAsnAspAlaThrGluIleLeu202530TyrSerHisValValLysProValProAlaHisProSerSerAsnSer354045ThrLeuAsnGlnAlaArgAsnGlyGlyArgHisPheSerSerThrGly505560LeuAspArgAsnSerArgValGlnValGlyCysArgGluLeuArgSer65707580ThrLysTyrIleSerAspGlyGlnCysThrSerIleSerProLeuLys859095GluLeuValCysAlaGlyGluCysLeuProLeuProValLeuProAsn100105110TrpIleGlyGlyGlyTyrGlyThrLysTyrTrpSerArgArgSerSer115120125GlnGluTrpArgCysValAsnAspLysThrArgThrGlnArgIleGln130135140LeuGlnCysGlnAspGlySerThrArgThrTyrLysIleThrValVal145150155160ThrAlaCysLysCysLysArgTyrThrArgGlnHisAsnGluSerSer165170175HisAsnPheGluSerValSerProAlaLysProAlaGlnHisHisArg180185190GluArgLysArgAlaSerLysSerSerLysHisSerLeuSer195200205<210>287<211>169<212>蛋白質<213>小鼠<400>287MetSerGlyLeuArgThrLeuLeuGlyLeuGlyLeuLeuValAlaGly151015SerArgLeuProArgValIleSerGlnGlnSerValCysArgAlaArg202530ProIleTrpTrpGlyThrGlnArgArgGlySerGluThrMetAlaGly354045AlaAlaValLysTyrLeuSerGlnGluGluAlaGlnAlaValAspGln505560GluLeuPheAsnGluTyrGlnPheSerValAspGlnLeuMetGluLeu65707580AlaGlyLeuSerCysAlaThrAlaIleAlaLysAlaTyrProProThr859095SerMetSerLysSerProProThrValLeuValIleCysGlyProGly100105110AsnAsnGlyGlyAspGlyLeuValCysAlaArgHisLeuLysLeuPhe115120125GlyTyrGlnProThrIleTyrTyrProLysArgProAsnLysProLeu130135140PheThrGlyLeuValThrGlnCysGlnLysMetAspIleProPheLeu145150155160GlyGluMetProProGluAspGlyMet165<210>288<211>114<212>蛋白質<213>小鼠<400>288MetSerValThrIleGlyArgLeuAlaLeuPheLeuIleGlyIleLeu151015LeuCysProValAlaProSerLeuThrArgSerTrpProGlyProAsp202530ThrCysSerLeuPheLeuGlnHisSerLeuSerLeuSerLeuArgLeu354045GlyGlnSerLeuGluGlyGlyLeuSerValCysPheHisValCysIle505560HisAlaCysGluCysValAlaCysCysArgValLeuTrpAspProLys65707580ProArgGlySerSerLeuCysArgTrpValLeuGlySerIleThrCys859095LeuPheMetTyrGluValGlyGlyTrpThrGlnGlyGlyLeuIleVal100105110SerLeu<210>289<211>46<212>蛋白質<213>小鼠<400>289MetHisTyrProCysLeuAlaCysLeuPheValAsnValHisTrpCys151015PheAlaTrpMetCysIleLeuValLysMetSerGluLeuLeuGluLeu202530GluLeuGluThrMetValSerCysLeuValAspValGlyAsn354045<210>290<211>199<212>蛋白質<213>小鼠<400>290MetValLeuProThrValLeuIleLeuLeuLeuSerTrpAlaAlaGly151015LeuGlyGlyGluThrArgProArgAlaAlaThrGluArgArgSerVal202530GlyProSerAlaArgArgGlyAlaGlyProArgValSerGlyLeuLeu354045GlyPheCysGlnLeuSerGlnLeuAlaSerAlaAspProGluArgArg505560SerProArgAlaIleValProArgAlaProArgProArgSerArgArg65707580ArgProCysLeuProGlyPheSerArgArgPheProArgGluArgArg859095SerProGlyGlnProProSerArgThrProGlnProProGlnProCys100105110ArgGlyProSerProGlyThrAlaGlnThrArgSerAsnLeuArgGly115120125TrpGlnArgGlyGlySerIleValLeuGlnAlaSerGluArgThrArg130135140AlaGlyCysArgThrProValCysValSerHisProSerAlaPhePro145150155160ProProArgAlaLeuPheGlyValPheValAlaSerAlaProGluVal165170175ValCysValCysValSerValValLeuSerValCysLeuLeuSerPro180185190ArgGlyLysThrLeuValAsp195<210>291<211>568<212>蛋白質<213>大鼠<400>291MetGluLeuLeuTyrTrpCysLeuLeuCysLeuLeuLeuProLeuThr151015SerArgThrGlnLysLeuProThrArgAspGluGluLeuPheGlnMet202530GlnIleArgAspLysAlaLeuPheHisAspSerSerValIleProAsp354045GlyAlaGluIleSerSerTyrLeuPheArgAspThrProArgArgTyr505560PhePheMetValGluGluAspAsnThrProLeuSerValThrValThr65707580ProCysAspAlaProLeuGluTrpLysLeuSerLeuGlnGluLeuPro859095GluGluSerSerAlaAspGlySerGlyAspProGluProLeuAspGln100105110GlnLysGlnGlnMetThrAspValGluGlyThrGluLeuPheSerTyr115120125LysGlyAsnAspValGluTyrPheLeuSerSerSerSerProSerGly130135140LeuTyrGlnLeuGluLeuLeuSerThrGluLysAspThrHisPheLys145150155160ValTyrAlaThrThrThrProGluSerAspGlnProTyrProAspLeu165170175ProTyrAspProArgValAspValThrSerIleGlyArgThrThrVal180185190ThrLeuAlaTrpLysGlnSerProThrAlaSerMetLeuLysGlnPro195200205IleGluTyrCysValValIleAsnLysGluHisAsnPheLysSerLeu210215220CysAlaAlaGluThrLysMetSerAlaAspAspAlaPheMetValAla225230235240ProLysProGlyLeuAspPheSerProPheAspPheAlaHisPheGly245250255PheProThrAspAsnLeuGlyLysAspArgSerPheLeuAlaLysPro260265270SerProLysValGlyArgHisValTyrTrpArgProLysValAspIle275280285LysLysIleCysIleGlySerLysAsnIlePheThrValSerAspLeu290295300LysProAsnThrGlnTyrTyrPheAspValPheMetValAsnThrAsn305310315320ThrAsnMetAsnThrAlaPheValGlyAlaPheAlaArgThrLysGlu325330335GluAlaLysGlnLysThrValGluLeuLysAspGlyArgValThrAsp340345350ValValValLysArgLysGlyLysLysPheLeuArgPheAlaProVal355360365SerSerHisGlnLysValThrLeuPheIleHisSerCysMetAspThr370375380ValGlnValGlnValArgArgAspGlyLysLeuLeuLeuSerGlnAsn385390395400ValGluGlyIleArgGlnPheGlnLeuArgGlyLysProLysGlyLys405410415TyrLeuIleArgLeuLysGlyAsnLysLysGlyAlaSerMetLeuLys420425430IleLeuAlaThrThrArgProSerLysHisAlaPheProSerLeuPro435440445AspAspThrArgIleLysAlaPheAspLysLeuArgThrCysSerSer450455460ValThrValAlaTrpLeuGlyThrGlnGluArgArgLysPheCysIle465470475480TyrArgLysGluValGlyGlyAsnTyrSerGluGluGlnLysArgArg485490495GluArgAsnGlnCysLeuGlyProAspThrArgLysLysSerGluLys500505510ValLeuCysLysTyrPheHisSerGlnAsnLeuGlnLysAlaValThr515520525ThrGluThrIleArgAspLeuGlnProGlyLysSerTyrLeuLeuAsp530535540ValTyrValValGlyHisGlyGlyHisSerValLysTyrGlnSerLys545550555560LeuValLysThrArgLysValCys565<210>292<211>123<212>蛋白質<213>小鼠<400>292MetLeuThrGluProAlaGlnLeuPheValHisLysLysAsnGlnPro151015ProSerHisSerSerLeuArgLeuHisPheArgThrLeuAlaGlyAla202530LeuAlaLeuSerSerThrGlnMetSerTrpGlyLeuGlnIleLeuPro354045CysLeuSerLeuIleLeuLeuLeuTrpAsnGlnValProGlyLeuGlu505560GlyGlnGluPheArgPheGlySerCysGlnValThrGlyValValLeu65707580ProGluLeuTrpGluAlaPheTrpThrValLysAsnThrValGlnThr859095GlnAspAspIleThrSerIleArgLeuLeuLysProGlnValLeuArg100105110AsnValSerValIleArgTrpGluGlyAspSer115120<210>293<211>66<212>蛋白質<213>小鼠<400>293MetAspValTrpSerGlyLeuProLeuGluThrLeuTrpIleTyrGlu151015AlaValLeuProTrpLeuLeuMetGlyGlnGlyHisAlaTrpValCys202530GlyProIleAlaLeuTrpValPheValAsnValProGlyLeuCysTyr354045HisGlnLysProPheArgCysProTrpSerGlyLeuLeuProGluAla505560LeuCys65<210>294<211>294<212>蛋白質<213>大鼠<400>294MetThrValPheArgLysValThrThrMetIleSerTrpMetLeuLeu151015AlaCysAlaLeuProCysAlaAlaAspProMetLeuGlyAlaPheAla202530ArgArgAspPheGlnLysGlyGlyProGlnLeuValCysSerLeuPro354045GlyProGlnGlyProProGlyProProGlyAlaProGlySerSerGly505560MetValGlyArgMetGlyPheProGlyLysAspGlyGlnAspGlyGln65707580AspGlyAspArgGlyAspSerGlyGluGluGlyProProGlyArgThr859095GlyAsnArgGlyLysGlnGlyProLysGlyLysAlaGlyAlaIleGly100105110ArgAlaGlyProArgGlyProLysGlyValSerGlyThrProGlyLys115120125HisGlyIleProGlyLysLysGlyProLysGlyLysLysGlyGluPro130135140GlyLeuProGlyProCysSerCysGlySerSerArgAlaLysSerAla145150155160PheSerValAlaValThrLysSerTyrProArgGluArgLeuProIle165170175LysPheAspLysIleLeuMetAsnGluGlyGlyHisTyrAsnAlaSer180185190SerGlyLysPheValCysSerValProGlyIleTyrTyrPheThrTyr195200205AspIleThrLeuAlaAsnLysHisLeuAlaIleGlyLeuValHisAsn210215220GlyGlnTyrArgIleArgThrPheAspAlaAsnThrGlyAsnHisAsp225230235240ValAlaSerGlySerThrIleLeuAlaLeuLysGluGlyAspGluVal245250255TrpLeuGlnIlePheTyrSerGluGlnAsnGlyLeuPheTyrAspPro260265270TyrTrpThrAspSerLeuPheThrGlyPheLeuIleTyrAlaAspGln275280285GlyAspProAsnGluVal290<210>295<211>243<212>蛋白質<213>大鼠<400>295MetArgProLeuLeuAlaLeuLeuLeuLeuGlyLeuAlaSerGlySer151015ProProLeuAspAspAsnLysIleProSerLeuCysProGlyGlnPro202530GlyLeuProGlyThrProGlyHisHisGlySerGlnGlyLeuProGly354045ArgAspGlyArgAspGlyArgAspGlyAlaProGlyAlaProGlyGlu505560LysGlyGluGlyGlyArgProGlyLeuProGlyProArgGlyGluPro65707580GlyProArgGlyGluAlaGlyProValGlyAlaIleGlyProAlaGly859095GluCysSerValProProArgSerAlaPheSerAlaLysArgSerGlu100105110SerArgValProProProAlaAspThrProLeuProPheAspArgVal115120125LeuLeuAsnGluGlnGlyHisTyrAspAlaThrThrGlyLysPheThr130135140CysGlnValProGlyValTyrTyrPheAlaValHisAlaThrValTyr145150155160ArgAlaSerLeuGlnPheAspLeuValLysAsnGlyGlnSerIleAla165170175SerPhePheGlnPhePheGlyGlyTrpProLysProAlaSerLeuSer180185190GlyGlyAlaMetValArgLeuGluProGluAspGlnValTrpValGln195200205ValGlyValGlyAspTyrIleGlyIleTyrAlaSerIleLysThrAsp210215220SerThrPheSerGlyPheLeuValTyrSerAspTrpHisSerSerPro225230235240ValPheAla<210>296<211>444<212>蛋白質<213>大鼠<400>296MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGlnProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140Ph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nCysHisCysValAspSerTyrThrGly260265270ProThrCysArgGluValProThrGlnLeuSerSerIleArgProAla275280285ProGlnHisSerSerSerLysAlaMetLysHis290295<210>333<211>109<212>蛋白質<213>小鼠<400>333GlyThrArgValGlyThrProTyrTyrMetSerProGluArgIleHis151015GluAsnGlyTyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeu202530LeuTyrGluMelAlaAlaLeuGlnSerProPheTyrGlyAspLysMet354045AsnLeuTyrSerLeuCysLysLysIleGluGlnCysAspTyrProPro505560LeuProSerAspHisTyrSerGluGluLeuArgGlnLeuValAsnIle65707580CysIleAsnProAspProGluLysArgProAspIleAlaTyrValTyr859095AspValAlaLysArgMetHisAlaCysThrAlaSerThr100105<210>334<211>787<212>蛋白質<213>小鼠<400>334LysValGluGlyGluGlyArgGlyArgTrpAlaLeuGlyLeuLeuArg151015ThrPheAspAlaGlyGluPheAlaGlyTrpGluLysValGlySerGly202530GlyPheGlyGlnValTyrLysValArgHisValHisTrpLysThrTrp354045LeuAlaIleLysCysSerProSerLeuHisValAspAspArgGluArg505560MetGluLeuLeuGluGluAlaLysLysMetGluMetAlaLysPheArg65707580TyrIleLeuProValTyrGlyIleCysGlnGluProValGlyLeuVal859095MetGluTyrMetGluThrGlySerLeuGluLysLeuLeuAlaSerGlu100105110ProLeuProTrpAspLeuArgPheArgIleValHisGluThrAlaVal115120125GlyMetAsnPheLeuHisCysMetSerProProLeuLeuHisLeuAsp130135140LeuLysProAlaAsnIleLeuLeuAspAlaHisTyrHisValLysIle145150155160SerAspPheGlyLeuAlaLysCysAsnGlyMetSerHisSerHisAsp165170175LeuSerMetAspGlyLeuPheGlyThrIleAlaTyrLeuProProGlu180185190ArgIleArgGluLysSerArgLeuPheAspThrLysHisAspValTyr195200205SerPheAlaIleValIleTrpGlyValLeuThrGlnLysLysProPhe210215220AlaAspGluLysAsnIleLeuHisIleMetMetLysValValLysGly225230235240HisArgProGluLeuProProIleCysArgProArgProArgAlaCys245250255AlaSerLeuIleGlyLeuMetGlnArgCysTrpHisAlaAspProGln260265270ValArgProThrPheGlnGluIleThrSerGluThrGluAspLeuCys275280285GluLysProAspGluGluValLysAspLeuAlaHisGluProGlyGlu290295300LysSerSerLeuGluSerLysSerGluAlaArgProGluSerSerArg305310315320LeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeuSer325330335GluLeuLeuSerGlnLeuAspSerGlyIleSerGlnThrLeuGluGly340345350ProGluGluLeuSerArgSerSerSerGluCysLysLeuProSerSer355360365SerSerGlyLysArgLeuSerGlyValSerSerValAspSerAlaPhe370375380SerSerArgGlySerLeuSerLeuSerPheGluArgGluAlaSerThr385390395400GlyAspLeuGlyProThrAspIleGlnLysLysLysLeuValAspAla405410415IleIleSerGlyAspThrSerArgLeuMetLysIleLeuGlnProGln420425430AspValAspLeuValLeuAspSerSerAlaSerLeuLeuHisLeuAla435440445ValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeuAsnAsn450455460AlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeuHisMet465470475480AlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeuAlaArg485490495LysThrSerValAsnAlaLysAspGluAspGlnTrpThrAlaLeuHis500505510PheAlaAlaGlnAsnGlyAspGluAlaSerThrArgLeuLeuLeuGlu515520525LysAsnAlaSerValAsnGluValAspPheGluGlyArgThrProMet530535540HisValAlaCysGlnHisGlyGlnGluAsnIleValArgThrLeuLeu545550555560ArgArgGlyValAspValGlyLeuGlnGlyLysAspAlaTrpLeuPro565570575LeuHisTyrAlaAlaTrpGlnGlyHisLeuProIleValLysLeuLeu580585590AlaLysGlnProGlyValSerValAsnAlaGlnThrLeuAspGlyArg595600605ThrProLeuHisLeuAlaAlaGlnArgGlyHisTyrArgValAlaArg610615620IleLeuIleAspLeuCysSerAspValAsnIleCysSerLeuGlnAla625630635640GlnThrProLeuHisValAlaAlaGluThrGlyHisThrSerThrAla645650655ArgLeuLeuLeuHisArgGlyAlaGlyLysGluAlaLeuThrSerGlu660665670GlyTyrThrAlaLeuHisLeuAlaAlaGlnAsnGlyHisLeuAlaThr675680685ValLysLeuLeuIleGluGluLysAlaAspValMetAlaArgGlyPro690695700LeuAsnGlnThrAlaLeuHisLeuAlaAlaAlaArgGlyHisSerGlu705710715720ValValGluGluLeuValSerAlaAspLeuIleAspLeuSerAspGlu725730735GlnGlyLeuSerAlaLeuHisLeuAlaAlaGlnGlyArgHisSerGln740745750ThrValGluThrLeuLeuLysHisGlyAlaHisIleAsnLeuGlnSer755760765LeuLysPheGlnGlyGlyGlnSerSerAlaAlaThrLeuLeuArgArg770775780SerLysThr785<210>335<211>194<212>蛋白質<213>小鼠<400>335ProGlyCysLysSerCysThrValCysArgHisGlyLeuCysArgSer151015ValGluLysAspSerValValCysGluCysHisProGlyTrpThrGly202530ProLeuCysAspGlnGluAlaArgAspProCysLeuGlyHisSerCys354045ArgHisGlyThrCysMetAlaThrGlyAspSerTyrValCysLysCys505560AlaGluGlyTyrGlyGlyAlaLeuCysAspGlnLysAsnAspSerAla65707580SerAlaCysSerAlaPheLysCysHisHisGlyGlnCysHisIleSer859095AspArgGlyGluProTyrCysLeuCysGlnProGlyPheSerGlyHis100105110HisCysGluGlnGluAsnProCysMetGlyGluIleValArgGluAla115120125IleArgArgGlnLysAspTyrAlaSerCysAlaThrAlaSerLysVal130135140ProIleMetGluCysArgGlyGlyCysGlyThrThrCysCysGlnPro145150155160IleArgSerLysArgArgLysTyrValPheGlnCysThrAspGlySer165170175SerPheValGluGluValGluArgHisLeuGluCysGlyCysArgAla180185190CysSer<210>336<211>274<212>蛋白質<213>人<400>336TyrArgTyrCysGlnHisArgCysValAsnLeuProGlySerPheArg151015CysGlnCysGluProGlyPheGlnLeuGlyProAsnAsnArgSerCys202530ValAspValAsnGluCysAspMetGlyAlaProCysGluGlnArgCys354045PheAsnSerTyrGlyThrPheLeuCysArgCysHisGlnGlyTyrGlu505560LeuHisArgAspGlyPheSerCysSerAspIleAspGluCysSerTyr65707580SerSerTyrLeuCysGlnTyrArgCysValAsnGluProGlyArgPhe859095SerCysHisCysProGlnGlyTyrGlnLeuLeuAlaThrArgLeuCys100105110GlnAspIleAspGluCysGluSerGlyAlaHisGlnCysSerGluAla115120125GlnThrCysValAsnPheHisGlyGlyTyrArgCysValAspThrAsn130135140ArgCysValGluProTyrIleGlnValSerGluAsnArgCysLeuCys145150155160ProAlaSerAsnProLeuCysArgGluGlnProSerSerIleValHis165170175ArgTyrMetThrIleThrSerGluArgSerValProAlaAspValPhe180185190GlnIleGlnAlaThrSerValTyrProGlyAlaTyrAsnAlaPheGln195200205IleArgAlaGlyAsnSerGlnGlyAspPheTyrIleArgGlnIleAsn210215220AsnValSerAlaMetLeuValLeuAlaArgProValThrGlyProArg225230235240GluTyrValLeuAspLeuGluMetValThrMetAsnSerLeuMetSer245250255TyrArgAlaSerSerValLeuArgLeuThrValPheValGlyAlaTyr260265270ThrPhe<210>337<211>316<212>蛋白質<213>小鼠<400>337HisGluGluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsn151015IleAspLeuGlyAspSerCysIleThrValGlyAsnThrThrThrHis202530ValMetLysAsnLeuLeuProGluThrThrTyrArgIleArgIleGln354045AlaIleAsnGluIleGlyValGlyProPheSerGlnPheIleLysAla505560LysThrArgProLeuProProSerProProArgLeuGluCysAlaAla65707580SerGlyProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLys859095ThrHisAlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArg100105110AsnLysArgPheIleSerIleTyrArgGlyProSerHisThrTyrLys115120125ValGlnArgLeuThrGluPheThrCysTyrSerPheArgIleGlnAla130135140MetSerGluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSer145150155160ThrThrLysSerValProProThrLeuLysAlaProArgValThrGln165170175LeuGluGlyAsnSerCysGluIlePheTrpGluThrValProProMet180185190ArgGlyAspProValSerTyrValLeuGlnValLeuValGlyArgAsp195200205SerGluTyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIle210215220SerGlyLeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCys225230235240ArgArgCysValAspThrSerGlnGluLeuSerGlyAlaPheSerPro245250255SerAlaAlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAsp260265270LeuGlyGlyMetGluGluAlaLysMetLysGlyMetMetProThrAsp275280285GluGlnPheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIle290295300LeuPheAlaPheIleLeuGlnTyrPheLeuMetLys305310315<210>338<211>237<212>蛋白質<213>小鼠<400>338MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThrLeuGlySerProLeuAlaGlyAlaLeu210215220HisIleLeuLeuValPheLeuIleSerLysLeuLeuPhe225230235<210>339<211>469<212>蛋白質<213>小鼠<400>339MetLeuCysLeuCysLeuTyrValProIleAlaGlyAlaAlaGlnThr151015GluPheGlnTyrPheGluSerLysGlyLeuProAlaGluLeuLysSer202530IlePheLysLeuSerValPheIleProSerGlnGluPheSerThrTyr354045ArgGlnTrpLysGlnLysIleValGlnAlaGlyAspLysAspLeuAsp505560GlyGlnLeuAspPheGluGluPheValHisTyrLeuGlnAspHisGlu65707580LysLysLeuArgLeuValPheLysSerLeuAspLysLysAsnAspGly859095ArgIleAspAlaGlnGluIleMetGlnSerLeuArgAspLeuGlyVal100105110LysIleSerGluGlnGlnAlaGluLysIleLeuLysSerMetAspLys115120125AsnGlyThrMetThrIleAspTrpAsnGluTrpArgAspTyrHisLeu130135140LeuHisProValGluAsnIleProGluIleIleLeuTyrTrpLysHis145150155160SerThrIlePheAspValGlyGluAsnLeuThrValProAspGluPhe165170175ThrValGluGluArgGlnThrGlyMetTrpTrpArgHisLeuValAla180185190GlyGlyGlyAlaGlyAlaValSerArgThrCysThrAlaProLeuAsp195200205ArgLeuLysValLeuMetGlnValHisAlaSerArgSerAsnAsnMet210215220CysIleValGlyGlyPheThrGlnMetIleArgGluGlyGlyAlaLys225230235240SerLeuTrpArgGlyAsnGlyIleAsnValLeuLysIleAlaProGlu245250255SerAlaIleLysPheMetAlaTyrGluGlnMetLysArgLeuValGly260265270SerAspGlnGluThrLeuArgIleHisGluArgLeuValAlaGlySer275280285LeuAlaGlyAlaIleAlaGlnSerSerIleTyrProMetGluValLeu290295300LysThrArgMetAlaLeuArgLysThrGlyGlnTyrSerGlyMetLeu305310315320AspCysAlaArgArgIleLeuAlaLysGluGlyValAlaAlaPheTyr325330335LysGlyTyrIleProAsnMetLeuGlyIleIleProTyrAlaGlyIle340345350AspLeuAlaValTyrGluThrLeuLysAsnThrTrpLeuGlnArgTyr355360365AlaValAsnSerAlaAspProGlyValPheValLeuLeuAlaCysGly370375380ThrIleSerSerThrCysGlyGlnLeuAlaSerTyrProLeuAlaLeu385390395400ValArgThrArgMetGlnAlaGlnAlaSerIleGluGlyAlaProGlu405410415ValThrMetSerSerLeuPheLysGlnIleLeuArgThrGluGlyAla420425430PheGlyLeuTyrArgGlyLeuAlaProAsnPheMetLysValIlePro435440445AlaValSerIleSerTyrValValTyrGluAsnLeuLysIleThrLeu450455460GlyValGlnSerArg465<210>340<211>99<212>蛋白質<213>小鼠<400>340MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu<210>341<211>431<212>蛋白質<213>小鼠<400>341MetAspAlaArgTrpTrpAlaValValValLeuAlaThrLeuProSer151015LeuGlyAlaGlyGlyGluSerProGluAlaProProGlnSerTrpThr202530GlnLeuTrpLeuPheArgPheLeuLeuAsnValAlaGlyTyrAlaSer354045PheMetValProGlyTyrLeuLeuValGlnTyrLeuArgArgLysAsn505560TyrLeuGluThrGlyArgGlyLeuCysPheProLeuValLysAlaCys65707580ValPheGlyAsnGluProLysAlaProAspGluValLeuLeuAlaPro859095ArgThrGluThrAlaGluSerThrProSerTrpGlnValLeuLysLeu100105110ValPheCysAlaSerGlyLeuGlnValSerTyrLeuThrTrpGlyIle115120125LeuGlnGluArgValMetThrGlySerTyrGlyAlaThrAlaThrSer130135140ProGlyGluHisPheThrAspSerGlnPheLeuValLeuMetAsnArg145150155160ValLeuAlaLeuValValAlaGlyLeuTyrCysValLeuArgLysGln165170175ProArgHisGlyAlaProMetTyrArgTyrSerPheAlaSerLeuSer180185190AsnValLeuSerSerTrpCysGlnTyrGluAlaLeuLysPheValSer195200205PheProThrGlnValLeuAlaLysAlaSerLysValIleProValMet210215220MetMetGlyLysLeuValSerArgArgSerTyrGluHisTrpGluTyr225230235240LeuThrAlaGlyLeuIleSerIleGlyValSerMetPheLeuLeuSer245250255SerGlyProGluProArgSerSerProAlaThrThrLeuSerGlyLeu260265270ValLeuLeuAlaGlyTyrIleAlaPheAspSerPheThrSerAsnTrp275280285GlnAspAlaLeuPheAlaTyrLysMetSerSerValGlnMetMetPhe290295300GlyValAsnLeuPheSerCysLeuPheThrValGlySerLeuLeuGlu305310315320GlnGlyAlaLeuLeuGluGlyAlaArgPheMetGlyArgHisSerGlu325330335PheAlaLeuHisAlaLeuLeuLeuSerIleCysSerAlaPheGlyGln340345350LeuPheIlePheTyrThrIleGlyGlnPheGlyAlaAlaValPheThr355360365IleIleMetThrLeuArgGlnAlaIleAlaIleLeuLeuSerCysLeu370375380LeuTyrGlyHisThrValThrValValGlyGlyLeuGlyValAlaVal385390395400ValPheThrAlaLeuLeuLeuArgValTyrAlaArgGlyArgLysGln405410415ArgGlyLysLysAlaValProThrGluProProValGlnLysVal420425430<210>342<211>51<212>蛋白質<213>小鼠<400>342LeuLysPheSerHisProCysLeuGluAspHisAsnSerTyrCysIle151015AsnGlyAlaCysAlaPheHisHisGluLeuLysGlnAlaIleCysArg202530CysPheThrGlyTyrThrGlyGlnArgCysGluHisLeuThrLeuThr354045SerTyrAla50<210>343<211>51<212>蛋白質<213>人<400>343LeuLysPheSerHisLeuCysLeuGluAspHisAsnSerTyrCysIle151015AsnGlyAlaCysAlaPheHisHisGluLeuGluLysAlaIleCysArg202530CysPheThrGlyTyrThrGlyGluArgCysGluHisLeuThrLeuThr354045SerTyrAla50<210>344<211>95<212>蛋白質<213>人<400>344AlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuTyrThrAlaArgVal151015AspGlySerLysCysLysCysSerArgLysGlyProLysIleArgTyr202530SerAspValLysLysLeuGluMetLysProLysTyrProHisCysGlu354045GluLysMetValIleIleThrThrLysSerValSerArgTyrArgGly505560GlnGluHisCysLeuHisProLysLeuGlnSerThrLysArgPheIle65707580LysTrpTyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu859095<210>345<211>77<212>蛋白質<213>小鼠<400>345SerLysCysLysCysSerArgLysGlyProLysIleArgTyrSerAsp151015ValLysLysLeuGluMetLysProLysTyrProHisCysGluGluLys202530MetValIleValThrThrLysSerMetSerArgTyrArgGlyGlnGlu354045HisCysLeuHisProLysLeuGlnSerThrLysArgPheIleLysTrp505560TyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu657075<210>346<211>77<212>蛋白質<213>人<400>346SerLysCysLysCysSerArgLysGlyProLysIleArgTyrSerAsp151015ValLysLysLeuGluMetLysProLysTyrProHisCysGluGluLys202530MetValIleIleThrThrLysSerValSerArgTyrArgGlyGlnGlu354045HisCysLeuHisProLysLeuGlnSerThrLysArgPheIleLysTrp505560TyrAsnAlaTrpAsnGluLysArgArgValTyrGluGlu657075<210>347<211>215<212>蛋白質<213>小鼠<400>347MetLeuSerLeuArgSerLeuLeuProHisLeuGlyLeuPheLeuCys151015LeuAlaLeuHisLeuSerProSerLeuSerAlaSerAspAsnGlySer202530CysValValLeuAspAsnIleTyrThrSerAspIleLeuGluIleSer354045ThrMetAlaAsnValSerGlyGlyAspValThrTyrThrValThrVal505560ProValAsnAspSerValSerAlaValIleLeuLysAlaValLysGlu65707580AspAspSerProValGlyThrTrpSerGlyThrTyrGluLysCysAsn859095AspSerSerValTyrTyrAsnLeuThrSerGlnSerGlnSerValPhe100105110GlnThrAsnTrpThrValProThrSerGluAspValThrLysValAsn115120125LeuGlnValLeuIleValValAsnArgThrAlaSerLysSerSerVal130135140LysMetGluGlnValGlnProSerAlaSerThrProIleProGluSer145150155160SerGluThrSerGlnThrIleAsnThrThrProThrValAsnThrAla165170175LysThrThrAlaLysAspThrAlaAsnThrThrAlaValThrThrAla180185190AsnThrThrAlaAsnThrThrAlaValThrThrAlaLysThrThrAla195200205LysSerLeuAlaIleArgThr210215<210>348<211>21<212>蛋白質<213>小鼠<400>348GlyTyrSerAspGlyTyrGlnValCysSerArgPheGlySerLysVal151015ProGlnPheLeuAsn<210>349<211>417<212>DNA<213>小鼠<400>349gctagccgtgcacccagctctccggagcgcgtgcaggcgagccgagcgccccgtccgcgg60ttctcgggcaggcgctgcgggctccccggctccccgccgtcccgggcacccgggcgggcc120atgcgcccgggctagagcgtagccgccggcatgccgctcccgctgctgctcgccgcgctc180tgcctcgccgcctccccggcgcccgcgcgcgcctgccagctgccgtcggagtggagaccc240ttgagcgaaggctgccgcgccgagctagccgagaccatcgtgtatgccaaggtgctggcg300ctgcaccccgaggtgcctggcctctacaactacctgccgtggcagtaccaagctggagag360ggagggctcttctactccgccgaggtggagatgcttgtgtgaccaaggcgtggggca417<210>350<211>1837<212>DNA<213>小鼠<400>350cccccacctgcccagccaagccgagtgccgccggctttgttcgctttgtcctcgcgcacc60taagcggccggcctggaagaacgccatcccggagagcgcacgcggcgtcgcaccaggtct120aacaacatgcctccacttctgcttctaccagccatctacatgctcctgttcttcagagtg180tccccgaccatctctcttcaggaagtgcatgtgaaccgggagaccatggggaagatcgct240gtggccagcaaattaatgtggtgctcagccgcggtcgacatcctgtttctgttagatggc300tctcacagcatcgggaaggggagcttcgagaggtccaagcgcttcgccatcgctgcctgt360gatgccctggacatcagccctggcagggtcagagtcggagccttgcagtttggttccact420cctcatctggaattccccttggactccttctcaactcgacaggaagtgaaggaaagcatc480aaggggatagttttcaaaggtgggcgcaccgagacgggcctagccctgaaacgcctgagc540agagggttccccggaggcagaaatggctctgtgccccagattcttatcatcgtcacggat600ggcaagtcccaggggcccgtggctctcccggctaagcagctgagagaaaggggcatcgtc660gtgtttgccgtaggagtccgttttcccaggtgggacgagctgctcacgctggccagtgag720ccgaaggaccggcatgtgctgttggctgagcaagtggaggatgccaccaatggcctcctc780agcaccctcagcagctccgcactctgcaccactgctgatccagactgcagggtggaacct840catccctgtgagcggaggacgctggagaccgtcagggagctcgctggcaatgccttgtgc900tggagaggatcaaggcaagcagacactgtgctggctctgccctgtcccttctacagctgg960aagagagtgttccagacacaccctgccaactgctacagaaccatctgtccaggcccctgt1020gactcccagccctgccaaaatggaggcacgtgcattccagaaggtgtggataggtaccac1080tgtctctgcccactggcattcggaggggaagtcaactgtgccccgaagctgagcctggaa1140tgcagaatcgatgtcctcttcctgctggacagttctgcaggcaccacattggggggcttc1200cggagggccaaggcctttgtcaagcgctttgtgcaggccgtgctgagggaggactcccga1260gcccgcgttgggatagccagttatggcaggaatctaatggtggcggtgccctgtcgggga1320gtaccagcattgtgccggacctgatcaggagccttgacagcattcccttcagcggtggcc1380cgaccctaaccgggagtgccttgctccaggtggcagagcacggctttgggagtgccagca1440ggactggtcaggacaggccacgcagagtagtagttctgctcactgaatcacgctcccagg1500atgaggtgtctgggccagcagctcacgcaagggctcgggagctactcctcctgggcgtgg1560gcagtgagatcctgcaggcggagctggtgaagatcaccggtagcccgaagcatgtgatgg1620tccacacagaccctcaggacctgtcagccaaatccagagctgcagaggaggctatgcagc1680cagccacggccaggctgccaggcacagtcactggacctggtcttcctgtggatgcctctg1740ctctgtgggacgtgagaactttgcccaaatgcagagcttcatcaggaaatgcaccctccg1800gtttgatgtgaatcctgatgtgacacaagttggcctg1837<210>351<211>941<212>DNA<213>小鼠<400>351taagccctcaggccctcctaatgctatccccctttgttcctgcagcgtggacccagtcag60cagccaggccatggagctctctgatgtcaccctcattgagggtgtgggtaacgaggtgat120ggtggtagcaggcgtggtggcgctgactctagccctggtcctagcctggctctccaccta180tgtagcagacagtggtaacaaccagctgctgggcaccattgtgtcagcaggtgacacgtc240tgttctccacctgggccatgtggaccagctggtaaaccaaggcactccagagccaaccga300acacccccatccatcagggggcaatgatgacaaggctgaagagaccagtgacagtggggg360agacgccactggagaacctggagctaggggagagatggagcccagcctggagcatctcct420ggacatccaaggcctgcctaaaaggcaagcaggcctggggagcagtcgcccagaagcccc480gctggggttagatgatggctcctgcctctctcccagccccagcctcatcaatgttcgcct540caagttcctcaatgacacggaggagctagctgtggccaggccagaggacactgtgggtac600cctaaaaaggtgagtaggccggagagaggccagttgctcgtgacttgttcctcagatgat660ggtttcctgaagaagctgtgcatatatgtgagcacaggagggattttaaggggaaatgga720gacttccatagacagaccttcagtgtctttcatgtccaggccttgatctctctagcctta780ttctttatccagtctttcctttcatccttgtagcaaatacttccctggacaagagaacca840aatgaagttgatctaccagggtcggctgctgcaggacccagcacgcacactgagttccct900gaacattaccaacaactgcgtgatccactgccaccgctcac941<210>352<211>571<212>DNA<213>小鼠<400>352gctgaotgtacctataattcaccatgaattacgtctgtgagttacctccgtgagctctca60ttgtgatttgagtatgtgtgcatgtggttggggctcagctgctgtgcgcctgacatccac120atttggatgtcttttggttccgtgaacaagtagaaattgcatgtgtctaccggtgacagt180gtggtgtcactgggccctgtgggtggctcacttacctctgattccgtctgtgggaaagtc240ccagtgtacccaaatgtggcattgttgcatgccttgggtgtgtgtgggagattgtctctg300tctctcagaccctttgtggctttgtctgttgaaagagacagagaccccttgtggttttct360cagctgagaaccctccctcctgggatgttgggtgtaaacttaactgctttgcaaagcctg420cccctcctcatgctgacccttcaatatctggcagtgcattgttcccaagccccccttgtc480tatgggaatgtcagggctctctcaccttgacagctgataattccattcctcgactcttga540gaactggcccttgctttgttttctctgcctg571<210>353<211>467<212>DNA<213>大鼠<400>353cggagaatgagcgggtggccgtggctgcagctgctgcggcggcactgacaggacacgagc60tctatgcctttccggctgcttatcccgctcggcctcgtgtgcgtgctgctgcccctgcac120catggtgcgccaggccccgaaggcaccgcgcccgaccccgcccactacagggagcgagtc180aaggccatgttctaccacgcctacgacagttacctggaaaatgcctttccctacgatgag240ctgagacctctcacctgtgacgggcacgacacctggggcagtttttctctgacactgatt300gatgccctggacaccttgctgattttggggaatacctctgaattccaaagagtggtggag360gttctccaggacaaacgtggactttgatatcgacgtcaatgcctctgtgttcgaaaccaa420catccgagtggtaggaggactcctttctgctcatctcttgtcaaaga467<210>354<211>528<212>DNA<213>大鼠<400>354gtgactcctgctgtaggaccctccaggaagcactggcctctcctacagagtcctccacct60agcaccggccttaatgctaaagccaaatgtggtttctgccctgcagcgtgcccctggtaa120tctcgagttgccactcccaagccagcccccactggccatatggcatcatatctgggggtc180aggagggcctgtgcaggctttggacagccacttgccacagcagaggagagagtgaggttt240ccaggagcagcaggaaggaagaccccagaattccccagggctctttgagtggtaatgttg300acttctggagagtctgcccaccttgtgctcacacaagcatggacaggacactgggacttt360tatcctgttgttaagctgtttccacagaagcccgttcaggtagttacttcacccacattg420gccctatagccagaggagtgccctggctaactgcagtgtgagcttgtaagcaacagaagt480gcccaggagctgaccccaaaggccaggaaggctcgagcttgccacttt528<210>355<211>473<212>DNA<213>小鼠<400>355ggcagcaggaccgcggtcactgagcctctgcaggtgtcaacaaggctcaaggagcaggat60ggatctcgatgtggttaacatgtttgtgattgcgggtgggaccctggccattccaatcct120ggcatttgttgcgtctttcctcctgtggccttcagcactgataagaatctattattggta180ctggcggaggacactgggcatgcaagttcgctacgcacaccatgaggactatcagttctg240ttactccttccggggcaggccaggacacaagccatccatccttatgctccatggattctc300cgcacacaaggacatgtggctcagcgtggtcaagttccttccgaagaacctgcacttggt360ctgtgtggacatgcctgggcatgaaggcaccacccgctcctccctggatgacctgtccat420agtggggcaagttaaaaggatacatcagtttgtagaatgccttaagctgaaca473<210>356<211>431<212>DNA<213>大鼠<400>356cttaactagcgcccccatccaccatgtttcctgacggattctagccttgtttgttttttt60caacctaaaaccaaatggaaatggccggagagctccagggcacctaggttccctggcttc120ggcttcggctgggctaacgcgcgagtgtggtgggactatcctaggaggtgttcctggaga180gagaggcgatggcgtcaagtagtaactggctgtccggagtgaatgtcgttcttgtgatgg240cgtacgggagcctggtattcgtattgctgtttatttttgtgaagagacaaatcatgcgct300ttgcaatgaaatctagaaggggacctcatgtccctgtgggacacaatgccccgaaggact360taaaagaggaaattgatattcggctatccagagttcaggacatcaagtatgaaccgcagc420tccttgcagat431<210>357<211>1206<212>DNA<213>小鼠<400>357ccaacactcgccatgcgttctggggcactgtggccgctgctttggggagccctggtctgg60acagtgggatccgtgggcgccgtgatgggctccgaggattctgtgcccggtggcgtgtgc120tggctccagcagggcagagaggccacctgcagtctggtgctgaagactcgtgtcagccgg180gaggagtgctgtgcttccggcaacatcaacaccgcctggtccaacttcacccacccaggc240aataaaatcagcctgctagggttcctgggcctcgtccactgcctcccctgcaaagattcc300tgcgacggagtggagtgcggccccggcaaggcgtgccgcatgctgggggggcgtccaaca360ctgcgaagttgcgtgcccaactgcgaggggyttcccgcgggcttccaggtctgcggctct420gatggcgccacctaccgggacgaatgcgaactgcgcaccgcgcgctgtcgcggacaccca480gacttgcgcgtcatgtaccgcggccgctgtcaaaagtcttgcgctcaggtagtgtgcccg540cgtccccagtcgtgccttgtggatcagaccggcagcgcacactgcgtggtgtgtcgcgct600gcgccctgcccagtaccttccaaccccggccaagaactctgtggcaacaacaacgttacc660tacatctcgtcgtgtcacctgcgccaggccacttgcttcctgggccgctccattggggtt720cggcacccaggcatctgcacaggtggccccaaagtaccagcagaggaggaagagaacttc780gtgtgagctgcagccactgggcctggcatttgacgccatcccgattttatttattgttat840agaaaatattctaatttatgtcacatggacatttcccaaacctggcctggaaccacttgg900ggatccccctgggatcctgagcacgtatcacaaggactgaagggagatttttataatagt960tggtatgtgccatcacccargtactgggatcaaagttagaacccaagacccctgctgccc1020agggatggcagctgcatggagatccccctgctatgatctccccacctgctttctaggctg1080gagctgtcgcagggcacagccgatgagttggtgtttgcatatggctggcctcagaccaga1140gcgggcaacatcaggtcagagaaacactgggctcattcctgtttggtccactcagggtga1200aacctg1206<210>358<211>1052<212>DNA<213>大鼠<400>358ccagaaagaacgatttagatgacagtttttagaaaggtgaccaccatgatctcctggatg60ctcttggcctgtgcccttccgtgtgctgctgacccaatgcttggtgcctttgctcgcagg120gacttccagaagggtggtcctcaactggtgtgcagtctgcctggtccccaaggccacctg180gccctccaggagcaccaggatcctcaggaatggtgggaagaatgggttttcctggtaagg240atggccaagacggccaggacggagaccgaggggacagtggagaagaaggtccacctggca300ggacaggcaaccgaggaaaacaaggaccaaagggcaaagctggggccattgggagagcgg360gtcctcgaggacccaagggggtcagtggtacccccgggaaacatggtataccgggcaaga420agggacctaagggcaagaaaggggaacctgggctcccaggcccctgtagctgcggcagta480gccgagccaagtcggccttttcggtggcggtaaccaagagttacccacgtgagcgactgc540ccatcaagtttgacaagattctgatgaatgagggaggccactacaatgcatccagtggca600agttcgtctgcagcgtgccagggatctattactttacctatgacattacgctggccaaca660aacacctggccatcggcctagtgcacaatggccagtaccgcattcggacttttgacgcca720acaccggcaaccacgacgtggcctcgggctccaccatcctagctctcaaggagggtgatg780aagtctggttacagattttctactcggagcagaatggactcttctacgacccttattgga840ccgacagcctgttcaccggcttcctcatctacgctgatcaaggagaccccaatgaggtat900agacaagctggggttgagcgtccaggcagggactaagattccgcaagggtgctgatagaa960gaggatctctgaactgaggctggggactggcagttcttgggagcttttattcccaggcaa1020gcctcctctggtgctgctttaaaaaaaaaaaa1052<210>359<211>1134<212>DNA<213>大鼠<400>359aattcggcacgaggcggtcagaacccgggcttctcgtttgtcctgaacggcactaccagg60gcggtggaagcagagatggcggagggcggtgggaggagaggcgtctagtcttgctggctc120agcaagcccgataagcatgaagctgctgtgtttggtggctgtggtggggtgcttgctggt180acccccggctcaagccaacaagagctctgaagatatccggtgcaaatgcatctgtccccc240ttacagaaacatcagcgggcacatttacaaccagaatgtgtctcagaaggactgcaactg300cctgcatgtggtggagcccatgccggtgcctggccatgatgtggaagcctactgcctgct360ctgtgagtgtaggtatgaggagcgcagcaccacaaccatcaaggtcattatcgtcatcta420cctgtctgtggtaggggccctcttactctacatggccttcctgatgctggtggaccctct480catccgaaagccggatgcctatactgagcagctgcacaatgaagaagagaatgaggatgc540ccgctccatggctgccgccgccgcatccattggaggaccccgagcaaacaccgtcctgga600gcgggtggaaggcgctcagcagcgatggaagctacaggtgcaggagcagcggaagacggt660cttcgatcgacacaagatgctcagttagatgattgccatggcagtgtcagggacccagac720ctcggctaccagcttctggggcagtcttccctgggtcttcccttcaaatgcccgtggcat780ttgtccttctccctctctctagaaatgtactcgactgttataactagggagtgggattgg840gtctttggtctctagtgtctctgtaggtctctggggtagaagggagggaaaggaaggcag900aagagaacagagatggttgagacggccacacgattggtgaaattcctccctcctgtcctc960gccgttcctcacagctccacatcttaaggatgtttatagctctttgggagacggagctgt1020gccgtcaatagctcggtgggtgcgacgaaagtgtgacccagccctcagcctgtgctctac1080gatgccgtggcccccattcccacttttncagtgccaatactttagcttggcctg1134<210>360<211>876<212>DNA<213>小鼠<400>360tgccagctgccccttcgagtgcttatcatcagcaacaacaagttaggagccctgcctcca60gacatcagcaccttgggaagcctgcggcagcttgatgtgagcagcaatgagctgcagtcc120ctgcccgtggagctgtgtagcctccgttccctgcgggatctcaatgttcgaaggaaccag180ctcagtaccctgcctgatgagctgggagaccttcctctggtccgcctggatttctcctgt240aaccgcatctcccgaatccccgtctccttctgccgcctcaggcacctgcaggtcgttctg300ctggatagcaaccccctacagagtccacctgcccagatatgcctgaaggggaaacttcac360atcttcaagtacctaacaatggaagctggccggaggggagccgccctcggggacctggtc420ccttcccgccccccaagttttagtccttgccctgccgaagatttatttccgggacgtcgt480tatgatggtggcctggactcaggcttccacagcgttgacagtggcagcaagaggtggtca540ggaaatgagtccacagatgatttttcagagctgtctttccggatctcggagctggctcgt600gatccccgggggcctagacaacctagggaagatggcgctggcgatggagacctggagcag660attgactttattgacagccacgttcctggggaagatgaagatcgaagtgcagctgaggag720cagctgccttctgaattaagccttgtagcaggggatgtggagaagccatctagcagcagg780cgagaggagcctgcaggggaggagaggcggcgcccagacactttgcagttgtggcaggaa840cgggagcggaagcaacagcaacagagtgggggatgg876<210>361<211>495<212>DNA<213>小鼠<400>361gtcgcgccagctgagagcccctaggtttgaccctcgtgcgggattccacgcggagggcaa60ggacagaggcccctctgttccccagggcctgctgaaggcagcgagaagcagcggccaact120caacttggcgggaaggaacctcggggaagtccctcagtgtgtttggagaataaatgtgga180cattcctgaagaggctaatcagaatctttcattcagttctactgaacgatggtgggatca240gacagatctgaccaaactcatcatctccagcaataaacttcagtctctctctgatgacct300ccgactcttgcctgcccttactgttcttgatatacatgataatcagctgacatctcttcc360ttcagctataagagagctagacaatcttcagaaacttaatgtcagccataacaaactgaa420aatactgcctgaagaaattacaagcttaaaaaacctgaggacgctgcacctccagcacaa480tgagctgacttgcat495<210>362<211>349<212>DNA<213>小鼠<400>362tctctgtctatcttgcctgctgtgagggtatcacccaggcccacttatccatctacagcg60agtagtatggcggccttccttgtaacaggctttttcttttctctcttcgtggtgcttggg120atggaacccagggctttgtttaggcctgacaaggctctgcccctgagctgtgccaagccc180acctccctctgtgtacaaagctcctttcttgggtgaccaacatcttcctgtctttgagca240accaaggccagatgcgagccacccagaagttaattaaaccaggttcatcgggagtttgct300gaaatgttaagcatactctgttctagagagggagtgaagaaaggggcca349<210>363<211>380<212>DNA<213>小鼠<400>363gagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaacaaagagacc60gacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaatcttgtctcc120atcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcatctatagaatc180tccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaacatccgggtt240acagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgctggatgaagtt300tacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgcaggacagcata360ggcagcatgggcctagggca380<210>364<211>351<212>DNA<213>小鼠<400>364gcggcagagaacgagatgccggtggctgtgggtccctacgggcagtcccagcccagctgc60ttcgaccgcgtgaagatgggctttgtcatgggttgcgccgtgggtatggcggccggggcc120ctgttcggcaccttctcctgtctcaggatcggaatgcggggtcgggagctgatgggcggc180attgggaaaaccatgatgcagagtggcggtacctttggcactttcatggccatcggaatg240ggcatacgatgctaattagggcacggatgccctgctacacccaaacttcctcatccattt300cgaaccttgtacaataaagtttttttcttcttgttaaaaaaaaaaaaaaaa351<210>365<211>854<212>DNA<213>大鼠<400>365gcggtggctcctctgtgtcccacgtcctgaggggctcaggacaagaaaggagcccacccc60cagccagtatgcagccgccctggggcctggcgctccctctgctgctcccctgggtggcag120gtggagtagggaccagcccacgggattattggttgccagcactggcacaccagcctgggg180tctgtcactacggaactaagacggcctgctgctatggctggaaaaggaacagcaaaggag240tatgtgaagctgtgtgtgagcccagatgcaagtttggtgagtgtgtgggaccgaataaat300gtagatgctttccaggatacaccgggaagacctgcagtcaagacgtgaatgagtgtgcat360tcaaaccccggccatgccagcacagatgtgtgaatacacacggtagctacaaatgctttt420gcctcagcggccacatgcttctaccagacgccacatgttcaaactccaggacatgtgcca480gaataaactgccagtacagttgtgaagacacagcagaagggccacgatgtgtgtgtccat540cctctggcctccgcctgggtccaaatggaagagtgtgcctagatatcgatgaatgtgctt600ctagcaaagcagtctgtccttccaatagaagatgtgtgaacacatttggaagctactact660gcaaatgtcacattggttttgaactgaaatatatcagtcgccgatatgattgtgtagata720taaatgagtgcactctgaatacccgtacgtgcagcccccatgccaattgcctcaataccc780aaggatccttcaagtgcaaatgcaagcagggatacagggggaatggactgcagtgttctg840tgattcctgaacat854<210>366<211>257<212>DNA<213>大鼠<400>366ggcgcacccatgtacttcagcgagggccgagagagaggcaaggtgtatgtctacaacctg60agacagaaccggtttgtttttaatggcactctgaaggattcccacagctaccagaacgcc120cggttcgggtcatgcattgcctccgttcaagacctcaaccaagattcctacaatgacgtg180gtggtgggggcccctcaggaggacagccacagaggggccatctacatcttccatggcttc240caaaccaacatcctgaa257<210>367<211>475<212>DNA<213>大鼠<400>367cttccaaaccaacatcctgaagaagcccgtgcagagaatatcagcctcagagctggctcc60cggcttgcagcattttggctgcagcatccacggacaactggacctcaatgaggacgggct120tgtggacctagcagtgggcgccctgggcaacgctgtggttttgtgggcgcgtcccgtagt180tcagatcaacgccagcctccactttgagccttccaagatcaacatcttccacaaggactg240caagcgcaatggcagggatgccacctgcctggctgccttcctctgcttcggacctatctt300cctggcaccccacttccacacagcaaccgtcggcatcaggtacaatgcaaccatggatga360gagacggtatatgccacgggcacatctggatgagggtgcagaccagttcaccaacagggc420tgtcctactctcttctggtcaggaacactgtcaaaggatcaacttccacgtcctg475<210>368<211>392<212>DNA<213>小鼠<400>368gccgcggagcaggaagcgagcagccggcggaggcgcggcggcgccgggccggccttgttt60tcctcaggctcgctccgctctgagccgcagcctcgcttgcctcaggctcgctctcggccg120cggccttctttccttcaggctcggtcgcggccttgcttgtcccaggcttgctccccggcc180gcctccgtcctctcttcaagctcgctctgcggccgttcccacctccttccaggctcgctc240cccgccaccgcattcctcctcctcctcccaggctcgctcccgggccgccgcccctcagcc300gcccaggctgcgccggtgctcgcgtggggccttgttgcgtttcagctcggggtcgccgca360ggggcggggcgctgagcggtctgccgcggcct392<210>369<211>824<212>DNA<213>大鼠<400>369cgggcactgtgactgccaagccggctatgggggcgaggcctgtggccagtgtggccttgg60ctactttgaggcagagcgcaacagcagccatctggtatgttcggcgtgctttggtccctg120tgcccgctgcacaggacccgaggaatcccactgtctgcagtgcaggaaaggctgggccct180gcatcacctcaagtgtgtagacatcgatgagtgtggcacagagcaagctacctgtggagc240cgaccagttctgtgtgaacacggaagggtcctatgagtgccgagattgtgcaaaggcctg300cctgggctgtatgggagcagggccagggccctgcaaaaaatgcagccgtggctaccagca360ggtgggctccaagtgcctagatgtggatgagtgtgagacagtggtgtgtccaggagagaa420cgagcagtgtgaaaacacggaaggtagctaccgctgtgtctgtgctgaaggcttcagaca480ggaggacggcatctgtgtgaaggagcagatcccagagtcggcgggcttcttcgcggagat540gacagaggacgaaatggtggtcctgcagcagatgttctttggtgtgatcatctgtgcact600ggccacacttgctgctaagggggacttggtgttcaccgccatcttcattggagctgtggc660agctatgactgggtactggttgtcagagcgcagtgaccgtgtgctggagggcttcatcaa720gggtagataatccctgccaccacttacaggatttcctcccacccaggctgcccctagagg780ttatttctctctcccgctggacacctgggacagcattgtttctc824<210>370<211>1663<212>DNA<213>小鼠<400>370gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacctcaagcctttccttttt780aaaataaggggttttgtatttgtccatatgtcaccacacatctgagctttataagcgcct840gggaggaacagtgagcatggttgagaccgttcacagcactactgctccgctccaggctta900caaagcttccgctcagagagcctggcggctctgtgcagctgccacaggctctcctgggct960tatgactggtcagagtttcagtgtgactccactgtggcccctgttgcagggcaattggga1020gcaggtccttctacatctgtgcctagaggaactcagtctacttaccagaaggagcttcat1080ccccaccccacccccacccgcaccccagctcattcccctgtcacgaccaggcaagtgatc1140cttaaaggagctgggtctttttcttgcaaactgagggtttctgaaaggtcggctgctttg1200gtagaagatgcttctgaggcatccaaagtccccagcagtgtgagaaaatgattctcgatg1260ttcgggaggacaagggaagatgcaggattagatgcaggacacacagccagagctacacat1320cctcttggcaatgggagctccccccccccaaagctttgtttctttccctcaccccaacag1380aaagtgcactccccctcagtgaatacgcaaacagcactgttctctgagttaggatgttag1440gacgatcctgcgccctgccctctcctgtgtacatattgccttcagtacccctcccccacc1500ccatgccacacactgcccctcattagaggccgcactgtatggctgtgtatctgctatgta1560aatgctgagacccctgagtgctgcatgcaggtttcatgttctttctaagatgaaaagaga1620aagtaataaaatatatttgaagttccccaaaaaaaaaaaaaaa1663<210>371<211>568<212>DNA<213>人<400>371ccgtcagtctagaaggataagagaaagaaagttaagcaactacaggaaatggctttggga60gttccaatatcagtctatcttttattcaacgcaatgacagcactgaccgaagaggcagcc120gtgactgtaacacctccaatcacagcccagcaaggtaactggacagttaacaaaacagaa180gctgacaacatagaaggacccatagccttgaagttctcacacctttgcctggaagatcat240aacagttactgcatcaacggtgcttgtgcattccaccatgagctagagaaagccatctgc300aggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaagacgaccactgtga360ggcctttgtgaagaattttcatcaaggcatctgtagagatcagtgagcccaaaattaaag420ttttcagatgaaacaacaaaacttgtcaagctgactagactcgaaaataatgaaagttgg480gatcacaatgaaatgagaagataaaattcagcgttggcctttagactttgccatccttaa540ggagtgatggaagccaagtgaacaagcc568<210>372<211>5583<212>DNA<213>大鼠<400>372ctggtgcagagcgtcgccaaggacgccgggagggaggcgggattgccaagatatcctcca60gtgaagtgcatgtgtgtgtgcaaaccatccttggctgtcgcgaagcagagaagacggctt120ggggctgctgctgtgccgcaggagtggagagaccccgtgagctgagccctgcgccccgca180tcaccgctcggcgcccccaaggctgcctgaatacccggtgcgccccggcgcgcgacatga240ccagtctctccgagggctctgctttggacctgccaggcccttgcgccttctagcttcggg300gggaatccactttgatcagggccaccattactgttaaagccccctcctcagccttgtact360cttcccactggaatcggatttgctagagggtgccgtggaatcggaagtcctcccttgtcc420tcaagcaaccagcctctgcatcttcgcggacactgcaagtaggagctcttttaccaccaa480gttgaagtcgcgctctgtcctcacagctgcttcggggtctaccccaagcctgagtcgggc540ctattgatattcaggacctgaagttgcccacggatcttgtgctctgctagaaaggcttgg600agagcggaggaaagacgtgtgcttctgtctgctctcctgccccatatcactgttccatat660tactgtgtgagcatctctccgggtgctgtgggctgcaagaccagcgccaggaactgggcc720tcggacaccgtccacttttcacgcaaccgaaagctaaagtccctcaaagcaaggggtctg780ttgggaagatgagtggcattggctggcagacactgtccctatctctggcgttagtgttgt840cgatcttgaacaaggtggcgcctcatgcgtgcccggcccagtgctcctgttcaggcagca900cagtggactgtcatgggctggcactgcgcagtgtgcccaggaatatcccccgcaacacgg960agagactggatttgaatggaaataacatcacaaggatcacgaagacagattttgcgggtc1020tcagacacctcagagttcttcagctcatggagaacaagatcagcaccatcgagaggggag1080cattccaggatcttaaggagctagaaagactgcgtttaaacagaaataaccttcagttgt1140ttcctgagctgctgtttcttgggactgcgaagctctaccggcttgatctcagtgaaaatc1200agattcaagcaattccaaggaaggctttccgtggtgcagttgacattaaaaatctgcagt1260tggattacaaccagatcagctgcattgaagatggggcattccgagctctgcgagatctgg1320aagtgctcactctgaacaataacaatattactagactttcagtggcaagtttcaaccata1380tgcctaaacttaggacatttcgactccactccaacaacctatactgcgactgccacctgg1440cctggctctcggactggcttcgccaaaggccacgggtgggcttgtacactcagtgtatgg1500gcccatcccacctgaggggccataatgtagcagaggttcaaaaacgagagtttgtctgca1560gtggtcaccagtcattcatggctccctcctgcagtgtgctgcactgcccgattgcttgta1620cctgtagcaacaacattgtagactgccgagggaaaggtctcactgagatccccacaaatc1680tgcctgagaccatcacagaaatacgtttggaacagaactccataagggtcatccctccag1740gagcattctcaccatacaaaaagcttcgacgactagacctgagtaataaccagatctcgg1800aacttgctccagatgccttccaaggactgcgttctctgaattcccttgtcctgtatggaa1860ataaaatcacagaactcccaaaaagtttatttgaaggactgttttccttacagctactat1920tattgaatgccaacaagataaactgccttcgggtagatgcttttcaggacctgcacaact1980tgaaccttctctccttatacgacaataagcttcagactgttgccaagggcaccttctcag2040ctctcagagccatccaaactatgcatttggcccagaatcctttcatttgtgactgccatc2100tcaagtggctagcggattatctccacaccaacccaattgagaccagcggtgcccgttgca2160ccagtccccgccgcctggctaacaaaagaattggacagatcaaaagcaagaaattccgtt2220gttcagctaaagagcagtatttcattccaggtacagaagattatcgatcaaaattaagtg2280gagactgctttgcagacttggcttgtcctgaaaaatgtcgctgtgaagggaccacagtag2340actgctccaatcaaaaactcaacaaaatcccagaccatattccccagtacacagcagagc2400tgcgtctcaataataatgaattcacagtgttagaagccacgggaatatttaagaaacttc2460ctcaattgcgtaaaatcaaccttagcaacaataagatcactgatatcgaggagggggcat2520tcgaaggtgcgtctggtgtgaatgagattctgcttaccagtaaccgtttggaaaatgttc2580agcataagatgttcaaaggattggagagcctcaaaacattgatgctgagaagtaatcgaa2640taagctgtgtgggaaacgacagtttcacaggactcggttctgtgcgtctgctctctttat2700atgacaatcaaattaccacagttgcaccaggagcatttggtactctccattcattatcta2760cactaaacctcttggccaatcctttcaactgtaactgtcacctggcatggcttggagaat2820ggctcagaaggaaaagaattgtaacaggaaatcctcgatgccaaaaaccctacttcttga2880aggaaataccaatccaggatgtagccattcaggacttcacctgtgatgacggaaacgatg2940ataatagctgctctccactctcccgttgtccttcggaatgtacttgcttggatacagtag3000tacgatgtagcaacaagggcttgaaggtcttacctaaaggcattccaagagatgtcacag3060aactgtatctggatgggaaccagtttacactggtcccgaaggaactctccaactacaaac3120atttaacacttatagacttaagtaacaacagaataagcaccctttccaaccaaagcttca3180gcaacatgacccaacttctcaccttaattctcagttacaaccgtctgagatgtatccctc3240cacggacctttgatggattgaaatctcttcgtttactgtctctacatggaaatgacattt3300ctgtcgtgcctgaaggtgcctttggtgacctttcagccttgtcacacttagcaattggag3360ccaaccctct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CysValGlyAspCysLeuCysLeu354045SerAspProLeuTrpLeuCysLeuLeuLysGluThrGluThrProCys505560GlyPheLeuSer65<210>377<211>107<212>蛋白質<213>大鼠<400>377MetProPheArgLeuLeuIleProLeuGlyLeuValCysValLeuLeu151015ProLeuHisHisGlyAlaProGlyProGluGlyThrAlaProAspPro202530AlaHisTyrArgGluArgValLysAlaMetPheTyrHisAlaTyrAsp354045SerTyrLeuGluAsnAlaPheProTyrAspGluLeuArgProLeuThr505560CysAspGlyHisAspThrTrpGlySerPheSerLeuThrLeuIleAsp65707580AlaLeuAspThrLeuLeuIleLeuGlyAsnThrSerGluPheGlnArg859095ValValGluValLeuGlnAspLysArgGlyLeu100105<210>378<211>95<212>蛋白質<213>大鼠<400>378MetTrpPheLeuProCysSerValProLeuValIleSerSerCysHis151015SerGlnAlaSerProHisTrpProTyrGlyIleIleSerGlyGlyGln202530GluGlyLeuCysArgLeuTrpThrAlaThrCysHisSerArgGlyGlu354045SerGluValSerArgSerSerArgLysGluAspProArgIleProGln505560GlySerLeuSerGlyAsnValAspPheTrpArgValCysProProCys65707580AlaHisThrSerMetAspArgThrLeuGlyLeuLeuSerCysCys859095<210>379<211>138<212>蛋白質<213>小鼠<400>379MetAspLeuAspValValAsnMetPheValIleAlaGlyGlyThrLeu151015AlaIleProIleLeuAlaPheValAlaSerPheLeuLeuTrpProSer202530AlaLeuIleArgIleTyrTyrTrpTyrTrpArgArgThrLeuGlyMet354045GlnValArgTyrAlaHisHisGluAspTyrGlnPheCysTyrSerPhe505560ArgGlyArgProGlyHisLysProSerIleLeuMetLeuHisGlyPhe65707580SerAlaHisLysAspMetTrpLeuSerValValLysPheLeuProLys859095AsnLeuHisLeuValCysValAspMetProGlyHisGluGlyThrThr100105110ArgSerSerLeuAspAspLeuSerIleValGlyGlnValLysArgIle115120125HisGlnPheValGluCysLeuLysLeuAsn130135<210>380<211>81<212>蛋白質<213>大鼠<400>380MetAlaSerSerSerAsnTrpLeuSerGlyValAsnValValLeuVal151015MetAlaTyrGlySerLeuValPheValLeuLeuPheIlePheValLys202530ArgGlnIleMetArgPheAlaMetLysSerArgArgGlyProHisVal354045ProValGlyHisAsnAlaProLysAspLeuLysGluGluIleAspIle505560ArgLeuSerArgValGlnAspIleLysTyrGluProGlnLeuLeuAla65707580Asp<210>381<211>257<212>蛋白質<213>小鼠<400>381MetArgSerGlyAlaLeuTrpProLeuLeuTrpGlyAlaLeuValTrp151015ThrValGlySerValGlyAlaValMetGlySerGluAspSerValPro202530GlyGlyValCysTrpLeuGlnGlnGlyArgGluAlaThrCysSerLeu354045ValLeuLysThrArgValSerArgGluGluCysCysAlaSerGlyAsn505560IleAsnThrAlaTrpSerAsnPheThrHisProGlyAsnLysIleSer65707580LeuLeuGlyPheLeuGlyLeuValHisCysLeuProCysLysAspSer859095CysAspGlyValGluCysGlyProGlyLysAlaCysArgMetLeuGly100105110GlyArgProThrLeuArgSerCysValProAsnCysGluGlyLeuPro115120125AlaGlyPheGlnValCysGlySerAspGlyAlaThrTyrArgAspGlu130135140CysGluLeuArgThrAlaArgCysArgGlyHisProAspLeuArgVal145150155160MetTyrArgGlyArgCysGlnLysSerCysAlaGlnValValCysPro165170175ArgProGlnSerCysLeuValAspGlnThrGlySerAlaHisCysVal180185190ValCysArgAlaAlaProCysProValProSerAsnProGlyGlnGlu195200205LeuCysGlyAsnAsnAsnValThrTyrIleSerSerCysHisLeuArg210215220GlnAlaThrCysPheLeuGlyArgSerIleGlyValArgHisProGly225230235240IleCysThrGlyGlyProLysValProAlaGluGluGluGluAsnPhe245250255Val<210>382<211>285<212>蛋白質<213>大鼠<400>382MetIleSerTrpMetLeuLeuAlaCysAlaLeuProCysAlaAlaAsp151015ProMetLeuGlyAlaPheAlaArgArgAspPheGlnLysGlyGlyPro202530GlnLeuValCysSerLeuProGlyProGlnGlyProProGlyProPro354045GlyAlaProGlySerSerGlyMetValGlyArgMetGlyPheProGly505560LysAspGlyGlnAspGlyGlnAspGlyAspArgGlyAspSerGlyGlu65707580GluGlyProProGlyArgThrGlyAsnArgGlyLysGlnGlyProLys859095GlyLysAlaGlyAlaIleGlyArgAlaGlyProArgGlyProLysGly100105110ValSerGlyThrProGlyLysHisGlyIleProGlyLysLysGlyPro115120125LysGlyLysLysGlyGluProGlyLeuProGlyProCysSerCysGly130135140SerSerArgAlaLysSerAlaPheSerValSerValThrLysSerTyr145150155160ProArgGluArgLeuProIleLysPheAspLysIleLeuMetAsnGlu165170175GlyGlyHisTyrAsnAlaSerSerGlyLysPheValCysSerValPro180185190GlyIleTyrTyrPheThrTyrAspIleThrLeuAlaAsnLysHisLeu195200205AlaIleGlyLeuValHisAsnGlyGlnTyrArgIleArgThrPheAsp210215220AlaAsnThrGlyAsnHisAspValAlaSerGlySerThrIleLeuAla225230235240LeuLysGluGlyAspGluValTrpLeuGlnIlePheTyrSerGluGln245250255AsnGlyLeuPheTyrAspProTyrTrpThrAspSerLeuPheThrGly260265270PheLeuIleTyrAlaAspGlnGlyAspProAsnGluVal275280285<210>383<211>183<212>蛋白質<213>大鼠<400>383MetLysLeuLeuCysLeuValAlaValValGlyCysLeuLeuValPro151015ProAlaGlnAlaAsnLysSerSerGluAspIleArgCysLysCysIle202530CysProProTyrArgAsnIleSerGlyHisIleTyrAsnGlnAsnVal354045SerGlnLysAspCysAsnCysLeuHisValValGluProMetProVal505560ProGlyHisAspValGluAlaTyrCysLeuLeuCysGluCysArgTyr65707580GluGluArgSerThrThrThrIleLysValIleIleValIleTyrLeu859095SerValValGlyAlaLeuLeuLeuTyrMetAlaPheLeuMetLeuVal100105110AspProLeuIleArgLysProAspAlaTyrThrGluGlnLeuHisAsn115120125GluGluGluAsnGluAspAlaArgSerMetAlaAlaAlaAlaAlaSer130135140IleGlyGlyProArgAlaAsnThrValLeuGluArgValGluGlyAla145150155160GlnGlnArgTrpLysLeuGlnValGlnGluGlnArgLysThrValPhe165170175AspArgHisLysMetLeuSer180<210>384<21l>292<212>蛋白質<213>小鼠<400>384CysGlnLeuProLeuArgValLeuIleIleSerAsnAsnLysLeuGly151015AlaLeuProProAspIleSerThrLeuGlySerLeuArgGlnLeuAsp202530ValSerSerAsnGluLeuGlnSerLeuProValGluLeuCysSerLeu354045ArgSerLeuArgAspLeuAsnValArgArgAsnGlnLeuSerThrLeu505560ProAspGluLeuGlyAspLeuProLeuValArgLeuAspPheSerCys65707580AsnArgIleSerArgIleProValSerPheCysArgLeuArgHisLeu859095GlnValValLeuLeuAspSerAsnProLeuGlnSerProProAlaGln100105110IleCysLeuLysGlyLysLeuHisIlePheLysTyrLeuThrMetGlu115120125AlaGlyArgArgGlyAlaAlaLeuGlyAspLeuValProSerArgPro130135140ProSerPheSerProCysProAlaGluAspLeuPheProGlyArgArg145150155160TyrAspGlyGlyLeuAspSerGlyPheHisSerValAspSerGlySer165170175LysArgTrpSerGlyAsnGluSerThrAspAspPheSerGluLeuSer180185190PheArgIleSerGluLeuAlaArgAspProArgGlyProArgGlnPro195200205ArgGluAspGlyAlaGlyAspGlyAspLeuGluGlnIleAspPheIle210215220AspSerHisValProGlyGluAspGluAspArgSerAlaAlaGluGlu225230235240GlnLeuProSerGluLeuSerLeuValAlaGlyAspValGluLysPro245250255SerSerSerArgArgGluGluProAlaGlyGluGluArgArgArgPro260265270AspThrLeuGlnLeuTrpGlnGluArgGluArgLysGlnGlnGlnGln275280285SerGlyGlyTrp290<210>385<211>164<212>蛋白質<213>小鼠<400>385SerArgGlnLeuArgAlaProArgPheAspProArgAlaGlyPheHis151015AlaGluGlyLysAspArgGlyProSerValProGlnGlyLeuLeuLys202530AlaAlaArgSerSerGlyGlnLeuAsnLeuAlaGlyArgAsnLeuGly354045GluValProGlnCysValTrpArgIleAsnValAspIleProGluGlu505560AlaAsnGlnAsnLeuSerPheSerSerThrGluArgTrpTrpAspGln65707580ThrAspLeuThrLysLeuIleIleSerSerAsnLysLeuGlnSerLeu859095SerAspAspLeuArgLeuLeuProAlaLeuThrValLeuAspIleHis100105110AspAsnGlnLeuThrSerLeuProSerAlaIleArgGluLeuAspAsn115120125LeuGlnLysLeuAsnValSerHisAsnLysLeuLysIleLeuProGlu130135140GluIleThrSerLeuLysAsnLeuArgThrLeuHisLeuGlnHisAsn145150155160GluLeuThrCys<210>386<211>71<212>蛋白質<213>小鼠<400>386SerLeuSerIleLeuProAlaValArgValSerProArgProThrTyr151015ProSerThrAlaSerSerMetAlaAlaPheLeuValThrGlyPhePhe202530PheSerLeuPheValValLeuGlyMetGluProArgAlaLeuPheArg354045ProAspLysAlaLeuProLeuSerCysAlaLysProThrSerLeuCys505560ValGlnSerSerPheLeuGly6570<210>387<211>126<212>蛋白質<213>小鼠<400>387GluTyrGluAlaArgValLeuGluLysSerLeuArgLysGluSerArg151015AsnLysGluThrAspLysValLysLeuThrTrpArgAspArgPhePro202530AlaTyrPheThrAsnLeuValSerIleIlePheMetIleAlaValThr354045PheAlaIleValLeuGlyValIleIleTyrArgIleSerThrAlaAla505560AlaLeuAlaMetAsnSerSerProSerValArgSerAsnIleArgVal65707580ThrValThrAlaThrAlaValIleIleAsnLeuValValIleIleLeu859095LeuAspGluValTyrGlyCysIleAlaArgTrpLeuThrLysIleGly100105110GluCysHisValGlnAspSerIleGlySerMetGlyLeuGly115120125<210>388<211>84<212>蛋白質<213>大鼠<400>388AlaAlaGluAsnGluMetProValAlaValGlyProTyrGlyGlnSer151015GlnProSerCysPheAspArgValLysMetGlyPheValMetGlyCys202530AlaValGlyMetAlaAlaGlyAlaLeuPheGlyThrPheSerCysLeu354045ArgIleGlyMetArgGlyArgGluLeuMetGlyGlyIleGlyLysThr505560MetMetGlnSerGlyGlyThrPheGlyThrPheMetAlaIleGlyMet65707580GlyIleArgCys<210>389<211>284<212>蛋白質<213>大鼠<400>389GlyGlySerSerValSerHisValLeuArgGlySerGlyGlnGluArg151015SerProProProAlaSerMetGlnProProTrpGlyLeuAlaLeuPro202530LeuLeuLeuProTrpValAlaGlyGlyValGlyThrSerProArgAsp354045TyrTrpLeuProAlaLeuAlaHisGlnProGlyValCysHisTyrGly505560ThrLysThrAlaCysCysTyrGlyTrpLysArgAsnSerLysGlyVal65707580CysGluAlaValCysGluProArgCysLysPheGlyGluCysValGly859095ProAsnLysCysArgCysPheProGlyTyrThrGlyLysThrCysSer100105110GlnAspValAsnGluCysAlaPheLysProArgProCysGlnHisArg115120125CysValAsnThrHisGlySerTyrLysCysPheCysLeuSerGlyHis130135140MetLeuLeuProAspAlaThrCysSerAsnSerArgThrCysAlaArg145150155160IleAsnCysGlnTyrSerCysGluAspThrAlaGluGlyProArgCys165170175ValCysProSerSerGlyLeuArgLeuGlyProAsnGlyArgValCys180185190LeuAspIleAspGluCysAlaSerSerLysAlaValCysProSerAsn195200205ArgArgCysValAsnThrPheGlySerTyrTyrCysLysCysHisIle210215220GlyPheGluLeuLysTyrIleSerArgArgTyrAspCysValAspIle225230235240AsnGluCysThrLeuAsnThrArgThrCysSerProHisAlaAsnCys245250255LeuAsnThrGlnGlySerPheLysCysLysCysLysGlnGlyTyrArg260265270GlyAsnGlyLeuGlnCysSerValIleProGluHis275280<210>390<211>85<212>蛋白質<213>大鼠<400>390GlyAlaProMetTyrPheSerGluGlyArgGluArgGlyLysValTyr151015ValTyrAsnLeuArgGlnAsnArgPheValPheAsnGlyThrLeuLys202530AspSerHisSerTyrGlnAsnAlaArgPheGlySerCysIleAlaSer354045ValGlnAspLeuAsnGlnAspSerTyrAsnAspValValValGlyAla505560ProGlnGluAspSerHisArgGlyAlaIleTyrIlePheHisGlyPhe65707580GlnThrAsnIleLeu85<210>391<211>158<212>蛋白質<213>大鼠<400>391PheGlnThrAsnIleLeuLysLysProValGlnArgIleSerAlaSer151015GluLeuAlaProGlyLeuGlnHisPheGlyCysSerIleHisGlyGln202530LeuAspLeuAsnGluAspGlyLeuValAspLeuAlaValGlyAlaLeu354045GlyAsnAlaValValLeuTrpAlaArgProValValGlnIleAsnAla505560SerLeuHisPheGluProSerLysIleAsnIlePheHisLysAspCys65707580LysArgAsnGlyArgAspAlaThrCysLeuAlaAlaPheLeuCysPhe859095GlyProIlePheLeuAlaProHisPheHisThrAlaThrValGlyIle100105110ArgTyrAsnAlaThrMetAspGluArgArgTyrMetProArgAlaHis115120125LeuAspGluGlyAlaAspGlnPheThrAsnArgAlaValLeuLeuSer130135140SerGlyGlnGluHisCysGlnArgIleAsnPheHisValLeu145150155<210>392<211>124<212>蛋白質<213>小鼠<400>392AlaAlaGluGlnGluAlaSerSerArgArgArgArgGlyGlyAlaGly151015ProAlaLeuPheSerSerGlySerLeuArgSerGluProGlnProArg202530LeuProGlnAlaArgSerArgProArgProSerPheLeuGlnAlaArg354045SerArgProCysLeuSerGlnAlaCysSerProAlaAlaSerValLeu505560SerSerSerSerLeuCysGlyArgSerHisLeuLeuProGlySerLeu65707580ProAlaThrAlaPheLeuLeuLeuLeuProGlySerLeuProGlyArg859095ArgProSerAlaAlaGlnAlaAlaProValLeuAlaTrpGlyLeuVal100105110AlaPheGlnLeuGlyValAlaAlaGlyAlaGlyArg115120<210>393<211>242<212>蛋白質<213>大鼠<400>393GlyHisCysAspCysGlnAlaGlyTyrGlyGlyGluAlaCysGlyGln151015CysGlyLeuGlyTyrPheGluAlaGluArgAsnSerSerHisLeuVal202530CysSerAlaCysPheGlyProCysAlaArgCysThrGlyProGluGlu354045SerHisCysLeuGlnCysArgLysGlyTrpAlaLeuHisHisLeuLys505560CysValAspIleAspGluCysGlyThrGluGlnAlaThrCysGlyAla65707580AspGlnPheCysValAsnThrGluGlySerTyrGluCysArgAspCys859095AlaLysAlaCysLeuGlyCysMetGlyAlaGlyProGlyProCysLys100105110LysCysSerArgGlyTyrGlnGlnValGlySerLysCysLeuAspVal115120125AspGluCysGluThrValValCysProGlyGluAsnGluGlnCysGlu130135140AsnThrGluGlySerTyrArgCysValCysAlaGluGlyPheArgGln145150155160GluAspGlyIleCysValLysGluGlnIleProGluSerAlaGlyPhe165170175PheAlaGluMetThrGluAspGluMetValValLeuGlnGlnMetPhe180185190PheGlyValIleIleCysAlaLeuAlaThrLeuAlaAlaLysGlyAsp195200205LeuValPheThrAlaIlePheIleGlyAlaValAlaAlaMetThrGly210215220TyrTrpLeuSerGluArgSerAspArgValLeuGluGlyPheIleLys225230235240GlyArg<210>394<211>99<212>蛋白質<213>小鼠<400>394MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu<210>395<211>103<212>蛋白質<213>人<400>395MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaAspAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysLeuLysLeuLysSerProTyrAsnValCys859095SerGlyGluArgArgProLeu100<210>396<211>1529<212>蛋白質<213>大鼠<400>396MetSerGlyIleGlyTrpGlnThrLeuSerLeuSerLeuAlaLeuVal151015LeuSerIleLeuAsnLysValAlaProHisAlaCysProAlaGlnCys202530SerCysSerGlySerThrValAspCysHisGlyLeuAlaLeuArgSer354045ValProArgAsnIleProArgAsnThrGluArgLeuAspLeuAsnGly505560AsnAsnIleThrArgIleThrLysThrAspPheAlaGlyLeuArgHis65707580LeuArgValLeuGlnLeuMetGluAsnLysIleSerThrIleGluArg859095GlyAlaPheGlnAspLeuLysGluLeuGluArgLeuArgLeuAsnArg100105110AsnAsnLeuGlnLeuPheProGluLeuLeuPheLeuGlyThrAlaLys115120125LeuTyrArgLeuAspLeuSerGluAsnGlnIleGlnAlaIleProArg130135140LysAlaPheArgGlyAlaValAspIleLysAsnLeuGlnLeuAspTyr145150155160AsnGlnIleSerCysIleGluAspGlyAlaPheArgAlaLeuArgAsp165170175LeuGluValLeuThrLeuAsnAsnAsnAsnIleThrArgLeuSerVal180185190AlaSerPheAsnHisMetProLysLeuArgThrPheArgLeuHisSer195200205AsnAsnLeuTyrCysAspCysHisLeuAlaTrpLeuSerAspTrpLeu210215220ArgGlnArgProArgValGlyLeuTyrThrGlnCysMetGlyProSer225230235240HisLeuArgGlyHisAsnValAlaGluValGlnLysArgGluPheVal245250255CysSerGlyHisGlnSerPheMetAlaProSerCysSerValLeuHis260265270CysProIleAlaCysThrCysSerAsnAsnIleValAspCysArgGly275280285LysGlyLeuThrGluIleProThrAsnLeuProGluThrIleThrGlu290295300IleArgLeuGluGlnAsnSerIleArgValIleProProGlyAlaPhe305310315320SerProTyrLysLysLeuArgArgLeuAspLeuSerAsnAsnGlnIle325330335SerGluLeuAlaProAspAlaPheGlnGlyLeuArgSerLeuAsnSer340345350LeuValLeuTyrGlyAsnLysIleThrGluLeuProLysSerLeuPhe355360365GluGlyLeuPheSerLeuGlnLeuLeuLeuLeuAsnAlaAsnLysIle370375380AsnCysLeuArgValAspAlaPheGlnAspLeuHisAsnLeuAsnLeu385390395400LeuSerLeuTyrAspAsnLysLeuGlnThrValAlaLysGlyThrPhe405410415SerAlaLeuArgAlaIleGlnThrMetHisLeuAlaGlnAsnProPhe420425430IleCysAspCysHisLeuLysTrpLeuAlaAspTyrLeuHisThrAsn435440445ProIleGluThrSerGlyAlaArgCysThrSerProArgArgLeuAla450455460AsnLysArgIleGlyGlnIleLysSerLysLysPheArgCysSerAla465470475480LysGluGlnTyrPheIleProGlyThrGluAspTyrArgSerLysLeu485490495SerGlyAspCysPheAlaAspLeuAlaCysProGluLysCysArgCys500505510GluGlyThrThrValAspCysSerAsnGlnLysLeuAsnLysIlePro515520525AspHisIleProGlnTyrThrAlaGluLeuArgLeuAsnAsnAsnGlu530535540PheThrValLeuGluAlaThrGlyIlePheLysLysLeuProGlnLeu545550555560ArgLysIleAsnLeuSerAsnAsnLysIleThrAspIleGluGluGly565570575AlaPheGluGlyAlaSerGlyValAsnGluIleLeuLeuThrSerAsn580585590ArgLeuGluAsnValGlnHisLysMetPheLysGlyLeuGluSerLeu595600605LysThrLeuMetLeuArgSerAsnArgIleSerCysValGlyAsnAsp610615620SerPheThrGlyLeuGlySerValArgLeuLeuSerLeuTyrAspAsn625630635640GlnIleThrThrValAlaProGlyAlaPheGlyThrLeuHisSerLeu645650655SerThrLeuAsnLeuLeuAlaAsnProPheAsnCysAsnCysHisLeu660665670AlaTrpLeuGlyGluTrpLeuArgArgLysArgIleValThrGlyAsn675680685ProArgCysGlnLysProTyrPheLeuLysGluIleProIleGlnAsp690695700ValAlaIleGlnAspPheThrCysAspAspGlyAsnAspAspAsnSer705710715720CysSerProLeuSerArgCysProSerGluCysThrCysLeuAspThr725730735ValValArgCysSerAsnLysGlyLeuLysValLeuProLysGlyIle740745750ProArgAspValThrGluLeuTyrLeuAspGlyAsnGlnPheThrLeu755760765ValProLysGluLeuSerAsnTyrLysHisLeuThrLeuIleAspLeu770775780SerAsnAsnArgIleSerThrLeuSerAsnGlnSerPheSerAsnMet785790795800ThrGlnLeuLeuThrLeuIleLeuSerTyrAsnArgLeuArgCysIle805810815ProProArgThrPheAspGlyLeuLysSerLeuArgLeuLeuSerLeu820825830HisGlyAsnAspIleSerValValProGluGlyAlaPheGlyAspLeu835840845SerAlaLeuSerHisLeuAlaIleGlyAlaAsnProLeuTyrCysAsp850855860CysAsnMetGlnTrpLeuSerAspTrpValLysSerGluTyrLysGlu865870875880ProGlyIleAlaArgCysAlaGlyProGlyGluMetAlaAspLysLeu885890895LeuLeuThrThrProSerLysLysPheThrCysGlnGlyProValAsp900905910ValThrIleGlnAlaLysCysAsnProCysLeuSerAsnProCysLys915920925AsnAspGlyThrCysAsnAsnAspProValAspPheTyrArgCysThr930935940CysProTyrGlyPheLysGlyGlnAspCysAspValProIleHisAla945950955960CysIleSerAsnProCysLysHisGlyGlyThrCysHisLeuLysGlu965970975GlyGluAsnAspGlyPheTrpCysThrCysAlaAspGlyPheGluGly980985990GluSerCysAspIleAsnIleAspAspCysGluAspAsnAspCysGlu99510001005AsnAsnSerThrCysValAspGlyIleAsnAsnTyrThrCysLeuCys101010151020ProProGluTyrThrGlyGluLeuCysGluGluLysLeuAspPheCys102510301035104AlaGlnAspLeuAsnProCysGlnHisAspSerLysCysIleLeuThr104510501055ProLysGlyPheLysCysAspCysThrProGlyTyrIleGlyGluHis106010651070CysAspIleAspPheAspAspCysGlnAspAsnLysCysLysAsnGly107510801085AlaHisCysThrAspAlaValAsnGlyTyrThrCysValCysProGlu109010951100GlyTyrSerGlyLeuPheCysGluPheSerProProMetValLeuLeu110511101115112ArgThrSerProCysAspAsnPheAspCysGlnAsnGlyAlaGlnCys112511301135IleIleArgValAsnGluProIleCysGlnCysLeuProGlyTyrLeu114011451150GlyGluLysCysGluLysLeuValSerValAsnPheValAsnLysGlu115511601165SerTyrLeuGlnIleProSerAlaLysValArgProGlnThrAsnIle117011751180ThrLeuGlnIleAlaThrAspGluAspSerGlyIleLeuLeuTyrLys118511901195120GlyAspLysAspHisIleAlaValGluLeuTyrArgGlyArgValArg120512101215AlaSerTyrAspThrGlySerHisProAlaSerAlaIleTyrSerVal122012251230GluThrIleAsnAspGlyAsnPheHisIleValGluLeuLeuThrLeu123512401245AspSerSerLeuSerLeuSerValAspGlyGlySerProLysIleIle125012551260ThrAsnLeuSerLysGlnSerThrLeuAsnPheAspSerProLeuTyr126512701275128ValGlyGlyMetProGlyLysAsnAsnValAlaSerLeuArgGlnAla128512901295ProGlyGlnAsnGlyThrSerPheHisGlyCysIleArgAsnLeuTyr130013051310IleAsnSerGluLeuGlnAspPheArgLysValProMetGlnThrGly131513201325IleLeuProGlyCysGluProCysHisLysLysValCysAlaHisGly133013351340ThrCysGlnProSerSerGlnSerGlyPheThrCysGluCysGluGlu134513501355136GlyTrpMetGlyProLeuCysAspGlnArgThrAsnAspProCysLeu136513701375GlyAsnLysCysValHisGlyThrCysLeuProIleAsnAlaPheSer138013851390TyrSerCysLysCysLeuGluGlyHisGlyGlyValLeuCysAspGlu139514001405GluGluAspLeuPheAsnProCysGlnValIleLysCysLysHisGly141014151420LysCysArgLeuSerGlyLeuGlyGlnProTyrCysGluCysSerSer142514301435144GlyPheThrGlyAspSerCysAspArgGluIleSerCysArgGlyGlu144514501455ArgIleArgAspTyrTyrGlnLysGlnGlnGlyTyrAlaAlaCysGln146014651470ThrThrLysLysValSerArgLeuGluCysArgGlyGlyCysAlaGly147514801485GlyGlnCysCysGlyProLeuArgSerLysArgArgLysTyrSerPhe149014951500GluCysThrAspGlySerSerPheValAspGluValGluLysValVal150515101515152LysCysGlyCysThrArgCysAlaSer1525<210>397<211>8<212>蛋白質<213>小鼠<400>397TrpTyrAsnAlaTrpAsnGluLys15<210>398<211>7<212>蛋白質<213>小鼠<400>398MetValIleIleThrThrLys15<210>399<211>2206<212>DNA<213>大鼠<400>399gtttcgtcttaacgccctctctgcgttggcagaactggccgtgggctcccgctggtacca60tggaacatctcagcccacacagactaagcggagactgatgttggtggcgttcctcggagc120atccgcggtgactgcaagtaccggtctcctgtggaagaaggctcacgcagaatctccacc180gagcgtcaacagcaagaagactgacgctggagataaggggaagagcaaggacacccggga240agtgtccagccatgaaggaagcgctgcagacactgcggccgagccttacccagaggagaa300gaagaagaagcgttctggattcagagacagaaaagtaatggagtatgagaataggatccg360agcctactccacaccagacaaaatcttccggtattttgccaccttgaaagtaatcaacga420acctggtgaaactgaagtgttcatgaccccacaggactttgtgcgctccataacacccaa480tgagaagcagccagaacacttgggcctggatcagtacataataaagcgcttcgatggaaa540gaaaattgcccaggaacgagaaaagtttgctgacgaaggcagcatcttctatacccttgg600agagtgtggactcatctccttctctgactacatcttcctcacaacggtgctctccactcc660tcagagaaatttcgaaattgccttcaagatgtttgacttgaatggagatggagaagtaga720catggaggagtttgagcaggttcaaagcatcattcgctcccagaccagcatgggcatgcg780tcacagagatcgtccaactactgggaacaccctcaagtctggcttatgttcggccctcac840gacctacttttttggagctgatctcaaagggaaactgaccattaaaaacttcctggaatt900tcagcgtaaactgcagcatgacgttctaaagctggagtttgaacgccatgacccggtaga960cgggagaatctctgagaggcagttcggtggcatgctgctggcctacagtggagtgcagtc1020caagaagctgaccgccatgcagaggcagctgaagaagcacttcaaggatgggaagggcct1080gactttccaggaggtggagaacttcttcactttcctgaagaacattaatgacgtggacac1140tgcgttaagcttttaccacatggctggagcatccctcgataaagtgaccatgcagcaagt1200ggccaggacagtggcgaaagtcgagctgtcggaccacgtgtgtgacgtggtgtttgcact1260ctttgactgcgacggcaatggggagctgagcaataaggagtttgtctccatcatgaagca1320gcggctgatgagaggcctggagaagcccaaggacatgggctttacccgtctcatgcaggc1380catgtggaaatgtgcccaagaaaccgcctgggactttgctctacccaaatagtaccccac1440ctcctgcaccttagcaccccgcaatcctggagtggccttcatgctgctgatgcttctggg1500agtagtgcccacatccccatctttctggaagtgacctctggcctcagctggctgacctct1560ccatcctcccctgacccagtcagtgttccgctaggctctgaatctgcagtcagatcaaag1620gtctaagacaggaacaagtcttcaaagcagagaccatagctcccttaaccagtgccccgt1680gggtaaatgcggggagccctcccacactggcagccccaggaggcatctctgcagtctctc1740actgtggatttaagtaacacaaacgtccctgccatcttcctcccactgttttaaagctgc1800aagtttggaaatactctggcaggcaaagggaagtctgtgatgaacggtaatgcagatgac1860cctggtaccctgatctggcagggcacctggtcaggggaagggtctgcgtcagacaccagc1920ggcaccaggaaggctctttgccaccagcacagctcccgattcaaagtcgctgctttgagc1980ggctctccagaacctcctgctcttttttttttcctcccggctccctgcgatgcctcctct2040gggactctgcttcactagagccagggctgagcccctgttccttgtgtcttgtcccctctc2100tatagacctgcagagcgcagctcagagcctatctgccctctgtctaatacactcgtaaat2160atcactttaattatagcactttgcaggaaataccccaaaaaaaaaa2206<210>400<211>160<212>DNA<213>小鼠<400>400tcgcaggacgctcactggacagcttgggcttttttcagttgattttatggtttgcatctt60tctctttctctttttctgtttcttgttcccctttccccttttcctggtgagaaagcacat120attactgagccattgcaagcaatgggaggggtccacaatg160<210>401<211>430<212>DNA<213>大鼠<400>401ggcaccagcccggcttctgtgctccgctcagtctccagcgatccctccctacctccgccc60tccatggcgtcgctcctgtgctgtgggcctaagctggccgcctgtggcatcgtcctcagc120gcctggggagtgatcatgttgataatgctcgggatatttttcaatgtccattctgctgtg180ttaattgaggatgtccccttcacagagaaagattttgagaacggccctcagaacatatac240aacctgtacgagcaagtcagctacaactgtttcatcgccgcgggcctctacctcctcctc300gggggcttctccttctgccaagttcgtctcaataagcgcaaggaatacatggtgcgctag360agcgcagtccgactctccccattcccctccttatttaaagactcctcagtccatctgttc420cactcatctg430<210>402<211>190<212>DNA<213>大鼠<400>402ccgaatacgcggccgcgtcgacatactgcctgtagagttagtatttctgttttttatatg60ttgcacactgaattgaagaaatgttggtttttcttgttttgttttagtttgtttctttgg120ttttgtttttggttttgctttttacttcccaggtttgactatttgccaatgccgtcgacg180cggccgcgaa190<210>403<211>1774<212>DNA<213>小鼠<400>403ccaaagtggagggcgagggccggggccggtgggctctggggctgctgcgcaccttcgacg60ccggcgaattcgcaggctgggagaaggtgggctcgggcggcttcgggcaggtgtacaagg120tgcgccatgtgcactggaagacgtggctcgcgatcaagtgctcgcccagtctgcacgtcg180acgacagggaacgaatggagctcctggaggaagctaagaagatggagatggccaagttcc240gatacattctacctgtgtacggcatatgccaggaacctgtcggcttggtcatggagtaca300tggagacaggctccctggagaagctgctggcctcagagccattgccttgggacctgcgct360ttcgcatcgtgcacgagacagccgtgggcatgaacttcctgcattgcatgtctccgccac420tgctgcacctagacctgaagccagcgaacatcctgctggatgcccactaccatgtcaaga480tttctgactttgggctggccaagtgcaatggcatgtcccactctcatgacctcagcatgg540atggcctgtttggtacaatcgcttacctccctccagagcgaattcgtgagaagagccgct600tgtttgacaccaaacatgatgtatacagcttcgccattgtgatctggggtgtgcttacac660agaagaagccatttgcagatgaaaagaacatcctacacatcatgatgaaagtggtaaagg720gccaccgcccagagctgccacccatctgcagaccccggccgcgtgcctgtgccagcctga780tagggataatgcaacggtgctggcatgcagacccacaggtgcggcccaccttccaagaaa840ttacctctgaaacagaagacctttgtgagaagcctgatgaggaggtgaaagacctggctc900atgagccaggcgagaaaagctctctagagtccaagagtgaggccaggcccgagtcctcac960gcctcaagcgcgcctctgctccccccttcgataacgactgcagtctctccgagttgctgt1020cacagttggactctgggatctcccagactcttgaaggccccgaagagctcagccgaagtt1080cctctgaatgcaagctcccatcgtccagcagtggcaagaggctctcgggggtgtcctcag1140tggactcagccttttcctccagaggatcgctgtcactgtcttttgagcgggaagcttcaa1200caggcgacctgggccccacagacatccagaagaagaagctagtggatgccatcatatcag1260gggacaccagcaggctgatgaagatcctacagccccaagatgtggacttggttctagaca1320gcagtgccagcctgctgcacctggctgtggaggccggacaggaggagtgtgtcaagtggc1380tgctgcttaacaatgccaaccccaacctgaccaacaggaagggctctacaccactgcata1440tggctgtggagcggaagggacgtggaattgtggagctactgctagcccggaagaccagtg1500tcaatgccaaggatgaagaccagtggactgccctgcactttgcagcccagaatggggatg1560aggccagcacaaggctgctgctagagaagaatgcttctgtcaatgaggtggactttgagg1620gccgaacacccatgcatgtagcctgccagcatggacaggagaacattgtgcgcaccctgc1680tccgccgtggtgtggatgtgggcctgcagggaaaggatgcctggttgcctctgcactatg1740ctgcctggcaaggccaccttcccattggtaagct1774<210>404<211>372<212>DNA<213>小鼠<400>404ccacagcacatcgtcctgactgtcctcttcccagggaccaagagctagagacccggctgt60gactgcccgcctctggggcttcctttagaggagacagtctttacccatctagactcctgc120caccctgactgctgacttacagctatgaggtcccggcttctgctgcccgtgccccatttg180ccaacgattcgggaaatgtcagaagagctgtcacatggggcagctgggcaggaaccccca240gcgtcccccagcctggatgactacgtcaggtgtatctgtcagctggcacagcccacctca300gtgctggacaaggtcacagcccagagccgtcccaacagaccctcccggccagcctggact360cgagagaagagg372<210>405<211>396<212>DNA<213>小鼠<400>405gagcttcgaagctttctccgtcttccaagacgacaggtttctggggccacaagaggccga60gcctcttcattttgttttcttctccaggctgaagacctgaacgtcaagttggaaggggag120ccttccatgcggaaaccaaagcagcggccgcggccggagcccctcatcatccccaccaag180gcgggcactttcatcgcccctcctgtctactccaacatcaccccttaccagagccacctg240cgctctcccgtgcgccttgctgaccacccctctgagcggagctttgagccccccccttac300acaccaccccccattctcagccccgtccgggaaggctctggcctctacttcaatgccatc360atatcaaccagcaacatcccggcccctcctgtatca396<210>406<211>444<212>蛋白質<213>大鼠<400>406MetLeuValAlaPheLeuGlyAlaSerAlaValThrAlaSerThrGly151015LeuLeuTrpLysLysAlaHisAlaGluSerProProSerValAsnSer202530LysLysThrAspAlaGlyAspLysGlyLysSerLysAspThrArgGlu354045ValSerSerHisGluGlySerAlaAlaAspThrAlaAlaGluProTyr505560ProGluGluLysLysLysLysArgSerGlyPheArgAspArgLysVal65707580MetGluTyrGluAsnArgIleArgAlaTyrSerThrProAspLysIle859095PheArgTyrPheAlaThrLeuLysValIleAsnGluProGlyGluThr100105110GluValPheMetThrProGlnAspPheValArgSerIleThrProAsn115120125GluLysGlnProGluHisLeuGlyLeuAspGlnTyrIleIleLysArg130135140PheAspGlyLysLysIleAlaGlnGluArgGluLysPheAlaAspGlu145150155160GlySerIlePheTyrThrLeuGlyGluCysGlyLeuIleSerPheSer165170175AspTyrIlePheLeuThrThrValLeuSerThrProGlnArgAsnPhe180185190GluIleAlaPheLysMetPheAspLeuAsnGlyAspGlyGluValAsp195200205MetGluGluPheGluGlnValGlnSerIleIleArgSerGlnThrSer210215220MetGlyMetArgHisArgAspArgProThrThrGlyAsnThrLeuLys225230235240SerGlyLeuCysSerAlaLeuThrThrTyrPhePheGlyAlaAspLeu245250255LysGlyLysLeuThrIleLysAsnPheLeuGluPheGlnArgLysLeu260265270GlnHisAspValLeuLysLeuGluPheGluArgHisAspProValAsp275280285GlyArgIleSerGluArgGlnPheGlyGlyMetLeuLeuAlaTyrSer290295300GlyValGlnSerLysLysLeuThrAlaMetGlnArgGlnLeuLysLys305310315320HisPheLysAspGlyLysGlyLeuThrPheGlnGluValGluAsnPhe325330335PheThrPheLeuLysAsnIleAsnAspValAspThrAlaLeuSerPhe340345350TyrHisMetAlaGlyAlaSerLeuAspLysValThrMetGlnGlnVal355360365AlaArgThrValAlaLysValGluLeuSerAspHisValCysAspVal370375380ValPheAlaLeuPheAspCysAspGlyAsnGlyGluLeuSerAsnLys385390395400GluPheValSerIleMetLysGlnArgLeuMetArgGlyLeuGluLys405410415ProLysAspMetGlyPheThrArgLeuMetGlnAlaMetTrpLysCys420425430AlaGlnGluThrAlaTrpAspPheAlaLeuProLys435440<210>407<211>53<212>蛋白質<213>小鼠<400>407ArgArgThrLeuThrGlyGlnLeuGlyLeuPheSerValAspPheMet151015ValCysIlePheLeuPheLeuPhePheCysPheLeuPheProPhePro202530LeuPheLeuValArgLysHisIleLeuLeuSerHisCysLysGlnTrp354045GluGlySerThrMet50<210>408<211>119<212>蛋白質<213>大鼠<400>408GlyThrSerProAlaSerValLeuArgSerValSerSerAspProSer151015LeuProProProSerMetAlaSerLeuLeuCysCysGlyProLysLeu202530AlaAlaCysGlyIleValLeuSerAlaTrpGlyValIleMetLeuIle354045MetLeuGlyIlePhePheAsnValHisSerAlaValLeuIleGluAsp505560ValProPheThrGluLysAspPheGluAsnGlyProGlnAsnIleTyr65707580AsnLeuTyrGluGlnValSerTyrAsnCysPheIleAlaAlaGlyLeu859095TyrLeuLeuLeuGlyGlyPheSerPheCysGlnValArgLeuAsnLys100105110ArgLysGluTyrMetValArg115<210>409<211>590<212>蛋白質<213>小鼠<400>409LysValGluGlyGluGlyArgGlyArgTrpAlaLeuGlyLeuLeuArg151015ThrPheAspAlaGlyGluPheAlaGlyTrpGluLysValGlySerGly202530GlyPheGlyGlnValTyrLysValArgHisValHisTrpLysThrTrp354045LeuAlaIleLysCysSerProSerLeuHisValAspAspArgGluArg505560MetGluLeuLeuGluGluAlaLysLysMetGluMetAlaLysPheArg65707580TyrIleLeuProValTyrGlyIleCysGlnGluProValGlyLeuVal859095MetGluTyrMetGluThrGlySerLeuGluLysLeuLeuAlaSerGlu100105110ProLeuProTrpAspLeuArgPheArgIleValHisGluThrAlaVal115120125GlyMetAsnPheLeuHisCysMetSerProProLeuLeuHisLeuAsp130135140LeuLysProAlaAsnIleLeuLeuAspAlaHisTyrHisValLysIle145150155160SerAspPheGlyLeuAlaLysCysAsnGlyMetSerHisSerHisAsp165170175LeuSerMetAspGlyLeuPheGlyThrIleAlaTyrLeuProProGlu180185190ArgIleArgGluLysSerArgLeuPheAspThrLysHisAspValTyr195200205SerPheAlaIleValIleTrpGlyValLeuThrGlnLysLysProPhe210215220AlaAspGluLysAsnIleLeuHisIleMetMetLysValValLysGly225230235240HisArgProGluLeuProProIleCysArgProArgProArgAlaCys245250255AlaSerLeuIleGlyIleMetGlnArgCysTrpHisAlaAspProGln260265270ValArgProThrPheGlnGluIleThrSerGluThrGluAspLeuCys275280285GluLysProAspGluGluValLysAspLeuAlaHisGluProGlyGlu290295300LysSerSerLeuGluSerLysSerGluAlaArgProGluSerSerArg305310315320LeuLysArgAlaSerAlaProProPheAspAsnAspCysSerLeuSer325330335GluLeuLeuSerGlnLeuAspSerGlyIleSerGlnThrLeuGluGly340345350ProGluGluLeuSerArgSerSerSerGluCysLysLeuProSerSer355360365SerSerGlyLysArgLeuSerGlyValSerSerValAspSerAlaPhe370375380SerSerArgGlySerLeuSerLeuSerPheGluArgGluAlaSerThr385390395400GlyAspLeuGlyProThrAspIleGlnLysLysLysLeuValAspAla405410415IleIleSerGlyAspThrSerArgLeuMetLysIleLeuGlnProGln420425430AspValAspLeuValLeuAspSerSerAlaSerLeuLeuHisLeuAla435440445ValGluAlaGlyGlnGluGluCysValLysTrpLeuLeuLeuAsnAsn450455460AlaAsnProAsnLeuThrAsnArgLysGlySerThrProLeuHisMet465470475480AlaValGluArgLysGlyArgGlyIleValGluLeuLeuLeuAlaArg485490495LysThrSerValAsnAlaLysAspGluAspGlnTrpThrAlaLeuHis500505510PheAlaAlaGlnAsnGlyAspGluAlaSerThrArgLeuLeuLeuGlu515520525LysAsnAlaSerValAsnGluValAspPheGluGlyArgThrProMet530535540HisValAlaCysGlnHisGlyGlnGluAsnIleValArgThrLeuLeu545550555560ArgArgGlyValAspValGlyLeuGlnGlyLysAspAlaTrpLeuPro565570575LeuHisTyrAlaAlaTrpGlnGlyHisLeuProIleGlyLys580585590<210>410<211>339<212>DNA<213>人<400>410atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaaggtaactggacagtt120aacaaaacagaagctgacaacatagaaggacccatagccttgaagttctcacacctttgc180ctggaagatcataacagttactgcatcaacggtgcttgtgcattccaccatgagctagag240aaagccatctgcaggtgttttactggttatactggagaaaggtgtctaaaattgaaatcg300ccttacaatgtctgttctggagaaagacgaccactgtga339<210>411<211>285<212>DNA<213>人<400>411atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaagctgacaacatagaa120ggacccatagccttgaagttctcacacctttgcctggaagatcataacagttactgcatc180aacggtgcttgtgcattccaccatgagctagagaaagccatctgcaggtgtctaaaattg240aaatcgccttacaatgtctgttctggagaaagacgaccactgtga285<210>412<211>460<212>DNA<213>人<400>412aagagaaagaaagttaagcaactacaggaaatggctttgggagttccaatatcagtctat60cttttattcaacgctgacaacatagaaggacccatagccttgaagttctcacacctttgc120ctggaagatcataacagttactgcatcaacggtgcttgtgcattccaccatgagctagag180aaagccatctgcaggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaaga240cgaccactgtgaggcctttgtgaagaattttcatcaaggcatctgtagagatcagtgagc300ccaaaattaaagttttcagatgaaacaacaaaacttgtcaagctgactagactcgaaaat360aatgaaagttgggatcacaatgaaatgagaagataaaattcagcgttggcctttagactt420tgccatccttaaggagtgatggaagccaagtgaacaagcc460<210>413<211>112<212>蛋白質<213>人<400>413MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnGlyAsnTrpThrValAsnLysThrGluAlaAspAsnIle354045GluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGluAspHis505560AsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGluLeuGlu65707580LysAlaIleCysArgCysPheThrGlyTyrThrGlyGluArgCysLeu859095LysLeuLysSerProTyrAsnValCysSerGlyGluArgArgProLeu100105110<210>414<211>94<212>蛋白質<213>人<400>414MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnAlaAspAsnIleGluGlyProIleAlaLeuLysPheSer354045HisLeuCysLeuGluAspHisAsnSerTyrCysIleAsnGlyAlaCys505560AlaPheHisHisGluLeuGluLysAlaIleCysArgCysLeuLysLeu65707580LysSerProTyrAsnValCysSerGlyGluArgArgProLeu8590<210>415<211>73<212>蛋白質<213>人<400>415MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaAsp151015AsnIleGluGlyProIleAlaLeuLysPheSerHisLeuCysLeuGlu202530AspHisAsnSerTyrCysIleAsnGlyAlaCysAlaPheHisHisGlu354045LeuGluLysAlaIleCysArgCysLeuLysLeuLysSerProTyrAsn505560ValCysSerGlyGluArgArgProLeu6570<210>416<211>312<212>DNA<213>人<400>416atggctttgggagttccaatatcagtctatcttttattcaacgcaatgacagcactgacc60gaagaggcagccgtgactgtaacacctccaatcacagcccagcaagctgacaacatagaa120ggacccatagccttgaagttctcacacctttgcctgggagatcataacagttactgcatc180aacggtgcttgtgcattccaccatgagctagagaaagccatctgcaggtgttttactggt240tatactggagaaaggtgtctaaaattgaaatcgccttacaatgtctgttctggagaaaga300cgaccactgtga312<210>417<211>103<212>蛋白質<213>人<400>417MetAlaLeuGlyValProIleSerValTyrLeuLeuPheAsnAlaMet151015ThrAlaLeuThrGluGluAlaAlaValThrValThrProProIleThr202530AlaGlnGlnAlaAspAsnIleGluGlyProIleAlaLeuLysPheSer354045HisLeuCysLeuGlyAspHisAsnSerTyrCysIleAsnGlyAlaCys505560AlaPheHisHisGluLeuGluLysAlaIleCysArgCysPheThrGly65707580TyrThrGlyGluArgCysLeuLysLeuLysSerProTyrAsnValCys859095SerGlyGluArgArgProLeu100<210>418<211>846<212>DNA<213>大鼠<400>418aggagagaaagagaagtgtgcacaaagaaacttgtattattattaattagcacctagctt60gtttgtgtctgatacaccaccaagtagtaattgttgaaaaaacgaagaagaaaaaaaaaa120aacaaaaaaaccaaacagtgggtactcaaataagataggagaaaaatgagagaacagacc180cagttctcgacccttgcttctcaaggtcctcccaccaggctgccaaagcaagatggtgtt240gctctgatccagtcagtattcttttgacttttttttttaatctccaggttttggttcagg300ctcccatattcataccctggctcatttagctttccctcatgttgtgggttcttctgtccc360tcacccccttactctccccactgatattcttcccagtcaagactgtggctctggaagaaa420tatccaccatttgcagagctgatgttctgtagatcgtaatgttgaagcgctgggtgtcct480ggttggcagaatcactcctgtattactctggtacataggtgtctcctgatagactccctg540gccttagtcatggggtgttttctagaggcagactaagacaggagtcaaaaaagatttaga600ggaaggagctgaggaaagaaagacagttgtgggaggaaaatcaagttctactcaggatcc660cgagtgtttctgtagatgtagattggaatgtgtccataacagagaggccagtgagagaca720tccccaaggacctgccaggctttccttcgctccaggaagacgcaccatcactcaaaaggg780gtttcctagaaagaaagacaagtgacttaaaaaatctgccagtgggttcttgaagtcatc840gaacct846<210>419<211>960<212>DNA<213>小鼠<400>419agagtatgaagccagagtcttagagaagtcactgagaaaagaatccagaaacaaagagac60cgacaaggtgaagctgacctggagggaccgattcccagcctatttcaccaatcttgtctc120catcatcttcatgatcgcagtgacatttgcaatcgtcctcggagttatcatctatagaat180ctccacagctgcagccttggccatgaactcctccccgtctgtgcggtccaacatccgggt240tacagtcacggccaccgctgttatcatcaacctcgtggtcatcattctgctggatgaagt300ttacggctgcattgccaggtggctcaccaagattggtgagtgccatgtgcaggacagcat360aggcagcatgggcctagggcagggccagccttgaagtgggcagcctggtcacagaactgt420ggctagtcccaacttcccctggcctggcctggctgtgagtggctagcagctggcacagtc480agtaccgtatgtctctcctcagaggtcccaaagacagagaagagctttgaggagaggcta540accttcaaggccttcctgctcaagtttgtgaactcttacactcccatcttctatgtcgcc600ttcttcaaaggccggtttgttggtcggcccggtgactacgtgtacatcttccgctctttc660cggatggaggagtgtgccccgggcggctgcctcatggagctctgtatccagctgagcatc720attatgctgggcaagcagctaatccagaacaatctcttcgagattggcatcccgaagatg780aaaaagttcatccgctacctgaagctgcgcagacagagcccctcagaccgtgaagagtac840gtgaagcggaagcagcgctatgaggtggacttcaacctcgaacctttcgccggcctcacg900cccgagtacatggaaatgatcattcagttcggctttgtcaccctgtttgttgcgtccttc960<210>420<211>1330<212>DNA<213>小鼠<400>420gcaacttggacactaaagctaggtaccagcctgttagtttacatgagttcaaaattcagg60tcagggtctctgaaatggagtctgaatttaaaagctttggcctctcatgtgaataataca120tatgtcatgtgtcatttgaatagtttcagtcacacacactttgtatttctctaagtgtaa180cgcatgtgtagtgggtggttgtagtatgatttctccgtctttcttgtttgaatgtttgga240cttgtgcacgtgtgcacatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatt300tgctcctgtggctatgtgcatgtgccatgtgggtgtgtgtgcttgtgggggccagaggtt360aggtaccttcctctatctctccaccctggtggtttttgttttgttttgttttgttttgga420ccaggtctatcactgataagctaggttggatggcttctgagaagagtctgcctctctgtc480cccctgcccctyctccccccagccctcaggttacagataagtgccacaagtccttgtcct540ttcaagtagcctctagggatccaggctcatatccttgtgcttactgactgagccacctct600cagctccctcagccccgttttacacgttaactttgtctcctgtctatgcctgctctcttc660agtgaccccttccgttttcctttcactcttttctctgaatagatttgtgtgcgagagact720attatcatatggatgcataaatatcatctgcaaagtcaatcgcaggaaagacttagagtc780tctttagctttatgactgtaaaggattccgcttcttgccattgattcagcttttttgcca840ttgatcctttattagagatcaattagagtcgtatacaaagaccttggctgggccctgagg900gtctatctcaggctaggccctgagggtctatctcaggctaggccctgagggtctatctca960ggatagatggatttaactgcttttctcaagacgcttttactctctcgttgaattcttttt1020aaacttttaattgacattgtacttgcattcttatgggaaacagggtgacccacacacatg1080tgtacacaggtacacacacagtcaggtcagcatagctggtatgttgttgtttatgttggg1140gacagtcagattggtattgtttttgcactgtgctgtggaacattggaaaaccttatctga1200tggtgaccctgtgcctactaacagccctcactaggatacattttggagtctctggcaacc1260acaattttgctctatttccatgagtccagcatctctactactgcatagaagtaaaaaaaa1320aaaaaaaaaa1330<210>421<211>880<212>DNA<213>小鼠<400>421aggaccttgaccgacatccagaccacgggacccgactggatgtctcaccctgcccctgca60ggccctgtcccttccaaaacaggcacttctgtcacaggatacttttttttttaacttaaa120tttgcttgggggaggggagcagttctagttccatgaggcacaaatggaggtcaaagagca180acttgccgatgtctcttctctcctcccactgtgtgggtagtaggaattgaatcaggttat240cgatcttggggctgagccatctctgtggcccacagagcacttatatgtggttacttgttg300ctctcacattgtcagtgtacagcttggtggcctttgtcactggcatgctctgtgacactg360ttgtgataaaaatgttgatgagtttacacaaatctagtaaattgaacccaagagccaagt420gtggtggtgtacccttaattccagcactttgggggcaagttcaggtagttctctgaattt480gagagcctcctggcccacatagtgagttccatggctgcgtagttgcaaaagaacaccaac540acctttcccccacaaatagaattgtactgaaggtcacagtcagagaaagcatagcaagga600tggctgctctgagcccctcctgtgcacttctgtagacctagccccggtgtctaaatggag660tctgattttagcacctgcacttgactgctgtgctccaccctgacccgccttytcctgatc720ccagattgctagaactttgaccaaaatgggacttaattggagttgtgattggkatgttca780ttgatttaaagtgctctttacattttaaggaaactaaccctttgggtaagaaaaaaaaaa840aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa880<210>422<211>533<212>DNA<213>小鼠<400>422cctaaatgctgggattaaaggcgtgcgccactactgccaggctgtttttttttttttttt60ttttttattaatgatctgccagacaaagagatgtcctttttggtgcaaaagtcacccaat120gcttgaagtcactatatttgattagctctgtaactgatacacaaataaaactttccatta180tggataatacattatctattattatttatctcttgttcatttttgcaatttctgtacttg240actcccagttgagtacaaggtgcctttggtggttttccaaggatcttgaggttacatgaa300attgctgatgatgtctgttgaaagcattgtatggaggcctgaggtatatttggcctgaga360gcagagtttttaaaatagagcctgctggaaaagctagctggagcttctgactactttaga420aaggcactgtttgaagcacaggccatgaagtaagacttgctttctagttaaattgaggtt480ttttgtttttttaagtcwttagtgtatagagatttcctacattttttgtggtt533<210>423<211>738<212>DNA<213>大鼠<400>423ataaggcacatttgcttcataaaataaaaaaaaaggaaatttacttagccgcatgtcagt60cacccaaattttgagtgtacaaatgaaatggaaaacatttattacacaaatttaattaca120attctagggaataaacatgcaaatcagatggagctcaatctgcaggcgctgatcctctcc180ccctggtttgcagtctgtgcacctcctggattcgcccgcgaccaggcagtcagaggcctg240gctcttgcaggcaggaggatcactgttgtaaagaacagcgtcacatttagcgcatctggc300gtagtagcagtttttaacactttgcgcaggtgcctcccttcccccacccgcgctttgtta360ggtctacctctctaaatctctgccttcctcgcacagtaagtgacctctccatgacaaagg420gcccccagacagcagttataaatcaatgtgttttgggtttgtttgtttgtttgttttgtt480ttaaagaaaaacccggccatgcttggtggcacttgcctttaatagtagcgcttggtagac540agaggcaagcggttctctgtaagttcaaggccagcctggtctacacagtgagaccgggtc600tcaaaaacaaaacaacaaaaaacaactcctattgaatccactacaggaagggggggcgcg660gatcactgtctgcaaactaaagtgacttgagctcctgtcacagcctttccagcaagggca720agcttctttattagttat738<210>424<211>1035<212>DNA<213>大鼠<400>424cctgaggcgactacggtgcgggtgccgggtgccgggtgcctacagcccccatcagcttcc60ccggggagattctgccgatttgtcacgagccatgctcaggaggcagctcgtctggtggca120cctgctggctttgcttttcctcccattttgcctgtgtcaagatgaatacatggagtctcc180acaagctggaggactgcccccagactgcagcaagtgttgccatggagattatggattccg240tggttaccaagggccccctggacccccaggtcctcctggcattccaggaaaccatggaaa300caatggaaataacggagccactggccacgaaggggccaagggtgagaaaggagacaaagg360cgacctggggcctcgaggggaacgggggcagcatggccccaaaggatagaagggataccc420aggggtgccaccagagctgcagattgcgttcatggcttctctagcgactcacttcagcaa480tcagaacagtggcattatcttcagcagtgttgagaccaacattggaaacttcttcgatgt540catgactggtagatttggggcccccgtatcaggcgtgtatttcttcaccttcagcatgat600gaagcatgaggacgtggaggaagtgtatgtgtaccttatgcacaatggtaacacggtgtt660cagcatgtacagctatgaaacaaagggaaaatcagatacatccagcaaccatgcagtgct720gaagttggccaaaggagatgaagtctggctaagaatgggcaacggtgccctccatgggga780ccaccagcgcttctctaccttcgcaggctttctgctttttgaaactaagtgatgaggaag840tcaggatagctccatgctaagggcgatttgtaggtgagctagggttgttaggatctgagg900ggtgttggagttgggcttctctatggagtatttaactgttacattggtcacactgctact960cattctaatggcataccaattatgttggatactttaggggctaggaagaatagaccacaa1020ggtaatattcccaga1035<210>425<211>835<212>DNA<213>大鼠<400>425gtgccctccgccgggtcgggatggagctgcctgccgtgaacttgaagttattctcctggt60tcactggctgttgacaacctggggctgcttggcgttctcaggctcctatgcttggggcaa120cttcactatcctggccctgggtgctgtgggctgtggcccagcgggactctgttgatgcca180ttggcatgtttcttggtggcttggttgccaccatcttcctggacattatctacattagca240tcttctactcaagcgttgccgttggggacactggccgcttcagtgccggcatggccatct300tcagcttgctgctgcaagcccttctcctgctgcctcgtctaccacatgcaccgggcagcg360agggggtgagctcccgctccgctcggatttcttcggaccttctcaggaacatagtgccta420ccagacaattgactcgtcagactcacctgcagacccccttgcaagcctggagaacaaggg480ccaagctgccccccgggggtactgaagctgtccctggccgtcctggggcccagcaggatg540cttgtcaccttctttactggacctacaatggggtatcctccattccctgccacagaggtg600gcctgagtcatgtgccctcggaggtcccagctgagaagagcccagtcctaattctccatg660ctgcccctccattcaagacacctgttaacccctgggctagaactgtggttggtttcttcc720cctcctccccatcactataacacacaaccgccgagctgtgcagagtgttcagggccatcc780aggccttatgggccaatgatcactgcctctcaggctaccccaaggtgacccagcc835<210>426<211>1337<212>DNA<213>小鼠<220><221>不確定<222>(626)...(626)<400>426accggcctcactatgtctgccattttcaattttcagagtctgttgactgtaatcttgctg60cttatatgtacatgtgcttatatccgatccctggcacccagcatcctggacagaaataaa120actggactattgggaatattttggaagtgtgcccgaattggggaacgcaagagtccttat180gtcgccatatgctgtatagtgatggccttcagcatcctcttcatacagtagctttggaaa240ctaccagcatgtgcttgctatcagactgtaaacaaggacttgcctccagaaaataatggg300aagaatggttaagccatttgtctctgaacatggaatgagataaacttcaagatgctgttc360tctatttttatgctattggaccaatgagctgaatgaataattaagatgtaacagttcaat420acacaggaatgtgattgtatccatcaacctcagttctctcactccagtattacattctgc480aaatgtcattctgttgtgtcaggactgcttttcataaggttcttcgggcacgaagtagaa540acccagtggcaaattccaaggctcctttgactagggcttcaaaataatgtcttcacagaa600tggtacctctagcgactgtcctattnttattgagaaaaaaacttgttctatttttgttgt660tgttactgttcttatggattgcattcatatttaaaccctttggattgctaaccagagtac720ctctattcttggcaaattccgcagtttattacaggtgtttaaagtattttaaacaaaact780ctgaatttctttagttagcctaagagttggcttctagtcacaaagatacagctgccacac840tgtgacgaagagcaccttagaaagaaaagcagcaagtgagcggtgagcaagtaagcaccg900tgcagtcttcgtgcaagtaagcaccgtgcagtcttcgttctctgtagtcttgtcttccaa960atagaacgtccatcgtagttacccaaaggtggtatttgtggtgttcttaatgcagtgctt1020taagtctagtgtatgttctgtcagcttgaactggaatctctcttgtaactttgtaggtta1080taaacatatctcatatctgctttagtctgggtactatgctctaagtacatttcagctttg1140acacagaatgtgaatagacgaatatcaaaggatacttacaagtttgtatccaacatttct1200tcaggttcagctgaaaatcagttactgtttcaaaacaaagaggaattaaatcctagctga1260aaactatacatagcatttattaattaattactgggtttaactgctctttttaaaagtttg1320aaaaaaaaaaaaaaaaa1337<210>427<211>780<212>DNA<213>小鼠<400>427gctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttgcgggctcg60cgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatctggtgggga120acacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaagtcaggag180gaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtggatcaactc240atggagctggccgggttgagctgtgccacggctattgccaaggcttatccccccacgtct300atgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacggaggggat360gggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatctattacccc420aaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaatggacatt480cctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccctagcggaa540tccaaccagacttactcatctcactgacggcacccaagaagtctgcaactcactttactg600gccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaagtaccagc660tgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagggaggtggg720taggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaaaaaaaaaa780<210>428<211>460<212>DNA<213>小鼠<400>428aatcatggcgccgtcgctgtggaaggggcttgtaggtgtcgggctttttgccctagccca60cgctgccttttcagctgcgcagcatcgttcttatatgcgactaacagaaaaggaagatga120atcattaccaatagatatagttcttcagacacttctggcctttgcagttacctgttatgg180catagttcatatcgcaggggagttcaaagacatggatgccacttcagaattaaagaataa240gacatttgataccttaaggaatcacccatctttttatgtgtttaaccatcgtggtcgagt300gctgttccggccttcagatgcaacaaattcttcaaacctagatgcattgtcctctaatac360atcgttgaagttacgaaagtttgactcactgcgccgttaagctttttacaaattaaataa420caggacagacacagaattgagtattggagtttggggtgta460<210>429<211>472<212>DNA<213>小鼠<400>429gaagcctcttcccatggaagcacactctaggagagagaaggcctctgggctccgcctggc60ctggcattatgaatgcagtggggtcagtgtgtggtggatgtgtgtactgggttggctttc120ctttttagtttttttactttttagtttagtttgttcttttccttccccaataaatcattc180tcacatgcttccatgtttgtttctgagaggtgggggctcaaatgtatagaaagtaggccc240cagtccataaggaggtgtgaacacacccccttactgcttatcacccatttgacaggaacg300cccaggaggggagggggaggggaagaggtgagttctgcacagtcggacatttctgttgct360tttgcatgtttaatatagacgttcctgtcgatccttgggagatcatggccttcagatatg420cacacgacctttgaattgtgcctactaattatagcaggggacttgggtaccc472<210>430<211>954<212>DNA<213>小鼠<400>430attagcggctcctcagcccagcaaatcctccactcatcatgcttcctcctgccattcatc60tctctctcattcccctgctctgcatcctgatgagaaactgtttggcttttaaaaatgatg120ccacagaaatcctttattcacatgtggttaaacctgtcccggcacaccccagcagcaaca180gcaccctgaatcaagccaggaatggaggcaggcatttcagtagcactggactggatcgaa240acagtcgagttcaagtgggctgcagggaactgcggtccaccaaatacatttcggacggcc300agtgcaccagcatcagccctctgaaggagctggtgtgcgcgggcgagtgcttgcccctgc360cggtgcttcccaactggatcggaggaggctacggaacaaagtactggagccggaggagct420ctcaggagtggcggtgtgtcaacgacaagacgcgcacccagaggatccagctgcagtgtc480aggacggcagcacgcgcacctacaaaatcaccgtggtcacggcgtgcaagtgcaagaggt540acacccgtcagcacaacgagtccagccacaactttgaaagcgtgtcgccagccaagcccg600cccagcaccacagagagcggaagagagccagcaaatccagcaagcacagtctgagctaga660cctggactgactaggaagcatctgctacccagatttgattgcttggaagactctctctcg720agcctgccattgctctttcctcacttgaaagtatatgctttctgctttgatcaagcccag780caggctgtccttctctgggactagcttttcctttgcaagtgtctcaagatgtaatgagtg840gtttgcagtgaaagccaggcatcctgtagtttccatcccctcccccatcccagtcatttc900tttaaaagcacctgatgctgcattctgttacagtttaaaaaaaaaaaaaaaaaa954<210>431<211>780<212>DNA<213>小鼠<400>431gctagtcgaatgtccgggctgcggacgctgctggggctggggctgctggttgcgggctcg60cgcctgccacgggtcatcagccagcagagtgtgtgtcgtgcaaggcccatctggtgggga120acacagcgccggggctcggagaccatggcgggcgctgcggtgaagtacttaagtcaggag180gaggctcaggccgtggaccaagagctttttaacgagtatcagttcagcgtggatcaactc240atggagctggccgggttgagctgtgccacggctattgccaaggcttatccccccacgtct300atgtccaagagtcccccgactgtcttggtcatctgtggccccggaaataacggaggggat360gggctggtctgtgcgcgacacctcaaactttttggttaccagccaactatctattacccc420aaaagacctaacaagcccctcttcactgggctagtgactcagtgtcagaaaatggacatt480cctttccttggtgaaatgcccccagaggatgggatgtagagaagggaaaccctagcggaa540tccaaccagacttactcatctcactgacggcacccaagaagtctgcaactcactttactg600gccgatatcattaccttgggggtcgctttgtaccacctgctctagagaagaagtaccagc660tgaacctgccatcttaccctgacacagagtgtgtctaccgtctacagtaagggaggtggg720taggcaggattctcaataaagacttggtactttctgtcttgaaaaaaaaaaaaaaaaaaa780<210>432<211>1144<212>DNA<213>小鼠<400>432cttctcagggcctgccacccaaataagtctggccctagcctcaactctctctcaggctgg60gccacaggaagctgctgactggccacttgacaccctccccctaaagctaatgtctgtgac120tatagggaggttagcactttttctaattggaattcttctctgtcctgtggccccatccct180cacccgctcttggcctggaccagatacatgcagcctctttctccagcacagcctttccct240gagcctgaggttagggcagagtttagagggtgggctaagtgtatgttttcatgtatgcat300tcatgcctgtgagtgtgtggcttgctgtcgtgtcctctgggatcccaagccacgcgggtc360ttccctctgtagatgggtcctgggttctatcacctgcttatttatgtacgaggttggggg420gtggacccagggtgggttgattgtctctttgtaaggaagtatgtgtcgggggtgacacga480ggctaagcccgagaaaccccgggagacagcactgcataagaaactggtttccmagactgc540agagggagctgcacttttgttttgaccaaaaacaaaaaacaaaacaaaacaaaaacaaaa600caaaaataactctgaagggcgggaggatacccaagcctgatgcctgagaggagtccctag660acttcagcaactccgctgcgtggcctgagcccagcgggagggatggggagagaatttttt720ggagtccgtgcctgtggtgggcagtcctgagccttcagctgaagcagtgctttttggctg780ccctcacctcgcactacttgaccttgaggctctgagtatctcctgtgcacaggagaagct840cctgcaccagaaagcaccaaarsccmtggcaccccatcttactccactctccccagggac900tcccaggtgggaactgctgtggcagtgagctcagcccggacagacactgccaaccctgtc960tcctggcattgggctccggctctacctccccaagcagggcgaggccccgccttctcagcc1020tagcaccacctgtccccgagtcttctcagcttgcccatcattctcggcgcccacacaggt1080gacagtcccaagtagataacctccatgggacaagttgggtgttgccttacccgcctgccc1140agcc1144<210>433<211>438<212>DNA<213>小鼠<400>433cttgagtctggagtgctgcaaataatagtatgcactatccctgcctggcatgtttgtttg60ttaatgtgcactggtgttttgcctggatgtgtatacttgtgaagatgtcagaactcctgg120agctggagttagagacaatggtgagctgccttgtggatgttgggaattgaacccaggtcc180tctggagaaataaccagtgctcttaaccactaagccatctcaacagccccaaattatttt240tttaataagttgcctcggtcatgttgtcttaatcagagcgatagaaaagtaactaatata300gattatttatgaattcaggtggcttaatggtatatgcatgaattagtagtaaaacaagaa360ctagggccagcaagtggcttaagggtgcctgctaaccatctcagccacctgagttcagtc420tccaggaaccacacagtg438<210>434<211>383<212>DNA<213>小鼠<400>434cccacgtctatgttcaccttcgttgttctggtaatcaccatcgtcatctgtctctgccac60gtctgctttggacacttcaaatacctcagtgcccacaactacaagattgaacacacagag120acagatgccgtgagctccagaagtaatggacggccccccactgctggcgctgtccccaaa180tctgcgaaatacatcgctcaggtgctgcaggactcagagggggacggggacggagatggg240gctcctgggagctcaggcgatgagcccccatcgtcctcctcccaagacgaggagttgctg300atgcctcctgatggcctcacggacacagacttccagtcatgcgaggacagcctcatagag360aatgagattcaccagtaaggggt383<210>435<211>405<212>DNA<213>大鼠<220><221>不確定<222>(114)...(114)<221>不確定<222>(346)...(346)<221>不確定<222>(353)...(353)<221>不確定<222>(387)...(388)<400>435ctcgtgccgaattcggcacgagtggcgagatggggatgcgccctggagccgactgggctg60cggtctgcgctttgtggccttcctggcgaccgagctgctccctcccttccagcnggcgaa120ttcagcccgacgagctgtggctttaccggaacccgtacgtgaaggcggaatacttcccca180ccggccccatgtttgtcattgcctttctcaccccactgtccctgatcttcttcgccaagt240ttctgaggaaagctgacgccgaccgacagcgagcaagcctgcctcgctgccagccttgcc300ctagcgctaaatggtgtctttaccaacatcataagactgatagtgngcaaggncacgccc360aaattgcttctaccgagtgttccccgnncgggattgcccattctt405<210>436<211>151<212>DNA<213>大鼠<400>436atactgcctgtagagttagtatttctgttttatatatgttgcacactgaattgaagaaat60gttggtttttcttgttttgttttagtttgtttctttggttttgtttttggttttgctttt120tacttcccaggtttgactatttgccaatgcc151<210>437<211>1715<212>DNA<213>小鼠<400>437cagaatatggctctgggggttctgatagcagtctgcctcttgttcaaagcaatgaaggca60gcactgagcgaagaagcagaggtgatccctcctagcacagcacagcagagcaactggaca120tttaacaacaccgaagctgactacatagaagaacctgtagctctgaagttctctcatcct180tgtctggaagaccataatagttactgcattaatggagcatgtgcattccaccatgagctg240aagcaagccatttgcagatgctttactggttatacgggacaacgatgtgagcatttgacc300ctaacttcgtatgctgtggattcttatgaaaaatacattgcgattgggattggcgtcgga360ttgctaattagtgcttttcttgctgtcttctattgctacataagaaaaaggtgtataaat420ctgaaatcaccctacatcatctgctctggagggagcccattgtgagaccttataagacat480agtcatcaagccatttgtcaaaagccacagggaatccaatggagatctttggatgataca540aaatgtgataagctaacttgaaaataatggtggtttgggtcacaatgcagtaactgacca600ttggttcttagctttggtcatcgttgggtgccatggaagctatgggaatgagctacagta660acagaagccaagttcactacccttctttgggtttgctgttgggtggttgttgtcactgca720ggaagatttgttctatacttctgaccatctcagatgtgaattttcattttaattgttttc780tactacacatcaatcaagtccaagtaatgccatttccgggttcttcgggcactcaacatt840ttgggccacccgcctcgatggacctaatagcaaagtatctgtccttatggaatttcaggg900aatttggtatcaatttttagatgaaaacagtgaatgtctcagctccttgagtgaaccaaa960gatgcattacacctaaaccactaaaagaaaatggaatatccaaggcagcataaatcctac1020ccagctggtgacaacagtttgcaaacttcattcatgtagtttggaagaagcagataaatt1080cctgaggactgaaagtcacctggacagcagatccagagcaggcaaaggtagctggttcct1140atatcgaccataaagcctgtgtgggctcatctgtcccctgatgtttttgcctatcatctc1200agccttacattggaagactcacacttggtatccatcgcttgaactgaagttcgacaattc1260acctaatgactaaaagcttacaattgttcccaaaatatataggaacaacagcatgtggaa1320tgtaaccattttttgacgtgttgatagcatatttgcacatgggttaaaaaaagaaacagt1380cgtagaaatacttattagggaatcagtatccctccttggaattgcttctgctacatgatt1440caatcttgggcaagtctcttatattctttgtggtttggttccattctctacaagacccat1500gcagttccaaaattgaactctaatagaactaaaaaatacctcctataactgcatggcagg1560caagattatcctcaatgcttccatcctcagccccgtttctaaccctcaaatacccacgaa1620tattatccttactatatattgtcatgttcagtttgtaaaataataacttattttgaaaag1680aaataaaaaatgaaattacaaagcaaaaaaaaaaa1715<210>438<211>1627<212>DNA<213>小鼠<400>438cgggagcctgctactgccctgctgggttccttggggccgactgtagccttgcctgtccac60agggtcgcttcggccccagctgtgcccacgtgtgtacatgcgggcaaggggcggcatgtg120acccagtgtcggggacttgcatctgtcctcccgggaagacgggaggccattgtgagcgcg180gctgtccccaggaccggtttggcaagggctgtgaacacaagtgtgcctgcaggaatgggg240gcctgtgtcatgctaccaatggcagctgctcctgccccctgggctggatggggccacact300gtgagcacgcctgccctgctgggcgctatggtgctgcctgcctcctggagtgttcctgtc360agaacaatggcagctgtgagcccacctccggcgcttgcctctgtggccctggcttctatg420gtcaagcttgtgaagacacctgccctgccggcttccatggatctggttgccagagagttt480gcgagtgtcaacagggcgctccctgtgaccctgtcagtggccggtgcctctgccctgctg540gcttccgtggccagttctgcgagagggggtgcaagccaggcttttttggagatggctgcc600tgcagcagtgtaactgccccacgggtgtgccctgtgatcccatcagcggcctctgccttt660gcccaccagggcgcgcaggaaccacatgtgacctagattgcagaagaggccgctttgggc720cgggctgtgccctgcgctgtgattgtgggggtggggctgactgcgaccccatcagtgggc780agtgccactgtgtggacagctacacgggacccacttgccgggaagtgcccacacagctgt840cctctatcagaccagcaccccagcactccagcagcaaggccatgaagcactaactcagag900gaacgcccacagaggcccactactgtgttccagcccaagggacccaggcctctgctggtg960actaagatagaggtggcacttttggatccacacctcttctggaaagccatggattgctgt1020ggacagctatggatagtcatatagccacacacccgggctccatggtcatggggaagaagg1080cctcctttggacacaaggaatccaggaagtcggctgggcttcgggccactgtttacatgg1140ggaccctgcaggctgtgctgtggaatcctggccctcttcagcgacctgggatgggaccaa1200ggtgggaatagacaaggccccacctgcctgccaggtccttctggtgctaggccatggact1260gctgcagccagccaactgtttacctggaaatgtagtccagaccatatttatataaggtat1320ttatgggcatctccacctgccgttatggtcctgggtcagatggaagctgcctgaccccag1380aacttaggcagtggcctgtggggt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cccatgaatgacaagaac600gtgtacgctctggggaagaatctactgctacaagctcggtggttccacatcttgggaatg660atgatgttcttctggtcctctgcccatcagtataagtgccacgtcattctcagcaatctc720aggagaaataagaaaggtgtggtcatccactgccagcacagaatcccctttggagactgg780ttcgagtatgtgtcttctgctaactacctagcagagctgatgatctacatctccatggct840gtcaccttcgggctccacaacgtaacctggtggctggtggtgacctatgtcttcttcagc900caagccttgtctgcgttcttcaaccacaggttctacaaaagcacatttgtgtcctaccca960aagcataggaaagctttcctcccgttcttgttttgaacaggctttatggtgaagagcgca1020gcccaggtgacaggttcccttcctcgagacgctgagacaggctgaagtacactttctgca1080gctggcgcccgccaggctgctaccgagctgcgcgctcttccaggacctcatccgctacgg1140gaagaccaagcagtccggctcgcggcgccccgccgtctgcagcccgggggatccactagt1200tctagagcgccgcc1214<210>442<211>1977<212>DNA<213>大鼠<400>442aaaataaccaaccaaacaaactttcctcttcccgctagaaaaaacaaattctttaaggat60ggagctgctctactggtgtttgctgtgcctcctgttaccactcacctccaggacccagaa120gctgcccaccagagatgaggaactttttcagatgcagatccgggataaggcattgtttca180cgattcatccgtgattccagatggagctgaaatcagcagttacctatttagagatacacc240tagaaggtatttcttcatggttgaggaagataacaccccactgtcagtcacagtgacacc300ttgtgatgcgcctttggaatggaagcttagcctccaggagctgcctgaggagtccagtgc360agatgggtcaggtgacccagaaccacttgaccagcagaagcagcagatgactgatgtgga420gggcacagaactgttctcctacaagggcaatgatgtagagtattttctgtcttcaagttc480cccatctggtttgtatcagttggagcttctttcaacagagaaagacacacatttcaaagt540atatgccaccaccactccagaatctgatcaaccataccctgacttaccatatgaccccag600agttgatgtgacctctattggacgtaccacagtcactttggcctggaagcaaagccccac660agcttctatgctgaaacaacccatagagtactgtgtggtcatcaacaaggagcacaattt720caaaagcctttgtgcagcagaaacaaaaatgagtgcagatgatgccttcatggtggcgcc780caaacctggcctagactttagcccctttgactttgcccatttcggatttccaacagataa840tttgggtaaggatcgcagcttcctggcaaagccttctcccaaagtggggcgccatgtcta900ctggaggcctaaggttgacataaaaaaaatctgcataggaagtaaaaatattttcacagt960ctccgacctgaagcccaatacccagtactactttgatgtcttcatggtcaataccaacac1020taacatgaacacagcttttgtgggtgcctttgccaggaccaaggaggaggcaaaacagaa1080gacagtggagctcaaagatgggagggtcacagatgtggtcgttaaaaggaaagggaaaaa1140gtttctacggtttgctccagtctcctctcaccaaaaagtcaccctctttattcactcttg1200tatggacactgttcaagtccaagtgagaagagatgggaagctgcttctgtcacagaatgt1260ggaaggcattcggcagttccagttaagaggaaaacccaaaggaaagtacctcattcgact1320gaaaggcaacaagaaaggagcatcaatgttgaaaatactagccaccaccaggcccagtaa1380gcacgcattcccctctcttcctgatgacacaagaatcaaagcctttgacaagctacgcac1440ttgctcttcagtcacggtggcttggcttggcacccaagagaggagaaagttttgtatcta1500cagaaaggaagtgggtggaaactacagtgaagagcagaagagaagagagagaaaccagtg1560cctaggaccagacaccagaaagaagtcagagaaggttctttgcaagtacttccacagcca1620aaacctgcagaaagcagtgacgacagagacaatcagagatctgcaacctggcaagtctta1680cctactggacgtttatgttgtaggacatgggggacactctgtgaagtatcagagtaaact1740tgtgaaaacaaggaaggtctgttagttaccttaagtgaagatcagtagaactcccggaga1800gatatggaatcacactgcctgttactgactactctcatgacaaacagaagttgtacttga1860aagaaaggataacaacatgtgtacattgatgcctgtgtaatgtaacgtggagacttgtat1920tcacgcacacctgtggtacttagggtccatctgtctaatgctggctaatgtcaaagg1977<210>443<211>1744<212>DNA<213>大鼠<400>443ctgacatgaagccccctagacccagagattggttcctgctgtgacatgcctaccatgtgg60ccacttcttcatgtcctctggcttgctctggtctgtggctctgttcacaccaccctgtca120aagtcagatgccaaaaaagctgcctcaaagacgctgctggaaaagactcagttttcggat180aaacctgtccaagaccggggtctggtggtgacggacatcaaagctgaggatgtggttctt240gaacatcgtagctactgctcagcaagggctcgggagagaaactttgctggagaggtccta300ggctatgtcactccatggaacagccatggctatgatgttgccaaggtctttgggagcaag360ttcacacagatctcaccagtctggttgcagctgaagagacgtggtcgggagatgtttgaa420atcacaggcctccatgatgtggaccaagggtggatgcgagctgtcaagaagcatgccaaa480ggcgtgcgcatagtgcctcggcttctgtttgaagactggacttacgatgatttccgaagc540gtcctagacagtgaggatgagatagaagagctcagcaagactgtggtacaggtggcaaag600aaccagcattttgacggctttgtggtggaggtctggagccagttgctgagccagaaacat660gtaggcctcattcacatgcttactcacttggctgaggcgctgcaccaggccaggctgctg720gtcattctggtcatcccacctgctgtcacccctgggactgaccagctgggcatgtttaca780cacaaggagtttgagcagctggcccccatactagatggcttcagcctcatgacatacgac840tactccacatcacagcagcctggccctaatgctccattgtcatggatccgagcctgtgtt900caggtcctagaccccaagtcacagtggcgtagcaagatcctcctgggattgaacttctat960ggcatggattatgcagcctccaaggatgcccgtgagcctgtcattggagccagggcagtt1020ttgaaggtggctctgccattggctgtctcatcccagcagatctggacattgggaagagga1080gggtccaccagtgccctactcctggcaggcttggggctggcctcagagccctgtacaaag1140agcgaggaggttccaaagaagagcctcttagatacagtttggcactggcagggagagcca1200ggagcactgtgtagaggtcgtcttcacacctggatcctagtgagcgcggtcccgcaggcc1260tgcacatgcctgtttcagtgatggcctcacgaggcagcaccggctctagctgcactgctt1320tctttgattagctttggccatgggagacacaggtagcagcatagcgggtcaggaacctct1380tgagcagatccaaccaaaggctttttgtcacttgccagctctgcatggtcagcctgtgac1440accgtctcactcaaggccttctggagttggccctcagctcagatgtcatgtgagggatac1500cctaaggagatgatggggctccctcttgcctgagcttgcaggattggatcttgggcagat1560cagggcagtggaaacgtcagaccttctacccgtacatacagacgctgaaggaccacaggc1620cccgtgtggtatgggacagccaggctgcggaacacttctttgagtacaagaagaatcgcg1680gcgggaggcacgttgtcttctacccaacgctgaagtctctgcaggtgcggctggagctag1740ccag1744<210>444<211>2157<212>DNA<213>小鼠<400>444cctgctgccctcttgcagacaggaaagacatggtctctgcgcccggatcctacagaagct60catggggagccccagactggcagccttgctcctgtctctcccgctactgctcatcggcct120cgctgtgtctgctcgggttgcctgcccctgcctgcggagttggaccagccactgtctcct180ggcctaccgtgtggataaacgttttgctggccttcagtggggctggttccctctcttggt240gaggaaatctaaaagtcctcctaaatttgaagactattggaggcacaggacaccagcatc300cttccagaggaagctgctaggcagcccttccctgtctgaggaaagccatcgaatttccat360cccctcctcagccatctcccacagaggccaacgcaccaaaagggcccagccttcagctgc420agaaggaagagaacatctccctgaagcagggtcacaaaagtgtggaggacctgaattctc480ctttgatttgctgcccgaggtgcaggctgttcgggtgactattcctgcaggccccaaggc540cagtgtgcgcctttgttatcagtgggcactggaatgtgaagacttgagtagcccttttga600tacccagaaaattgtgtctggaggccacactgtagacctgccttatgaattccttctgcc660ctgcatgtgcatagaggcctcctacctgcaagaggacactgtgaggcgcaaaaagtgtcc720cttccagagctggcctgaagcttatggctcagacttctggcagtcaatacgcttcactga780ctacagccagcacaatcagatggtcatggctctgacactccgctgcccactgaaactgga840ggcctccctctgctggaggcaggacccactcacaccctgcgaaacccttcccaacgccac900agcacaggagtcagaaggatggtatatcctggagaatgtggacttgcacccccagctctg960ctttaagttctcatttgaaaacagcagccacgttgaatgtccccaccagagtggctctct1020cccatcctggactgtgagcatggatacccaggcccagcagctgacgcttcacttttcttc1080gaggacatatgccaccttcagtgctgcctggagtgacccaggtttggggccggatacccc1140catgcctcctgtgtacagcatcagccagacccagggctcagtcccagtgacgctagacct1200catcatccccttcctgaggcaggagaattgcatcctggtgtggaggtcagatgtccattt1260tgcctggaagcacgtcttgtgtcctgatgacgccccttaccctactcagctgttgctccg1320gtccctaggctccggtcgaacaaggccagttttactcctacatgcagcggactcagaggc1380acagcgacgcctggtgggagctttggccgaactgctgcggacggcgctgggaggtggacg1440cgacgtgatcgtggatctctgggaagggacgcacgtagcacgcattggaccactgccgtg1500gctttgggcagcgcgggagcgcgtggcgcgggagcagggcacagtgctgctcctgtggaa1560ctgtgcgggtcccagcaccgcctgcagcggtgacccgcaggctgcgtcccttcgcacctt1620gttgtgcgctgctccacgtccgctgctgctcgcctacttcagtcgcctctgcgccaaagg1680tgacatcccccggccgctgcgcgctctgccacgctaccgcctgcttcgtgacctgccgcg1740cctgctgagagcactggatgctcagcctgccaccctagcctccagctggagtcaccttgg1800ggctaagcggtgcttgaaaaaccgtctggagcagtgtcacctgctggaacttgaggctgc1860caaagatgactaccaaggctcaaccaatagtccctgtggtttcagctgtctgtagcctca1920gcctgtgtagcaacagcaggaactccagaatgaggcctcacacatgtactctttgggggt1980gcttcttgtcccccaaaccgtaagactcaccttaagtcccacacttgaccaacctccctc2040acatttgctccctcttagagttcctgagaggaacttgggctttcctgataggtcctcagc2100cctttctgagaaggagggacgatttttccatttcttttcaaaactgaaaaaaaaaaa2157<210>445<211>2250<212>DNA<213>小鼠<220><221>不確定<222>(2219)...(2219)<400>445aaaagagactccacccactccagtagaccggggactaaaacagaaattctgagaaagcag60caagaagcagaagaaatagctatttcacagcagtaacagaagctacctgctataataaag120acctcaacactgctgaccatgatcagcccagcctggagcctcttcctcatcgggactaaa180attgggctgttcttccaagtggcacctctgtcagttgtggctaaatcctgtccatctgta240tgtcgctgtgacgcaggcttcatttactgtaacgatcgctctctgacatccattccagtg300ggaattccggaggatgctacaacactctaccttcagaacaaccaaataaacaatgttggg360attccttccgatttgaagaacttgctgaaagtacaaagaatatacctataccacaacagt420ttagatgaattccctaccaaccttccaaagtatgtcaaagagttacatttgcaagagaat480aacataaggactatcacctatgattcactttcgaaaattccgtatctggaagagttacac540ttggatgataactcagtctcggctgttagcatcgaagagggagcatttcgagacagtaac600tatctgcggctgctttttctgtcccgtaaccaccttagcacaatcccggggggcttgccc660aggactattgaggaattacgcctggatgacaatcgcatatcaacgatctcttccccatca720cttcatggtctcacaagcctgaaacgcctggttttagatggaaacttgttgaacaaccat780ggtttgggtgacaaagttttcttcaacttagtaaacttaacagagctgtccctggtgagg840aattccttgacagcagcgccagtgaaccttcccggcacaagcctgaggaagctttacctt900caagacaaccatatcaaccgggtacccccaaatgctttttcttatttaaggcagctgtat960cgactcgatatgtctaataataacctaagcaatttacctcagggtatctttgatgatttg1020gacaatataacccaactgattcttcgcaacaatccttggtattgtggatgcaagatgaaa1080tgggtacgagactggttacagtcgctaccggtgaaggtcaatgtgcgtgggctcatgtgc1140caagccccagaaaaggtccgtggaatggctatcaaggacctcagtgcagaactgtttgat1200tgtaaagacagtgggattgtgagcaccattcagataaccactgcaatacccaacacagca1260tatcctgctcaaggacagtggccagctcctgtgaccaaacaaccagatattaaaaacccc1320aagctcattaaggatcagcgaactacaggcagcccctcacggaaaacaattttaattact1380gtgaaatctgtcacccctgacacaatccacatatcctggagacttgctctgcctatgact1440gctctgcgactcagctggcttaaactgggccatagcccagcctttggatctataacagaa1500acaatcgtaacaggagaacgcagtgaatacttggtcaccgccctagaacctgaatcaccc1560tatagagtatgcatggttcccatggaaaccagtaacctttacctgtttgatgaaacacct1620gtttgtattgagacccaaactgcccctcttcgaatgtacaaccccacaaccaccctcaat1680cgagagcaagagaaagaaccttacaaaaatccaaatttacctttggctgccatcattggt1740ggggctgtggccctggtaagcatcgccctccttgctttggtgtgttggtatgtgcatagg1800aacgggtcactgttttcacggaactgtgcgtacagcaaagggcggaggagaaaggatgac1860tatgcagaagccggtactaagaaagacaactccatcctggaaatcagggaaacttctttc1920cagatgctaccgataagcaatgaacccatctccaaggaggagtttgtaatacacaccata1980tttcctccgaatgggatgaatctgtacaagaacaacctcagtgagagcagtagtaaccgg2040agctacagagacagtggcatcccagactcggaccactcacactcatgatgcaaggaggtc2100ccacaccagactgttccgggtttttttttaaaaaacctaagaaaggtgatggtaggaact2160ctgttctactgcaaaacactggaaaagagactgagagaagcaatgtacntgtacatttgc2220catataatttatatttaagaactttttatt2250<210>446<211>1685<212>DNA<213>大鼠<220><221>不確定<222>(1482)...(1482)<400>446gcggctcgggatggcggcccccatggaccggacccatggtggccgggcagcccgggcgct60gcggcgggctctggcgctggcctcgctggccgggctattgctgagcggcctggcgggtgc120tctccccaccctcgggcccggctggcggcgccaaaaccccgagccgccggcctcccgcac180ccgctcgctgctgctggacgccgcttcgggccagctgcgcctggagtacggcttccaccc240cgatgcggtggcctgggctaacctcaccaacgccatccgcgagactgggtgggcctatct300ggacctgggcacaaatggcagctacaagtggatcccccgggctgcaggcctatgcagctg360gtgtggtggaggcctctgtgtccgaggagctcatctacatgcactggatgaacacggtgg420tcaattactgcggccccttcgagtacgaagtcggctactgtgagaagctcaagagcttcc480tggaggccaacctggagtggatgcagagggaaatggagcttagcccggactcgccatact540ggcaccaggtgcggctgaccctcgggctgcagctgaagaggcctggaggacagctatgaa600ggccgtttaaccttcccaactgggaggttcaacatcaaacccttggggttcctcctgctg660caggaatctctggagatctggaagacctagagacagccctgaataagaccaacgaccaag720cgcttccgtgggctccggttcgtgctctgccctcatcaagctgctgcccggcagccatga780tctcctggtggctcacaacacttggaactcctaccagaacatgttacgcatcatcatgga840gtcccccgggctgcagttccgggaggggccgcaagaaggagtaccccctgattgccggca900acaacttgattttttcgtcttacccgggcaccatcttctccggtgatgacttctacatcc960tgggcagtgggctggtcaccctggagaccaccaatcggcaacaaagaacccaagcgctgt1020ggaagtacgtgcaaccccagggctgtgtgctggagtggattcgaaacattgtggccaacc1080cgcctggccttggatggggccacctgggcagatgtcttcaggcggttcaatagtggcacg1140tataataaccagtggatgattgtggactacaaggcattcatccccaatgggcccagccct1200ggaagccgggtgctcaccatcctagaacagatcccgggcatggtggtggtggcatccccc1260gggctgcaggaattcgatatcaagcttatcgatacacgtcgaaccctcgagccaagatct1320tccagagggaccagtcactagtagaggacgtagacaccatggtccggctcatgaggtaca1380atgacttccttcatgaccctctgtcgttgtgtgaggcctgcagcccgaagcccaacgcag1440agaacgccatctctgccccgctctgatctcaaccctgctaantggctcctacccatttca1500ggccctgcgtcagcgcgcccatggcggcattgatgtgaaggtgaccagcgttgcactggc1560taagtacatgagcatgctggcagccagtggccccacgtgggaccagttgccaccgttcca1620gtggagtaaatcaccattccacaacatgctgcacatgggccaagcctgatctttggatgt1680tctca1685<210>447<211>1890<212>DNA<213>大鼠<400>447gcggaagcagccgcaggtatggcggctgccatgccgctgggtttatcgttgctgttgctg60gtgctagtggggcagggctgctgtggccgcgtggagggcccacgcgacagcctgcgagag120gaactcgttatcactccgctgccttccggcgacgtggccgccacattccagttccgcacg180cgttgggattccgatctgcagcgggaaggagtgtcccattacaggctcttccctaaagcc240ctgggacagttgatctccaagtactctctgcgggagctacacctgtcattcacgcaaggc300ttttggaggacccgatactgggggccacccttcctgcaggctccatcaggtgcagagctc360tgggtctggttccaagacactgtcacagatgtggataagtcttggaaggagctcagtaat420gtcctctcagggatcttctgcgcgtccctcaacttcatcgactccaccaataccgtcact480cccacagcctccttcaaacctctggggctggccaatgacactgaccactacttcctgcgc540tatgctgtgctgccccgggaggtcgtctgcaccgagaatctcacgccgtggaagaagctc600ctgccctgtagctccaaggcagggctgtccgtgctactgaaagcagatcgattgttccac660accagttaccactcccaggcagtgcatatccggccaatctgcagaaatgctcactgcacc720agtatctcctgggagctgaggcagaccctttcagttgtctttgatgccttcatcaccgga780caggggaagaaagactggtctctcttccgcatgttctcccggactctcacagaggcctgt840ccattggcatctcagagcctagtttatgtggacatcacaggctacagccaggacaacgaa900acactggaggtgagccctcccccaacttccacataccaggatgtcattttgggcaccagg960aagacctatgccgtctatgacttgtttgacacagccatgatcaataactcccgaaacctc1020aacatccagctcaaatggaagagacccccagataatgaagccctgcccgtgcccttcctg1080catgcacagcggtacgtgagtggttatgggctacagaagggcgagctgagcaccctgttg1140tacaactctcatccttaccgggccttccctgtgctgctactggatgctgtgccctggtac1200ctgcggctgtatgtgcacaccctcaccatcacctccaagggcaaggataataaaccaagt1260tatatccactaccagcctgcccaggaccggcagcagccccacctcctggagatgctcatt1320cagctgccggccaactccgtcaccaaggtctccatccagtttgaacgagccctgctcaag1380tggacagaatacacgccagaccccaaccatggcttctatgtcagcccatctgtcctcagt1440gcccttgtgcccagcatggtggcagccaaaccagtggactgggaagagagccctctcttc1500aacaccttgttcccggtgtctgatggctccagctactttgtccgactctacacagagccc1560ttgctagtgaacctgcccacccccgacttcagcatgccctacaatgtgatctgccttaca1620tgcactgtggtggccgtgtgctatggctccttctacaatctcctcacccgaaccttccac1680attgaagagcccaaatccggcggcctggccaagcggctggctaacctcatccggcgtgct1740cgtggtgttccccctctctaagattccctttcttcagcaactacagcttcatactcacct1800gccccaggggagcagtggcagggctttttctgccatgccctctttccccagagttagctt1860ctgaagctaactccccctggatctggtctg1890<210>448<211>1272<212>DNA<213>大鼠<400>448cggcacgagcggccccgaagggggctgcacgggcgacttggcggcgatggctcgagctcc60ggcggcgacgacggtggccggaggcggcggctcctcctccttctcctcctgggcttgggc120ccggcggtgatccgagctggcggccgcggccccccgatgagactgttggcgggctggctg180tgcctgagcctggcgtccgtgtggctggcgcggaggatgtggacgctgcggagcccgctc240tcccgctctctgtacgtgaacatgactagcggccctggcgggccagcggcggccacgggc300ggcgggaaggacacgcaccagtggtatgtgtgcaacagagagaaattatgcgaatcactt360cagtctgtctttgttcagagttatcttgaccaaggaacacagatcttcttaaacaacagc420attgagaaatctggctggctatttatccaactctatcattcttttgtatcatctgttttt480agcctgtttatgtctagaacatctattaacgggttgctaggaagaggctccatgtttgtg540ttctcaccagatcagtttcagagactgcttaaaattaatccggactggaaaacccataga600cttcttgatttaggtgctggagatggagaagtcacgaaaatcatgagccctcattttgaa660gaaatttatgccactgaactttctgaaacaatgatctggcagctccagaagaagaaatac720agagtgcttggtataaatgaatggcagaatacagggttccagtatgatgtcatcagctgc780ttaaatctgctggatcgctgtgatcagcctctgacattgttaaaagatatcagaagtgtc840ttggagcccacccaaggcagggtcatcctggccttggttttgccctttcatccctatgtg900gaaaacgtaggtggcaagtgggagaaaccatcagaaattctggaaatcaagggacagaat960tgggaagagcaagtgaatagcctgcctgaggtgttcaggaaagctggctttgtcatcgaa1020gctttcactagactgccatacctgtgtgaaggtgacatgtacaatgactactatgttctg1080gacgacgctgtctttgttctcagaccagtgtaaacatgtggaggcccaagtcttcagagt1140cacccctggaatctgccctccagaagaggaggtgcatccagtgatgtgagggggacctct1200ggggactgtcattctcagtatcatgtaggaatttaaaaagccaaaatactaattctttct1260ttgtagtgtgta1272<210>449<211>936<212>DNA<213>大鼠<400>449gggccgccgagtcccgccgggtcggtgtagctcgctgccgacgctgcgacgctcgtgggt60gccgtgttcggcttttcctgtctacttcagtgcaccgctgcagctccggcctcgggtctg120acgcgccacagcatggcttccgctttggaggagttgcagaaagacctagaagaggtcaaa180gtgctgctggaaaagtccactaggaaaagactacgtgatactcttacaaatgaaaaatcc240aagattgagacggaactaaggaacaagatgcagcagaagtcacagaagaaaccagaattt300gataatgaaaagccagctgctgtggttgctcctcttacaacagggtacactgtgaaaatc360agtaattatggatgggatcagtcagataagtttgtgaaaatctacattactttaactgga420gttcatcaggttcctgctgagaatgtgcaagtacacttcacagagaggtcatttgatctt480ttggtaaaaaacctcaatggcaagaattactccatgattgtgaacaatcttttgaaacct540atctctgtggaaagcagttcaaaaaaagtcaagactgatacagttattatcctatgtaga600aagaaagcagaaaacacacgatgggactacttaactcaggtggaaaaagaatgcaaagag660aaagaaaagccttcctacgacactgaggcagatcctagtgagggattaatgaatgttcta720aagaaaatttatgaagatggagatgatgacatgaagcgaaccattaataaagcgtgggtg780gaatcccgagagaagcaagccagggaagacacagaattctgaggctttaaaagtcctgtg840ggaaccgtcatgtggagtgctcgtgtttccagtagggactgttggtgaactgcacacatg900tgttcatgtgggtatgtagttttggacagatgacta936<210>450<211>433<212>DNA<213>小鼠<400>450aaagttctttttcttttctttttcttttttttgtgtgtgtgtgttttggtttgttgttgt60tttggttttcctggaactcactctgtagaccagctagccccaaactcagaaatctgcctc120ccgagtgctgggactaagggtgtgcaccaccactgccctggtgcagatgactcctttaag180gagctagagtaacccttgttcgcctcggtgagagtctgagaatcaggcgctttggctaca240cagctcaatttacacagccaagcctttagcttctatgtgtgctgggcatggacagagcct300cctcatcgccagtgatgatggccgggtttccaggcagccgtggtcctgtctgaatattgt360ctctaactgccacagtttcagagaaaggggaacaagttctcctttgcttcttgccctccc420agatagacccttg433<210>451<211>1225<212>DNA<213>小鼠<400>451agaacattcgagaatatgttcggtggatgatgtattggattgtctttgcgatcttcatgg60cagcagaaaccttcacagacatcttcatttcctggtccggcccaaggattggcaggccat120ggggttgggaagggcctcaccaccaccaccacctggcctctggctcacacaaacccctcc180ccttgcttacacacaggttcccgttttattacgagttcaagatggcttttgtgctgtggc240tgctctcaccttacaccaagggggccagcctgctttaccgaaagtttgtccacccatccc300tatcccgccatgagaaggagatcgacgcatgtatcgtgcaggcaaaggagcgcagctatg360aaaccatgctcagttttgggaagcggagcctcaacatcgctgcctcagctgctgtgcagg420ctgctaccaagagtcaaggcgctctagctggaaggctacggagtttctctatgcaagacc480tgcgctctatccctgacacccctgtccccacctaccaagatcccctctacctggaagacc540aggtaccccgacgtagaccccctattggataccggccaggcggcctgcagggcagtgaca600cagaggatgagtgttggtcagacaatgagattgtcccccagccacctgttgggccccgag660agaagcctctaggccgcagccagagccttcgggtggtcaagaggaagccattgactcgag720agggcacctcacgctccctgaaggtccgaaccccgaaaaaggccatgccctcagacatgg780acagctagagtctgcagattgaggccaccttacctctggagccagcaggggacctttcgc840tgctacaccagctaccggggttctgctccgtctggcttgtgcctaaatggcacatggcgt900ggtaccctgcacagggagacattcactgtaccaaagcagcccaggcctggggcctattta960ttgccttcctctgccttttgctttctcagacatgggaccagagccccaccagtccctacc1020gacgaaaccaaaagtccaaccagctgtgttcattccttcttgtccttcaaaatacttgac1080agccttttccaaggcctggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt1140ttacgtacactagctgcatgtttcgtgttggtgagtgaggtcaggcttatgaatattttt1200atataaataaataccaaacagtgaa1225<210>452<211>445<212>DNA<213>小鼠<400>452caaatgcttacttttctggtgcagaaagattgttgggaacagacaggaaccaatgtggga60attcaacttcaagttcaaaaaacagtcccctaggttaaagagcaagtgtacaggaggatt120gcagcctcccgttcagtacgaagatgttcataccaatccagaccaggactgctgcctact180gcaggtcaccaccctcaatttcatctttattccgattgtcatgggaatgatatttactct240gtttactatcaatgtgagcacggacatgcggcatcatcgagtgagactggtgttccaaga300ttcccctgtccatggtggtcggaaactgcgcagtgaacagggtgtgcaagtcatcctgga360ccagtgcacagcgttcggctctttgactggtggcatcctcagtacccattctccctgaga420gcgtagttactgcttcccatccctt445<210>453<211>2792<212>DNA<213>小鼠<400>453gaagagccgtgcaataatgggtctgaaatccttgcttataacatcgatctgggagacagc60tgcattactgtgggcaacactaccacacacgtgatgaagaacctccttccagaaacgaca120taccggatcagaattcaggctatcaatgaaattggagttggaccatttagtcagttcatt180aaagcaaaaactcggccattaccgccttcgcctcctaggcttgagtgtgctgcgtctggt240cctcagagcctgaagctcaagtggggagacagtaactccaagacacatgctgctggtgac300atggtgtacacactacagctggaagacaggaacaagaggtttatctcaatctaccgagga360cccagccacacctacaaggtccagagactgacagagtttacctgctactccttcaggatc420caggcaatgagcgaggcaggggaggggccttactcagaaacctacaccttcagcacaacc480aaaagcgtgcctcccaccctcaaagcacctcgagtgacgcagttagaagggaattcctgt540gaaatcttctgggagacggtaccaccgatgagaggcgaccctgtgagctacgttctacag600gtgctggttggaagagactctgagtacaagcaggtgtacaagggagaagaagccacattc660caaatctcaggcctccagagcaacacagattacaggttccgcgtgtgtgcctgccgccgc720tgtgtggacacgtctcaggagctcagtggcgcgttcagcccctctgcggctttcatgtta780caacagcgtgaggttatgcttacaggggacctgggaggcatggaagaggccaagatgaag840ggcatgatgcccaccgacgaacagtttgctgcactcatcgtgcttggcttcgcgaccctg900tccattttgtttgcctttatattacagtacttcttaatgaagtaaatccagcaggccagt960ggtatgctcggaacgccacacgttttaatacacatttactcagagcctcccctttttacg1020ctgtttcgttctttgatttatacgcttctcttgttttacacatttagctaggggaaagag1080tttggctgcacctatttgagatgcaaaactaggaagaggttaaactggatttttttttaa1140acaataataaataaaggaataaagaagagaaggaagcggcgggcaagctccagacaccga1200gagccagtgtgcccaacgagcttgccttgtcgggcttccccgtgtgcttctggtctgttc1260ccactgatgtctttcgcaagcctttgatcatcttgtgtgttacagttcagtaatttatat1320tcacagtcatttcttgatcatctatacctgttaacagaatcacagtgtatgtagttcagg1380gctgggattccggtgttgtcagagtattgccacatgagaatattcagtgtgccttcggag1440gaggccacctcgaccatccttacgtcactcagttacgtaactgtgttagctcatctaagt1500caaagtgtgtactttaatctaaaatgttttattactctgtatcccttatgattttaacac1560tatgagttgcctgtctaagaagtcacataaccaaatgcgcctataaatgatagagcattg1620tagattttcacatcggtccatagcagtaactttaagagggcattgtgcaatagttagttg1680tttcttgttcggctactttaaaagctgctttaacttgtctgtctgtctttgtacataact1740acttctaatataatcactagagttattatattctgttatgtttgaccggaattatgtgac1800gagagctcatggcagttgtgaactgtctccttacatgttggcccatcatatttgaaagac1860ttgcctttggctattctttggggtgtcagtgacgtgaatgaagttgaataccatatttca1920gtgcccatgatactaatgtagcagtagatagaaatcttactgataaagcccaccacaagg1980gaaccatttacatttgtcctgtttctgggggcttcatctggccgcatggagagagggagt2040ggaaactggctgtgagcatgagatgtttgggggccaaagagcctactagattctctccct2100gggtctgtcactaatttgctttgtgacctctctgtgcctgttttcccatgcatgagtaat2160caaatcaaatggggattcaatacctgtaagtgctaagagaccttggatccaccggtgcta2220tgtaagtgcggagaatcactctcacggattcacttagagtcatgaggtaatgagttctaa2280cccaaagtcattggatccctcaaccaagtccacaatgttcaagtacctcagggacactta2340agaagttggaggtgcaactgtattccaaaagggtgcgacagacacagccgattcccctct2400tcctgtttttttgtatatttttgctccttggtttttcttgatcatagctactttgtgctt2460ggtctatgttgtctatgatgcagtaagtaccctgtactagcttatactattcccatacca2520aagtcatggggaaaccaacattattttgttttgggtttatttatactctattctgcatac2580agtactttaaatgccaatgacagtgcaatctttatttattgtaatgttaaatgtacttat2640tactaatgtgccctcctagcatgttatattttgtgtgttttatactttttgtaattttag2700gtcagtttagttccttggcaacatctgtagtattagccttctgacatctttcttgtgttt2760ttaaagataagagcatctaactcattaaatgc2792<210>454<211>1808<212>DNA<213>小鼠<400>454gacttctgctagtacttgctcctggcggtggctgagcaaccggtctcaccagcatgctct60gcctgtgcctgtatgtgcccatcgccggggcggctcagactgagttccagtactttgagt120ccaaggggcttcctgccgagctgaaatccatcttcaaactcagtgtctttatcccctctc180aagagttctccacataccgccaatggaagcagaaaattgtgcaagcaggtgacaaggacc240ttgatgggcaactggactttgaagagtttgtacattacctccaagatcatgagaaaaaac300tgaggctggtgttcaagagtctggacaaaaagaatgatggtcgaatcgatgctcaggaga360tcatgcagtccctgcgggacctgggtgtcaagatctcggaacagcaggcggagaagattc420ttaagagcatggataagaatggcacgatgaccatcgactggaacgagtggagggactacc480acctcctgcaccctgtggagaacatcccggagatcatcctgtactggaagcactcgacga540tcttcgatgtcggtgagaatctgacagtcccagatgagttcacagtggaggagaggcaga600cggggatgtggtggaggcacctggtggcaggaggtggggcaggggcagtttccagaacct660gcactgcccccctggacagactgaaggtgctcatgcaggtccatgcctcccgcagcaaca720acatgtgcatcgtaggtggattcacacagatgattcgagaagggggagccaagtcactct780ggcggggcaacggcatcaatgtcctcaaaattgcccctgagtcggccatcaaattcatgg840catatgagcagatgaaacggcttgtcggtagtgatcaggagacgctgaggatccacgaaa900ggcttgtggcaggctccttggccggagccattgcccagagtagcatctacccaatggagg960ttctgaagacccgaatggccctgcggaaaacaggacagtactccggcatgctggactgtg1020ccaggaggatcttggctaaagagggtgtagctgccttctacaaaggctacatccccaaca1080tgctggggatcatcccctatgctggcatcgacctagctgtctatgagacattgaaaaata1140cctggctccagcgctacgcagtaaacagtgcagaccccggtgtgttcgtgctcctggcct1200gtggtactatctccagtacttgtggccagctggccagctacccactagccctggtcagga1260cccggatgcaggcacaagcctccattgagggcgcacctgaggtaaccatgagcagcctct1320tcaaacagattctgcggactgagggggcctttgggctctaccgggggctggcccccaact1380tcatgaaggtgatcccggctgtgagcatcagctacgtggtctacgaaaacctgaagatca1440ccctgggcgtgcagtctcggtgacgggagggtggtggacttggtgagcctgggctgcggc1500ccagggtatgcagccacctcattctgtgaatgtgccaacactaagctgacttacccaagc1560tgtgaaacccaggataccataggggacgggcagggagctggcaagctctgggctggttct1620gctgacctggcagaccttcgtgtctcttccaaggaagacctgtggatgttccttggggtt1680caggggtcagtaagatgtaggctcctgcactagagacaggacgttttcctcagtgcctgc1740cagatagcgagcttggatgccagcttagttcttccatctcgttcactcagccggacctca1800gccacggg1808<210>455<211>1121<212>DNA<213>大鼠<220><221>不確定<222>(1095)...(1095)<400>455gcggtcagaacccgggcttctcgtttgtcctgaacggcactaccagggcggtggaagcag60agatggcggagggcggtgggaggagaggcgtctagtcttgctggctcagcaagcccgata120agcatgaagctgctgtgtttggtggctgtggtggggtgcttgctggtacccccggctcaa180gccaacaagagctctgaagatatccggtgcaaatgcatctgtcccccttacagaaacatc240agcgggcacatttacaaccagaatgtgtctcagaaggactgcaactgcctgcatgtggtg300gagcccatgccggtgcctggccatgatgtggaagcctactgcctgctctgtgagtgtagg360tatgaggagcgcagcaccacaaccatcaaggtcattatcgtcatctacctgtctgtggta420ggggccctcttactctacatggccttcctgatgctggtggaccctctcatccgaaagccg480gatgcctatactgagcagctgcacaatgaagaagagaatgaggatgcccgctccatggct540gccgccgccgcatccattggaggaccccgagcaaacaccgtcctggagcgggtggaaggc600gctcagcagcgatggaagctacaggtgcaggagcagcggaagacggtcttcgatcgacac660aagatgctcagttagatgattgccatggcagtgtcagggacccagacctcggctaccagc720ttctggggcagtcttccctgggtcttcccttcaaatgcccgtggcatttgtccttctccc780tctctctagaaatgtactcgactgttataactagggagtgggattgggtctttggtctct840agtgtctctgtaggtctctggggtagaagggagggaaaggaaggcagaagagaacagaga900tggttgagacggccacacgattggtgaaattcctccctcctgtcctcgccgttcctcaca960gctccacatcttaaggatgtttatagctctttgggagacggagctgtgccgtcaatagct1020cggtgggtgcgacgaaagtgtgacccagccctcagcctgtgctctacgatgccgtggccc1080ccattcccacttttncagtgccaatactttagcttggcctg1121<210>456<211>75<212>蛋白質<213>小鼠<400>456LysProLeuProMetGluAlaHisSerArgArgGluLysAlaSerGly151015LeuArgLeuAlaTrpHisTyrGluCysSerGlyValSerValTrpTrp202530MetCysValLeuGlyTrpLeuSerPheLeuValPheLeuLeuPheSer354045LeuValCysSerPheProSerProIleAsnHisSerHisMetLeuPro505560CysLeuPheLeuArgGlyGlyGlySerAsnVal657075<210>457<211>49<212>蛋白質<213>大鼠<400>457ThrAlaCysArgValSerIleSerValLeuTyrMetLeuHisThrGlu151015LeuLysLysCysTrpPhePheLeuPheCysPheSerLeuPheLeuTrp202530PheCysPheTrpPheCysPheLeuLeuProArgPheAspTyrLeuPro354045Met<210>458<211>296<212>蛋白質<213>小鼠<400>458GlyAlaCysTyrCysProAlaGlyPheLeuGlyAlaAspCysSerLeu151015AlaCysProGlnGlyArgPheGlyProSerCysAlaHisValCysThr202530CysGlyGlnGlyAlaAlaCysAspProValSerGlyThrCysIleCys354045ProProGlyLysThrGlyGlyHisCysGluArgGlyCysProGlnAsp505560ArgPheGlyLysGlyCysGluHisLysCysAlaCysArgAsnGlyGly65707580LeuCysHisAlaThrAsnGlySerCysSerCysProLeuGlyTrpMet859095GlyProHisCysGluHisAlaCysProAlaGlyArgTyrGlyAlaAla100105110CysLeuLeuGluCysSercysGlnAsnAsnGlySerCysGluProThr115120125SerGlyAlaCysLeuCysGlyProGlyPheTyrGlyGlnAlaCysGlu130135140AspThrCysProAlaGlyPheHisGlySerGlyCysGlnArgValCys145150155160GluCysGlnGlnGlyAlaProCysAspProValSerGlyArgCysLeu165170175CysProAlaGlyPheArgGlyGlnPheCysGluArgGlyCysLysPro180185190GlyPhePheGlyAspGlyCysLeuGlnGlnCysAsnCysProThrGly195200205ValProCysAspProIleSerGlyLeuCysLeuCysProProGlyArg210215220AlaGlyThrThrCysAspLeuAspCysArgArgGlyArgPheGlyPro225230235240GlyCysAlaLeuArgCysAspCysGlyGlyGlyAlaAspCysAspPro245250255IleSerGlyGlnCysHisCysValAspSerTyrThrGlyProThrCys260265270ArgGluValProThrGlnLeuSerSerIleArgProAlaProGlnHis275280285SerSerSerLysAlaMetLysHis290295<210>459<211>106<212>蛋白質<213>小鼠<400>459ValGlyThrProTyrTyrMetSerProGluArgIleHisGluAsnGly151015TyrAsnPheLysSerAspIleTrpSerLeuGlyCysLeuLeuTyrGlu202530MetAlaAlaLeuGlnSerProPheTyrGlyAspLysMetAsnLeuTyr354045SerLeuCysLysLysIleGluGlnCysAspTyrProProLeuProSer505560AspHisTyrSerGluGluLeuArgGlnLeuValAsnIleCysIleAsn65707580ProAspProGluLysArgProAspIleAlaTyrValTyrAspValAla859095LysArgMetHisAlaCysThrAlaSerThr100105<210>460<211>53<212>蛋白質<213>小鼠<400>460MetCysAlaGlyHisGlyGlnSerLeuLeuIleAlaSerAspAspGly151015ArgValSerArgGlnProTrpSerCysLeuAsnIleValSerAsnCys202530HisSerPheArgGluArgGlyThrSerSerProLeuLeuLeuAlaLeu354045ProAspArgProLeu50<210>461<211>261<212>蛋白質<213>小鼠<400>461AsnIleArgGluTyrValArgTrpMetMetTyrTrpIleValPheAla151015IlePheMetAlaAlaGluThrPheThrAspIlePheIleSerTrpSer202530GlyProArgIleGlyArgProTrpGlyTrpGluGlyProHisHisHis354045HisHisLeuAlaSerGlySerHisLysProLeuProLeuLeuThrHis505560ArgPheProPheTyrTyrGluPheLysMetAlaPheValLeuTrpLeu65707580LeuSerProTyrThrLysGlyAlaSerLeuLeuTyrArgLysPheVal859095HisProSerLeuSerArgHisGluLysGluIleAspAlaCysIleVal100105110GlnAlaLysGluArgSerTyrGluThrMetLeuSerPheGlyLysArg115120125SerLeuAsnIleAlaAlaSerAlaAlaValGlnAlaAlaThrLysSer130135140GlnGlyAlaLeuAlaGlyArgLeuArgSerPheSerMetGlnAspLeu145150155160ArgSerIleProAspThrProValProThrTyrGlnAspProLeuTyr165170175LeuGluAspGlnValProArgArgArgProProIleGlyTyrArgPro180185190GlyGlyLeuGlnGlySerAspThrGluAspGluCysTrpSerAspAsn195200205GluIleValProGlnProProValGlyProArgGluLysProLeuGly210215220ArgSerGlnSerLeuArgValValLysArgLysProLeuThrArgGlu225230235240GlyThrSerArgSerLeuLysValArgThrProLysLysAlaMetPro245250255SerAspMetAspSer260<210>462<211>138<212>蛋白質<213>小鼠<400>462LysCysLeuLeuPheTrpCysArgLysIleValGlyAsnArgGlnGlu151015ProMetTrpGluPheAsnPheLysPheLysLysGlnSerProArgLeu202530LysSerLysCysThrGlyGlyLeuGlnProProValGlnTyrGluAsp354045ValHisThrAsnProAspGlnAspCysCysLeuLeuGlnValThrThr505560LeuAsnPheIlePheIleProIleValMetGlyMetIlePheThrLeu65707580PheThrIleAsnValSerThrAspMetArgHisHisArgValArgLeu859095ValPheGlnAspSerProValHisGlyGlyArgLysLeuArgSerGlu100105110GlnGlyValGlnValIleLeuAspGlnCysThrAlaPheGlySerLeu115120125ThrGlyGlyIleLeuSerThrHisSerPro130135<210>463<211>314<212>蛋白質<213>小鼠<400>463GluGluProCysAsnAsnGlySerGluIleLeuAlaTyrAsnIleAsp151015LeuGlyAspSerCysIleThrValGlyAsnThrThrThrHisValMet202530LysAsnLeuLeuProGluThrThrTyrArgIleArgIleGlnAlaIle354045AsnGluIleGlyValGlyProPheSerGlnPheIleLysAlaLysThr505560ArgProLeuProProSerProProArgLeuGluCysAlaAlaSerGly65707580ProGlnSerLeuLysLeuLysTrpGlyAspSerAsnSerLysThrHis859095AlaAlaGlyAspMetValTyrThrLeuGlnLeuGluAspArgAsnLys100105110ArgPheIleSerIleTyrArgGlyProSerHisThrTyrLysValGln115120125ArgLeuThrGluPheThrCysTyrSerPhcArgIleGlnAlaMetSer130135140GluAlaGlyGluGlyProTyrSerGluThrTyrThrPheSerThrThr145150155160LysSerValProProThrLeuLysAlaProArgValThrGlnLeuGlu165170175GlyAsnSerCysGluIlePheTrpGluThrValProProMetArgGly180185190AspProValSerTyrValLeuGlnValLeuValGlyArgAspSerGlu195200205TyrLysGlnValTyrLysGlyGluGluAlaThrPheGlnIleSerGly210215220LeuGlnSerAsnThrAspTyrArgPheArgValCysAlaCysArgArg225230235240CysValAspThrSerGlnGluLeuSerGlyAlaPheSerProSerAla245250255AlaPheMetLeuGlnGlnArgGluValMetLeuThrGlyAspLeuGly260265270GlyMetGluGluAlaLysMetLysGlyMetMetProThrAspGluGln275280285PheAlaAlaLeuIleValLeuGlyPheAlaThrLeuSerIleLeuPhe290295300AlaPheIleLeuGlnTyrPheLeuMetLys305310<210>464<211>1663<212>DNA<213>小鼠<400>464gcagcacccagcgccaagcgcaccaggcaccgcgacagacggcaggagcacccatcgacg60ggcgtactggagcgagccgagcagagcagagagaggcgtgcttgaaaccgagaaccaagc120cgggcggcatcccccggccgccgcacgcacaggccggcgccctccttgcctccctgctcc180ccaccgcgcccctccggccagcatgaggctcctggcggccgcgctgctcctgctgctcct240ggcgctgtgcgcctcgcgcgtggacgggtccaagtgtaagtgttcccggaaggggcccaa300gatccgctacagcgacgtgaagaagctggaaatgaagccaaagtacccacactgcgagga360gaagatggttatcgtcaccaccaagagcatgtccaggtaccggggccaggagcactgcct420gcaccctaagctgcagagcaccaaacgcttcatcaagtggtacaatgcctggaacgagaa480gcgcagggtctacgaagaatagggtggacgatcatggaaagaaaaactccaggccagttg540agagacttcagcagaggactttgcagattaaaataaaagccctttctttctcacaagcat600aagacaaattatatattgctatgaagctcttcttaccagggtcagtttttacattttata660gctgtgtgtgaaaggcttccagatgtgagatccagctcgcctgcgcaccagacttcatta720caagtggctttttgctgggcggttggcggggggcggggggacctcaagcctttccttttt780aaaataaggggttttgtatttgtccatatgtcaccacacatctgagctttataagcgcct840gggaggaacagtgagcatggttgagaccgttcacagcactactgctccgctccaggctta900caaagcttccgctcagagagcctggcggctctgtgcagctgccacaggctctcctgggct960tatgactggtcagagtttcagtgtgactccactgtggcccctgttgcagggcaattggga1020gcaggtccttctacatctgtgcctagaggaactcagtctacttaccagaaggagcttcat1080ccccaccccacccccacccgcaccccagctcattcccctgtcacgaccaggcaagtgatc1140cttaaaggagctgggtctttttcttgcaaactgagggtttctgaaaggtcggctgctttg1200gtagaagatgcttctgaggcatccaaagtccccagcagtgtgagaaaatgattctcgatg1260ttcgggaggacaagggaagatgcaggattagatgcaggacacacagccagagctacacat1320cctcttggcaatgggagctccccccccccaaagctttgtttctttccctcaccccaacag1380aaagtgcactccccctcagtgaatacgcaaacagcactgttctctgagttaggatgttag1440gacgatcctgcgccctgccctctcctgtgtacatattgccttcagtacccctcccccacc1500ccatgccacacactgcccctcattagaggccgcactgtatggctgtgtatctgctatgta1560aatgctgagacccctgagtgctgcatgcaggtttcatgttctttctaagatgaaaagaga1620aagtaataaaatatatttgaagttccccaaaaaaaaaaaaaaa1663<210>465<211>99<212>蛋白質<213>小鼠<400>465MetArgLeuLeuAlaAlaAlaLeuLeuLeuLeuLeuLeuAlaLeuCys151015AlaSerArgValAspGlySerLysCysLysCysSerArgLysGlyPro202530LysIleArgTyrSerAspValLysLysLeuGluMetLysProLysTyr354045ProHisCysGluGluLysMetValIleValThrThrLysSerMetSer505560ArgTyrArgGlyGlnGluHisCysLeuHisProLysLeuGlnSerThr65707580LysArgPheIleLysTrpTyrAsnAlaTrpAsnGluLysArgArgVal859095TyrGluGlu權利要求1.一種分離的多核苷酸，它包含選自以下的核苷酸序列(a)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述的序列；(b)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的互補序列；(c)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向互補序列；(d)SEQIDNO1-119、198-276、349-372、399-405、410-412、416、418-455和464描述序列的反向序列；(e)根據使用上述工作參數的計算機算法BLASTP測定，與選自以上(a)-(d)中的任一種序列相同的可能性至少為99％的序列；以及(f)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與選自以上(a)-(d)中的任一種序列的同一性至少為50％的核苷酸序列。2.一種表達載體，它包含權利要求1的分離多核苷酸。3.一種宿主細胞，它是用權利要求2的表達載體轉化的宿主細胞。4.一種分離的多肽，它包含選自以下的氨基酸序列(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；(b)根據使用上述工作參數的計算機算法BLASTP測定，與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列相同的可能性至少為99％的序列；以及(c)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列的同一性至少為50％的序列。5.一種分離的多核苷酸，它編碼權利要求4的多肽。6.一種表達載體，它包含權利要求5的分離多核苷酸。7.一種宿主細胞，它是用權利要求6的表達載體轉化的宿主細胞。8.一種分離的多肽，它至少包含具有選自以下的氨基酸序列的多肽的功能部分(a)SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列；(b)根據使用上述工作參數的計算機算法BLASTP測定，與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465序列相同的可能性至少為99％的序列；以及(c)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO120-197、275-348、373-398、406-409、413-415、417、456-463和465提供的序列的同一性至少為50％的序列。9.一種刺激患者角質細胞生長和運動的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。10.權利要求9的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、342、343、395、397和398；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO187、196、342、343、395、397和398序列的同一性至少為約50％的序列。11.一種抑制患者癌細胞生長的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。12.權利要求11的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO187、196、342、343、397和398序列的同一性至少為50％的序列。13.一種調節患者血管發生的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。14.權利要求13的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO187、196、342、343、397和398序列的同一性至少為50％的序列。15.一種抑制患者腫瘤血管發生和血管形成的方法，該方法包括給予患者含權利要求4的多肽的組合物。16.權利要求15的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、342、343、397和398；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO187、196、340、342-346、397和398序列的同一性至少為50％的序列。17.一種調節患者皮膚炎癥的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。18.權利要求17的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO338和347；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO338和347序列的同一性至少為50％的序列。19.一種刺激患者上皮細胞生長的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。20.權利要求19的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO129和348；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO129和348序列的同一性至少為50％的序列。21.一種抑制患者體內HIV-1結合白細胞的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。22.權利要求21的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO340、344、345、346和465序列的同一性至少為50％的序列。23.一種治療患者炎癥性疾病的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。24.權利要求23的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO340、344、345、346和465序列的同一性至少為50％的序列。25.一種治療患者癌癥的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。26.權利要求25的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO340、344、345、346和465；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO340、344、345、346和465序列的同一性至少為50％的序列。27.一種治療患者神經性疾病的方法，該方法包括給予所述患者含權利要求4的多肽的組合物。28.權利要求27的方法，其中所述多肽包含選自以下的氨基酸序列(a)SEQIDNO187、196、340、342-346、397和398；(b)根據使用上述工作參數的計算機算法BLASTP和以上定義的同一性測試測定，與SEQIDNO187、196、340、342-346、397和398序列的同一性至少為50％的序列。全文摘要本發明提供編碼哺乳動物皮膚細胞表達的多肽的分離多核苷酸以及包含所述分離多核苷酸的表達載體和宿主細胞。本發明還提供使用所述多核苷酸和多肽的方法。文檔編號A61K48/00GK1373774SQ00810237公開日2002年10月9日申請日期2000年5月15日優先權日1999年5月14日發明者J·D·瓦特森,L·斯特拉錢,R·安魯斯特,M·斯勒曼,K·D·庫姆布勒,J·G·穆里森申請人:吉尼西斯研究及發展有限公司